choline has been researched along with Insulin Resistance in 22 studies
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland." | 7.91 | Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population. ( Gao, X; Randell, E; Sun, G; Tian, Y; Zhou, H, 2019) |
| "Dietary betaine supplement could ameliorate insulin resistance (IR) in animals, but no data are available for choline." | 7.85 | High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population. ( Gao, X; Sun, G; Wang, Y, 2017) |
| "Our findings underscore the importance of changes in TMAO, choline and L-carnitine in improving insulin sensitivity during a weight-loss intervention for obese patients." | 5.30 | Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. ( Bray, GA; DiDonato, JA; Heianza, Y; Li, X; Qi, L; Sacks, FM; Sun, D, 2019) |
| " The mechanisms underlying gut microbiota-mediated development of NAFLD include modulation of host energy metabolism, insulin sensitivity, and bile acid and choline metabolism." | 4.98 | Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota. ( Han, R; Li, H; Ma, J, 2018) |
| "In general, increasing dietary choline and betaine along with moderate and high physical activity improved insulin resistance, increased HDL, and lowered FBS in the higher tertiles of dietary choline and betaine." | 4.31 | The interactive relationship of dietary choline and betaine with physical activity on circulating creatine kinase (CK), metabolic and glycemic markers, and anthropometric characteristics in physically active young individuals. ( Ardekani, AM; Farhangi, MA; Fayyazishishavan, E; Soleimani, E, 2023) |
| "Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021) |
| "We investigated the relationships between serum choline and betaine levels with metabolic syndrome-related indices in the general population of Newfoundland." | 3.91 | Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population. ( Gao, X; Randell, E; Sun, G; Tian, Y; Zhou, H, 2019) |
| "Dietary betaine supplement could ameliorate insulin resistance (IR) in animals, but no data are available for choline." | 3.85 | High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population. ( Gao, X; Sun, G; Wang, Y, 2017) |
| "Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity and type 2 diabetes, both of which are associated with insulin resistance and epigenetic changes." | 3.79 | Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. ( Cao, JM; Cao, Y; Gong, XJ; Guo, J; Guo, M; Li, D; Lun, YZ; Luo, N; Sun, WP; Tian, YJ; Zhou, SS, 2013) |
| " The present results suggest that the coupling of high levels of choline and low levels of methionine plays an important role in the development of insulin resistance and liver steatosis." | 3.77 | Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. ( Bachmair, EM; Boekschoten, MV; Brennan, L; Coort, SL; Daniel, H; Evelo, C; Gibney, MJ; Keijer, J; Kleemann, R; McLoughlin, GA; Muller, M; Roos, Bd; Rubio-Aliaga, I; Sailer, M; van Erk, M; van Schothorst, EM, 2011) |
| "To clarify the causal relationship between insulin resistance and the development of NASH, steatohepatitis was induced in obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) and nondiabetic control Long-Evans Tokushima Otsuka (LETO) rats by feeding them a methionine and choline-deficient (MCD) diet." | 3.74 | Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. ( Akahori, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa, N; Misu, H; Nakanuma, Y; Ota, T; Sakurai, M; Takamura, T; Uno, M; Zen, Y, 2007) |
| "Hyperleptinaemia plays an important role in hyper-responsiveness to MTX in NASH-cirrhotic rat livers with portal hypertension." | 1.38 | Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis. ( Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 7 (31.82) | 2.80 |
| Authors | Studies |
|---|---|
| Poursalehi, D | 1 |
| Lotfi, K | 1 |
| Mirzaei, S | 1 |
| Asadi, A | 1 |
| Akhlaghi, M | 1 |
| Saneei, P | 1 |
| Soleimani, E | 1 |
| Ardekani, AM | 1 |
| Fayyazishishavan, E | 1 |
| Farhangi, MA | 1 |
| Andersen, CJ | 1 |
| Huang, L | 1 |
| Zhai, F | 1 |
| Esposito, CP | 1 |
| Greco, JM | 1 |
| Zhang, R | 1 |
| Woodruff, R | 1 |
| Sloan, A | 1 |
| Van Dyke, AR | 1 |
| Yamauchi, A | 1 |
| Tone, T | 1 |
| Toledo, A | 1 |
| Igarashi, K | 1 |
| Sugimoto, K | 1 |
