Page last updated: 2024-08-21

oleanolic acid and Insulin Resistance

oleanolic acid has been researched along with Insulin Resistance in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (13.64)29.6817
2010's14 (63.64)24.3611
2020's5 (22.73)2.80

Authors

AuthorsStudies
Auwerx, J; Genet, C; Lobstein, A; Mioskowski, C; Saladin, R; Sato, H; Strehle, A; Thomas, C; Wagner, A1
Bae, K; Ha, do T; Ngoc, TM; Nhiem, NX; Thu, NB; Tuan, DT; Yim, N1
Deguchi, T; Hashiguchi, H; Kawade, S; Nishio, Y; Ogiso, K; Shayo, SC1
Gu, J; Min, Z; Wang, R; Wang, S; Yan, Y1
Claro-Cala, CM; de Sotomayor, MA; Herrera, MD; Miñano, J; Pérez-Montero, M; Quintela, JC; Rodríguez-Rodríguez, AR1
Bi, C; Dong, N; Li, Y; Lv, H; Shan, A; Wang, J; Xue, C; Zhang, L1
Alves, APNN; Carvalho, AA; Chaves, MH; Fonseca, SGC; Lima, RP; Nunes, PIG; Oliveira, FTB; Rao, VS; Santos, FA; Silva, RAC; Viana, AFSC; Viana, DA1
Cao, M; Cheng, X; Fan, J; Hai, C; Hao, Y; Li, G; Li, S; Long, Z; Peng, J; Su, H; Su, S; Wang, X; Wu, G; Xu, Z1
Du, LB; Hai, CX; Jin, L; Li, WL; Liao, N; Pauluhn, J; Peng, J; Wang, S; Wang, X; Wang, Z; Zhang, JL; Zhao, YY1
Bishayee, A; Deshmukh, RR; Kumar, P; Kumar, S; Sharma, H1
Hai, C; Li, W; Liao, N; Liu, R; Qin, X; Wang, X; Wang, Z; Zhang, W; Zhang, X1
Gu, T; Li, Y; Wang, J; Yamahara, J1
Cai, J; Guo, J; Zhao, L; Zhu, E1
Cui, J; Jia, N; Li, Y; Wen, A; Wu, Y; Xi, M; Zhang, T1
Camer, D; Cheng, L; Dinh, CH; Huang, XF; Szabo, A; Wang, H; Yu, Y1
Duarte, MF; Oliveira, PJ; Silva, FS1
Dinda, AK; Gupta, YK; Maulik, SK; Prabhakar, P; Reeta, KH1
Fussenegger, M; Shao, J; Wang, Y; Xie, M; Xue, S; Yang, L; Ye, H; Yin, J; Yu, Y1
Anand, S; Balakrishnan, A; Lakshmi, BS; Muthusamy, VS; Nithya, N; Sangeetha, KN; Sujatha, S; Velmurugan, D1
Cao, PP; Hai, CX; Hu, JX; Li, YL; Liang, X; Liao, N; Liu, JZ; Peng, J; Wang, X; Wu, H1
Jyothi Kumari, P; Lakshmi, BS; Sangeetha, KN; Shilpa, K1
Mitsuyoshi, H; Nakashima, T; Okanoue, T; Sumida, Y1

Reviews

3 review(s) available for oleanolic acid and Insulin Resistance

ArticleYear
Pentacyclic triterpenes: New tools to fight metabolic syndrome.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Nov-15, Volume: 50

    Topics: Animals; Heart; Humans; Insulin Resistance; Liver; Metabolic Syndrome; Muscle, Skeletal; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid

2018
Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?
    Journal of agricultural and food chemistry, 2016, Apr-20, Volume: 64, Issue:15

    Topics: Anti-Inflammatory Agents; Betulinic Acid; Body Weight; Diabetes Mellitus, Type 2; Dietary Supplements; Hypoglycemic Agents; Illusions; Insulin Resistance; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes

2016
[Treatment of nonalcoholic steatohepatitis (NASH)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2004, Volume: 101, Issue:11

    Topics: Cysteine; Diet; Drug Combinations; Fatty Liver; Glycine; Hepatitis; Humans; Insulin Resistance; Liver Transplantation; Obesity; Oleanolic Acid; Oxidative Stress; Ursodeoxycholic Acid; Vitamin E

2004

Other Studies

19 other study(ies) available for oleanolic acid and Insulin Resistance

ArticleYear
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea.
    Biochemical and biophysical research communications, 2007, Nov-03, Volume: 362, Issue:4

    Topics: Administration, Oral; Animals; Hyperglycemia; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Olea; Plant Extracts; Receptors, G-Protein-Coupled; Treatment Outcome

2007
Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.
    Bioorganic & medicinal chemistry letters, 2009, Oct-01, Volume: 19, Issue:19

    Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin Resistance; Paeonia; Phosphorylation; Terpenes; Triterpenes

2009
Repeated glucose spikes and insulin resistance synergistically deteriorate endothelial function and bardoxolone methyl ameliorates endothelial dysfunction.
    PloS one, 2022, Volume: 17, Issue:1

    Topics: Animals; Aorta, Thoracic; Blood Glucose; Diet, Western; Endothelium, Vascular; Insulin Resistance; Male; Metabolic Syndrome; NF-E2-Related Factor 2; Oleanolic Acid; Rats; Rats, Wistar

