1,2,3,7,8-pentachlorodibenzo-p-dioxin profile

1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), also known as **pentaCDD**, is a highly toxic and persistent organic pollutant belonging to the family of **dioxins**.

**Here's why it's important for research:**

* **Environmental Contamination:** PeCDD is a by-product of various industrial processes, including waste incineration, chemical manufacturing, and metal processing. It can accumulate in the environment and pose risks to human health and ecosystems.

* **Human Health Risks:** PeCDD is a potent **carcinogen**, meaning it can cause cancer. It also disrupts the endocrine system, potentially leading to developmental and reproductive problems. Exposure to PeCDD has been linked to immune suppression, liver damage, and other health issues.

* **Environmental Persistence:** PeCDD is highly resistant to breakdown in the environment. It can persist for decades in soil, water, and air, posing long-term threats to wildlife and human health.

* **Bioaccumulation:** PeCDD can accumulate in food chains, leading to higher concentrations in organisms at the top of the food web, including humans.

**Research on PeCDD focuses on:**

* **Understanding its environmental fate and transport:** Researchers study how PeCDD moves through the environment, how it transforms, and where it accumulates.
* **Assessing human exposure:** Studies aim to identify sources of human exposure to PeCDD, quantify exposure levels, and develop strategies to minimize risk.
* **Developing remediation technologies:** Researchers work on methods to remove or neutralize PeCDD from contaminated sites and prevent further contamination.
* **Developing analytical methods:** Research is ongoing to improve analytical methods for detecting and quantifying PeCDD in environmental and biological samples.
* **Investigating biological effects:** Scientists study the mechanisms of PeCDD toxicity, including its interaction with cellular receptors and its effects on gene expression.

**PeCDD research is crucial for protecting human health and the environment.** It helps us understand the risks associated with this pollutant, develop effective remediation strategies, and inform policies aimed at preventing further contamination.

ID Source	ID
PubMed CID	38439
CHEMBL ID	137220
CHEBI ID	81501
SCHEMBL ID	2885718
MeSH ID	M0146430

Synonym
dibenzo-p-dioxin, 1,2,3,7,8-pentachloro-
1,2,3,7,8-pentachlorodibenzodioxin
brn 1626844
1,2,3,7,8-pentachlorodibenzo(b,e)(1,4)dioxin
1,2,3,7,8-pentachlorodibenzo-p-dioxin
1,2,3,7,8-pentachloro-dibenzo[1,4]dioxine
CHEMBL137220 ,
chebi:81501 ,
1,2,3,7,8-pecdd
40321-76-4
C18099
pcdd 54
1,2,3,7,8-pncdd
bdbm50408363
FT-0673578
2ne6h0qpch ,
unii-2ne6h0qpch
dibenzo(b,e)(1,4)dioxin, 1,2,3,7,8-pentachloro-
1,2,3,7,8-pentachlorodibenzo(b,e)(1,4)dioxin [mi]
1,2,3,7,8-pcdd
SCHEMBL2885718
DTXSID7052078
FSPZPQQWDODWAU-UHFFFAOYSA-N
1,2,3,7,8-pentachlorooxanthrene #
Q27155426
1,2,3,7,8-penta-chlorodibenzo-p-dioxin
1,2,3,7,8-pentachlorodibenzo-p-dioxin 50 microg/ml in nonane

Excerpt	Reference	Relevance
"Male Sprague-Dawley rats were treated with an LD20, LD50 and LD80 respectively, of tetra-, penta-, hexa-, hepta-CDD and a mixture of the four CDDs, all carrying chlorine substituents in the biologically crucial 2, 3, 7, and 8 positions."	( Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part II: Structure-activity relationships with inhibition of hepatic phosphoenolpyruvate carboxykinase, pyruvate carboxylase, and gamma-glutamyl transpeptidase activities Kettrup, A; Lebofsky, M; Rozman, K; Stahl, BU; Weber, LW, 1992)	0.28
" The obtained LD50 value and (TEF) was for tetra-CDD 43 micrograms/kg (1), penta-CDD 206 micrograms/kg (0."	( Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part I: Acute toxicity and toxic equivalency factors (TEFs). Kettrup, A; Rozman, K; Stahl, BU, 1992)	0.28
"The toxic equivalent (TEQ) approach is traditionally used in risk evaluation of dioxins."	( Factorial design applied for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes. Eide, I; Olsvik, PA; Søfteland, L, 2009)	0.35

