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eicosapentaenoic acid ethyl ester and Insulin Resistance

eicosapentaenoic acid ethyl ester has been researched along with Insulin Resistance in 8 studies

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"The purpose of the present study was to test whether hyperlipidaemia and insulin resistance in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be improved by dietary supplementation with purified eicosapentaenoic acid (EPA) or oleic acid (OA)."7.71Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia. ( Ishimura, N; Mawatari, K; Minami, A; Nakaya, Y; Okada, K; Sakamoto, S; Takishita, E, 2002)
"We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid derived from fish oil, in comparison to lard on the development of hypertension and insulin resistance in Dahl salt-sensitive (Dahl-S) rats fed a high-sucrose diet (HSD), a model of salt-sensitive hypertension."7.70Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in Dahl salt-sensitive rats. ( Ikeda, Y; Ishikawa, T; Mori, Y; Murakawa, Y; Nobukata, H; Shibutani, Y; Tajima, N; Yokoyama, J, 1999)
"We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid derived from fish oil, in comparison to the effects of lard, olive oil, safflower oil, or distilled water as the control on the development of insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) with obesity."7.69Influence of highly purified eicosapentaenoic acid ethyl ester on insulin resistance in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus. ( Hata, S; Ikeda, Y; Ishikawa, T; Katoh, S; Mori, Y; Murakawa, Y; Nobukata, H; Shibutani, Y; Tajima, N; Yokoyama, J, 1997)
" Eicosapentaenoic acid-enriched phospholipids (EPA-PL) significantly ameliorate insulin resistance and elevate the level of hepatic lipolysis, which may have a synergistic effect with SCS in alleviating obesity-related insulin resistance via multiple mechanisms."3.91Synergistic effect of sea cucumber saponins and EPA-enriched phospholipids on insulin resistance in high-fat diet-induced obese mice. ( Ding, L; Han, XQ; Shi, HH; Wang, YM; Xue, CH; Zhang, LY; Zhang, TT, 2019)
"The purpose of the present study was to test whether hyperlipidaemia and insulin resistance in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats can be improved by dietary supplementation with purified eicosapentaenoic acid (EPA) or oleic acid (OA)."3.71Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia. ( Ishimura, N; Mawatari, K; Minami, A; Nakaya, Y; Okada, K; Sakamoto, S; Takishita, E, 2002)
"We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid derived from fish oil, in comparison to lard on the development of hypertension and insulin resistance in Dahl salt-sensitive (Dahl-S) rats fed a high-sucrose diet (HSD), a model of salt-sensitive hypertension."3.70Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in Dahl salt-sensitive rats. ( Ikeda, Y; Ishikawa, T; Mori, Y; Murakawa, Y; Nobukata, H; Shibutani, Y; Tajima, N; Yokoyama, J, 1999)
"We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid, on the development of diabetes, insulin resistance, and abnormalities of blood coagulation in male WBN/Kob rats, a model of spontaneous diabetes mellitus."3.70Long-term administration of highly purified eicosapentaenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats. ( Ishikawa, T; Nobukata, H; Obata, M; Shibutani, Y, 2000)
"We investigated the effect of long-term administration of highly purified eicosapentaenoic acid ethyl ester (EPA-E), an n-3 polyunsaturated fatty acid derived from fish oil, in comparison to the effects of lard, olive oil, safflower oil, or distilled water as the control on the development of insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) with obesity."3.69Influence of highly purified eicosapentaenoic acid ethyl ester on insulin resistance in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus. ( Hata, S; Ikeda, Y; Ishikawa, T; Katoh, S; Mori, Y; Murakawa, Y; Nobukata, H; Shibutani, Y; Tajima, N; Yokoyama, J, 1997)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Lee, M1
Ovbiagele, B1
Saver, JL1
Peng, J2
Zhou, Y1
Hong, Z1
Wu, Y1
Cai, A1
Xia, M1
Deng, Z1
Yang, Y1
Song, T1
Xiong, J1
Wei, H1
Han, XQ1
Zhang, LY1
Ding, L1
Shi, HH1
Xue, CH1
Zhang, TT1
Wang, YM1
Pérez-Echarri, N1
Pérez-Matute, P1
Marcos-Gómez, B1
Martínez, JA1
Moreno-Aliaga, MJ1
Mori, Y2
Murakawa, Y2
Katoh, S1
Hata, S1
Yokoyama, J2
Tajima, N2
Ikeda, Y2
Nobukata, H3
Ishikawa, T3
Shibutani, Y3
Obata, M1
Minami, A1
Ishimura, N1
Sakamoto, S1
Takishita, E1
Mawatari, K1
Okada, K1
Nakaya, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cellular and Molecular Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) on Adipose Tissue: Potential Application in Human Obesity[NCT01138774]103 participants (Actual)Interventional2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

8 other studies available for eicosapentaenoic acid ethyl ester and Insulin Resistance

ArticleYear
Intensive Medical Management to Prevent Large and Small Artery Atherothrombotic Stroke: Time to Expand the Horizon.
    JAMA, 2021, Jul-20, Volume: 326, Issue:3

    Topics: Eicosapentaenoic Acid; Folic Acid; Glucagon-Like Peptide-1 Receptor; Humans; Hyperlipidemias; Hypogl

2021
Maternal eicosapentaenoic acid feeding promotes placental angiogenesis through a Sirtuin-1 independent inflammatory pathway.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2019, Volume: 1864, Issue:2

    Topics: Angiogenesis Inducing Agents; Animals; Diet, High-Fat; Dietary Supplements; Eicosapentaenoic Acid; F

2019
Synergistic effect of sea cucumber saponins and EPA-enriched phospholipids on insulin resistance in high-fat diet-induced obese mice.
    Food & function, 2019, Jul-17, Volume: 10, Issue:7

    Topics: Adipose Tissue; Adipose Tissue, White; Animals; Chemokine CCL2; Diet, High-Fat; Disease Models, Anim

2019
Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats.
    The British journal of nutrition, 2009, Volume: 101, Issue:7

    Topics: Adipose Tissue, White; Animals; Apelin; Blood Glucose; Carrier Proteins; Diet; Eicosapentaenoic Acid

2009
Influence of highly purified eicosapentaenoic acid ethyl ester on insulin resistance in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:12

    Topics: Animals; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, A

1997
Effect of highly purified eicosapentaenoic acid ethyl ester on insulin resistance and hypertension in Dahl salt-sensitive rats.
    Metabolism: clinical and experimental, 1999, Volume: 48, Issue:9

    Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Carrier Proteins; Catecholamines; Diabetes Mell

1999
Long-term administration of highly purified eicosapentaenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:7

    Topics: Animals; Blood Coagulation Disorders; Diabetes Mellitus; Eicosapentaenoic Acid; Fibrinolysis; Glucos

2000
Effect of eicosapentaenoic acid ethyl ester v. oleic acid-rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia.
    The British journal of nutrition, 2002, Volume: 87, Issue:2

    Topics: Abdomen; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dietary Sup

2002