palmitic acid has been researched along with Insulin Resistance in 315 studies
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aimed to establish a model of palmitic acid (PA)‑induced insulin resistance (IR) in C2C12 cells and to determine the mechanism underlying how resveratrol (RSV) improves IR." | 8.31 | Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells. ( Liu, C; Pan, X; Song, G; Wang, C; Wang, X; Zhang, X; Zhang, Z; Zhao, M, 2023) |
| " Glucose consumption was analyzed to investigate the effect of all compounds on palmitic acid (PA)-mediated insulin resistance (IR) in HepG2 cells, and achigermalides D-F, desacetylherbohde A, and 4E,10E-3-(2-methylbutyroyloxy)-germacra-4,10(1)-diene-12,6α-olide appreciably enhanced the glucose consumption at low concentrations of 1." | 8.12 | Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway. ( Chen, H; Du, K; Duan, JJ; Feng, WS; Li, M; Ma, T; Pan, H; Sun, YJ; Xue, GM; Xue, JF; Zhang, WD; Zhao, CG, 2022) |
| "N6-Methyladenosine (m6A) modification is involved in many pathological processes, including insulin resistance (IR)." | 8.12 | Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line. ( Jiao, Y; Wei, N; Williams, A, 2022) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 8.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| "Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes." | 8.02 | Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. ( Arias, C; Bastián-Eugenio, CE; Sánchez-Alegría, K; Vaca, L, 2021) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 7.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| " Oxymatrine reduced body weight, and improved glucose tolerance and insulin resistance in the HFDHFr + OMT group compared with HFDHFr group." | 7.96 | Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease. ( Chen, S; Huang, W; Li, Y; Ren, L; Song, G; Wang, Y; Yang, L; Zhang, H, 2020) |
| "The natural triterpenoid compound celastrol ameliorates insulin resistance (IR) in animal models, but the underlying molecular mechanism is unclear." | 7.91 | Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway. ( Cao, FF; Peng, B; Uzan, G; Wang, Y; Xue, XC; You, J; Zhang, DH; Zhang, X, 2019) |
| "Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance." | 7.91 | Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. ( Du, M; Lei, X; Li, Y; Ren, F; Teng, W; Xie, S, 2019) |
| "Leukotriene B4 (LTB4) production via the 5-lipoxygenase (5-LO) pathway contributes to the development of insulin resistance in adipose and hepatic tissues, but the role of LTB4 in skeletal muscle is relatively unknown." | 7.85 | 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. ( Cheon, HG; Choi, HE; Kwak, HJ, 2017) |
| " Palmitic acid (C16:0), dihomo-γ-linolenic acid (C20:3n-6) and D6 desaturase were associated with an increase probability of insulin resistance, whereas nervonic acid (C24:1) and SCD1 were significantly associated with a lower insulin resistance probability." | 7.83 | Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance. ( Chen, H; Du, J; Fang, M; Li, H; Li, S; Li, W; Xu, M, 2016) |
| "The excess of saturated free fatty acids, such as palmitic acid, that induces lipotoxicity in hepatocytes, has been implicated in the development of non-alcoholic fatty liver disease also associated with insulin resistance." | 7.81 | Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection. ( González-Rodríguez, Á; Kozma, SC; Muntané, J; Pardo, V; Valverde, ÁM, 2015) |
| " L6 muscle cells were incubated with palmitic acid (PA) to induce insulin resistance and then treated with metformin and/or the AMPK inhibitor, compound C." | 7.81 | Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway. ( Bi, Y; Bu, R; Cao, S; Shi, J; Tang, S; Wu, W; Yin, W; Zhu, D, 2015) |
| "To study the effect of conditioned media for rat bone marrow mesenchymal stem cells (BMSCs-CM) on palmitic acid (PA)-induced insulin resistance (IR) in HepG2 cells and its underlying molecular mechanisms." | 7.81 | [Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells]. ( Han, W; Hao, H; Mu, Y; Sun, X, 2015) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 7.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "We have found that polyunsaturated fatty acids, in particular arachidonic and eicosapentaenoic acids prevent palmitic acid-induced myocellular insulin resistance." | 7.78 | Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells. ( Ashida, H; Kawabata, K; Kawasaki, K; Sawada, K; Yamamoto, N; Yamashita, T, 2012) |
| "We investigated whether diosgenin, a widely used steroidal sapogenin, exerted protection against palmitate (PA)-induced inflammation and insulin resistance in the endothelium." | 7.78 | Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways. ( Gao, X; Huang, F; Kou, J; Liu, B; Liu, K; Zhao, W, 2012) |
| "To explore the adipose tissue endocrine mechanism of pioglitazone and its possible prophylactic role in insulin resistance." | 7.78 | The adipose tissue endocrine mechanism of the prophylactic protective effect of pioglitazone in high-fat diet-induced insulin resistance. ( Gong, Y; Li, C; Li, J; Liu, Y; Mu, Y; Pan, C; Tian, H; Xiao, Y, 2012) |
| "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway." | 7.77 | Curcumin improves insulin resistance in skeletal muscle of rats. ( Kong, T; Li, R; Li, Y; Liu, LY; Na, LX; Sun, CH; Zhang, YL, 2011) |
| "The purpose of the study is to investigate the effect of 8-hydroxy-dihydroberberine on insulin resistance induced by high free fatty acid (FFA) and high glucose in 3T3-L1 adipocytes and its possible molecular mechanism." | 7.75 | [8-hydroxy-dihydroberberine ameliorated insulin resistance induced by high FFA and high glucose in 3T3-L1 adipocytes]. ( Chen, G; Dong, H; Lu, FE; Wang, ZS; Wei, SC; Xu, LJ; Yi, P; Zou, X, 2009) |
| " Cells exposed to angiotensin II remained viable and did not show signs of hypertrophy." | 7.74 | Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells). ( Alfarano, C; Cerbai, E; Mannucci, E; Mugelli, A; Nediani, C; Raimondi, L; Sartiani, L, 2008) |
| "In order to study the effects of troglitazone on insulin resistance associated with elevated plasma free fatty acid (FFA), the hindquarters of rats treated with troglitazone for 14 days were perfused with a medium containing 15 mmol/l glucose, 0-1,000 microU/ml insulin, and 0 or 1." | 7.70 | Troglitazone reduces free fatty acid-induced insulin resistance in perfused rat hindquarter. ( Mokuda, O; Sakamoto, Y, 1998) |
| "Patients with type 2 diabetes respond differently to sitagliptin, an oral anti-hyperglycemic medication." | 5.91 | The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway. ( Aleteng, QQ; Jiang, S; Li, L; Ma, R; Quan, L; Zhu, J, 2023) |
| "Nonalcoholic fatty liver disease (NAFLD) is characterized by lipotoxicity and ectopic lipid deposition within hepatocytes." | 5.62 | Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. ( Li, J; Teng, W; Xie, S, 2021) |
| "Insulin resistance is defined as a failure to trigger the activation of the PI3K-AKT pathway by normal levels of insulin; therefore, it is well linked to metabolic disorders." | 5.62 | Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance. ( Imoto, M; Itoh, S; Nagasawa, Y; Tashiro, E, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver without alcohol consumption and includes hepatic inflammation and damage." | 5.51 | Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice. ( Choi, SE; Cui, R; Han, SJ; Heo, YJ; Hong, SA; Hwang, Y; Jung, IR; Kang, Y; Kim, HJ; Lee, KW; Lee, SJ; Son, Y, 2019) |
| "Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties." | 5.51 | Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019) |
| "Melatonin plays an important role in regulating circadian rhythms." | 5.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "The eruptive xanthomata are formed in vivo under realization of biological function of endoecology." | 5.46 | [The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata]. ( Rozhkova, TA; Samokhodskaya, LM; Titov, VN, 2017) |
| "Palmitic acid is a negative regulator of insulin activity." | 5.43 | Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. ( Chavez-Reyes, J; Guerrero-Hernandez, A; Gustavo Vazquez-Jimenez, J; Manuel Galindo-Rosales, J; Olivares-Reyes, JA; Romero-Garcia, T; Rueda, A; Valdes-Flores, J; Zarain-Herzberg, A, 2016) |
| "Insulin resistance was induced by feeding a high fat diet to Sprague-Dawley rats." | 5.43 | Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle. ( Cao, Y; Chang, S; Cui, J; Dong, J; Li, J; Long, R; Zhang, Y; Zheng, X; Zhou, Y; Zhu, S, 2016) |
| "Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal degradation." | 5.43 | Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism. ( Bae, YA; Cheon, HG; Choi, HE; Jang, J; Kwak, HJ; Park, SK, 2016) |
| "Obesity is the result of a positive energy balance and often leads to difficulties in maintaining normal postprandial metabolism." | 5.42 | Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects. ( Feng, R; Guo, F; Jiao, J; Li, Y; Liu, L; Sun, C, 2015) |
| "Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue." | 5.42 | Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. ( James, J; Roy, D; Shihabudeen, MS; Thirumurugan, K, 2015) |
| "After 4 wk of treatment, alveolar bone loss was determined by micro-computed tomography." | 5.40 | Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. ( Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X, 2014) |
| "Palmitic acid (PA) was chosen as a stimulant to induce ROS production in endothelial cells and successfully established insulin resistance evidenced by the specific impairment of insulin PI3K signaling." | 5.39 | Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. ( Cheng, XL; Gao, XJ; Liu, BL; Liu, K; Qin, MJ; Qin, XY; Qin, Y; Wang, Q; Xie, GY; Zhang, DY; Zhou, L, 2013) |
| "The aging rats showed hyperinsulinemia and hyperlipidemia, and insulin resistance as examined by the decreased glucose decay constant rate during insulin tolerance test (kITT)." | 5.39 | Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. ( Cai, L; Feng, H; Gong, D; Guan, L; Wu, Q; Yang, M; Yuan, B; Zhao, J; Zhao, X; Zou, Y, 2013) |
| "Increased inflammation was associated with impaired glucose tolerance and hyperinsulinemia as a result of reduced hepatic but not skeletal muscle insulin sensitivity." | 5.37 | Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. ( Fynch, SL; Galic, S; Graham, KL; Hewitt, KA; Honeyman, JE; Kay, TW; Sachithanandan, N; Steinberg, GR, 2011) |
| "Insulin resistance is defined as the decrease in the glucose disposal in response to insulin by the target tissues." | 5.32 | High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. ( Calderón, V; Reynoso, R; Salgado, LM, 2003) |
| " The slope of the angiotensin II dose-response curve correlated significantly with the basal plasma palmitate concentration." | 5.32 | Vascular response to angiotensin II in upper body obesity. ( Halliwill, JR; Jensen, MD; Joyner, MJ; Nielsen, S, 2004) |
| "We recently reported that lowering the high, habitual palmitic acid (PA) intake in ovulating women improved insulin sensitivity and both inflammatory and oxidative stress." | 5.20 | Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes. ( Anathy, V; Bunn, JY; Crain, KI; Ebenstein, DB; Fukagawa, NK; Kien, CL; Matthews, DE; Poynter, ME; Pratley, RE; Tarleton, EK, 2015) |
| " In a double-blind, parallel dietary intervention study, 52 healthy but overweight postmenopausal women were randomized to receive either partially hydrogenated soybean oil (15 g/d TFA) or a control oil (mainly oleic and palmitic acid) for 16 weeks." | 5.15 | Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women. ( Astrup, A; Bendsen, NT; Chabanova, E; Haugaard, SB; Larsen, TM; Stender, S, 2011) |
| " However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans." | 4.98 | Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus. ( Barroso, E; Palomer, X; Pizarro-Delgado, J; Vázquez-Carrera, M, 2018) |
| "The present study aimed to establish a model of palmitic acid (PA)‑induced insulin resistance (IR) in C2C12 cells and to determine the mechanism underlying how resveratrol (RSV) improves IR." | 4.31 | Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells. ( Liu, C; Pan, X; Song, G; Wang, C; Wang, X; Zhang, X; Zhang, Z; Zhao, M, 2023) |
| "C2C12 myotubes were challenged by palmitic acid (PA) to mimic the obese microenvironment and inflammation, cell vitality, and glucose utilization were determined." | 4.31 | Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders. ( Chiang, CC; Hsieh, CC; Huang, CY; Huang, PY; Kuo, CH; Kuo, HC; Lin, PY, 2023) |
| "The study aims to investigate the effects of PZ-DHA on insulin resistance in the skeletal muscle and the related mechanisms; we used palmitic acid (PA)-treated C2C12 myotubes as an insulin resistance model." | 4.12 | Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance ( Chen, J; Dong, Q; Qiu, Y; Si, X; Sun, T; Wang, J; Wu, W; Wu, Z; Zhang, R, 2022) |
| " Glucose consumption was analyzed to investigate the effect of all compounds on palmitic acid (PA)-mediated insulin resistance (IR) in HepG2 cells, and achigermalides D-F, desacetylherbohde A, and 4E,10E-3-(2-methylbutyroyloxy)-germacra-4,10(1)-diene-12,6α-olide appreciably enhanced the glucose consumption at low concentrations of 1." | 4.12 | Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway. ( Chen, H; Du, K; Duan, JJ; Feng, WS; Li, M; Ma, T; Pan, H; Sun, YJ; Xue, GM; Xue, JF; Zhang, WD; Zhao, CG, 2022) |
| " To simulate a similar in-vivo condition, we persuaded insulin resistance in H9c2 cells by palmitic acid (PA) treatment." | 4.12 | Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress. ( Alam, MJ; Arava, S; Banerjee, SK; Bugga, P; Katare, P; Maulik, SK; Meghwani, H; Mohammed, SA, 2022) |