Excerpt	Relevance	Reference
" By 8 days after dosing PEPCK activities were dose-dependently decreased after administration of all four CDDs and their mixture."	( Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part II: Structure-activity relationships with inhibition of hepatic phosphoenolpyruvate carboxykinase, pyruvate carboxylase, and gamma-glutamyl transpeptidase activities Kettrup, A; Lebofsky, M; Rozman, K; Stahl, BU; Weber, LW, 1992)	0.28
" The dose-response to the mixture confirmed the hypothesis of strict additivity in the acute toxicity of the four CDD homologues."	( Comparative toxicity of four chlorinated dibenzo-p-dioxins (CDDs) and their mixture. Part I: Acute toxicity and toxic equivalency factors (TEFs). Kettrup, A; Rozman, K; Stahl, BU, 1992)	0.28
"Treatment of 25-day-old female Sprague-Dawley rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly lowered constitutive uterine peroxidase activity and decreased uterine wet weights in a dose-response fashion."	( 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Astroff, B; Safe, S, 1990)	0.28
" In the PHAH-group dosed 1 microgram TEQ/kg body wt/week, the volume fraction of the liver occupied by foci was significantly lower compared to the TEQ equivalent dosed TCDD group (3."	( Induction of altered hepatic foci by a mixture of dioxin-like compounds with and without 2,2',4,4',5,5'-hexachlorobiphenyl in female Sprague-Dawley rats. Brouwer, A; Haag-Grönlund, M; Koeman, JH; Scheu, G; van den Berg, M; van der Plas, SA; Wärngård, L; Wester, P, 1999)	0.3
" The slopes of the dose-response curves generated by individual PCDDs and/or their mixture were similar."	( Toxic equivalency factors of polychlorinated dibenzo-p-dioxins in an ovulation model: validation of the toxic equivalency concept for one aspect of endocrine disruption. Gao, X; Rozman, KK; Son, DS; Terranova, PF, 1999)	0.3
" The estimated parameters indicated that congener-specific dose-response shapes were significantly different, that additivity failed for these congeners, and that the ratios of ED50's did not predict the response seen for the mixture."	( Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds. Bailer, AJ; Portier, CJ; Toyoshiba, H; Walker, NJ, 2004)	0.32
" The value of acute median lethal dosage (LD50) of 1,2,3,7,8-PeCDD was determined in acute lethality tests."	( The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo. Liu, Z; Sun, W; Wang, L; Xiao, F; Yang, Y; Zhao, Y; Zheng, M, 2008)	0.35
" Primary hepatocyte cultures from Atlantic salmon were exposed for 24h and qPCR was employed to create CYP1A dose-response curves and to quantify the transcriptional levels of eight genes (CYP1A, UDPGT, HSP70, GR, GPX, MnSOD, GST and p53)."	( Factorial design applied for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes. Eide, I; Olsvik, PA; Søfteland, L, 2009)	0.35

