phlorhizin has been researched along with Insulin Resistance in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 9 (32.14) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R | 1 |
| Chhimwal, J; Kumar, S; Padwad, YS; Patial, V; Purohit, R; Singh, R | 1 |
| Chen, J; Gou, X; Peng, L; Peng, T; Tang, L; Xie, J; Yi, K; Zhang, XY | 1 |
| Chung, SJ; Hwang, JY; Jang, TS; Kim, JK; Kim, KH; Seo, SO; So, HM; Yoon, SY; Yu, JS | 1 |
| Chen, J; Jin, Y; Li, RP; Li, YJ; Liu, G; Mei, XR; Wang, ZG; Xie, J; Yi, K; Zhang, XY | 1 |
| Ito, K; Kashiwagi, Y; Kimura, H; Nagoshi, T; Oi, Y; Tanaka, TD; Tanaka, Y; Yoshii, A; Yoshimura, M; Yoshino, T | 1 |
| Kumar, S; Padwad, Y; Purohit, R; Sharma, R; Sinha, K | 1 |
| Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K | 1 |
| Henry, RR; Mudaliar, S; Polidori, D; Zambrowicz, B | 1 |
| Cho, SJ; Choi, MS; Jung, UJ; Ryu, R; Shin, SK | 1 |
| Gao, Z; Hu, H; Li, X; Liu, G; Mei, X; Wang, Z; Zhang, X; Zou, L | 1 |
| Thomson, SC; Vallon, V | 1 |
| Balteau, M; Beauloye, C; Bertrand, L; Brady, NR; de Meester, C; Des Rosiers, C; Gailly, P; Ginion, A; Horman, S; Hue, L; Sommereyns, C; Tajeddine, N; Vanoverschelde, JL | 1 |
| Abcouwer, SF; Barber, AJ; Fort, PE; Gardner, TW; Losiewicz, MK; Nakamura, M; Reiter, CE; Singh, RS | 1 |
| Gavrilova, O; Jou, W; Kim, H; LeRoith, D; Setser, J; Sun, H; Yakar, S; Zhang, Y; Zhao, H | 1 |
| Bronson, SK; Gardner, TW; Hong, EG; Jun, JY; Jung, DY; Kim, JH; Kim, JK; Ko, HJ; Ma, Z; Sumner, AD; Vary, TC; Zhang, Z | 1 |
| Kim, JY; Kim, YW; Lee, SK | 1 |
| Allen, LE; Caro, JF; Colberg, J; Considine, RV; Lanza-Jacoby, S; Morales, LM; Nyce, MR; Serrano, J; Triester, S | 1 |
| Efendić, S; Kawano, Y; Krook, A; Roth, RA; Song, XM; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Kuwajima, M; Murakami, T; Ogino, T; Shima, K; Zhu, M | 1 |
| Fujimiya, M; Fujita, Y; Hidaka, H; Kashiwagi, A; Kikkawa, R; Kojima, H | 1 |
| Dimitrakoudis, D; Klip, A; Marette, A; Rodgers, CD; Shi, Q; Vranic, M | 1 |
| Shen, D; Zhang, S; Zhu, M | 1 |
| Dong, J; Fillmore, JJ; Kahn, BB; Kahn, CR; Kim, JK; Kotani, K; Peroni, OD; Perret, P; Shulman, GI; Zisman, A; Zong, H | 1 |
| Dimitrakoudis, D; Klip, A; Vranic, M | 1 |
| Bailbe, D; Blondel, O; Portha, B | 1 |
| Helderman, JH; Imamura, T; Koffler, M; Santeusanio, F | 1 |
| DeFronzo, RA; Papachristou, D; Rossetti, L; Shulman, GI; Smith, D | 1 |
3 review(s) available for phlorhizin and Insulin Resistance
| Article | Year |
|---|---|
Sodium-Glucose Cotransporter Inhibitors: Effects on Renal and Intestinal Glucose Transport: From Bench to Bedside.
Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Glucose; Glycosuria; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Mucosa; Kidney; Phlorhizin; Renal Elimination; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2015 |
Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition.
Topics: Diabetes Mellitus, Type 2; Glucose; Humans; Hyperglycemia; Insulin Resistance; Kidney; Phlorhizin; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2017 |
Effects of hyperglycemia on glucose transporters of the muscle: use of the renal glucose reabsorption inhibitor phlorizin to control glycemia.
Topics: Animals; Binding, Competitive; Blood Glucose; Cytochalasin B; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose Transporter Type 4; Glycosylation; Humans; Hyperglycemia; Insulin; Insulin Resistance; Intestinal Absorption; Kidney Tubules, Proximal; Monosaccharide Transport Proteins; Multigene Family; Muscle Proteins; Muscles; Organ Specificity; Phlorhizin; Rats; Subcellular Fractions | 1992 |
25 other study(ies) available for phlorhizin and Insulin Resistance
| Article | Year |
|---|---|
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance
Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters; Glucose; Humans; Inflammation; Insulin; Insulin Resistance; Muscle Fibers, Skeletal; Palmitic Acid; Phlorhizin | 2022 |
Phloretin and phlorizin mitigates inflammatory stress and alleviate adipose and hepatic insulin resistance by abrogating PPARγ S273-Cdk5 interaction in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; Mice; Obesity; Phloretin; Phlorhizin; PPAR gamma | 2023 |
Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity.