| "N6-Methyladenosine (m6A) modification is involved in many pathological processes, including insulin resistance (IR)." | 4.12 | Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line. ( Jiao, Y; Wei, N; Williams, A, 2022) |
| "Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid." | 4.02 | Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. ( Amine, H; Benomar, Y; Taouis, M, 2021) |
| "Palmitic acid (PA) is a saturated fatty acid whose high consumption has been largely associated with the development of different metabolic alterations, such as insulin resistance, metabolic syndrome, and type 2 diabetes." | 4.02 | Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells. ( Arias, C; Bastián-Eugenio, CE; Sánchez-Alegría, K; Vaca, L, 2021) |
| " The study was carried out on human hepatocellular carcinoma cells (HepG2) incubated with VK2 and/or palmitic acid (PA)." | 4.02 | Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway. ( Bzdęga, W; Chabowski, A; Harasim-Symbor, E; Konstantynowicz-Nowicka, K; Kołakowski, A; Kurzyna, PF; Żywno, H, 2021) |
| " We analyzed the lipid kinetics of palmitic acid (PA) in hepatoma liver cells cultured in vitro in which insulin resistance has been induced by high glucose supplementation." | 3.96 | Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics. ( Altieri, IG; Averna, M; Bongiorno, D; Cefalù, AB; Di Gaudio, F; Fayer, F; Giammanco, A; Greco, M; Indelicato, S; Mattina, A; Noto, D; Scrimali, C; Spina, R, 2020) |
| " However, in VAT, GCs induce DNL, higher palmitic acid (PA), macrophage infiltration, and proinflammatory cytokine levels, accompanied by systemic nonesterified fatty acid (NEFA) elevation, hyperinsulinemia, and higher homeostatic model assessment for insulin resistance (HOMA-IR) levels compared with diet-induced obesity." | 3.96 | Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity. ( García-Eguren, G; Giró, O; Hanzu, FA; Sala-Vila, A; Vega-Beyhart, A, 2020) |
| " Oxymatrine reduced body weight, and improved glucose tolerance and insulin resistance in the HFDHFr + OMT group compared with HFDHFr group." | 3.96 | Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease. ( Chen, S; Huang, W; Li, Y; Ren, L; Song, G; Wang, Y; Yang, L; Zhang, H, 2020) |
| "The insulin resistance state of pancreatic α-cells seems to be related to glucagon hypersecretion in type 2 diabetes." | 3.96 | Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells. ( Di Mauro, S; Di Pino, A; Filippello, A; Malaguarnera, R; Piro, S; Purrello, F; Scamporrino, A; Scicali, R, 2020) |
| " The iron chelator deferoxamine dramatically inhibited PA-induced insulin resistance, and iron donors impaired insulin sensitivity by activating JNK." | 3.91 | Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells. ( Choi, SE; Cui, R; Jeon, JY; Kang, Y; Kim, HJ; Kim, TH; Lee, HJ; Lee, KW; Lee, SJ, 2019) |
| "The natural triterpenoid compound celastrol ameliorates insulin resistance (IR) in animal models, but the underlying molecular mechanism is unclear." | 3.91 | Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway. ( Cao, FF; Peng, B; Uzan, G; Wang, Y; Xue, XC; You, J; Zhang, DH; Zhang, X, 2019) |
| " For primary skeletal muscle satellite cells, inhibition of differentiation was observed in palmitic acid-induced insulin resistance model." | 3.91 | Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes. ( Fan, S; Han, S; Hassan, HM; Jiang, Z; Sun, Z; Wang, L; Wang, T; Xu, D; Zhang, L; Zhao, G; Zhou, W, 2019) |
| "Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance." | 3.91 | Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. ( Du, M; Lei, X; Li, Y; Ren, F; Teng, W; Xie, S, 2019) |
| " Herein, we evaluated the in vitro protective effects of an ACN rich extract against palmitic acid (PA)-induced hypertrophy, inflammation, and insulin resistance in 3T3-L1 adipocytes." | 3.91 | Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes. ( Bashllari, R; Cimino, F; Cristani, M; Molonia, MS; Muscarà, C; Occhiuto, C; Saija, A; Speciale, A, 2019) |
| "Leukotriene B4 (LTB4) production via the 5-lipoxygenase (5-LO) pathway contributes to the development of insulin resistance in adipose and hepatic tissues, but the role of LTB4 in skeletal muscle is relatively unknown." | 3.85 | 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. ( Cheon, HG; Choi, HE; Kwak, HJ, 2017) |
| "In the present experiment, we used HepG2 cells, a human hepatoma cell line, and a MSC-HepG2 transwell culturing system to investigate the anti-inflammatory mechanism of human umbilical cord-derived MSCs (UC-MSCs) under palmitic acid (PA) and lipopolysaccharide (LPS)-induced insulin resistance in vitro." | 3.85 | Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats. ( Dong, L; Han, Q; Han, W; Hao, H; Liu, J; Mu, Y; Song, X; Sun, X, 2017) |
| "Increased plasma levels of free fatty acids, including palmitic acid (PA), cause insulin resistance in endothelium characterized by a decreased synthesis of insulin-mediated vasodilator nitric oxide (NO), and by an increased production of the vasoconstrictor protein, endothelin-1." | 3.85 | Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors. ( Cimino, F; Ferrari, D; Fratantonio, D; Molonia, MS; Saija, A; Speciale, A; Virgili, F, 2017) |
| " Resveratrol alleviated high-calorie diet-induced insulin resistance and endoplasmic reticulum stress, increased expression of SIRT1, and reversed expression of adipokines in varying degrees in both subcutaneous and visceral adipose tissues." | 3.85 | Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid. ( Chen, G; Chen, L; Dai, F; Fang, Z; Gui, L; Lu, Y; Wang, N; Wang, T; Zhang, Q, 2017) |
| "The present study aimed to decipher the mechanism of action of selected anti-diabetic plants extracts on palmitic acid mediated insulin resistance in muscle cells." | 3.83 | Attenuation of palmitate induced insulin resistance in muscle cells by harmala, clove and river red gum. ( Afridi, SK; Aftab, MF; Begum, S; Ghaffar, S; Murtaza, M; Syed, SA; Waraich, RS, 2016) |
| " In this study, we explored the effects of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), arachidonic acid (AA), and long-chain polyunsaturated fatty acids (PUFAs) on palmitic acid (PA)-induced inflammatory responses and insulin resistance in C2C12 myotubes." | 3.83 | Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes. ( Chen, CW; Chen, HW; Chen, PY; Chen, SC; Lii, CK; Liu, KL; Sun, HL; Wu, YL, 2016) |
| " Palmitic acid (C16:0), dihomo-γ-linolenic acid (C20:3n-6) and D6 desaturase were associated with an increase probability of insulin resistance, whereas nervonic acid (C24:1) and SCD1 were significantly associated with a lower insulin resistance probability." | 3.83 | Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance. ( Chen, H; Du, J; Fang, M; Li, H; Li, S; Li, W; Xu, M, 2016) |
| "The excess of saturated free fatty acids, such as palmitic acid, that induces lipotoxicity in hepatocytes, has been implicated in the development of non-alcoholic fatty liver disease also associated with insulin resistance." | 3.81 | Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection. ( González-Rodríguez, Á; Kozma, SC; Muntané, J; Pardo, V; Valverde, ÁM, 2015) |
| " L6 muscle cells were incubated with palmitic acid (PA) to induce insulin resistance and then treated with metformin and/or the AMPK inhibitor, compound C." | 3.81 | Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway. ( Bi, Y; Bu, R; Cao, S; Shi, J; Tang, S; Wu, W; Yin, W; Zhu, D, 2015) |
| "To study the effect of conditioned media for rat bone marrow mesenchymal stem cells (BMSCs-CM) on palmitic acid (PA)-induced insulin resistance (IR) in HepG2 cells and its underlying molecular mechanisms." | 3.81 | [Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells]. ( Han, W; Hao, H; Mu, Y; Sun, X, 2015) |
| " This study examined the effect of a novel neuroprotective curcuminoid, CNB-001 [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl)vinyl)-2-methoxy-phenol], on glucose intolerance and insulin signaling in high-fat diet (HFD)-fed mice." | 3.80 | Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance. ( Hua, Y; Lapchak, PA; Lehmann, TE; Nair, S; Panzhinskiy, E; Ren, J; Topchiy, E, 2014) |
| "APS treatment ameliorated hyperglycemia, hyperlipidemia, and insulin resistance and decreased the elevation of myostatin expression and malondialdehyde production in skeletal muscle of noninsulin-dependent diabetic KKAy mice." | 3.79 | Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways. ( Hao, Y; Liu, M; Luo, J; Luo, T; Qin, J; Wei, L, 2013) |
| " Coculture of activated macrophages with human muscle cells impairs insulin signaling and induces atrophy signaling pathways in the human muscle cells; this is exacerbated by the addition of palmitic acid." | 3.78 | DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages. ( Dubé, J; Finlin, BS; Kern, PA; Nolen, GT; Peterson, CA; Rasouli, N; Starnes, CP; Varma, V, 2012) |
| "We have found that polyunsaturated fatty acids, in particular arachidonic and eicosapentaenoic acids prevent palmitic acid-induced myocellular insulin resistance." | 3.78 | Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells. ( Ashida, H; Kawabata, K; Kawasaki, K; Sawada, K; Yamamoto, N; Yamashita, T, 2012) |
| "We investigated whether diosgenin, a widely used steroidal sapogenin, exerted protection against palmitate (PA)-induced inflammation and insulin resistance in the endothelium." | 3.78 | Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways. ( Gao, X; Huang, F; Kou, J; Liu, B; Liu, K; Zhao, W, 2012) |
| "To explore the adipose tissue endocrine mechanism of pioglitazone and its possible prophylactic role in insulin resistance." | 3.78 | The adipose tissue endocrine mechanism of the prophylactic protective effect of pioglitazone in high-fat diet-induced insulin resistance. ( Gong, Y; Li, C; Li, J; Liu, Y; Mu, Y; Pan, C; Tian, H; Xiao, Y, 2012) |
| "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway." | 3.77 | Curcumin improves insulin resistance in skeletal muscle of rats. ( Kong, T; Li, R; Li, Y; Liu, LY; Na, LX; Sun, CH; Zhang, YL, 2011) |
| " In addition, it was validated if IMTG palmitic acid is associated with insulin resistance as suggested earlier." | 3.76 | Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control. ( Haugaard, SB; Madsbad, S; Mu, H; Vaag, A, 2010) |
| "Palmitic acid (16:0), the major saturated fatty acid (SFA) in the diet and in adipose tissue, was negatively correlated with insulin sensitivity (r = -0." | 3.76 | Adipose tissue fatty acids and insulin sensitivity in elderly men. ( Arnlöv, J; Cederholm, T; Iggman, D; Risérus, U; Sjögren, P; Vessby, B, 2010) |
| "We found strong positive relationships between adipose tissue TG content of the fatty acids myristic acid (14:0) and stearic acid (18:0) with insulin sensitivity (HOMA model) (p < 0." | 3.75 | Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans. ( Dennis, AL; Frayn, KN; Harnden, KE; Hodson, L; Humphreys, SM; Micklem, KJ; Neville, MJ; Roberts, R, 2009) |
| " On the other hand, the antioxidant, Taurine at 10mM concentrations was capable of reversing the oleate-induced insulin resistance in myocytes as manifested from the glucose uptake data." | 3.75 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. ( Adeli, K; Fantus, IG; Medhat, AM; Ragheb, R; Seoudi, DM; Shanab, GM, 2009) |
| "The purpose of the study is to investigate the effect of 8-hydroxy-dihydroberberine on insulin resistance induced by high free fatty acid (FFA) and high glucose in 3T3-L1 adipocytes and its possible molecular mechanism." | 3.75 | [8-hydroxy-dihydroberberine ameliorated insulin resistance induced by high FFA and high glucose in 3T3-L1 adipocytes]. ( Chen, G; Dong, H; Lu, FE; Wang, ZS; Wei, SC; Xu, LJ; Yi, P; Zou, X, 2009) |
| " Cells exposed to angiotensin II remained viable and did not show signs of hypertrophy." | 3.74 | Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells). ( Alfarano, C; Cerbai, E; Mannucci, E; Mugelli, A; Nediani, C; Raimondi, L; Sartiani, L, 2008) |
| "Oleic acid and palmitic acid may induce insulin resistance in 3T3-L1 adipocytes and preadipocytes." | 3.73 | Effects of fatty acid regulation on visfatin gene expression in adipocytes. ( Cianflone, K; Hu, XF; Lu, HL; Wang, HW; Wen, Y; Wu, J, 2006) |
| "In order to study the effects of troglitazone on insulin resistance associated with elevated plasma free fatty acid (FFA), the hindquarters of rats treated with troglitazone for 14 days were perfused with a medium containing 15 mmol/l glucose, 0-1,000 microU/ml insulin, and 0 or 1." | 3.70 | Troglitazone reduces free fatty acid-induced insulin resistance in perfused rat hindquarter. ( Mokuda, O; Sakamoto, Y, 1998) |
| "Beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) consists of a nonmetabolizable long-chain fatty acid designed to probe the effect exerted by fatty acids on insulin sensitivity." | 3.69 | Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. ( Bar-Tana, J; Itach, E; Kalderon, B; Mayorek, N, 1997) |
| "Six subjects in the obese-NAFLD group were also evaluated before and after a diet-induced weight loss of 10%." | 2.94 | Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. ( Beals, JW; Chondronikola, M; Field, T; Hellerstein, MK; Klein, S; Nyangau, E; Okunade, AL; Patterson, BW; Schweitzer, GG; Shankaran, M; Sirlin, CB; Smith, GI; Talukdar, S; Yoshino, M, 2020) |
| "Insulin sensitivity was assessed using a hyperinsulinemic-euglycemic clamp." | 2.82 | Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose. ( Blaak, EE; Diamant, M; Goossens, GH; Jans, A; Jocken, JW; Konings, E; Moors, CC; van der Zijl, NJ, 2016) |
| "Body weight was kept constant throughout the study." | 2.70 | Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults. ( Bray, GA; Champagne, CM; DeLany, JP; Denkins, YM; Lefevre, M; Lovejoy, JC; Most, MM; Rood, JC; Smith, SR; Veldhuis, J, 2002) |
| "Palmitic acid is a saturated fat found in foods that lead to obesity, cardiovascular disease, and Type II diabetes." | 2.47 | The twists and turns of sphingolipid pathway in glucose regulation. ( Deevska, GM; Nikolova-Karakashian, MN, 2011) |