Class	Description
polychlorinated dibenzodioxine	Any dibenzodioxine in which two or more hydrogens have been replaced by chlorines.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cytochrome P450 1A1	Rattus norvegicus (Norway rat)	EC50 (µMol)	0.0794	0.0015	2.2057	10.0000	AID39064
Aryl hydrocarbon receptor	Homo sapiens (human)	EC50 (µMol)	0.0794	0.0015	1.9769	10.0000	AID39064
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
blood vessel development	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of adaptive immune response	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of T cell mediated immune response to tumor cell	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Aryl hydrocarbon receptor	Homo sapiens (human)
xenobiotic metabolic process	Aryl hydrocarbon receptor	Homo sapiens (human)
apoptotic process	Aryl hydrocarbon receptor	Homo sapiens (human)
response to xenobiotic stimulus	Aryl hydrocarbon receptor	Homo sapiens (human)
response to toxic substance	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of gene expression	Aryl hydrocarbon receptor	Homo sapiens (human)
cAMP-mediated signaling	Aryl hydrocarbon receptor	Homo sapiens (human)
intracellular receptor signaling pathway	Aryl hydrocarbon receptor	Homo sapiens (human)
regulation of B cell proliferation	Aryl hydrocarbon receptor	Homo sapiens (human)
circadian regulation of gene expression	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Aryl hydrocarbon receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Aryl hydrocarbon receptor	Homo sapiens (human)
negative regulation of inflammatory response	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to molecule of bacterial origin	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to cAMP	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to forskolin	Aryl hydrocarbon receptor	Homo sapiens (human)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nuclear receptor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription cis-regulatory region binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Aryl hydrocarbon receptor	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
TFIID-class transcription factor complex binding	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription coactivator binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
DNA-binding transcription factor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
nuclear receptor activity	Aryl hydrocarbon receptor	Homo sapiens (human)
protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
TBP-class protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
protein homodimerization activity	Aryl hydrocarbon receptor	Homo sapiens (human)
protein heterodimerization activity	Aryl hydrocarbon receptor	Homo sapiens (human)
Hsp90 protein binding	Aryl hydrocarbon receptor	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Aryl hydrocarbon receptor	Homo sapiens (human)
E-box binding	Aryl hydrocarbon receptor	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Aryl hydrocarbon receptor	Homo sapiens (human)
nuclear aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
nucleus	Aryl hydrocarbon receptor	Homo sapiens (human)
nucleoplasm	Aryl hydrocarbon receptor	Homo sapiens (human)
cytoplasm	Aryl hydrocarbon receptor	Homo sapiens (human)
cytosol	Aryl hydrocarbon receptor	Homo sapiens (human)
chromatin	Aryl hydrocarbon receptor	Homo sapiens (human)
transcription regulator complex	Aryl hydrocarbon receptor	Homo sapiens (human)
protein-containing complex	Aryl hydrocarbon receptor	Homo sapiens (human)
cytosolic aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
aryl hydrocarbon receptor complex	Aryl hydrocarbon receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID39064	Affinity on cytosolic Aromatic hydrocarbon receptor (Ah)	1997	Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26	Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (9.09)	18.7374
1990's	12 (36.36)	18.2507
2000's	10 (30.30)	29.6817
2010's	8 (24.24)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	33 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
choline [no description available]	1.99	1	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
dibenzofuran Dibenzofurans: Compounds that include the structure of dibenzofuran.. dibenzofurans : Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof.. dibenzofuran : A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.	2.41	2	dibenzofurans; mancude organic heterotricyclic parent; polycyclic heteroarene	xenobiotic
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	1.99	1	imidazole
bw 284 c 51 [no description available]	1.99	1
1-methylimidazole 1-methyl-1H-imidazole : A 1H-imidazole having a methyl substituent at the N-1 position.	1.99	1	imidazoles
tacrine Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.	1.99	1	acridines; aromatic amine	EC 3.1.1.7 (acetylcholinesterase) inhibitor
