am 251 has been researched along with Insulin Resistance in 9 studies
AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results indicate that the cannabinoid CB1 inverse agonist AM 251 represents a promising therapeutic strategy for the treatment of obesity and metabolic syndrome." | 7.79 | Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats. ( Aranda, P; Errami, M; Galisteo, M; Llopis, J; López-Chaves, C; López-Jurado, M; Martínez, R; Merroun, I; Porres, JM; Sánchez-González, C; Zarzuelo, A, 2013) |
| "Our results indicate that the cannabinoid CB1 inverse agonist AM 251 represents a promising therapeutic strategy for the treatment of obesity and metabolic syndrome." | 3.79 | Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats. ( Aranda, P; Errami, M; Galisteo, M; Llopis, J; López-Chaves, C; López-Jurado, M; Martínez, R; Merroun, I; Porres, JM; Sánchez-González, C; Zarzuelo, A, 2013) |
| "CNR1 is upregulated in states of type 2 diabetes and insulin resistance." | 1.46 | Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. ( Eriksson, JW; Kamble, PG; Katsogiannos, P; Lau Börjesson, J; Pereira, MJ; Sidibeh, CO; Skrtic, S; Sundbom, M; Svensson, MK, 2017) |
| "Skeletal muscle insulin sensitivity is affected by acute CB1R modulation." | 1.37 | Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. ( Bandsma, RH; Jin, T; Lewis, GF; Shao, W; Song, D; Xi, L; Xiao, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merroun, I | 1 |
| Sánchez-González, C | 1 |
| Martínez, R | 1 |
| López-Chaves, C | 1 |
| Porres, JM | 1 |
| Aranda, P | 1 |
| Llopis, J | 1 |
| Galisteo, M | 1 |
| Zarzuelo, A | 1 |
| Errami, M | 1 |
| López-Jurado, M | 1 |
| Ravussin, Y | 1 |
| Xiao, C | 2 |
| Gavrilova, O | 1 |
| Reitman, ML | 1 |
| Chen, CC | 2 |
| Lee, TY | 2 |
| Kwok, CF | 2 |
| Hsu, YP | 2 |
| Shih, KC | 2 |
| Lin, YJ | 2 |
| Ho, LT | 2 |
| Sidibeh, CO | 1 |
| Pereira, MJ | 1 |
| Lau Börjesson, J | 1 |
| Kamble, PG | 1 |
| Skrtic, S | 1 |
| Katsogiannos, P | 1 |
| Sundbom, M | 1 |
| Svensson, MK | 1 |
| Eriksson, JW | 1 |
| Zhao, W | 1 |
| Fong, O | 1 |
| Muise, ES | 1 |
| Thompson, JR | 1 |
| Weingarth, D | 1 |
| Qian, S | 1 |
| Fong, TM | 1 |
| Song, D | 1 |
| Bandsma, RH | 1 |
| Xi, L | 1 |
| Shao, W | 1 |
| Jin, T | 1 |
| Lewis, GF | 1 |
| Irwin, N | 2 |
| Hunter, K | 2 |
| Frizzell, N | 1 |
| Flatt, PR | 2 |
9 other studies available for am 251 and Insulin Resistance
| Article | Year |
|---|---|
Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Topics: Animals; Biomarkers; Cannabinoid Receptor Antagonists; Eating; Energy Metabolism; Fatty Liver; Insul | 2013 |
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
Topics: Adipose Tissue, Brown; Animals; Biomarkers; Body Composition; Body Weight; Cold Temperature; Deoxygl | 2014 |
Major urinary protein 1 interacts with cannabinoid receptor type 1 in fatty acid-induced hepatic insulin resistance in a mouse hepatocyte model.
Topics: Animals; Blotting, Western; Diet, High-Fat; Fatty Acids; Gene Silencing; Hepatocytes; Insulin Resist | 2015 |
Cannabinoid receptor type 1 mediates high-fat diet-induced insulin resistance by increasing forkhead box O1 activity in a mouse model of obesity.
Topics: Animals; Cannabinoid Receptor Agonists; Citrate (si)-Synthase; Diet, High-Fat; DNA-Binding Proteins; | 2016 |
Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.
Topics: Adipose Tissue; Aged; Dexamethasone; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fe | 2017 |
Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters.
Topics: Adipose Tissue; Animals; Cannabinoid Receptor Agonists; Down-Regulation; Homozygote; Insulin; Insuli | 2010 |
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice.
Topics: Animals; Central Nervous System; Glucose; Glucose Clamp Technique; Insulin Resistance; Male; Mice; M | 2011 |
Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.
Topics: Animals; Blood Glucose; Body Weight; Eating; Female; Hypoglycemic Agents; Insulin; Insulin Resistanc | 2008 |
Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Topics: Animals; Appetite; Area Under Curve; Blood Glucose; Body Weight; Dietary Fats; Drug Evaluation, Prec | 2008 |