| "Obesity is a major contributing factor for metabolic-associated fatty liver disease (MAFLD)." | 1.91 | FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation. ( Chen, C; Gao, D; Li, X; Wang, J; Yang, L; Yang, W; Yu, C; Zhang, F; Zhang, JS, 2023) |
| "Patients with type 2 diabetes respond differently to sitagliptin, an oral anti-hyperglycemic medication." | 1.91 | The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway. ( Aleteng, QQ; Jiang, S; Li, L; Ma, R; Quan, L; Zhu, J, 2023) |
| "Improved insulin sensitivity was accompanied by increased glucose transporter 4 (Glut4) expression in conjunction with decreased soleus free fatty acid and IMC lipid content, as well as CD36 expression." | 1.72 | Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance. ( Habibi, J; Hulse, JL; Igbekele, AE; Jia, G; Li, J; Sowers, JR; Whaley-Connell, A; Zhang, B, 2022) |
| "Ultrasound was used to estimate NAFLD at admission." | 1.72 | Long-chain saturated fatty acids and its interaction with insulin resistance and the risk of nonalcoholic fatty liver disease in type 2 diabetes in Chinese. ( Jiang, LP; Sun, HZ, 2022) |
| "Palmitic acid effects were dependent on TLR4 and impaired by methyltransferase inhibition and AMPK activation." | 1.72 | Weight cycling induces innate immune memory in adipose tissue macrophages. ( Boney, LY; Caslin, HL; Cottam, MA; Hasty, AH; Piñon, JM, 2022) |
| "Nonalcoholic fatty liver disease (NAFLD) is characterized by lipotoxicity and ectopic lipid deposition within hepatocytes." | 1.62 | Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. ( Li, J; Teng, W; Xie, S, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for diabetes, is now recognized as the most common liver disease worldwide." | 1.62 | Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. ( Chen, L; Cui, C; Cui, Y; Guo, X; He, Q; Hu, H; Liang, K; Sha, S; Song, J; Sun, L; Wang, C; Wang, L; Yang, M; Zang, N, 2021) |
| "Insulin resistance is defined as a failure to trigger the activation of the PI3K-AKT pathway by normal levels of insulin; therefore, it is well linked to metabolic disorders." | 1.62 | Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance. ( Imoto, M; Itoh, S; Nagasawa, Y; Tashiro, E, 2021) |
| "Furthermore, most people with type 2 diabetes are either obese or overweight, with the associated dyslipidaemia contributing to the development of insulin resistance and increased cardiovascular risk." | 1.56 | Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion. ( Bagnati, M; Berry, MD; Billacura, MP; Caton, PW; Cripps, MJ; Fair, K; Hanna, K; Hitman, GA; Jones, TA; Lowe, R; Nelson, C; Ogunkolade, BW; Sayers, SR; Turner, MD, 2020) |
| "Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal." | 1.56 | Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism. ( Astrup, A; Auwerx, J; Barrès, R; Bork-Jensen, J; Grarup, N; Hansen, AN; Hansen, T; Ingerslev, LR; Pedersen, O; Ribel-Madsen, R; Small, L; Williams, K; Wohlwend, M; Workman, CT, 2020) |
| "Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver without alcohol consumption and includes hepatic inflammation and damage." | 1.51 | Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice. ( Choi, SE; Cui, R; Han, SJ; Heo, YJ; Hong, SA; Hwang, Y; Jung, IR; Kang, Y; Kim, HJ; Lee, KW; Lee, SJ; Son, Y, 2019) |
| "Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties." | 1.51 | Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. ( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019) |
| "These results provide a new potential treatment for obesity in the future." | 1.51 | Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. ( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019) |
| "Insulin resistance is a key feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling." | 1.48 | BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes. ( Luo, J; Shi, D; Wu, N; Xu, Q; Zhang, R, 2018) |
| "Insulin resistance is generally responsible for the pathogenesis of type 2 diabetes mellitus (T2DM)." | 1.48 | Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate. ( Cheng, J; Ding, Y; Du, Y; Lu, A; Lu, L; Meng, C; Yao, Q; Ye, X; Yu, W; Zhao, Z, 2018) |
| "Hepatic insulin sensitivity is critical for glucose homeostasis, and insulin resistance is a fundamental syndrome found in various metabolic disorders, including obesity and type 2 diabetes." | 1.48 | Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1. ( Chen, H; Huang, J; Huang, K; Li, J; Wang, Y; Xue, W; Yuan, Y; Zhang, W; Zhang, Y; Zheng, L; Zhu, X, 2018) |
| "The effect of hyperlipidemia on hepatic HPS expression was evaluated in primary hepatocytes and liver of mice." | 1.48 | Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle. ( Abd El-Aty, AM; Chung, YH; Jeong, JH; Jung, TW; Kim, HC, 2018) |
| "Insulin resistance is a critical process in the initiation and progression of diabetic nephropathy (DN)." | 1.48 | Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. ( An, XR; Jin, SJ; Li, XX; Wei, W; Xu, M, 2018) |
| "Melatonin plays an important role in regulating circadian rhythms." | 1.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "Insulin sensitivity was scored by Akt phosphorylation and glucose transporter 4 (GLUT4) translocation, while pro-inflammatory indices were estimated by IκBα degradation and cytokine expression." | 1.48 | Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells. ( Bilan, PJ; Brozinick, JT; Frendo-Cumbo, S; Hoang Bui, H; Jacobson, MR; Klip, A; Liu, Z; Milligan, PL; Pillon, NJ; Zierath, JR, 2018) |
| "Hepatic insulin resistance was induced by palmitic acid (PA) in the HepG2 cells, which were then treated with EPO (5 or 10 U/ml) or specific phosphoinositide 3‑kinase (PI3K) inhibitors, wortmannin or LY294002." | 1.46 | Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells. ( Bi, Y; Ge, Z; Meng, R; Tang, S; Zhang, H; Zhu, D, 2017) |
| "The eruptive xanthomata are formed in vivo under realization of biological function of endoecology." | 1.46 | [The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata]. ( Rozhkova, TA; Samokhodskaya, LM; Titov, VN, 2017) |
| "Palmitic acid treatment caused mitochondrial damage and leakage of mitochondrial DNA into the cytosol." | 1.46 | STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. ( Abe, JI; Fujiwara, K; LeMaire, SA; Luo, W; Mao, Y; Shen, YH; Song, J; Wang, XL; Wu, W; Xu, H; Yuan, L; Zhang, L, 2017) |
| "Palmitic acid is a negative regulator of insulin activity." | 1.43 | Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. ( Chavez-Reyes, J; Guerrero-Hernandez, A; Gustavo Vazquez-Jimenez, J; Manuel Galindo-Rosales, J; Olivares-Reyes, JA; Romero-Garcia, T; Rueda, A; Valdes-Flores, J; Zarain-Herzberg, A, 2016) |
| "Berberine (BBR) is an isoquinoline alkaloid extract that has shown promise as a hypoglycemic agent in the management of diabetes in animal and human studies." | 1.43 | Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. ( Chang, W; Chen, L; Hatch, GM, 2016) |
| "Insulin sensitivity was measured by hyperinsulinaemic-euglycaemic clamp in humans and via insulin-stimulated glucose uptake in myotubes." | 1.43 | ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. ( Bosma, M; Gemmink, A; Hesselink, MK; Hoeks, J; Jörgensen, JA; Moonen-Kornips, E; Nascimento, EB; Phielix, E; Schaart, G; Schrauwen, P; Sparks, LM, 2016) |
| "Insulin resistance was induced by feeding a high fat diet to Sprague-Dawley rats." | 1.43 | Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle. ( Cao, Y; Chang, S; Cui, J; Dong, J; Li, J; Long, R; Zhang, Y; Zheng, X; Zhou, Y; Zhu, S, 2016) |
| "Bortezomib is an anti-cancer agent that induces ER stress by inhibiting proteasomal degradation." | 1.43 | Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism. ( Bae, YA; Cheon, HG; Choi, HE; Jang, J; Kwak, HJ; Park, SK, 2016) |
| "Obesity-associated insulin resistance is a major pathogenesis of type 2 diabetes mellitus and is characterized by defects in insulin signaling." | 1.42 | Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules. ( Akagawa, M; Ishii, M; Maeda, A; Tani, S, 2015) |
| "A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis." | 1.42 | Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. ( Bears, M; Camporez, JP; Cline, GW; Gattu, AK; Jurczak, MJ; Kumashiro, N; Majumdar, SK; Petersen, MC; Rahimi, Y; Samuel, VT; Shulman, GI; Vatner, DF, 2015) |
| "Obesity is the result of a positive energy balance and often leads to difficulties in maintaining normal postprandial metabolism." | 1.42 | Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects. ( Feng, R; Guo, F; Jiao, J; Li, Y; Liu, L; Sun, C, 2015) |
| "Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumulation and TNF-α overexpression in skeletal muscle." | 1.42 | TNF-α knockdown alleviates palmitate-induced insulin resistance in C2C12 skeletal muscle cells. ( Bakhtiyari, S; Haghani, K; Pashaei, S; Taheripak, G; Vakili, S, 2015) |
| "As obesity is one of the major risk factors of chronic and end-stage renal disease, we studied the role of Smad3 signaling in the pathogenesis of obesity-related renal disease." | 1.42 | Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance. ( Bertram, JF; Caruana, G; Dai, L; Fu, P; Howard, V; Jiang, X; Li, J; Nikolic-Paterson, DJ; Puelles, VG; Qu, X; Ren, Y; Sleeman, MW; Sun, YB, 2015) |
| "Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose tissue." | 1.42 | Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance. ( James, J; Roy, D; Shihabudeen, MS; Thirumurugan, K, 2015) |
| "Chronic inflammation is associated with insulin resistance, a characteristic of type 2 diabetes (T2D)." | 1.42 | Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. ( Chen, J; He, C; Hu, X; Huang, Q; Wang, Y; Xu, Y; Xue, J; Zeng, Q; Zhang, W, 2015) |
| "Obvious obese feathers associated with type 2 diabetes were observed in HFD feeding mice, with decreased circulating irisin level and FNDC5/irisin secretion in adipose tissues." | 1.42 | Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice. ( Chen, X; Chen, Y; Yang, Z; Zhao, Q, 2015) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in parallel with the prevalence of obesity." | 1.42 | GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. ( Isobe, K; Nishio, N, 2015) |
| " The excess calories are stored as triglycerides in adipose tissue, but also may accumulate ectopically in other organs, including the kidney, which contributes to the damage through a toxic process named lipotoxicity." | 1.42 | Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes. ( Chen, S; Izquierdo-Lahuerta, A; Martínez-García, C; Medina-Gomez, G; Velasco, I; Vivas, Y; Yeo, TK, 2015) |
| "After 4 wk of treatment, alveolar bone loss was determined by micro-computed tomography." | 1.40 | Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome. ( Huang, Y; Jin, J; Kirkwood, KL; Li, Y; Lopes-Virella, MF; Lu, Z; Machado, ER; Yu, H; Zhang, X, 2014) |
| "Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR)." | 1.40 | Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people. ( Amouzou, C; Bisbal, C; Breuker, C; Fabre, O; Kitzmann, M; Mercier, J; Salehzada, T, 2014) |
| "Palmitic acid (PA) was chosen as a stimulant to induce ROS production in endothelial cells and successfully established insulin resistance evidenced by the specific impairment of insulin PI3K signaling." | 1.39 | Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. ( Cheng, XL; Gao, XJ; Liu, BL; Liu, K; Qin, MJ; Qin, XY; Qin, Y; Wang, Q; Xie, GY; Zhang, DY; Zhou, L, 2013) |
| "Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake." | 1.39 | Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. ( Ang, J; Bonala, S; Chua, H; Gluckman, PD; Kambadur, R; Lee, M; Lee, YS; Leow, MK; Lim, R; Lokireddy, S; McFarlane, C; Meng, KC; Sharma, M; Shyong, TE; Sreekanth, P, 2013) |
| "The aging rats showed hyperinsulinemia and hyperlipidemia, and insulin resistance as examined by the decreased glucose decay constant rate during insulin tolerance test (kITT)." | 1.39 | Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. ( Cai, L; Feng, H; Gong, D; Guan, L; Wu, Q; Yang, M; Yuan, B; Zhao, J; Zhao, X; Zou, Y, 2013) |
| "Glycogen synthesis was assessed by [¹⁴C]glucose incorporation." | 1.38 | Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells. ( Ferré, P; Foufelle, F; Hage Hassan, R; Hainault, I; Hajduch, E; Lasnier, F; Samama, C; Vilquin, JT, 2012) |
| "Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, and an increased risk for liver cirrhosis and cancer." | 1.38 | Elovl6 promotes nonalcoholic steatohepatitis. ( Atsumi, A; Ishii, K; Kobayashi, K; Kuba, M; Matsumori, R; Matsuzaka, T; Murata, S; Nakagawa, Y; Nakamuta, M; Nie, T; Shimada, M; Shimano, H; Shinozaki, H; Sone, H; Suzuki, H; Suzuki-Kemuriyama, N; Takahashi, A; Takekoshi, K; Yahagi, N; Yamada, N; Yatoh, S, 2012) |
| "2-Deoxyglucose uptake was measured in LAR knockdown and control cells using d-[2-(3)H]glucose." | 1.38 | Leukocyte antigen-related inhibition attenuates palmitate-induced insulin resistance in muscle cells. ( Bakhtiyari, S; Golestani, A; Gorgani-Firuzjaee, S; Meshkani, R, 2012) |
| "Obesity is associated with insulin resistance in the peripheral vasculature and is an important risk factor for coronary artery disease." | 1.37 | Preserved insulin vasorelaxation and up-regulation of the Akt/eNOS pathway in coronary arteries from insulin resistant obese Zucker rats. ( Andriantsitohaina, R; Contreras, C; García-Sacristán, A; Martínez, MC; Prieto, D; Sánchez, A, 2011) |
| "Increased inflammation was associated with impaired glucose tolerance and hyperinsulinemia as a result of reduced hepatic but not skeletal muscle insulin sensitivity." | 1.37 | Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance. ( Fynch, SL; Galic, S; Graham, KL; Hewitt, KA; Honeyman, JE; Kay, TW; Sachithanandan, N; Steinberg, GR, 2011) |