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.03	1	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	1.99	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
benz(a)anthracene benz(a)anthracene: 4 fused rings of which one is angular in contrast to the linear NAPHTHACENES. tetraphene : An angular ortho-fused polycyclic arene consisting of four fused benzene rings.	2.03	1	ortho-fused polycyclic arene; tetraphenes
physostigmine Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	1.99	1	carbamate ester; indole alkaloid	antidote to curare poisoning; EC 3.1.1.8 (cholinesterase) inhibitor; miotic
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	1.98	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
neostigmine bromide neostigmine bromide : The bromide salt of neostigmine.	1.99	1	bromide salt
dibenzo(1,4)dioxin dibenzo(1,4)dioxin: structure	2.05	1	dibenzodioxine; heteranthrene; mancude organic heterotricyclic parent; oxacycle; polycyclic heteroarene
edrophonium bromide [no description available]	1.99	1
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	1.99	1	C-nitro compound; imidazoles	antitubercular agent
1,2,3,4-tetrachlorobenzene 1,2,3,4-tetrachlorobenzene : A tetrachlorobenzene carrying chloro groups at positions 1, 2 , 3 and 4.. tetrachlorobenzene : Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.	2.1	1	tetrachlorobenzene
2-methylimidazole [no description available]	1.99	1
chlormequat Chlormequat: A plant growth regulator that is commonly used on ornamental plants.. chlormequat : A quaternary ammonium ion that is choline in which the hydroxy group has been replaced by a chlorine. Its salts (particularly the chloride salt, known as chlormequat chloride) are used as plant growth retardants.	1.99	1	quaternary ammonium ion	plant growth retardant
3-hydroxyphenyltrimethylammonium 3-hydroxyphenyltrimethylammonium: RN given refers to parent cpd; structure	1.99	1
1-methyl-2-nitroimidazole [no description available]	1.99	1
2,3,7,8-tetrachlorodibenzodioxine Tetrachlorodibenzodioxin: A mixture of isomers.	1.99	1	polychlorinated dibenzodioxine
2,4,2',4'-tetrachlorobiphenyl 2,4,2',4'-tetrachlorobiphenyl: structure. 2,2',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.	1.99	1	dichlorobenzene; tetrachlorobiphenyl
butyrylcholine butyrylcholine: RN given refers to parent cpd	1.99	1	acylcholine
octachlorodibenzo-4-dioxin octachlorodibenzo-4-dioxin: RN given refers to unlabeled parent cpd	1.99	1	polychlorinated dibenzodioxine
butyrylthiocholine Butyrylthiocholine: A sulfur-containing analog of butyrylcholine which is hydrolyzed by butyrylcholinesterase to butyrate and thiocholine. It is used as a reagent in the determination of butyrylcholinesterase activity.. butyrylthiocholine : A quaternary ammonium ion obtained by the formal condensation of the carboxy group of butyric acid with the thiol group of thiocholine. It is used as a reagent for determination of butyrylcholinesterase activity.	1.99	1	quaternary ammonium ion
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	2.01	1	diatomic chlorine; gas molecular entity	bleaching agent
2-chlorodibenzofuran 2-chlorodibenzofuran: structure	1.99	1
1,2,3,4-tetrachlorodibenzofuran 1,2,3,4-tetrachlorodibenzofuran: structure in first source	2.03	1
1,2,3,4-tetrachlorodibenzodioxin 1,2,3,4-tetrachlorodibenzodioxin: structure given in first source	1.99	1	polychlorinated dibenzodioxine
pcb 118 [no description available]	2.43	2	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl: RN given refers to parent cpd. 3,3',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.	1.99	1	dichlorobenzene; tetrachlorobiphenyl
2,3,3',4,4'-pentachlorobiphenyl [no description available]	1.99	1	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
2,3,4,5-tetrachlorobiphenyl tetrachlorobiphenyl : Any polychlorobiphenyl with molecular formula C12H6Cl4.	1.99	1	tetrachlorobenzene; tetrachlorobiphenyl
1,2,7,8-tetrachlorodibenzo-p-dioxin 1,2,7,8-tetrachlorodibenzo-p-dioxin: structure in first source	1.99	1
2,4,5,2',4',5'-hexachlorobiphenyl [no description available]	7.68	3	hexachlorobiphenyl
1,2,3,4,6,7,8-heptachlorodibenzodioxin 1,2,3,4,6,7,8-heptachlorodibenzodioxin: contaminant of pentachlorophenol	3.51	8	polychlorinated dibenzodioxine
thiocholine Thiocholine: A mercaptocholine used as a reagent for the determination of CHOLINESTERASES. It also serves as a highly selective nerve stain.	1.99	1
2,3,4,2',3',4'-hexachlorobiphenyl [no description available]	2.1	1
2,3,3',4,4',5-hexachlorobiphenyl [no description available]	2.43	2	dichlorobenzene; hexachlorobiphenyl; tetrachlorobenzene
2,8-dichlorodibenzo-4-dioxin 2,8-dichlorodibenzo-4-dioxin: metabolite for 2,3,7,8-TCDD	1.99	1
1,2,3,4,7,8-hexachlorodibenzodioxin 1,2,3,4,7,8-hexachlorodibenzodioxin: structure given in first source	2.9	4	polychlorinated dibenzodioxine
1,2,4-trichlorodibenzo-1,4-dioxin 1,2,4-trichlorodibenzo-1,4-dioxin: structure given in first source	1.99	1
