phloretin has been researched along with Insulin Resistance in 10 studies
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phloretin and its glycoside phlorizin have been reported to prevent obesity induced by high-fat diet (HFD), but the effect of 3-OH phloretin, a catechol metabolite of phloretin, has not been investigated." | 8.31 | 3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue. ( Cao, NT; Choi, H; Jang, J; Kang, HS; Nguyen, NA; Seon, JE; Woo, SM; Yee, SM; Yun, CH, 2023) |
| "The rising prevalence of type 2 diabetes mellitus (T2DM) and accompanying insulin resistance is alarming globally." | 5.91 | Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice. ( Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R, 2023) |
| "Phloretin treatment significantly blocks high-fat diet-induced weight gain but did not induce weight loss in obese animals." | 5.46 | Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. ( Alsanea, S; Gao, M; Liu, D, 2017) |
| "Phloretin and its glycoside phlorizin have been reported to prevent obesity induced by high-fat diet (HFD), but the effect of 3-OH phloretin, a catechol metabolite of phloretin, has not been investigated." | 4.31 | 3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue. ( Cao, NT; Choi, H; Jang, J; Kang, HS; Nguyen, NA; Seon, JE; Woo, SM; Yee, SM; Yun, CH, 2023) |
| "The rising prevalence of type 2 diabetes mellitus (T2DM) and accompanying insulin resistance is alarming globally." | 1.91 | Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice. ( Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R, 2023) |
| "Phloretin treatment significantly blocks high-fat diet-induced weight gain but did not induce weight loss in obese animals." | 1.46 | Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. ( Alsanea, S; Gao, M; Liu, D, 2017) |
| "Improvement of insulin sensitivity is also suggested by the overexpression of genes associated with insulin signal transduction, such as CAP, PDK1 and Akt2." | 1.36 | Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin. ( Amiot, MJ; El Yazidi, C; Hassan, M; Malezet-Desmoulins, C; Margotat, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maccari, R | 1 |
| Ottanà, R | 1 |
| Woo, SM | 1 |
| Nguyen, NA | 1 |
| Seon, JE | 1 |
| Jang, J | 1 |
| Yee, SM | 1 |
| Cao, NT | 1 |
| Choi, H | 1 |
| Yun, CH | 1 |
| Kang, HS | 1 |
| Kumar, S | 3 |
| Chhimwal, J | 1 |
| Singh, R | 1 |
| Patial, V | 1 |
| Purohit, R | 2 |
| Padwad, YS | 1 |
| Shen, X | 2 |
| Wang, L | 2 |
| Zhou, N | 2 |
| Gai, S | 1 |
| Liu, X | 2 |
| Zhang, S | 2 |
| Sinha, K | 1 |
| Sharma, R | 1 |
| Padwad, Y | 1 |
| Shu, G | 1 |
| Lu, NS | 1 |
| Zhu, XT | 1 |
| Xu, Y | 1 |
| Du, MQ | 1 |
| Xie, QP | 1 |
| Zhu, CJ | 1 |
| Xu, Q | 1 |
| Wang, SB | 1 |
| Wang, LN | 1 |
| Gao, P | 1 |
| Xi, QY | 1 |
| Zhang, YL | 1 |
| Jiang, QY | 1 |
| Alsanea, S | 1 |
| Gao, M | 1 |
| Liu, D | 1 |
| Mi, L | 1 |
| Hu, Z | 1 |
| Hassan, M | 1 |
| El Yazidi, C | 1 |
| Malezet-Desmoulins, C | 1 |
| Amiot, MJ | 1 |
| Margotat, A | 1 |
| Luiken, JJ | 1 |
| Koonen, DP | 1 |
| Willems, J | 1 |
| Zorzano, A | 1 |
| Becker, C | 1 |
| Fischer, Y | 1 |
| Tandon, NN | 1 |
| Van Der Vusse, GJ | 1 |
| Bonen, A | 1 |
| Glatz, JF | 1 |
10 other studies available for phloretin and Insulin Resistance
| Article | Year |
|---|---|
Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents.
Topics: Animals; Antineoplastic Agents; Antitubercular Agents; Diabetes Mellitus; Humans; Hypoglycemic Agent | 2012 |
3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue.
Topics: Adipose Tissue; Adipose Tissue, White; Animals; Diet, High-Fat; Inflammation; Insulin Resistance; Ma | 2023 |
Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Mice; Obesi | 2023 |
Beneficial effects of combination therapy of phloretin and metformin in streptozotocin-induced diabetic rats and improved insulin sensitivity in vitro.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Insulin Recept | 2020 |
Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/Cdk5 interaction in differentiated adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cyclin-Dependent Kinase 5; Glucose; Insulin | 2019 |
Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Blood Glucose; CCAAT-Enhancer-Binding Proteins; Cel | 2014 |
Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis.
Topics: Adipose Tissue, White; Adiposity; Animals; Antioxidants; Diet, High-Fat; Drug Evaluation, Preclinica | 2017 |
Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro.
Topics: Animals; Blood Glucose; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Glucose; Gl | 2017 |
Gene expression profiling of 3T3-L1 adipocytes exposed to phloretin.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipokines; Animals; Carbohydrate Metabolism; Gene Expressio | 2010 |
Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36.
Topics: Androstadienes; Animals; Biological Transport; CD36 Antigens; Deoxyglucose; Diabetes Mellitus, Type | 2002 |