| " Accordingly, dose-response curves for insulin-mediated suppression of the FoxO1-induced gluconeogenic genes and for de novo glucose production were right shifted, and insulin-stimulated glucose oxidation and glycogen synthesis were impaired." | 1.37 | Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. ( Galbo, T; Nishimura, E; Olsen, GS; Quistorff, B, 2011) |
| "Palmitate-induced inflammation is involved in the development of insulin resistance in skeletal muscle cells." | 1.36 | Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells. ( Blanco-Vaca, F; Coll, T; Escolà-Gil, JC; Laguna, JC; Palomer, X; Sánchez, RM; Vázquez-Carrera, M, 2010) |
| "Insulin sensitivity was assessed by the minimal model analysis." | 1.36 | Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. ( Avogaro, A; Bortoluzzi, A; Ceolotto, G; Cobelli, C; Dalla Man, C; de Kreutzenberg, SV; Fadini, GP; Papparella, I; Semplicini, A, 2010) |
| "Lipid-induced insulin resistance is associated with inflammatory state in epidemiological studies." | 1.36 | Overactivation of NF-κB impairs insulin sensitivity and mediates palmitate-induced insulin resistance in C2C12 skeletal muscle cells. ( Ding, H; Guo, Y; Li, D; Wu, W; Zhang, J, 2010) |
| "Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and atherosclerosis." | 1.36 | Palmitate and insulin synergistically induce IL-6 expression in human monocytes. ( Bunn, RC; Cockrell, GE; Fowlkes, JL; Lumpkin, CK; Ou, Y; Thrailkill, KM, 2010) |
| "Insulin resistance was present in SHR skeletal muscle." | 1.35 | FAT/CD36 expression is not ablated in spontaneously hypertensive rats. ( Bonen, A; Glatz, JF; Han, XX; Lally, J; Luiken, JJ; Snook, LA; Tandon, NN, 2009) |
| "Skeletal muscle insulin resistance is associated with lipid accumulation, but whether insulin resistance is due to reduced or enhanced flux of long-chain fatty acids into the mitochondria is both controversial and unclear." | 1.35 | Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. ( Allen, TL; Bruce, CR; Carpenter, K; Cooney, GJ; Febbraio, MA; Hoy, AJ; Kraegen, EW; Turner, N; Watt, MJ, 2009) |
| "Obesity is characterized by adipose tissue expansion as well as macrophage infiltration of adipose tissue." | 1.35 | Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. ( Gurley, C; Kern, PA; McGehee, RE; Nolen, GT; Peterson, CA; Phanavanh, B; Rasouli, N; Simpson, P; Starks, T; Varma, V; Yao-Borengasser, A, 2009) |
| "Cellular insulin resistance is the hallmark of type 2 diabetes and predominantly affects adipose and muscle cells." | 1.35 | Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy. ( Coward, RJ; Lennon, R; Mathieson, PW; Pons, D; Sabin, MA; Saleem, MA; Shield, JP; Tavaré, JM; Wei, C; Welsh, GI, 2009) |
| "Dyslipidemia is common in patients with HIV infection." | 1.33 | Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. ( Cade, WT; DeMoss, A; Fontana, L; Klein, S; Laciny, E; Patterson, BW; Powderly, WG; Reeds, DN; Yarasheski, KE, 2006) |
| "We hypothesised that in subjects with type 2 diabetes muscle malonyl-CoA (an inhibitor of fatty acid oxidation) would be elevated at baseline in comparison with control subjects and in particular during physiological hyperinsulinaemia with hyperglycaemia." | 1.33 | Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. ( Bell, JA; Cadenas, JG; Fujita, S; Rasmussen, BB; Volpi, E, 2006) |
| "JNKs are attractive targets for treatment of obesity and type-2 diabetes." | 1.33 | Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. ( Galimi, F; Karin, M; Lee, MS; Naugler, W; Solinas, G, 2006) |
| "Insulin resistance is defined as the decrease in the glucose disposal in response to insulin by the target tissues." | 1.32 | High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. ( Calderón, V; Reynoso, R; Salgado, LM, 2003) |
| " The slope of the angiotensin II dose-response curve correlated significantly with the basal plasma palmitate concentration." | 1.32 | Vascular response to angiotensin II in upper body obesity. ( Halliwill, JR; Jensen, MD; Joyner, MJ; Nielsen, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (2.54) | 18.2507 |
| 2000's | 48 (15.24) | 29.6817 |
| 2010's | 200 (63.49) | 24.3611 |
| 2020's | 59 (18.73) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, KY | 1 |
| Chien, SJ | 1 |
| Tan, BC | 1 |
| Chen, YW | 1 |
| Tiwary, S | 1 |
| Nandwani, A | 1 |
| Khan, R | 1 |
| Datta, M | 1 |
| Molonia, MS | 4 |
| Occhiuto, C | 3 |
| Muscarà, C | 3 |
| Speciale, A | 4 |
| Ruberto, G | 1 |
| Siracusa, L | 1 |
| Cristani, M | 3 |
| Saija, A | 4 |
| Cimino, F | 4 |
| Ceja-Galicia, Z | 1 |
| Calderón-DuPont, D | 1 |
| Daniel, A | 1 |
| Chiu, LM | 1 |
| Díaz-Villaseñor, A | 1 |
| Dai, HB | 1 |
| Wang, HY | 1 |
| Wang, FZ | 1 |
| Qian, P | 1 |
| Gao, Q | 2 |
| Zhou, H | 2 |
| Zhou, YB | 1 |
| Li, J | 11 |
| Xie, S | 2 |
| Teng, W | 2 |
| Quan, X | 1 |
| Guo, Q | 2 |
| Li, X | 5 |
| Liang, Y | 1 |
| Cui, M | 1 |
| Huang, S | 3 |
| Wang, J | 7 |
| Li, B | 2 |
| Chen, J | 5 |
| Wu, Z | 1 |
| Si, X | 1 |
| Zhang, R | 2 |
| Sun, T | 1 |
| Dong, Q | 1 |
| Wu, W | 4 |
| Qiu, Y | 1 |
| Xue, GM | 1 |
| Zhao, CG | 1 |
| Xue, JF | 1 |
| Du, K | 1 |
| Duan, JJ | 1 |
| Pan, H | 1 |
| Li, M | 4 |
| Chen, H | 4 |
| Sun, YJ | 1 |
| Feng, WS | 1 |
| Ma, T | 1 |
| Zhang, WD | 1 |
| Ávalos, Y | 1 |
| Hernández-Cáceres, MP | 1 |
| Lagos, P | 1 |
| Pinto-Nuñez, D | 1 |
| Rivera, P | 1 |
| Burgos, P | 1 |
| Díaz-Castro, F | 1 |
| Joy-Immediato, M | 1 |
| Venegas-Zamora, L | 1 |
| Lopez-Gallardo, E | 1 |
| Kretschmar, C | 1 |
| Batista-Gonzalez, A | 1 |
| Cifuentes-Araneda, F | 1 |
| Toledo-Valenzuela, L | 1 |
| Rodriguez-Peña, M | 1 |
| Espinoza-Caicedo, J | 1 |
| Perez-Leighton, C | 1 |
| Bertocchi, C | 1 |
| Cerda, M | 1 |
| Troncoso, R | 1 |
| Parra, V | 1 |
| Budini, M | 1 |
| Burgos, PV | 1 |
| Criollo, A | 1 |
| Morselli, E | 1 |
| Bugga, P | 1 |
| Mohammed, SA | 1 |
| Alam, MJ | 1 |
| Katare, P | 1 |
| Meghwani, H | 1 |
| Maulik, SK | 1 |
| Arava, S | 1 |
| Banerjee, SK | 1 |
| Hulse, JL | 1 |
| Habibi, J | 1 |
| Igbekele, AE | 1 |
| Zhang, B | 2 |
| Whaley-Connell, A | 1 |
| Sowers, JR | 1 |
| Jia, G | 1 |
| Jiao, Y | 1 |
| Williams, A | 1 |
| Wei, N | 1 |
| Zhu, P | 3 |
| Zhang, JJ | 1 |
| Cen, Y | 1 |
| Yang, Y | 1 |
| Wang, F | 1 |
| Gu, KP | 1 |
| Yang, HT | 1 |
| Wang, YZ | 1 |
| Zou, ZQ | 1 |
| Jiang, LP | 1 |
| Sun, HZ | 1 |
| Caslin, HL | 1 |
| Cottam, MA | 1 |
| Piñon, JM | 1 |
| Boney, LY | 1 |
| Hasty, AH | 1 |
| Su, Q | 1 |
| Huang, J | 3 |
| Chen, X | 9 |
| Wang, Y | 14 |
| Shao, M | 1 |
| Yan, H | 1 |
| Chen, C | 3 |
| Ren, H | 1 |
| Zhang, F | 4 |
| Ni, Y | 1 |
| Jose, PA | 1 |
| Zhong, J | 1 |
| Yang, J | 3 |
| Wang, C | 7 |
| Zhang, W | 3 |
| Liu, W | 1 |
| Lv, Z | 1 |
| Gui, R | 1 |
| Li, Y | 15 |
| Sun, X | 3 |
| Liu, P | 4 |
| Fan, X | 2 |
| Yang, S | 1 |
| Xiong, Y | 1 |
| Qian, L | 1 |
| Zhou, Q | 1 |
| Lu, Z | 4 |
| Wang, B | 2 |
| Li, L | 5 |
| You, M | 1 |
| Wang, L | 7 |
| Cao, T | 1 |
| Zhao, Y | 2 |
| Li, Q | 2 |
| Mou, A | 1 |
| Shu, W | 1 |
| He, H | 2 |
| Zhao, Z | 2 |
| Liu, D | 2 |
| Zhu, Z | 1 |
| Gao, P | 1 |
| Yan, Z | 1 |
| Yang, W | 2 |
| Gao, D | 2 |
| Yang, L | 4 |
| Yu, C | 1 |
| Zhang, JS | 1 |
| Chowdhury, N | 1 |
| Yu, H | 3 |
| Syn, WK | 1 |
| Lopes-Virella, M | 1 |
| Yilmaz, Ö | 1 |
| Huang, Y | 3 |
| Jiang, X | 2 |
| Zhou, Y | 4 |
| Gu, Y | 2 |
| Ding, Y | 3 |
| Luo, J | 3 |
| Pang, N | 1 |
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| Pei, L | 1 |
| Pan, J | 1 |
| Gao, M | 1 |
| Ma, S | 2 |
| Xiao, Y | 2 |
| Wu, F | 1 |
| Ma, R | 1 |
| Quan, L | 1 |
| Aleteng, QQ | 1 |
| Zhu, J | 1 |
| Jiang, S | 2 |
| Pan, X | 1 |
| Liu, C | 5 |
| Wang, X | 6 |
| Zhao, M | 1 |
| Zhang, Z | 2 |
| Zhang, X | 6 |
| Song, G | 3 |
| Han, X | 1 |
| Yang, F | 3 |
| Hou, Z | 2 |
| Sun, Q | 1 |
| Su, T | 1 |
| Lv, W | 1 |
| Wang, Z | 3 |
| Yuan, C | 1 |
| Zhang, G | 2 |
| Pi, X | 1 |
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| Liu, H | 1 |
| Huang, PY | 1 |
| Chiang, CC | 1 |
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| Lin, PY | 1 |
| Kuo, HC | 1 |
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| Hsieh, CC | 1 |
| Jeon, JY | 2 |
| Choi, SE | 5 |
| Ha, ES | 3 |
| Lee, HB | 1 |
| Kim, TH | 3 |
| Han, SJ | 4 |
| Kim, HJ | 6 |
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| Kang, Y | 5 |
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| Hu, H | 2 |
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| Liu, J | 6 |
| Oh, Y | 1 |
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| Xie, T | 1 |
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| Li, XY | 1 |
| Leung, PS | 1 |
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| Ogunkolade, BW | 1 |
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| Schweitzer, GG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health[NCT02706262] | 180 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Effect of Dietary Macronutrient Composition on Liver Substrate Metabolism[NCT01371396] | 24 participants (Actual) | Interventional | 2007-09-01 | Completed | |||
| "Stress and Biomarkers of Aging: a Novel Stress Management Program With the Cognitive Restructuring Method Pythagorean Self-Awareness Intervention in Healthy Individuals and in Subjects With Type 2 Diabetes Mellitus."[NCT04763525] | 48 participants (Actual) | Interventional | 2018-10-04 | Completed | |||
| Full-fat Yogurt and Glucose Tolerance[NCT03577119] | 13 participants (Actual) | Interventional | 2018-06-01 | Completed | |||
| Palmitate Metabolism and Insulin Resistance[NCT01612234] | 70 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Impact of Ageing on Adipose, Muscle and Systemic Inflammation[NCT02777138] | 24 participants (Anticipated) | Observational | 2016-05-31 | Active, not recruiting | |||
| Effect of Oral Supplementation With One Form of L-arginine on Vascular Endothelial Function in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02354794] | 36 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Characterization of the Metabolic Fate of an Oral L-arginine Form in Healthy Subjects Featuring Risk Factors Related to the Metabolic Syndrome.[NCT02352740] | 32 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Muscle Insulin Resistance In Aging[NCT02230839] | 200 participants (Anticipated) | Interventional | 2014-06-30 | Active, not recruiting | |||
| Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity - the MISTY Study[NCT03065140] | 50 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| Copenhagen Obesity Risk Assessment Study - A Double Blind Randomized Dietary Intervention Study Examining the Effect of a High Intake of Trans Fatty Acids on Abdominal Obesity and Risk Markers of Type 2 Diabetes and Cardiovascular Disease.[NCT00655902] | 52 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| Pilot Study of the Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome[NCT02153983] | Phase 1/Phase 2 | 77 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation in Both Skeletal Muscle and Adipose Tissue[NCT01911091] | 56 participants (Anticipated) | Interventional | 2013-07-31 | Active, not recruiting | |||
| Uncovering the 'ORIGINS' of Diabetes[NCT02226640] | 80 participants (Actual) | Observational | 2010-11-30 | Completed | |||
| Investigating the Effects of Aerobic and Resistance Training in Vivo on Skeletal Muscle Metabolism in Vitro in Primary Human Muscle Cells (MoTrMyo)[NCT04334343] | 400 participants (Anticipated) | Interventional | 2020-11-01 | Recruiting | |||
| The Effect of Palmitoleic Acid (POA) Supplementation on Insulin Sensitivity and Lipogenesis in Overweight and Obese Individuals[NCT05560971] | 40 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Insulin and Sarcopenia in the Elderly[NCT00690534] | Phase 1 | 88 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Mechanisms by Which Strength Training Ameliorates the Metabolic Syndrome[NCT00727779] | 50 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change (3 month minus minus baseline) in calculated homeostasis model of insulin sensitivity, calculated from derived from fasting glucose and insulin values = fasting insulin (microU/L) x fasting glucose (nmol/L)/22.5) using intent-to-treat. Higher values represent a worse outcome. There are no data from the evaluation-only participants, since they were not followed longitudinally. (NCT02153983)
Timeframe: Baseline to 3 months
| Intervention | units on a scale (Mean) |
|---|---|
| Obese Adults With Metabolic Syndrome Randomized to Placebo | 1.1 |
| Obese Adults With Metabolic Syndrome Randomized to Colchicine | -0.3 |
| Open Label Patients With Type 2 Diabetes | 8.4 |
Change (3 month minus minus baseline) in insulin sensitivity value, calculated from frequently-sampled intravenous glucose tolerance tests by Bergman's Minimal Model using intent-to-treat. Higher values represent a better outcome. There are no data from the evaluation-only participants, since they were not followed longitudinally. (NCT02153983)
Timeframe: Baseline to 3 months
| Intervention | 10^-5*min^-1*mU^-1*mL (Mean) |
|---|---|
| Obese Adults With Metabolic Syndrome Randomized to Placebo | 0.20 |
| Obese Adults With Metabolic Syndrome Randomized to Colchicine | 0.41 |
| Open Label Patients With Type 2 Diabetes | -0.45 |
Change (3 month minus minus baseline) in High-Sensitivity C-reactive protein concentrations using intent-to-treat. Higher values represent a worse outcome. There are no data from the evaluation-only participants, since they were not followed longitudinally. (NCT02153983)
Timeframe: Baseline to 3 months
| Intervention | mg/L (Mean) |
|---|---|
| Obese Adults With Metabolic Syndrome Randomized to Placebo | 0.5 |
| Obese Adults With Metabolic Syndrome Randomized to Colchicine | -2.8 |
| Open Label Patients With Type 2 Diabetes | -3.7 |
6 reviews available for palmitic acid and Insulin Resistance
| Article | Year |
|---|---|
Human embryonic stem cell-derived cardiomyocytes as an in vitro model to study cardiac insulin resistance.