2,3,7,8-tetrabromodibenzo-4-dioxin 2,3,7,8-tetrabromodibenzo-4-dioxin: structure given in first source. 2,3,7,8-tetrabromodibenzodioxine : An organobromine compound that is dibenzodioxine carrying four bromo substituents at positions 2, 3, 7 and 8.	1.99	1	dibenzodioxine; organobromine compound
2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran: toxic product which was generated in Italy due to an explosion in a plant manufacturing 2,4,5-trichlorophenol	2.73	3	polychlorinated dibenzofuran
chlorodiphenyl (54% chlorine) Chlorodiphenyl (54% Chlorine): A mixture of polychlorinated biphenyls that induces hepatic microsomal UDP-glucuronyl transferase activity towards thyroxine.. Aroclor 1254 : A mixture of polychlorobiphenyls of unspecified composition, containing 54% chlorine (X = Cl or H).	2.1	1
2,3,4,7,8-pentachlorodibenzofuran 2,3,4,7,8-pentachlorodibenzofuran: structure given in first source	2.92	4	polychlorinated dibenzofuran
1,2,3,7,8-pentachlorodibenzofuran 1,2,3,7,8-pentachlorodibenzofuran: structure given in first source; RN given refers to parent cpd	1.99	1	polychlorinated dibenzofuran
1,2,3,6,7,8-hexachlorodibenzodioxin 1,2,3,6,7,8-hexachlorodibenzodioxin: contaminant of pentachlorophenol	2.92	4	polychlorinated dibenzodioxine
1,2,3,4,7,8-hexachlorodibenzofuran [no description available]	1.99	1	polychlorinated dibenzofuran
2,3,4,4'5-pentachlorobiphenyl [no description available]	1.99	1	monochlorobenzenes; pentachlorobiphenyl; tetrachlorobenzene
1,3-di-(4-imidazolino-2-methoxyphenoxy)propane 1,3-di-(4-imidazolino-2-methoxyphenoxy)propane: structure given in first source	1.99	1
3,4,5,3',4'-pentachlorobiphenyl 3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.	2.74	3	pentachlorobiphenyl; trichlorobenzene
propamidine propamidine: structure given in first source. propamidine : A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.	1.99	1	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
norharman norharman: RN given refers to parent cpd. beta-carboline : The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.	1.99	1	beta-carbolines; mancude organic heterotricyclic parent	fungal metabolite; marine metabolite
hexamidine hexamidine : A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.	1.99	1	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
2-ethylimidazole [no description available]	1.99	1
2-phenylimidazole [no description available]	1.99	1
1,4-dioxin 1,4-dioxine : An oxacycle that is 4H-pyran in which the methylene group at position 4 is replaced by an oxygen. Non-aromatic.	2.05	1	oxacycle
2-aminoimidazole 2-aminoimidazole: from catabolism of arginine	1.99	1
hexyltrimethylammonium hexyltrimethylammonium: RN given refers to parent cpd	1.99	1
trimethyl(4-oxopentyl)ammonium trimethyl(4-oxopentyl)ammonium: RN given refers to parent cpd; acetylcholine antag. N,N,N-trimethyl-N-(4-oxopentyl)ammonium : A quaternary ammonium ion in which the substituents on nitrogen are methyl (three) and 4-oxopentyl.	1.99	1	quaternary ammonium ion
2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one [no description available]	1.99	1
beta-carboline-3-carboxylic acid ethyl ester beta-carboline-3-carboxylic acid ethyl ester: isolated from brain tissue & urine; extremely potent displacer of diazepam from brain benzodiazepam receptors; structure in first source	1.99	1	beta-carbolines
beta-carboline-3-carboxylic acid methyl ester beta-carboline-3-carboxylic acid methyl ester: structure given in first source	1.99	1	beta-carbolines
1,3-di(4-imidazolinophenoxyl)propane 1,3-di(4-imidazolinophenoxyl)propane: structure given in first source	1.99	1
3-ethoxy-beta-carboline 3-ethoxy-beta-carboline: high affinity benzodiazepine receptor ligand with partial inverse agonist properties	1.99	1
tert-butyl beta-carboline-3-carboxylate tert-butyl beta-carboline-3-carboxylate: benzodiazepine receptor antagonist	1.99	1
butamidine butamidine: RN refers to HCl; structure in first source	1.99	1
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	3.81	11
3-chlorodibenzofuran 3-chlorodibenzofuran: structure given in first source	1.99	1
1-(4-hydroxybenzyl)imidazole-2-thiol 1-(4-hydroxybenzyl)imidazole-2-thiol: RN & structure given in first source; RN not in Chemline 3/87	1.99	1
3-propoxy-beta-carboline 3-propoxy-beta-carboline: structure in first source	1.99	1
harman harman: a beta-carboline; RN given refers to parent cpd; structure. harman : An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, Passiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.	1.99	1	harmala alkaloid; indole alkaloid fundamental parent; indole alkaloid	anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
1-Ethyl-9H-pyrido[3,4-b]indole [no description available]	1.99	1	harmala alkaloid
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	1.97	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
sk&f 102698 [no description available]	1.99	1