| Miyai, H | 1 |
| Deng, D | 1 |
| Nakamura, J | 1 |
| Lim, HS | 1 |
| Kaku, T | 1 |
| Hirano, E | 1 |
| Shindo, T | 1 |
| León-Mimila, P | 1 |
| Villamil-Ramírez, H | 1 |
| Li, XS | 1 |
| Shih, DM | 1 |
| Hui, ST | 1 |
| Ocampo-Medina, E | 1 |
| López-Contreras, B | 1 |
| Morán-Ramos, S | 1 |
| Olivares-Arevalo, M | 1 |
| Grandini-Rosales, P | 1 |
| Macías-Kauffer, L | 1 |
| González-González, I | 1 |
| Hernández-Pando, R | 1 |
| Gómez-Pérez, F | 1 |
| Campos-Pérez, F | 1 |
| Aguilar-Salinas, C | 1 |
| Larrieta-Carrasco, E | 1 |
| Villarreal-Molina, T | 1 |
| Wang, Z | 1 |
| Lusis, AJ | 1 |
| Hazen, SL | 1 |
| Huertas-Vazquez, A | 1 |
| Canizales-Quinteros, S | 1 |
| DiBella, M | 1 |
| Thomas, MS | 1 |
| Alyousef, H | 1 |
| Millar, C | 1 |
| Blesso, C | 1 |
| Malysheva, O | 1 |
| Caudill, MA | 1 |
| Fernandez, ML | 1 |
| Suchacki, KJ | 1 |
| Morton, NM | 1 |
| Vary, C | 1 |
| Huesa, C | 1 |
| Yadav, MC | 1 |
| Thomas, BJ | 1 |
| Turban, S | 1 |
| Bunger, L | 1 |
| Ball, D | 1 |
| Barrios-Llerena, ME | 1 |
| Guntur, AR | 1 |
| Khavandgar, Z | 1 |
| Cawthorn, WP | 1 |
| Ferron, M | 1 |
| Karsenty, G | 1 |
| Murshed, M | 1 |
| Rosen, CJ | 1 |
| MacRae, VE | 1 |
| Millán, JL | 1 |
| Farquharson, C | 1 |
| Heianza, Y | 1 |
| Sun, D | 1 |
| Li, X | 1 |
| DiDonato, JA | 1 |
| Bray, GA | 1 |
| Sacks, FM | 1 |
| Qi, L | 1 |
| Han, R | 1 |
| Ma, J | 1 |
| Li, H | 1 |
| Gao, X | 2 |
| Randell, E | 1 |
| Tian, Y | 1 |
| Zhou, H | 1 |
| Sun, G | 2 |
| Li, D | 1 |
| Tian, YJ | 1 |
| Guo, J | 1 |
| Sun, WP | 1 |
| Lun, YZ | 1 |
| Guo, M | 1 |
| Luo, N | 1 |
| Cao, Y | 1 |
| Cao, JM | 1 |
| Gong, XJ | 1 |
| Zhou, SS | 1 |
| Gautheron, J | 1 |
| Vucur, M | 1 |
| Schneider, AT | 1 |
| Severi, I | 1 |
| Roderburg, C | 1 |
| Roy, S | 1 |
| Bartneck, M | 1 |
| Schrammen, P | 1 |
| Diaz, MB | 1 |
| Ehling, J | 1 |
| Gremse, F | 1 |
| Heymann, F | 1 |
| Koppe, C | 1 |
| Lammers, T | 1 |
| Kiessling, F | 1 |
| Van Best, N | 1 |
| Pabst, O | 1 |
| Courtois, G | 1 |
| Linkermann, A | 1 |
| Krautwald, S | 1 |
| Neumann, UP | 1 |
| Tacke, F | 1 |
| Trautwein, C | 1 |
| Green, DR | 1 |
| Longerich, T | 1 |
| Frey, N | 1 |
| Luedde, M | 1 |
| Bluher, M | 1 |
| Herzig, S | 1 |
| Heikenwalder, M | 1 |
| Luedde, T | 1 |
| Pandey, S | 1 |
| Garabadu, D | 1 |
| Wang, Y | 1 |
| Jacobs, RL | 2 |
| Zhao, Y | 1 |
| Koonen, DP | 1 |
| Sletten, T | 1 |
| Su, B | 1 |
| Lingrell, S | 1 |
| Cao, G | 1 |
| Peake, DA | 1 |
| Kuo, MS | 1 |
| Proctor, SD | 1 |
| Kennedy, BP | 1 |
| Dyck, JR | 1 |
| Vance, DE | 2 |
| Rubio-Aliaga, I | 1 |
| Roos, Bd | 1 |
| Sailer, M | 1 |
| McLoughlin, GA | 1 |
| Boekschoten, MV | 1 |
| van Erk, M | 1 |
| Bachmair, EM | 1 |
| van Schothorst, EM | 1 |
| Keijer, J | 1 |
| Coort, SL | 1 |
| Evelo, C | 1 |
| Gibney, MJ | 1 |
| Daniel, H | 1 |
| Muller, M | 1 |
| Kleemann, R | 1 |
| Brennan, L | 1 |
| Saccà, F | 1 |
| Quarantelli, M | 1 |
| Rinaldi, C | 1 |
| Tucci, T | 1 |
| Piro, R | 1 |
| Perrotta, G | 1 |
| Carotenuto, B | 1 |
| Marsili, A | 1 |
| Palma, V | 1 |
| De Michele, G | 1 |
| Brunetti, A | 1 |
| Brescia Morra, V | 1 |
| Filla, A | 1 |
| Salvatore, M | 1 |
| Yang, YY | 1 |
| Huang, YT | 1 |
| Tsai, TH | 1 |
| Hou, MC | 1 |
| Lee, FY | 1 |
| Lee, SD | 1 |
| Lin, HC | 1 |
| Zeisel, SH | 1 |
| Wu, G | 1 |
| Zhang, L | 1 |
| Li, T | 1 |
| Zuniga, A | 1 |
| Lopaschuk, GD | 1 |
| Li, L | 1 |
| Ota, T | 1 |
| Takamura, T | 1 |
| Kurita, S | 1 |
| Matsuzawa, N | 1 |
| Kita, Y | 1 |
| Uno, M | 1 |
| Akahori, H | 1 |
| Misu, H | 1 |
| Sakurai, M | 1 |
| Zen, Y | 1 |
| Nakanuma, Y | 1 |
| Kaneko, S | 1 |
| Long, SD | 1 |
| Pekala, PH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)[NCT00072995] | 811 participants | Interventional | 2003-09-30 | Completed | |||
| A Patient Centric Motor Neuron Disease Activities of Daily Living Scale[NCT02852278] | 410 participants (Actual) | Observational | 2016-12-31 | Completed | |||
| Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| FRUVEDomics Study: Use of a Behavioral Nutrition Intervention in Young Adults to Identify Modifiable Metabolomics and Microbiome Risk[NCT03115866] | 53 participants (Actual) | Interventional | 2015-01-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for choline and Insulin Resistance
| Article | Year |
|---|---|
Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota.