Topics: Cell Differentiation; Cell Line; Cell Lineage; Diabetic Cardiomyopathies; Embryonic Stem Cells; Ener | 2018 |
Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Insulin-Secreting Cells; Oleic Acid; | 2018 |
[THE EXCESS OF PALMITIC FATTY ACID IN FOOD AS MAIN CAUSE OF LIPOIDOSIS OF INSULIN-DEPENDENT CELLS: SKELETAL MYOCYTES, CARDIO-MYOCYTES, PERIPORTAL HEPATOCYTES, KUPFFER MACROPHAGES AND B-CELLS OF PANCREAS].
Topics: Adipocytes; B-Lymphocytes; Dietary Fats; Hepatocytes; Humans; Insulin; Insulin Resistance; Insulin-S | 2016 |
The twists and turns of sphingolipid pathway in glucose regulation.
Topics: Animals; Ceramides; Diabetes Mellitus, Type 2; Dietary Fats; Glucose; Humans; Hyperglycemia; Insulin | 2011 |
[Prevention of atherosclerosis. Excess of palmitic acid in food--a cause of hypercholesterolemia, inflammatory syndrome, insulin resistance in myocytes, and apoptosis].
Topics: Apoptosis; Atherosclerosis; Dietary Fats; Humans; Hypercholesterolemia; Inflammation; Insulin Resist | 2011 |
Time-dependent effects of fatty acids on skeletal muscle metabolism.
Topics: Animals; Fatty Acids, Nonesterified; Glucose; Glycogen; Humans; Hypoglycemic Agents; Insulin; Insuli | 2007 |
10 trials available for palmitic acid and Insulin Resistance
| Article | Year |
|---|---|
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease.
Topics: Adult; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Lipogenesis; Liver; Male; Non-alc | 2020 |
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis.
Topics: Adiposity; Adult; Algorithms; Biomarkers; Body Mass Index; Cross-Sectional Studies; Deuterium Oxide; | 2015 |
Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.
Topics: Adolescent; Adult; Body Composition; Cross-Over Studies; Cytokines; Diet; Female; Gene Expression Re | 2015 |
Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.
Topics: Adolescent; Adult; Body Composition; Cross-Over Studies; Cytokines; Diet; Female; Gene Expression Re | 2015 |
Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.
Topics: Adolescent; Adult; Body Composition; Cross-Over Studies; Cytokines; Diet; Female; Gene Expression Re | 2015 |
Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes.
Topics: Adolescent; Adult; Body Composition; Cross-Over Studies; Cytokines; Diet; Female; Gene Expression Re | 2015 |
Altered Skeletal Muscle Fatty Acid Handling in Subjects with Impaired Glucose Tolerance as Compared to Impaired Fasting Glucose.
Topics: Biomarkers; Blood Glucose; Diglycerides; Double-Blind Method; Fasting; Female; Gene Expression Regul | 2016 |
Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity.
Topics: Adaptation, Physiological; Adult; Biopsy; Blood Glucose; Diet, Carbohydrate-Restricted; Energy Intak | 2010 |
Gastric bypass surgery is associated with near-normal insulin suppression of lipolysis in nondiabetic individuals.
Topics: Adult; Blood Glucose; Case-Control Studies; Cross-Sectional Studies; Down-Regulation; Fatty Acids, N | 2011 |
Effect of trans-fatty acid intake on insulin sensitivity and intramuscular lipids--a randomized trial in overweight postmenopausal women.
Topics: Aged; Blood Glucose; C-Peptide; Dietary Fats, Unsaturated; Fatty Acids, Nonesterified; Female; Glyce | 2011 |
Relationship between adipose tissue lipolytic activity and skeletal muscle insulin resistance in nondiabetic women.
Topics: Adipose Tissue; Adult; Aged; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucose Clamp Te | 2012 |
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Topics: Adolescent; Adult; Aging; Body Composition; Cohort Studies; Cross-Over Studies; Diet; Dietary Fats; | 2013 |
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Topics: Adolescent; Adult; Aging; Body Composition; Cohort Studies; Cross-Over Studies; Diet; Dietary Fats; | 2013 |
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Topics: Adolescent; Adult; Aging; Body Composition; Cohort Studies; Cross-Over Studies; Diet; Dietary Fats; | 2013 |
A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.
Topics: Adolescent; Adult; Aging; Body Composition; Cohort Studies; Cross-Over Studies; Diet; Dietary Fats; | 2013 |
Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults.
Topics: Adult; Body Weight; Cross-Over Studies; Dietary Fats, Unsaturated; Double-Blind Method; Female; Huma | 2002 |
299 other studies available for palmitic acid and Insulin Resistance
| Article | Year |
|---|---|
RNA editing of 5-HT
Topics: Adenosine Deaminase; Animals; Calcium; Calcium Signaling; Cell Line; Cyclic AMP Response Element-Bin | 2021 |
GRP75 mediates endoplasmic reticulum-mitochondria coupling during palmitate-induced pancreatic β-cell apoptosis.
Topics: Animals; Apoptosis; Calcium; Cell Line; Cell Line, Tumor; Endoplasmic Reticulum; Glucose Tolerance T | 2021 |
Effects of a pinitol-rich
Topics: Adipocytes; Animals; Glycyrrhiza; Humans; Hypertrophy; Inflammation; Inositol; Insulin; Insulin Resi | 2022 |
Leptin and adiponectin synthesis and secretion in mature 3T3-L1 adipocytes are differentially down-regulated by arsenic and palmitic acid exposure throughout different stages of adipogenesis.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipokines; Adiponectin; Animals; Arsenic; Arsenites; Cell D | 2022 |
Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes.
Topics: Adipocytes; Adrenomedullin; Animals; Inflammation; Insulin; Insulin Resistance; Obesity; Palmitic Ac | 2022 |
Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Ceramides; Diet, High-Fat; Hep G2 Cells; Humans; | 2021 |
Malus toringoides (Rehd.) Hughes improves glucose and lipid metabolism and liver injury in high fructose-induced mice.
Topics: Animals; Fructose; Glucose; Hyperlipidemias; Hypertension; Insulin Resistance; Lipid Metabolism; Liv | 2022 |
Docosahexaenoic Acid Ester of Phloridzin Reduces Inflammation and Insulin Resistance
Topics: AMP-Activated Protein Kinases; Cell Line; Diabetes Mellitus, Type 2; Docosahexaenoic Acids; Esters; | 2022 |
Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway.
Topics: Achillea; Glucose; Hep G2 Cells; Humans; Inflammasomes; Insulin Resistance; NLR Family, Pyrin Domain | 2022 |
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.
Topics: Animals; Autophagy; Cilia; Diabetes Mellitus, Type 2; Humans; Hypothalamus; Insulin; Insulin Resista | 2022 |
Empagliflozin prohibits high-fructose diet-induced cardiac dysfunction in rats via attenuation of mitochondria-driven oxidative stress.
Topics: Animals; Benzhydryl Compounds; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mel | 2022 |
Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance.
Topics: Aldosterone; Animals; CD36 Antigens; Diet, High-Fat; Dietary Fats; Dietary Sugars; Fatty Acids, None | 2022 |
Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line.
Topics: Adenosine; Animals; Antioxidants; Blood Glucose; Cell Line; Glucose Transporter Type 4; Insulin Rece | 2022 |
High Endogenously Synthesized N-3 Polyunsaturated Fatty Acids in Fat-1 Mice Attenuate High-Fat Diet-Induced Insulin Resistance by Inhibiting NLRP3 Inflammasome Activation via Akt/GSK-3β/TXNIP Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Carrier Proteins; Di | 2022 |
Long-chain saturated fatty acids and its interaction with insulin resistance and the risk of nonalcoholic fatty liver disease in type 2 diabetes in Chinese.
Topics: Diabetes Mellitus, Type 2; East Asian People; Fatty Acids; Humans; Insulin Resistance; Myristic Acid | 2022 |
Weight cycling induces innate immune memory in adipose tissue macrophages.
Topics: Adipose Tissue; Animals; Culture Media, Conditioned; Diabetes Mellitus; Glucose; Insulin Resistance; | 2022 |
Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Insulin; Insulin Resistance; Insulysin; Kidney; | 2023 |
ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance.
Topics: Animals; Autophagy; Hepatocytes; Humans; Insulin Resistance; Liver; Mice; Palmitic Acid; Reactive Ox | 2023 |
Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.
Topics: Animals; Body Weight; Diet, High-Fat; Inflammation; Insulin Resistance; Macrophages; Mice; Mice, Inb | 2023 |
FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Epigenesis, Genetic; Fibroblast Growth Factor 1; In | 2023 |
The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome.
Topics: Animals; Ceramides; Diet, High-Fat; Imipramine; Inflammation; Insulin Resistance; Lipopolysaccharide | 2023 |
Improving Mitochondrial Function in Skeletal Muscle Contributes to the Amelioration of Insulin Resistance by Nicotinamide Riboside.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Insulin; Insulin Resistance; Male; Mice; Mic | 2023 |
The impact of sitagliptin in palmitic acid-induced insulin resistance in human HepG2 cells through the suppressor of cytokine signaling 3/phosphoinositide 3-kinase/protein kinase B pathway.
Topics: Cytokines; Diabetes Mellitus, Type 2; Glucose; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans | 2023 |
Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells.
Topics: Culture Media; Humans; Insulin Resistance; Palmitic Acid; Phosphatidylinositol 3-Kinases; Proto-Onco | 2023 |
4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes.
Topics: Animals; Carrier Proteins; Cell Line; Diet, High-Fat; Hepatocytes; Insulin; Insulin Resistance; Male | 2023 |
Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders.
Topics: Animals; Diet; Glucose; Glucose Intolerance; Inflammation; Insulin Resistance; Metabolic Diseases; M | 2023 |
GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity.
Topics: Acetylation; Enzyme Activation; Glucagon-Like Peptide 1; Glucose Transporter Type 4; Humans; Insulin | 2019 |
The saturated fatty acid palmitate induces insulin resistance through Smad3-mediated down-regulation of FNDC5 in myotubes.
Topics: Animals; Binding Sites; Cell Line; Down-Regulation; Fibronectins; Gene Knockdown Techniques; Gene Kn | 2019 |
Fibroblast growth factor 21 protects against lipotoxicity-induced pancreatic β-cell dysfunction via regulation of AMPK signaling and lipid metabolism.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Antibodies, Monoclonal, Humanized; A | 2019 |
Ginsenoside Rg1 ameliorates palmitic acid-induced insulin resistance in HepG2 cells in association with modulating Akt and JNK activity.
Topics: Cell Line, Tumor; Ginsenosides; Gluconeogenesis; Glucose; Hep G2 Cells; Humans; Insulin; Insulin Res | 2019 |
Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Gene Expression Profiling; Glucose; Humans; In | 2020 |
Gegen Qinlian Decoction Ameliorates Hepatic Insulin Resistance by Silent Information Regulator1 (SIRT1)-Dependent Deacetylation of Forkhead Box O1 (FOXO1).
Topics: Animals; China; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Forkhead Box Protein | 2019 |
Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Citrates; Diet, High-Fat; Hep G2 Cells; | 2019 |
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
Topics: Diabetes Mellitus, Type 2; Fatty Acids; Gene Expression Regulation; Glucose; Glucose Transporter Typ | 2019 |
RNA-sequencing analysis reveals the potential contribution of lncRNAs in palmitic acid-induced insulin resistance of skeletal muscle cells.
Topics: Animals; Cell Line; Down-Regulation; Gene Expression Profiling; Gene Ontology; Gene Regulatory Netwo | 2020 |
Topics: Animals; Antigens, Surface; Bone Morphogenetic Protein Receptors, Type II; CD36 Antigens; Cell Line; | 2020 |
Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics.
Topics: Algorithms; Culture Media; Deuterium; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectromet | 2020 |
Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Body Weight; Diet, High-Fat; Gene Expression Regula | 2020 |
Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts.
Topics: Adenylate Kinase; Animals; Fibronectins; Glucose; Insulin Resistance; Mice; Myoblasts; Palmitic Acid | 2020 |
Long-term hypercortisolism induces lipogenesis promoting palmitic acid accumulation and inflammation in visceral adipose tissue compared with HFD-induced obesity.
Topics: Animals; Corticosterone; Cushing Syndrome; Cytokines; Diet, High-Fat; Fatty Acids; Fatty Acids, None | 2020 |
Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C
Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Line; Gene Knockout Techniques; Insulin Resistance; | 2020 |
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.
Topics: Animals; Cell Line; Chromatin; Diabetes Mellitus, Type 2; Enhancer Elements, Genetic; Female; Gene E | 2020 |
Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease.
Topics: Alkaloids; Animals; Body Weight; Diet, High-Fat; Gene Knockdown Techniques; Hep G2 Cells; Humans; In | 2020 |
Cyanidin-3-O-glucoside restores insulin signaling and reduces inflammation in hypertrophic adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Animals; Anthocyanins; Fatty Acid-Binding Prote | 2020 |
A high fat diet with a high C18:0/C16:0 ratio induced worse metabolic and transcriptomic profiles in C57BL/6 mice.