2022
Effect of Nano-Oleanolic Acid Combined With Lipid-Lowering Ketones on Insulin Resistance in Rats with Gestational Diabetes.
    Journal of biomedical nanotechnology, 2022, Feb-01, Volume: 18, Issue:2

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Humans; Insulin Resistance; Ketones; Lipids; Oleanolic Acid; Pregnancy; Rats

2022
Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice.
    Nutrients, 2020, Jan-26, Volume: 12, Issue:2

    Topics: Adiposity; Animals; Aorta, Thoracic; Biomarkers; Blood Glucose; Diet, High-Fat; Diet, Mediterranean; Disease Models, Animal; Disease Progression; Insulin Resistance; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Olive Oil; Triterpenes; Vasoconstriction; Vasodilation; Weight Gain

2020
Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis.
    Journal of agricultural and food chemistry, 2021, Jul-21, Volume: 69, Issue:28

    Topics: Animals; Diet, High-Fat; Insulin Resistance; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleanolic Acid; Rats

2021
α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2021, Volume: 54, Issue:10

    Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Insulin Resistance; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleanolic Acid; Sterol Regulatory Element Binding Protein 1

2021
Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling.
    Free radical biology & medicine, 2018, 08-20, Volume: 124

    Topics: 3T3-L1 Cells; Adiposity; Animals; Antithyroid Agents; Cell Differentiation; Chlorodiphenyl (54% Chlorine); Diet, High-Fat; Gene Expression Regulation; Hepatocyte Nuclear Factor 1-beta; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Obesity; Oleanolic Acid; Oxidation-Reduction; PPAR gamma; Signal Transduction

2018
Nano-oleanolic acid alleviates metabolic dysfunctions in rats with high fat and fructose diet.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Animals; Diet, High-Fat; Fructose; Insulin Resistance; Lipid Metabolism; Liver; Male; Metabolic Diseases; Nanoparticles; Oleanolic Acid; Oxidative Stress; Pancreas; Rats, Sprague-Dawley

2018
Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects.
    Molecular and cellular endocrinology, 2013, Aug-25, Volume: 376, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gluconeogenesis; Hypolipidemic Agents; Injections, Intraperitoneal; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Transgenic; Mitochondrial Turnover; Oleanolic Acid; Organ Size; Reactive Oxygen Species

2013
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats.
    Toxicology and applied pharmacology, 2014, Jun-01, Volume: 277, Issue:2

    Topics: Adipose Tissue; Animals; Biomarkers; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Fatty Acids, Nonesterified; Fructose; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Oleanolic Acid; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors

2014
Stimulating effect of a new triterpene derived from Anoectochilus elwesii on glucose uptake in insulin-resistant human HepG2 cells.
    Natural product research, 2014, Volume: 28, Issue:23

    Topics: Biological Transport; Cell Survival; Drugs, Chinese Herbal; Glucose; Hep G2 Cells; Humans; Insulin Resistance; Models, Animal; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Orchidaceae

2014
Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:7

    Topics: Animals; Aralia; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Oleanolic Acid; Oxidation-Reduction; Plant Bark; Plant Roots; Rats; Rats, Wistar; Saponins; Streptozocin; Triglycerides

2015
Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet.
    Molecular and cellular endocrinology, 2015, Sep-05, Volume: 412

    Topics: Animals; Cell Movement; Diet, High-Fat; Fatty Liver; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Macrophages; Male; Mice, Inbred C57BL; Obesity; Oleanolic Acid

2015
α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017, Volume: 42, Issue:1

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Antioxidants; Diet, Carbohydrate Loading; Dose-Response Relationship, Drug; Fructose; Gene Expression Regulation; Hyperglycemia; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Liver; Male; Metabolic Syndrome; Oleanolic Acid; Oxidative Stress; PPAR alpha; Random Allocation; Rats, Wistar

2017
A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 02-01, Volume: 25, Issue:2

    Topics: Animals; Cell Engineering; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Design; Gene Expression Regulation; Gene Regulatory Networks; Genetic Engineering; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Liver Diseases; Male; Mice; Mice, Transgenic; Oleanolic Acid; Synthetic Biology

2017
3beta-taraxerol of Mangifera indica, a PI3K dependent dual activator of glucose transport and glycogen synthesis in 3T3-L1 adipocytes.
    Biochimica et biophysica acta, 2010, Volume: 1800, Issue:3

    Topics: 3T3 Cells; Adipocytes; Animals; Blood Glucose; Cell Survival; Deoxyglucose; Diabetes Mellitus, Type 2; Enzyme Activation; Glucose; Glycogen; Humans; Insulin Resistance; Mangifera; Mice; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Plant Extracts

2010
Antidiabetic effect of oleanolic acid: a promising use of a traditional pharmacological agent.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:7

    Topics: Animals; Antioxidants; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Membrane Potential, Mitochondrial; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction

2011
Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2013, Feb-15, Volume: 20, Issue:3-4

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Glucose; Glucose Transporter Type 4; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Mangifera; Mice; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phytotherapy; Plant Extracts; Rosiglitazone; Thiazolidinediones

2013