deferoxamine has been researched along with Insulin Resistance in 5 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during obesity induced by diet in mice." | 8.31 | Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction. ( Caria, CREP; de Morais, TR; Ferreira, APT; Gambero, A; Gotardo, EMF; Ribeiro, ML, 2023) |
| "Cardiovascular diseases are a common cause of morbidity and mortality in subjects on regular hemodialysis." | 5.40 | Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload. ( Alnahal, AA; Fathy, A; Fathy, T; Tahan, M, 2014) |
| "In this work, we analyzed deferoxamine effects on adipose tissue fibro-inflammation during obesity induced by diet in mice." | 4.31 | Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction. ( Caria, CREP; de Morais, TR; Ferreira, APT; Gambero, A; Gotardo, EMF; Ribeiro, ML, 2023) |
| " The iron chelator deferoxamine dramatically inhibited PA-induced insulin resistance, and iron donors impaired insulin sensitivity by activating JNK." | 3.91 | Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells. ( Choi, SE; Cui, R; Jeon, JY; Kang, Y; Kim, HJ; Kim, TH; Lee, HJ; Lee, KW; Lee, SJ, 2019) |
| "Deferiprone was the most effective chelator to improve glucose homeostasis in chronically transfused thalassemics." | 1.48 | Glucose Homeostasis and Effect of Chelation on β Cell Function in Children With β-Thalassemia Major. ( Bagmar, S; Dabas, A; Gomber, S; Madhu, SV, 2018) |
| "Cardiovascular diseases are a common cause of morbidity and mortality in subjects on regular hemodialysis." | 1.40 | Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload. ( Alnahal, AA; Fathy, A; Fathy, T; Tahan, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gotardo, EMF | 1 |
| de Morais, TR | 1 |
| Ferreira, APT | 1 |
| Caria, CREP | 1 |
| Ribeiro, ML | 1 |
| Gambero, A | 1 |
| Gomber, S | 1 |
| Dabas, A | 1 |
| Bagmar, S | 1 |
| Madhu, SV | 1 |
| Cui, R | 1 |
| Choi, SE | 1 |
| Kim, TH | 1 |
| Lee, HJ | 1 |
| Lee, SJ | 1 |
| Kang, Y | 1 |
| Jeon, JY | 1 |
| Kim, HJ | 1 |
| Lee, KW | 1 |
| Alnahal, AA | 1 |
| Tahan, M | 1 |
| Fathy, A | 1 |
| Fathy, T | 1 |
| Fargion, S | 1 |
| Dongiovanni, P | 1 |
| Guzzo, A | 1 |
| Colombo, S | 1 |
| Valenti, L | 1 |
| Fracanzani, AL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Gut Hormones and Hepcidin in Type 2 Diabetes Mellitus[NCT02413762] | 1,512 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for deferoxamine and Insulin Resistance
| Article | Year |
|---|---|
Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction.
Topics: Adipose Tissue; Animals; Deferoxamine; Humans; Inflammation; Insulin Resistance; Liver; Mice; Mice, | 2023 |
Glucose Homeostasis and Effect of Chelation on β Cell Function in Children With β-Thalassemia Major.
Topics: Adolescent; beta-Thalassemia; Blood Glucose; Chelation Therapy; Child; Child, Preschool; Deferiprone | 2018 |
Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.
Topics: Adult; Animals; Antigens, CD; Case-Control Studies; Cells, Cultured; Deferoxamine; Diabetes Mellitus | 2019 |
Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload.
Topics: Adult; Biomarkers; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Carotid Intima-Media Thic | 2014 |
Iron and insulin resistance.
Topics: Cell Line, Tumor; Deferoxamine; Diet; Energy Intake; Fatty Liver; Female; Gene Expression; Glucokina | 2005 |