Topics: Animals; Body Weight; Diet, High-Fat; Fatty Acids; Insulin Resistance; Interleukin-6; Lipid Metaboli | 2020 |
Omega-3 polyunsaturated fatty acids prevent obesity by improving tricarboxylic acid cycle homeostasis.
Topics: Animals; Cell Survival; Citric Acid Cycle; Diet, High-Fat; Docosahexaenoic Acids; Fatty Acids, Omega | 2021 |
Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells.
Topics: Animals; Cell Line, Tumor; Glucagon; Glucagon-Secreting Cells; Inositol; Insulin; Insulin Resistance | 2020 |
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes.
Topics: Animals; COP9 Signalosome Complex; Diabetes Mellitus, Type 2; Hep G2 Cells; Humans; Inflammation; In | 2020 |
Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes.
Topics: 14-3-3 Proteins; Animals; CD36 Antigens; Cell Differentiation; Glucose; Glucose Transporter Type 4; | 2021 |
Pyrroloquinoline Quinone Modifies Lipid Profile, but Not Insulin Sensitivity, of Palmitic Acid-Treated L6 Myotubes.
Topics: Animals; Biological Transport, Active; Cell Line; Diglycerides; Fatty Acid Transport Proteins; Fatty | 2020 |
The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance.
Topics: Adipose Tissue; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Type 2; Diet, High-Fat | 2020 |
The Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes.
Topics: Cells, Cultured; Eicosapentaenoic Acid; Glucose; Humans; Inflammation; Insulin; Insulin Resistance; | 2021 |
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Culture Media, Conditioned; Diabetes Mellitus, Type | 2021 |
Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity.
Topics: Animals; Biomarkers; Calcium; Cell Communication; Cell Line; Cells, Cultured; Cytokines; Diet, High- | 2021 |
Oleic Acid and Eicosapentaenoic Acid Reverse Palmitic Acid-induced Insulin Resistance in Human HepG2 Cells via the Reactive Oxygen Species/JUN Pathway.
Topics: Eicosapentaenoic Acid; Hep G2 Cells; Humans; Hydrogen Peroxide; Insulin Resistance; Oleic Acid; Palm | 2021 |
Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma.
Topics: Cell Line, Tumor; Humans; Inflammation; Insulin Resistance; Neoplasm Proteins; Neuroblastoma; Palmit | 2021 |
Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An
Topics: Acetyl-CoA Carboxylase; Animals; Fatty Acid Synthases; Gene Expression Regulation; Hep G2 Cells; Hum | 2021 |
PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1.
Topics: Animals; Autophagy; Cell Line; Forkhead Box Protein O1; Humans; Insulin Resistance; Myocytes, Cardia | 2021 |
Impaired Ca
Topics: Alstrom Syndrome; Animals; Blood Glucose; Calcium; Calcium Signaling; Diabetes Mellitus, Type 2; Dis | 2021 |
Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells.
Topics: Adenosine Triphosphate; Calcium; Cell Line, Tumor; Cytosol; Energy Metabolism; Fatty Acids; Humans; | 2021 |
Involvement of miR-3180-3p and miR-4632-5p in palmitic acid-induced insulin resistance.
Topics: Gene Expression Regulation; Hep G2 Cells; Humans; Insulin; Insulin Receptor Substrate Proteins; Insu | 2021 |
Vitamin K2 as a New Modulator of the Ceramide De Novo Synthesis Pathway.
Topics: Biosynthetic Pathways; Carcinoma, Hepatocellular; Ceramides; Chromatography, High Pressure Liquid; G | 2021 |
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferase | 2021 |
Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway.
Topics: Cell Survival; Chalcones; Cytokines; Glucose; Hep G2 Cells; Humans; Inflammasomes; Insulin Resistanc | 2021 |
Differential Gene Expression and Biological Analyses of Primary Hepatocytes Following D-Chiro-Inositol Supplement.
Topics: Animals; Biomarkers; Dietary Supplements; Enzyme Inhibitors; Gene Expression Regulation; Gluconeogen | 2021 |
Attenuation of palmitate induced insulin resistance in muscle cells by harmala, clove and river red gum.
Topics: Animals; Cell Line; Glucose; Hypoglycemic Agents; Insulin; Insulin Receptor Substrate Proteins; Insu | 2016 |
Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells.
Topics: Androstadienes; Chemokine CCL2; Chromones; Epoetin Alfa; Forkhead Box Protein O1; Glucose; Glycogen | 2017 |
5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes.
Topics: AMP-Activated Protein Kinases; Animals; Arachidonate 5-Lipoxygenase; Cell Line; Endoplasmic Reticulu | 2017 |
BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.
Topics: Animals; Catalytic Domain; Cell Line, Transformed; Gene Expression Regulation; Glucose; Glucose Tran | 2018 |
Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance.
Topics: eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; GTP Phosphohydrolases; Hep G2 Cel | 2017 |
Egr2 enhances insulin resistance via JAK2/STAT3/SOCS-1 pathway in HepG2 cells treated with palmitate.
Topics: Animals; Early Growth Response Protein 2; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Janus K | 2018 |
Hemin Improves Insulin Sensitivity and Lipid Metabolism in Cultured Hepatocytes and Mice Fed a High-Fat Diet.
Topics: Animals; Biomarkers; Blood Glucose; Cells, Cultured; Diet, High-Fat; Dose-Response Relationship, Dru | 2017 |
Preventive effect of oleate on palmitate-induced insulin resistance in skeletal muscle and its mechanism of action.
Topics: Animals; Insulin Resistance; Male; Muscle, Skeletal; Oleic Acid; Palmitic Acid; Rats; Rats, Sprague- | 2017 |
Metabolic pathways of oleic and palmitic acid are intensified in PCOS patients with normal androgen levels.
Topics: Adult; Androgens; Female; gamma-Linolenic Acid; Humans; Insulin Resistance; Metabolic Networks and P | 2017 |
Puerarin acts on the skeletal muscle to improve insulin sensitivity in diabetic rats involving μ-opioid receptor.
Topics: Animals; Cell Membrane; Diabetes Mellitus, Experimental; Gene Expression Regulation; Glucose; Glucos | 2018 |
Glucagon-like peptide-1 analog prevents obesity-related glomerulopathy by inhibiting excessive autophagy in podocytes.
Topics: Animals; Autophagy; Blood Glucose; Cell Line; Cytoprotection; Diet, High-Fat; Disease Models, Animal | 2018 |
Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats.
Topics: Animals; Caspase 3; Coculture Techniques; Diabetes Mellitus, Experimental; Female; Fetal Blood; Gene | 2017 |
Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1.
Topics: Animals; Blood Glucose; Diet, High-Fat; Epigenesis, Genetic; Gene Expression Regulation; Glucosamine | 2018 |
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Endoplasmic Reticulum Stress; Enzyme Activation; ErbB | 2018 |
Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy.
Topics: Alprostadil; Animals; Autophagy; Cell Survival; Diabetes Mellitus, Type 2; Diabetic Nephropathies; D | 2018 |
Excessive Autophagy Activation and Increased Apoptosis Are Associated with Palmitic Acid-Induced Cardiomyocyte Insulin Resistance.
Topics: Animals; Apoptosis; Autophagy; Cell Line; Diabetic Cardiomyopathies; Insulin Resistance; Myocytes, C | 2017 |
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.
Topics: Adiposity; Animals; Eating; Glucose; HEK293 Cells; Homeostasis; Humans; Inflammation; Insulin Resist | 2018 |
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.
Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultu | 2018 |
Ceramide stearic to palmitic acid ratio predicts incident diabetes.
Topics: Aged; Angina Pectoris; Body Mass Index; Ceramides; Cohort Studies; Coronary Angiography; Diabetes Me | 2018 |
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
Topics: alpha-2-HS-Glycoprotein; Animals; Dietary Fats; Endoplasmic Reticulum Stress; Fatty Liver; Hep G2 Ce | 2018 |
Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.
Topics: Animals; Diet, High-Fat; Gene Expression Regulation; Humans; Inflammation; Insulin Resistance; Mice, | 2018 |
Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.
Topics: Animals; Fatty Acids; Glucose Transporter Type 4; Inflammation; Insulin Resistance; Muscle Fibers, S | 2018 |
Vernonia amygdalina Delile extract inhibits the hepatic gluconeogenesis through the activation of adenosine-5'monophosph kinase.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Activ | 2018 |
Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity.
Topics: Adolescent; Adult; Exercise; Glycogen; Healthy Volunteers; Humans; Insulin Resistance; Lipid Metabol | 2018 |
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Topics: Amitriptyline; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Down-Regulation; End | 2018 |
Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
Topics: Animals; Diet, Fat-Restricted; Diet, High-Fat; Glucagon-Like Peptide 1; Glucose; HEK293 Cells; Human | 2018 |
The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Nucleus; Endoribonucleases; Fibroblast Growth Factors; Gluco | 2018 |
Iron overload by transferrin receptor protein 1 regulation plays an important role in palmitate-induced insulin resistance in human skeletal muscle cells.
Topics: Adult; Animals; Antigens, CD; Case-Control Studies; Cells, Cultured; Deferoxamine; Diabetes Mellitus | 2019 |
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice.
Topics: AMP-Activated Protein Kinases; Animals; Cell Differentiation; Cell Line; Diet, High-Fat; Endoplasmic | 2018 |
Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway.
Topics: Animals; Down-Regulation; Gene Expression Regulation; Glucose Transporter Type 4; Hep G2 Cells; Huma | 2019 |
Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men.
Topics: Adult; Amino Acids, Branched-Chain; Asian People; Blood Glucose; Carbon Isotopes; Fatty Acids, Nones | 2018 |
Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adult; Animals; Female; Gene Silencing; Glucose Transporter | 2018 |
Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high-fat-diet-induced pre-diabetes.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Cell Differentiation; Diabetes Mellitus, Type 2; Die | 2019 |
Attenuation of Free Fatty Acid-Induced Muscle Insulin Resistance by Rosemary Extract.
Topics: Animals; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose; Insulin Resistance; Muscle | 2018 |
lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression.
Topics: Activating Transcription Factor 4; Animals; Diet, High-Fat; Down-Regulation; Forkhead Box Protein O1 | 2019 |
Theaflavins Improve Insulin Sensitivity through Regulating Mitochondrial Biosynthesis in Palmitic Acid-Induced HepG2 Cells.
Topics: Biflavonoids; Catechin; Hep G2 Cells; Humans; Insulin Resistance; Mitochondria; Palmitic Acid | 2018 |
[The disturbance of unification of coupled biochemical reactions in synthesis of endogenous ω-9 oleic acid. The resistance to insulin, stearic triglycerides and pathogenesis of eruptive xanthomata].
Topics: Apolipoproteins E; Apoptosis; Biological Transport; Cholesterol; Glucose; Hepatocytes; Humans; Infla | 2017 |
Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.
Topics: 3T3 Cells; AMP-Activated Protein Kinases; Animals; Aspalathus; Carnitine O-Palmitoyltransferase; Cel | 2019 |
Oleic acid protects insulin-secreting INS-1E cells against palmitic acid-induced lipotoxicity along with an amelioration of ER stress.
Topics: Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Glucose; | 2019 |
Nucleophosmin/B23 contributes to hepatic insulin resistance through the modulation of NF-κB pathway.
Topics: Animals; Glucose; Hep G2 Cells; Humans; Insulin Resistance; Liver; Mice, Inbred C57BL; NF-kappa B; N | 2019 |
Mangiferin Improved Palmitate-Induced-Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPAR
Topics: Animals; Carnitine O-Palmitoyltransferase; CD36 Antigens; Cell Line; Cell Survival; Fatty Acids, Non | 2019 |
Palmitic acid causes insulin resistance in granulosa cells via activation of JNK.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Fatty Acids; Female; Glucose; Granulosa Cells; | 2019 |
Sumoylation of PPARγ contributes to vascular endothelium insulin resistance through stabilizing the PPARγ-NcoR complex.
Topics: Endothelium, Vascular; Gene Regulatory Networks; Glucose; Human Umbilical Vein Endothelial Cells; Hu | 2019 |
Inhibitory effect of 17β‑estradiol on triglyceride synthesis in skeletal muscle cells is dependent on ESR1 and not ESR2.
Topics: Animals; Cell Line; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fat | 2019 |
Silencing of SAA1 inhibits palmitate- or high-fat diet induced insulin resistance through suppression of the NF-κB pathway.
Topics: Animals; Blood Glucose; Blotting, Western; Cell Line, Tumor; Diet, High-Fat; Enzyme-Linked Immunosor | 2019 |
The Haematococcus pluvialis extract enriched by bioaccumulation process with Mg(II) ions improves insulin resistance in equine adipose-derived stromal cells (EqASCs).
Topics: Adipose Tissue; Animals; Antioxidants; Cell Proliferation; Cell Shape; Cell Survival; Cells, Culture | 2019 |
Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Proliferation; Clone Cells; Di | 2019 |
Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.
Topics: Animals; Ceramides; Enzyme Inhibitors; Glucose; Glycogen; Hep G2 Cells; Hepatocytes; Humans; Insulin | 2019 |
Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anthocyanins; Anti-Inflammatory Agents; Hypertrophy; Insulin Resi | 2019 |
Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation.
Topics: Hep G2 Cells; Humans; Insulin Resistance; Oxidative Stress; Palmitic Acid; Stilbenes; Triglycerides | 2019 |
Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression.
Topics: Active Transport, Cell Nucleus; Adult; alpha-2-HS-Glycoprotein; AMP-Activated Protein Kinases; Docos | 2019 |
Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells.
Topics: Adenosine Triphosphate; Amides; Animals; Cell Line; Glucose; Insulin; Insulin Receptor Substrate Pro | 2019 |
High molecular weight adiponectin reduces glucolipotoxicity-induced inflammation and improves lipid metabolism and insulin sensitivity via APPL1-AMPK-GLUT4 regulation in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Adiponectin; AMP-Activated Protein K | 2019 |
Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Line; Cell Nucleus; | 2013 |
Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression.
Topics: Bile Acids and Salts; Diglycerides; Disease Progression; Fatty Liver; HEK293 Cells; Hep G2 Cells; Hu | 2013 |
Amelioration of palmitate-induced insulin resistance in C₂C₁₂ muscle cells by rooibos (Aspalathus linearis).
Topics: Animals; Aspalathus; Cell Line; Hyperinsulinism; Insulin Resistance; Mice; Muscle, Skeletal; Palmiti | 2013 |
Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Hydrogen Peroxide; Insulin Resistance; Male; Mitoc | 2013 |
Hyperinsulinemia and skeletal muscle fatty acid trafficking.