Topics: Animals; Bile Acids and Salts; Choline; Dietary Supplements; Energy Metabolism; Fecal Microbiota Tra | 2018 |
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.
Topics: Animals; Betaine; Carbon; Choline; Energy Metabolism; Humans; Insulin Resistance; Metabolic Networks | 2013 |
4 trials available for choline and Insulin Resistance
| Article | Year |
|---|---|
Consumption of Different Egg-Based Diets Alters Clinical Metabolic and Hematological Parameters in Young, Healthy Men and Women.
Topics: Adult; Cholesterol; Choline; Diet; Female; Humans; Insulin Resistance; Lipid Metabolism; Male | 2023 |
Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome.
Topics: Adult; Aged; Cholesterol, LDL; Choline; Cross-Over Studies; Dietary Supplements; Eating; Eggs; Femal | 2020 |
Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.
Topics: Adult; Amino Acids; Carnitine; Choline; Diet, Reducing; Female; Gastrointestinal Microbiome; Glucose | 2019 |
A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results.
Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Arginine; Choline; Creatine; Double-B | 2012 |
16 other studies available for choline and Insulin Resistance
| Article | Year |
|---|---|
Association between methyl donor nutrients and metabolic health status in overweight and obese adolescents.
Topics: Adolescent; Betaine; Body Mass Index; Choline; Cross-Sectional Studies; Female; Health Status; Human | 2022 |
The interactive relationship of dietary choline and betaine with physical activity on circulating creatine kinase (CK), metabolic and glycemic markers, and anthropometric characteristics in physically active young individuals.
Topics: Adolescent; Betaine; Choline; Cross-Sectional Studies; Diet; Exercise; Humans; Insulin Resistance; U | 2023 |
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate C | 2020 |
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female | 2021 |
PHOSPHO1 is a skeletal regulator of insulin resistance and obesity.
Topics: Animals; Choline; Energy Metabolism; Glucose; Homeostasis; Insulin Resistance; Male; Mice; Obesity; | 2020 |
Low serum choline and high serum betaine levels are associated with favorable components of metabolic syndrome in Newfoundland population.
Topics: Adult; Betaine; Blood Glucose; Blood Pressure; Choline; Female; Humans; Insulin Resistance; Lipids; | 2019 |
Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
Topics: Animals; Betaine; Choline; CpG Islands; Dietary Supplements; DNA; DNA Damage; DNA Methylation; Epige | 2013 |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
Topics: Adipocytes; Adipose Tissue, White; Animals; Apoptosis; Body Mass Index; Caspase 8; Choline; Choline | 2016 |
Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats.
Topics: Amnesia; Animals; Blood Glucose; Brain Diseases; Brain-Derived Neurotrophic Factor; Choline; Diabete | 2017 |
High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population.
Topics: Adult; Betaine; Blood Glucose; Choline; Diet; Diet Surveys; Fasting; Feeding Behavior; Female; Human | 2017 |
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity.
Topics: Animals; Betaine; Choline; Diet; Dietary Fats; Dietary Supplements; Energy Metabolism; Fatty Liver; | 2010 |
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention.
Topics: Animals; Blood Glucose; Carbon; Cholesterol; Choline; Dietary Fats; Fatty Liver; Hyperglycemia; Insu | 2011 |
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fa | 2012 |
Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action.
Topics: Animals; Base Sequence; Choline; DNA Primers; Glucagon; Gluconeogenesis; Glucose Tolerance Test; Ins | 2013 |
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, T | 2007 |
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.
Topics: 3T3 Cells; 5,8,11,14-Eicosatetraynoic Acid; Adipose Tissue; Animals; Arachidonic Acid; Ceramides; Ch | 1996 |