Topics: Animals; Anti-Obesity Agents; Bacteria; Diet, High-Fat; Dietary Supplements; Endotoxemia; Fatty Acids, Volatile; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Insulin Resistance; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Obesity; Phlorhizin; Phytochemicals; Tight Junctions; Weight Gain | 2020 |
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cell Line; Diabetes Mellitus, Type 2; Glucose; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Palmitates; Phlorhizin; Phosphorylation; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Signal Transduction | 2021 |
Purified Phlorizin from
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Diet, High-Fat; Humans; Inflammation; Insulin Resistance; Liver; Mice; Mice, Obese; Obesity; Phlorhizin; Plant Extracts; Rosaceae | 2018 |
Cardiac ischemia-reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diet, High-Fat; Disease Models, Animal; Glucose Transporter Type 4; Glucosides; Insulin Resistance; Isolated Heart Preparation; Male; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocytes, Cardiac; Obesity; Phlorhizin; Signal Transduction; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes | 2019 |
Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/Cdk5 interaction in differentiated adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cyclin-Dependent Kinase 5; Glucose; Insulin Resistance; Mice; Phloretin; Phlorhizin; Phosphorylation; PPAR gamma; Protein Interaction Domains and Motifs | 2019 |
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin | 2013 |
Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet.
Topics: Adipose Tissue; Animals; Blood Glucose; Diet, High-Fat; Dietary Supplements; Hyperglycemia; Inflammation; Inflammation Mediators; Insulin Resistance; Lipid Metabolism; Liver; Male; Malus; Mice, Inbred C57BL; Mice, Obese; Obesity; Phlorhizin; Phytotherapy; Plant Extracts | 2016 |
Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice.
Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Energy Intake; Fatty Acids, Volatile; Gastrointestinal Microbiome; Hypoglycemic Agents; Insulin Resistance; Lipopolysaccharides; Male; Mice, Mutant Strains; Mice, Obese; Phlorhizin | 2016 |
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
Topics: 6-Aminonicotinamide; Acetylglucosamine; Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glycosylation; Hyperglycemia; Insulin Resistance; Male; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Pentose Phosphate Pathway; Phlorhizin; Protein Processing, Post-Translational; Protein Transport; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Reactive Oxygen Species; Sodium-Glucose Transporter 1 | 2011 |
Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance.
Topics: Animals; Cell Death; Diabetes Mellitus; Diabetic Retinopathy; Hyperglycemia; Insulin; Insulin Resistance; Phlorhizin; Rats; Retina; Signal Transduction | 2011 |
Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Transgenic; Phlorhizin | 2004 |
Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucose; Glucose Clamp Technique; Glucose Transporter Type 4; Hyperglycemia; Hypertrophy, Left Ventricular; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Oxygen Consumption; Phlorhizin; Protein Kinase C-epsilon; Triglycerides; Ventricular Remodeling | 2007 |
Effects of phlorizin and acipimox on insulin resistance in STZ-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Hypolipidemic Agents; Insulin Resistance; Phlorhizin; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin | 1995 |
Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia.
Topics: Adult; Animals; Diabetes Mellitus, Type 2; Diglycerides; Female; Humans; Insulin; Insulin Resistance; Isoenzymes; Liver; Male; Middle Aged; Obesity; Phlorhizin; Protein Kinase C; Rats; Receptor, Insulin | 1995 |
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.
Topics: Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Phlorhizin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Mutant Strains | 1997 |
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Genotype; Hyperglycemia; Insulin; Insulin Resistance; Islets of Langerhans; Male; Niacinamide; Obesity; Pancreatectomy; Phenotype; Phlorhizin; Rats; Rats, Inbred WKY; Rats, Mutant Strains; Rats, Wistar; Rats, Zucker | 1998 |
Increased intestinal glucose absorption and postprandial hyperglycaemia at the early step of glucose intolerance in Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Food; Gene Expression; Glucose; Glucose Intolerance; Glucose Tolerance Test; Hyperglycemia; Insulin Resistance; Intestinal Absorption; Intestines; Male; Monosaccharide Transport Proteins; Obesity; Phlorhizin; Rats; Rats, Long-Evans; Xylose | 1998 |
Glucose rapidly decreases plasma membrane GLUT4 content in rat skeletal muscle.
Topics: Animals; Blood Glucose; Cell Membrane; Diabetes Mellitus, Experimental; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Rats; Rats, Sprague-Dawley | 1999 |
Experimental study on the treatment of diabetes by phloridzin in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Pancreas; Pancreatectomy; Phlorhizin; Random Allocation; Rats; Rats, Wistar | 1998 |
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
Topics: Adipose Tissue; Age of Onset; Animals; Depression, Chemical; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Hyperglycemia; Insulin; Insulin Infusion Systems; Insulin Resistance; Kidney Tubules; Liver; Male; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phlorhizin; Prediabetic State; Protein Transport | 2001 |
Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Kinetics; Phlorhizin; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucagon; Glycosuria; Hyperglycemia; Insulin Resistance; Kidney; Male; Phlorhizin | 1988 |
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glycosuria; Hyperglycemia; Hyperinsulinism; Insulin Resistance; Male; Phlorhizin; Rats; Rats, Inbred Strains | 1987 |