Topics: Adult; Carbon Radioisotopes; Carnitine; Cohort Studies; Down-Regulation; Fatty Acids, Nonesterified; | 2013 |
Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Human Umbilical | 2013 |
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity.
Topics: Adult; Animals; Carrier Proteins; Down-Regulation; Gene Knockdown Techniques; Humans; Insulin; Insul | 2013 |
Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Antioxidants; Cell Line; Dose-Response Relation | 2013 |
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.
Topics: Carrier Proteins; Caspase 1; Cell Line; Crystallography, X-Ray; Dietary Fats; Dimerization; Docosahe | 2013 |
Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Blood | 2014 |
Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-κB pathways.
Topics: Animals; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Extracellular Signa | 2013 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance.
Topics: Adiposity; Animals; Catalytic Domain; Cell Line; Cell Survival; Curcumin; Dietary Fats; Endoplasmic | 2014 |
Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; ATP-Binding Cassette Transporters; Case-Control Studies; D | 2014 |
Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells.
Topics: Animals; Cattle; Cell Line, Tumor; Cell Survival; Cerebral Cortex; Cyclic AMP-Dependent Protein Kina | 2014 |
Clustering effects on postprandial insulin secretion and sensitivity in response to meals with different fatty acid compositions.
Topics: Adult; Blood Glucose; Body Mass Index; Cluster Analysis; Diabetes Mellitus, Type 2; Diet; Dietary Fa | 2014 |
Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Cell Line; Diet, High-Fat; Fatty Acids; Glucose; In | 2014 |
Melatonin rescues 3T3-L1 adipocytes from FFA-induced insulin resistance by inhibiting phosphorylation of IRS-1 on Ser307.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Gene Expression Regulation; Glucose; Glucos | 2014 |
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance.
Topics: Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fatty Acids | 2014 |
CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Cell Line; Gene Expression Regulation; | 2014 |
Metabolic syndrome exacerbates inflammation and bone loss in periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Animals; Chemokine CCL2; Cytokines; Diet, | 2015 |
Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules.
Topics: Benzoates; Fatty Acids, Nonesterified; Furans; Gene Expression Regulation; Hep G2 Cells; Humans; Ins | 2015 |
Silencing miR-106b improves palmitic acid-induced mitochondrial dysfunction and insulin resistance in skeletal myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Line; ERRalpha Estrogen-Related Receptor; Gene Expression Regu | 2015 |
Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.
Topics: Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Insulin; Insulin Resistance; Liver; Palmitic | 2015 |
Diabetes: Hepatic lipogenesis independent of insulin in type 2 diabetes mellitus--a paradox clarified.
Topics: Animals; Insulin; Insulin Resistance; Liver; Palmitic Acid; Signal Transduction; Triglycerides | 2015 |
Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance.
Topics: Animals; Body Composition; Diet, High-Fat; Feeding Behavior; Glucose; Heart Diseases; HSP72 Heat-Sho | 2015 |
18-carbon polyunsaturated fatty acids ameliorate palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes.
Topics: Animals; Cell Line; Fatty Acids, Unsaturated; Inflammation; Inflammation Mediators; Insulin Resistan | 2015 |
Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects.
Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Energy Metabolism; Fasting; Female; Gas Chromatograp | 2015 |
Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity.
Topics: 3T3-L1 Cells; Adipocytes; Adult; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Fema | 2015 |
Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease.
Topics: Adult; Aged; Autophagy-Related Protein 7; Case-Control Studies; Cell Line, Tumor; Cytokine Receptor | 2015 |
Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition.
Topics: Animals; Antioxidants; Cell Line; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mus | 2015 |
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Coenzyme A Ligases; Cysteine Endopeptida | 2015 |
Modest decrease in PGC1α results in TAG accumulation but not in insulin resistance in L6 myotubes.
Topics: Animals; Blotting, Western; Cell Line; Ceramides; Chromatography, Gas; Diglycerides; Fatty Acids; Gl | 2015 |
TNF-α knockdown alleviates palmitate-induced insulin resistance in C2C12 skeletal muscle cells.
Topics: Animals; Blotting, Western; Cell Line; Gene Knockdown Techniques; Insulin Resistance; Mice; Muscle, | 2015 |
Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.
Topics: Animals; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation; Hepa | 2015 |
Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway.
Topics: AMP-Activated Protein Kinases; Animals; Enzyme Activation; Insulin; Insulin Receptor Substrate Prote | 2015 |
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.
Topics: Animals; Cells, Cultured; Dietary Fats; Enzyme Inhibitors; Fibrosis; Flavonoids; Gene Knockdown Tech | 2015 |
Intravenous Mycobacterium Bovis Bacillus Calmette-Guérin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice.
Topics: Adiponectin; Adipose Tissue, White; Animals; BCG Vaccine; Gene Expression Regulation; Hep G2 Cells; | 2015 |
Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.
Topics: Angiotensin II; Animals; Apoptosis; Atherosclerosis; Blotting, Western; Cell Line; Cell Proliferatio | 2015 |
[Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromones; Culture Media, Conditioned; Glucose; Hep G2 Cell | 2015 |
Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance.
Topics: 3T3-L1 Cells; Adipokines; Adipose Tissue; Animals; Chenodeoxycholic Acid; Gene Expression Regulation | 2015 |
Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.
Topics: Adult; Biomarkers; Blood Glucose; Case-Control Studies; Chronic Disease; Cytokines; Diabetes Mellitu | 2015 |
Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.
Topics: Adipose Tissue; Animals; Biomarkers; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Diet, High | 2015 |
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance.
Topics: Adipogenesis; Aging; Animals; Body Weight; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cricetu | 2015 |
Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells.
Topics: Analysis of Variance; Animals; Body Weight; Diet, High-Fat; Dose-Response Relationship, Drug; Endopl | 2015 |
Long-chain polyunsaturated fatty acids amend palmitate-induced inflammation and insulin resistance in mouse C2C12 myotubes.
Topics: Animals; Cell Line; Cell Survival; Cytokines; Extracellular Signal-Regulated MAP Kinases; Fatty Acid | 2016 |
Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Computational Biology; Cytokines; Gen | 2015 |
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
Topics: Apoptosis; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endothelial Cells; Fatty | 2016 |
Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes.
Topics: Actin Cytoskeleton; Animals; Apoptosis; Cell Line; Cytochalasin D; Endoplasmic Reticulum Stress; Inf | 2015 |
PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
Topics: Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Chemokine CCL2; Gene Expression Regul | 2016 |
Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes.
Topics: Animals; Berberine; Biological Transport; Cell Line; Diacylglycerol O-Acyltransferase; Diglycerides; | 2016 |
Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9).
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regulati | 2016 |
ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.
Topics: Adenine Nucleotide Translocator 1; Animals; Fatty Acids; Humans; In Vitro Techniques; Insulin; Insul | 2016 |
Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance.
Topics: Animals; Cell Line; Cyclooxygenase 2; Fatty Acids; Fatty Acids, Monounsaturated; Gene Expression Reg | 2016 |
Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone.
Topics: Adipocytes; Animals; Apoptosis; Endoplasmic Reticulum Stress; Glucose Transporter Type 4; HEK293 Cel | 2016 |
Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle.
Topics: Animals; CD36 Antigens; Diet, High-Fat; Emodin; Fatty Acid Transport Proteins; Gene Expression Regul | 2016 |
Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance.
Topics: Animals; Blood Glucose; Caveolae; Caveolin 3; CD36 Antigens; Cell Line; Diet, High-Fat; Disease Mode | 2016 |
Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism.
Topics: AMP-Activated Protein Kinases; Animals; Bortezomib; Cell Line; Cytoprotection; Endoplasmic Reticulum | 2016 |
Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway.
Topics: Animals; Biological Transport; Cell Line; Chemokine CCL2; Gene Expression Regulation; Glucose; Gluco | 2016 |
Supplementing dietary sugar promotes endoplasmic reticulum stress-independent insulin resistance and fatty liver in goose.
Topics: Animals; Cells, Cultured; Dietary Carbohydrates; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2016 |
Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Endothelium; Gene Expression Regulation; Human Umb | 2016 |
PINK1 alleviates palmitate induced insulin resistance in HepG2 cells by suppressing ROS mediated MAPK pathways.
Topics: Animals; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Insulin; Insulin Resistance; MAP Ki | 2016 |
[THE UNESTERIFIED FATTY ACIDS IN BLOOD PLASMA AND INTERCELLULAR MEDIUM: EFFECT OF INSULIN AND ALBUMIN (THE LECTURE)].
Topics: Adenosine Triphosphate; Adipose Tissue; Biological Transport; Fatty Acids, Nonesterified; Glucose; H | 2016 |
Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways.
Topics: Adiponectin; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; I-kappa B Kinase; Inflammati | 2016 |
Thioredoxin interacting protein mediates lipid-induced impairment of glucose uptake in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; | 2016 |
Fatty acid synthesis configures the plasma membrane for inflammation in diabetes.
Topics: Adipose Tissue; Animals; Cell Adhesion; Cell Membrane; Cell Movement; Cholesterol; Diabetes Mellitus | 2016 |
AMP-activated protein kinase-mediated expression of heat shock protein beta 1 enhanced insulin sensitivity in the skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Chromatography, Liqui | 2017 |
Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antipsychotic Agents; Area Under Curve; Benzodiazepines; Blood | 2016 |
Losartan Improves Palmitate-Induced Insulin Resistance in 3T3-L1 Adipocytes Through Upregulation of Src Phosphorylation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Insulin Resistance; Losartan; Mice; Palmitic Acid; Phosphorylatio | 2017 |
Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors.
Topics: Anthocyanins; Antioxidants; Cells, Cultured; Endothelium, Vascular; Glucosides; Human Umbilical Vein | 2017 |
Influence of resveratrol on endoplasmic reticulum stress and expression of adipokines in adipose tissues/adipocytes induced by high-calorie diet or palmitic acid.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Adipose Tissue; Animals; Cell Differentiation; Endoplasmic Ret | 2017 |
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity.
Topics: Active Transport, Cell Nucleus; Adipose Tissue; Animals; Cell Line, Tumor; Coculture Techniques; Die | 2017 |
TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance.
Topics: Animals; Autophagy; Endothelial Cells; Fatty Acid Transport Proteins; Insulin Resistance; Male; Mice | 2017 |
Fatty acid metabolism in patients with PPARgamma mutations.
Topics: Adipose Tissue; Adult; Amino Acid Substitution; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, | 2008 |
Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells.
Topics: Animals; Cell Line; Cells, Cultured; Chemokine CCL2; Culture Media, Conditioned; Glucose Transporter | 2009 |
Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent.
Topics: Animals; Cell Line; Deoxyglucose; Electrophoretic Mobility Shift Assay; Fatty Acids; Glucose Transpo | 2009 |
Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization.
Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Gene Knockdown Techniques; | 2009 |
FAT/CD36 expression is not ablated in spontaneously hypertensive rats.
Topics: Adipose Tissue; Animals; Biological Transport, Active; CD36 Antigens; Cell Membrane; Fatty Acids; Ge | 2009 |
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.
Topics: Animals; Carnitine O-Palmitoyltransferase; Dietary Fats; Electroporation; Fatty Acids; Glucose Clamp | 2009 |
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.
Topics: Adipocytes; Adipose Tissue; Biopsy; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; | 2009 |
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.
Topics: Adult; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Fatty Acids, Nonesterif | 2009 |
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Topics: Animals; Blood Pressure; Cells, Cultured; Dietary Fats; Disease Models, Animal; Dose-Response Relati | 2009 |
cis-9,trans-11-Conjugated linoleic acid activates AMP-activated protein kinase in attenuation of insulin resistance in C2C12 myotubes.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Enzyme Activation; Fatty Acids; Glucose; Insulin | 2009 |
Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.
Topics: Body Composition; Cell Survival; Endoplasmic Reticulum; Fatty Acids, Nonesterified; Gene Expression | 2009 |
Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes.
Topics: Cell Line; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glucose; Glycogen; Hepatocy | 2009 |
Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet.
Topics: 3-Hydroxybutyric Acid; Acetyl-CoA Carboxylase; Animals; Cholesterol; Diet; Dietary Fats; Glucose Cla | 2009 |
12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Arachido | 2009 |
Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy.
Topics: Adenosine Triphosphate; Cell Line; Cell Survival; Ceramides; Diabetic Nephropathies; Fatty Acids; Ge | 2009 |
Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways.
Topics: Animals; Antioxidants; Cell Line; Enzyme Activation; Fatty Acids, Nonesterified; Glucose; Insulin; I | 2009 |
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Topics: Animals; Base Sequence; Dietary Fats; Gluconeogenesis; Hypothalamus; Insulin Resistance; Isoenzymes; | 2009 |
Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Fatty Acids; Glucose; Insulin; Insu | 2010 |
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.
Topics: Animals; Central Nervous System; Diet; Dietary Fats; Eating; Energy Metabolism; Enzyme Activation; F | 2009 |
Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells.
Topics: Animals; Cell Differentiation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; DNA Primers; Drug Syne | 2010 |
Desaturation of excess intramyocellular triacylglycerol in obesity: implications for glycemic control.
Topics: Analysis of Variance; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diabetes Mellitus, Ty | 2010 |
Adipophilin protein expression in muscle--a possible protective role against insulin resistance.
Topics: Animals; Cell Line; Dietary Fats; Insulin; Insulin Resistance; Membrane Proteins; Mice; Muscle, Skel | 2010 |
Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Cell Culture Techniques; Cell Survival; Endoplasmic Reticul | 2010 |
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms.
Topics: Angiogenesis Inhibitors; Atherosclerosis; Carotid Arteries; Down-Regulation; Glucose; Glucose Tolera | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cyc | 2010 |
JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes.
Topics: Acetyl-CoA Carboxylase; Animals; Blood Glucose; Fatty Acids, Nonesterified; Gene Silencing; Genes; G | 2010 |
Adipose tissue fatty acids and insulin sensitivity in elderly men.
Topics: Adipose Tissue; Aged; Chromatography, Gas; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dieta | 2010 |
Curcumin improves insulin resistance in skeletal muscle of rats.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Biological Transport; Cell Line; Curcumin; Deoxygluco | 2011 |
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.
Topics: Adaptation, Physiological; Bicycling; Biopsy; Blood Glucose; Case-Control Studies; Diglycerides; Glu | 2010 |
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.