Condition	Relationship Strength	Studies
Hepatocellular Carcinoma [description not available]	2.17	1
Cancer of Liver [description not available]	2.17	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.17	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.17	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	3.1	5
Abdominal Obesity [description not available]	2.13	1
Insulin Sensitivity [description not available]	2.13	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.13	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.4	2
Acute Liver Injury, Drug-Induced [description not available]	1.98	1
Liver Dysfunction [description not available]	1.98	1
Weight Reduction [description not available]	1.98	1
Liver Diseases Pathological processes of the LIVER.	1.98	1
Weight Loss Decrease in existing BODY WEIGHT.	1.98	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.98	1
Experimental Hepatoma [description not available]	2	1
Condition, Preneoplastic [description not available]	2	1
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2	1
Genetic Predisposition [description not available]	2.01	1
Breast Cancer [description not available]	1.97	1
Breast Neoplasms Tumors or cancer of the human BREAST.	1.97	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.97	1

1,2,3,7,8-pentachlorodibenzo-p-dioxin

Cross-References

Synonyms (27)

Research Excerpts

Toxicity

Dosage Studied

Drug Classes (1)

Protein Targets (2)

Activation Measurements

Biological Processes (22)

Molecular Functions (16)

Ceullar Components (10)

Bioassays (1)

Research

Studies (33)

Market Indicators

Research Demand Index: 11.32

Study Types