Page last updated: 2024-11-13

oleoylcarnitine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

oleoylcarnitine: adenine nucleotide translocase antagonist; RN given refers to (Z)-(+-)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(R)-oleoylcarnitine : An O-acyl-L-carnitine in which the acyl group is specified as oleoyl. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID46907933
CHEMBL ID4531406
CHEBI ID84651
MeSH IDM0088054

Synonyms (35)

Synonym
oleoylcarnitine
oleoyl l-carnitine
(r)-[(9z)-octadecenoyl]carnitine
38677-66-6
o-(9z)-octadecenoyl-(r)-carnitine
(9z)-octadecenoyl-l-carnitine
(3r)-3-{[(9z)-octadec-9-enoyl]oxy}-4-(trimethylazaniumyl)butanoate
(r)-oleoylcarnitine
oleoyl-l-carnitine
CHEBI:84651
c18:1(.delta.9-cis) carnitine
IPOLTUVFXFHAHI-WHIOSMTNSA-N
1-propanaminium, 3-carboxy-n,n,n-trimethyl-2-(((9z)-1-oxo-9-octadecenyl)oxy)-, inner salt, (2r)-
oleoyllevocarnitine
1-propanaminium, 3-carboxy-n,n,n-trimethyl-2-((1-oxo-9-octadecenyl)oxy)-, inner salt, (r-(z))-
oleoylcarnitine, (-)-
IQ19DDF3A0 ,
unii-iq19ddf3a0
(z)-(+-)-3-carboxy-n,n,n-trimethyl-2-((1-oxo-9-octadecenyl)oxy)-1-propanaminium
c18:1(delta9-cis) carnitine, oleoyl l-carnitine, powder
oleoyl-l-carnitine, analytical standard
c18:1(delta9-cis) carnitine, oleoyl l-carnitine, chloroform
o-oleoyl-l-carnitine
HY-113261
Q27157965
(3r)-3-[(z)-octadec-9-enoyl]oxy-4-(trimethylazaniumyl)butanoate
CS-0059453
bdbm50537046
CHEMBL4531406 ,
MS-27503
9-octadecenoyl carnitine
XO160382
l-oleoylcarnitine
DTXSID501033061
AKOS040733903
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
glycine transporter 2 inhibitorAny glycine transporter inhibitor that interferes with the action of glycine 2 transporters.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
monounsaturated fatty acyl-L-carnitineAn O-acylcarnitine in which the R is a monounsaturated fatty acyl chain.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)IC50 (µMol)0.34000.026012.7472128.0000AID1638510
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
neurotransmitter transportSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
chemical synaptic transmissionSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
synaptic transmission, glycinergicSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
glycine import across plasma membraneSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
sodium ion transmembrane transportSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
glycine:sodium symporter activitySodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
metal ion bindingSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
endosomeSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
plasma membraneSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
membraneSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
dense core granuleSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
presynaptic membraneSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
glycinergic synapseSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
plasma membraneSodium- and chloride-dependent glycine transporter 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1638510Reversible non-competitive inhibition of human GlyT2a expressed in Xenopus laevis oocytes by two-electrode voltage clamp electrophysiology2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (22.22)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.29

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.29 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index29.12 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.29)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]