Topics: Adaptation, Physiological; Bicycling; Biopsy; Blood Glucose; Case-Control Studies; Diglycerides; Glu | 2010 |
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.
Topics: Adaptation, Physiological; Bicycling; Biopsy; Blood Glucose; Case-Control Studies; Diglycerides; Glu | 2010 |
Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes.
Topics: Adaptation, Physiological; Bicycling; Biopsy; Blood Glucose; Case-Control Studies; Diglycerides; Glu | 2010 |
Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model.
Topics: Adipose Tissue; Animals; Azo Compounds; Body Composition; Disease Models, Animal; Energy Intake; Fat | 2010 |
Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes.
Topics: Animals; Cells, Cultured; Enzyme Activation; Insulin Resistance; Isoenzymes; Mice; Muscle Fibers, Sk | 2010 |
Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle.
Topics: Adenylate Kinase; Animals; Bicyclic Monoterpenes; Biological Transport; Gene Expression Regulation; | 2010 |
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.
Topics: Animals; Gene Expression Regulation, Enzymologic; Glycogen; Hep G2 Cells; Hepatocytes; Humans; Insul | 2010 |
Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.
Topics: Animals; Carbon Radioisotopes; Case-Control Studies; Disease Models, Animal; Fasting; Fatty Acids; H | 2010 |
Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes.
Topics: ADAM Proteins; ADAM17 Protein; Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Chromans; | 2010 |
Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress.
Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Cell Count; Cell Line; Cell Survival; C | 2010 |
Overactivation of NF-κB impairs insulin sensitivity and mediates palmitate-induced insulin resistance in C2C12 skeletal muscle cells.
Topics: Animals; Cell Line; Deoxyglucose; Gene Expression Regulation; Gene Silencing; Glucose Transporter Ty | 2010 |
A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diabetes Mellitus, Type 2; Female; Gene Deletion; | 2010 |
Palmitate and insulin synergistically induce IL-6 expression in human monocytes.
Topics: Cell Line, Tumor; Ceramides; Coenzyme A; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, No | 2010 |
Restoration of skeletal muscle leptin response does not precede the exercise-induced recovery of insulin-stimulated glucose uptake in high-fat-fed rats.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Biological Transport; Blood Glucose; | 2011 |
Ghrelin inhibits insulin resistance induced by glucotoxicity and lipotoxicity in cardiomyocyte.
Topics: AMP-Activated Protein Kinases; Animals; Cell Shape; Cells, Cultured; Chromones; Deoxyglucose; Enzyme | 2011 |
Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.
Topics: Actins; Animals; Cell Line; Cell Nucleus; Down-Regulation; Enzyme Activation; Fatty Acids; HMGA Prot | 2011 |
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Fatty Acids; Humans; Inflammation; Inflamma | 2011 |
A single prior bout of exercise protects against palmitate-induced insulin resistance despite an increase in total ceramide content.
Topics: Animals; Ceramides; Diglycerides; Energy Metabolism; Enzyme Inhibitors; Female; Fumonisins; Glucose; | 2011 |
[8-hydroxy-dihydroberberine ameliorated insulin resistance induced by high FFA and high glucose in 3T3-L1 adipocytes].
Topics: 3T3-L1 Cells; Adipocytes; Animals; Berberine; Cell Differentiation; Glucose; Hypoglycemic Agents; In | 2009 |
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.
Topics: Animals; Blood Proteins; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Si | 2011 |
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.
Topics: Aminoimidazole Carboxamide; Animals; Autophagy; Carrier Proteins; Caspase 1; Dietary Fats; Enzyme Ac | 2011 |
Preserved insulin vasorelaxation and up-regulation of the Akt/eNOS pathway in coronary arteries from insulin resistant obese Zucker rats.
Topics: Animals; Blotting, Western; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Insulin; In | 2011 |
Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.
Topics: Animals; Inflammation; Insulin; Insulin Resistance; Lipopolysaccharides; Liver; Macrophages; Male; M | 2011 |
Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes.
Topics: Adenoviridae Infections; Animals; Blood Glucose; Cholesterol; Cytokines; Enzyme-Linked Immunosorbent | 2011 |
DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages.
Topics: Adult; Anti-Inflammatory Agents; Apoptosis; Atrophy; Cell Differentiation; Coculture Techniques; Doc | 2012 |
Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells.
Topics: Animals; Biomarkers; Cell Line; Cells, Cultured; Endoplasmic Reticulum Stress; Endoribonucleases; Gl | 2012 |
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle.
Topics: Animals; Cell Line; Dynamins; Fatty Acids; Glucose; Insulin Resistance; Mice; Mitochondria, Muscle; | 2012 |
Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism.
Topics: Animals; Cells, Cultured; Fatty Acids, Nonesterified; Glucose; Insulin; Insulin Resistance; Lipogene | 2011 |
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.
Topics: Animals; Catechin; Cell Line; Curcumin; Enzyme Activation; Fatty Acids, Nonesterified; Insulin Recep | 2012 |
Lipid-induced endoplasmic reticulum stress in liver cells results in two distinct outcomes: adaptation with enhanced insulin signaling or insulin resistance.
Topics: Adaptation, Physiological; Animals; Cell Line, Tumor; Endoplasmic Reticulum Stress; Hepatocytes; Hum | 2012 |
The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.
Topics: Adipocytes; Adipose Tissue; Animals; Antigens, CD; Antigens, Surface; Coculture Techniques; Dietary | 2012 |
Fibroblast growth factor-21 protects human skeletal muscle myotubes from palmitate-induced insulin resistance by inhibiting stress kinase and NF-κB.
Topics: 4-Chloro-7-nitrobenzofurazan; Blotting, Western; Deoxyglucose; Enzyme Activation; Fibroblast Growth | 2012 |
Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells.
Topics: Animals; Cell Line; Cell Survival; Deoxyglucose; Down-Regulation; Fatty Acids, Unsaturated; Glucose | 2012 |
Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance.
Topics: Aged; alpha-2-HS-Glycoprotein; Animals; Biomarkers; Diabetes Mellitus; Endoplasmic Reticulum; Fatty | 2012 |
Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance.
Topics: 3T3 Cells; Adipocytes; Adipose Tissue; Amino Acid Sequence; Animals; Chromatography, Affinity; Chrom | 2012 |
Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Fatty Acids; Gene Expression Regulation; GTP Phosp | 2012 |
Elovl6 promotes nonalcoholic steatohepatitis.
Topics: Acetyltransferases; Analysis of Variance; Animals; Blood Glucose; Carrier Proteins; Cholesterol; Die | 2012 |
Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates.
Topics: Acetic Acid; Animals; Biotransformation; Body Composition; Carbon Isotopes; Deuterium; Fatty Acids; | 2012 |
Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cells, Cultured; Diosgenin; Dose-Response Rela | 2012 |
Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Endoplasmic Reticulum Stress; Insuli | 2012 |
Leukocyte antigen-related inhibition attenuates palmitate-induced insulin resistance in muscle cells.
Topics: Animals; Cells, Cultured; Deoxyglucose; Down-Regulation; Gene Expression Regulation, Enzymologic; Ge | 2012 |
Endoplasmic reticulum stress is involved in podocyte apoptosis induced by saturated fatty acid palmitate.
Topics: Apoptosis; Cells, Cultured; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat- | 2012 |
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.
Topics: Animals; Blood Glucose; Eating; eIF-2 Kinase; Glucose; Glucose Intolerance; Insulin Receptor Substra | 2012 |
Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia.
Topics: Acetyl-CoA Carboxylase; Acetyltransferases; Animals; Fatty Acid Elongases; Fatty Acid Synthases; Fem | 2013 |
The adipose tissue endocrine mechanism of the prophylactic protective effect of pioglitazone in high-fat diet-induced insulin resistance.
Topics: Adiponectin; Adipose Tissue; Animals; Cerebrosides; Diet, High-Fat; Gene Expression; Gene Knockdown | 2012 |
G-protein coupled receptor 120 is involved in glucose metabolism in fat cells.
Topics: 3T3 Cells; Adipocytes; Animals; Down-Regulation; Glucose; Glucose Transporter Type 4; Insulin Recept | 2012 |
[The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides].
Topics: Animals; Apoptosis; Fatty Liver; Hepatocytes; Insulin Resistance; Lipid Metabolism; Liver; Non-alcoh | 2012 |
Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase.
Topics: Cells, Cultured; DNA; Fatty Acids, Unsaturated; Gene Expression; Glucose; Glutamine-Fructose-6-Phosp | 2003 |
Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects.
Topics: Adult; CD36 Antigens; Cells, Cultured; Chromans; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids | 2003 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinas | 2003 |
Skeletal muscle cells from insulin-resistant (non-diabetic) individuals are susceptible to insulin desensitization by palmitate.
Topics: Adult; Cells, Cultured; Deoxyglucose; Female; Glycogen; Glycogen Synthase Kinase 3; Humans; Insulin; | 2003 |
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.
Topics: Aged; Biological Transport; Body Mass Index; Carrier Proteins; CD36 Antigens; Diabetes Mellitus, Typ | 2004 |
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B.
Topics: Active Transport, Cell Nucleus; Carrier Proteins; Cell Line; Fatty Acids; Glucose; Humans; Insulin R | 2004 |
Vascular response to angiotensin II in upper body obesity.
Topics: Acetylcholine; Adult; Angiotensin II; Blood Glucose; Body Composition; Dose-Response Relationship, D | 2004 |
Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells.
Topics: Acetates; Animals; Cell Line; Gene Expression Regulation; Insulin Resistance; Mice; Myoblasts, Skele | 2005 |
Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cells, Cultured; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2005 |
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.
Topics: Adolescent; Adult; Dietary Fats; Glucose; Glucose Clamp Technique; Humans; In Vitro Techniques; Insu | 2005 |
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.
Topics: Adolescent; Adult; Dietary Fats; Glucose; Glucose Clamp Technique; Humans; In Vitro Techniques; Insu | 2005 |
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.
Topics: Adolescent; Adult; Dietary Fats; Glucose; Glucose Clamp Technique; Humans; In Vitro Techniques; Insu | 2005 |
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.
Topics: Adolescent; Adult; Dietary Fats; Glucose; Glucose Clamp Technique; Humans; In Vitro Techniques; Insu | 2005 |
Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia.
Topics: Adiponectin; Adipose Tissue; Adult; Blood Glucose; Body Composition; Cholesterol, HDL; Dyslipidemias | 2006 |
PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
Topics: Animals; Biopsy; Cell Nucleus; Cells, Cultured; Down-Regulation; Forkhead Box Protein O1; Forkhead T | 2005 |
Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Fibroblasts; I-kappa B Proteins | 2006 |
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.
Topics: Amino Acid Transport System A; Amino Acid Transport Systems; Amino Acids; Aminoisobutyric Acids; Ani | 2006 |
Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA.
Topics: Adult; Blood Glucose; Carbon Isotopes; Case-Control Studies; Diabetes Mellitus, Type 2; Fatty Acids; | 2006 |
Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restriction.
Topics: Aconitate Hydratase; Adipose Tissue; Animals; Blotting, Western; Body Composition; Caloric Restricti | 2006 |
Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance.
Topics: Animals; Dietary Fats; Fatty Acids; Glucose; Hindlimb; Inflammation; Insulin; Insulin Resistance; Li | 2007 |
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Cells, Cultured; Enzyme Activation; Fatty Acids; Gene E | 2006 |
Effects of fatty acid regulation on visfatin gene expression in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cytokines; Dose-Response Relationship, Drug | 2006 |
Adipose tissue, hepatic, and skeletal muscle insulin sensitivity in extremely obese subjects with acanthosis nigricans.
Topics: Acanthosis Nigricans; Adipose Tissue; Adolescent; Adult; Fatty Acids, Nonesterified; Female; Glucose | 2006 |
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.
Topics: Animals; Aorta, Thoracic; Body Composition; Body Weight; Cells, Cultured; Dietary Fats; Disease Mode | 2007 |
Two phases of palmitate-induced insulin resistance in skeletal muscle: impaired GLUT4 translocation is followed by a reduced GLUT4 intrinsic activity.
Topics: Animals; Glucose Transporter Type 4; Glucose Transporter Type 5; Insulin Resistance; Male; Metabolic | 2007 |
Innate immune pathway links obesity to insulin resistance.
Topics: Animals; Aorta; Dietary Fats; Disease Models, Animal; Humans; Immunity, Innate; Inflammation; Insuli | 2007 |
Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats.
Topics: Animals; Cats; Diabetes Mellitus, Type 2; Disease Progression; Fatty Acids, Nonesterified; Female; I | 2007 |
Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells).
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line; Cell Survival; Glucose; | 2008 |
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
Topics: Adiponectin; Female; Glucose; Humans; Insulin; Insulin Resistance; Middle Aged; Obesity; Oxidation-R | 2008 |
Respective role of plasma nonesterified fatty acid oxidation and total lipid oxidation in lipid-induced insulin resistance.
Topics: Adult; Calorimetry; Carbon Isotopes; Deuterium; Fatty Acids, Nonesterified; Female; Glucose; Glycero | 1995 |
Saturated fatty acid-induced insulin resistance in rat adipocytes.
Topics: Adipocytes; Animals; Biological Transport; Cells, Cultured; Deoxyglucose; Fatty Acids, Nonesterified | 1994 |
Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo.
Topics: Adipose Tissue; Animals; Blood Glucose; Cholesterol; Fatty Acids, Nonesterified; Glucose; Glucose Cl | 1997 |
Troglitazone reduces free fatty acid-induced insulin resistance in perfused rat hindquarter.
Topics: Animals; Chromans; Fatty Acids, Nonesterified; Hindlimb; Hypoglycemic Agents; Insulin; Insulin Resis | 1998 |
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Ceramides; Glycogen; Glycoge | 1999 |
Fatty acid inhibition of glucose-stimulated insulin secretion is enhanced in pancreatic islets from insulin-resistant rats.
Topics: Analysis of Variance; Animals; Cells, Cultured; Diet; Dietary Fats; Fructose; Glucose; In Vitro Tech | 1999 |
Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Deoxyglucose; Diabetes Mellitus, Type 2; Dow | 1999 |
Peripheral insulin sensitivity is decreased by elevated non-esterified fatty acid level in dexamethasone-treated rats.
Topics: Animals; Dexamethasone; Fatty Acids, Nonesterified; Glucagon; Glucocorticoids; Insulin; Insulin Resi | 1999 |
PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Carbachol; Dietary Fats; Drug Synergism; Fastin | 2001 |