poliothrysoside and Insulin-Resistance

poliothrysoside has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for poliothrysoside and Insulin-Resistance

ArticleYear
Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis.
    European journal of medicinal chemistry, 2014, Oct-30, Volume: 86

    In our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from Flacourtia indica, possessing antidiabetic potential. Subsequently, fifteen derivatives (2-16) were synthesized to assess the activity profile of this class. All the compounds were analyzed for their glucose uptake potency in chronic insulin-induced insulin resistant 3T3-L1 adipocytes. Interestingly, compound 2 exhibited strong ability to increase the insulin sensitivity, primarily activating the AMPK signaling pathway and also inhibited the adipogenesis in 3T3-L1 adipocytes, in concentration dependent manner. Overall, these studies suggest the potential of poliothrysoside and its derivatives as promising leads for non-insulin dependent type 2 diabetes (T2D).

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Benzoates; Dose-Response Relationship, Drug; Enzyme Activation; Glucosides; Hypoglycemic Agents; Insulin Resistance; Mice; Molecular Structure; Structure-Activity Relationship

2014