Page last updated: 2024-11-11

4-trimethylammonio-3-((tetradecylcarbamoyl)amino)butyrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9843897
CHEMBL ID1231506
CHEMBL ID106227
SCHEMBL ID3685373
MeSH IDM0445292

Synonyms (24)

Synonym
CHEMBL1231506
teglicar
(3r)-3-{[(tetradecylamino)carbonyl]amino}-4-(trimethylammonio)butanoate
teglicar [inn]
bdbm50122839
chembl106227
[3-carboxy-2-(3-tetradecyl-ureido)-propyl]-trimethyl-ammonium
unii-8v3vq6hmii
4-trimethylammonio-tdcab
(3r)-3-((tetradecylaminocarbonyl)amino)-4-(trimethylazaniumyl)butanoate
250694-07-6
8v3vq6hmii ,
SCHEMBL3685373
AKOS027323786
st1326
st1326, (r)-3-(3-tetradecylureido)-4-(trimethylammonio)butanoate, powder
(3r)-3-[(tetradecylcarbamoyl)amino]-4-(trimethylammonio)butanoate
st1326; (r)-n-tetradecylcarbamoyl-aminocarnitine
HY-16482
(3r)-3-(tetradecylcarbamoylamino)-4-(trimethylazaniumyl)butanoate
(r)-3-(3-tetradecylureido)-4-(trimethylammonio)butanoate
CS-0006357
Q27271060
MS-26779
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carnitine O-palmitoyltransferase 2, mitochondrialRattus norvegicus (Norway rat)IC50 (µMol)0.38000.38002.09335.1000AID719698
Carnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)IC50 (µMol)0.16000.16002.03003.9000AID719674
Carnitine O-palmitoyltransferase 1, liver isoform Rattus norvegicus (Norway rat)IC50 (µMol)58.80000.04000.06500.0900AID49183
Carnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)IC50 (µMol)1.05001.05001.05001.0500AID719720
Carnitine O-palmitoyltransferase 1, muscle isoformRattus norvegicus (Norway rat)IC50 (µMol)56.41000.38002.03255.1000AID49186; AID719675; AID719698
Carnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)IC50 (µMol)3.42500.12594.244010.0000AID719675; AID719719
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
long-chain fatty acid metabolic processCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
in utero embryonic developmentCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
fatty acid beta-oxidationCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
carnitine shuttleCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
carnitine metabolic processCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
positive regulation of cold-induced thermogenesisCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
response to hypoxiaCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
long-chain fatty acid metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
glucose metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
fatty acid beta-oxidationCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
triglyceride metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
carnitine shuttleCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to nutrientCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to xenobiotic stimulusCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
carnitine metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
regulation of lipid storageCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to organic cyclic compoundCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
epithelial cell differentiationCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
positive regulation of fatty acid beta-oxidationCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
eating behaviorCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to alkaloidCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
positive regulation of innate immune responseCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to ethanolCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
aflatoxin metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
regulation of insulin secretionCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
cellular response to fatty acidCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
liver regenerationCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
response to tetrachloromethaneCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
fatty acid metabolic processCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
fatty acid metabolic processCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
fatty acid beta-oxidationCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
carnitine shuttleCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
carnitine metabolic processCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
response to blue lightCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
long-chain fatty acid transportCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
carnitine O-palmitoyltransferase activityCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
protein bindingCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
carnitine O-octanoyltransferase activityCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
acyltransferase activityCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
carnitine O-palmitoyltransferase activityCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
protein-macromolecule adaptor activityCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
identical protein bindingCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
palmitoleoyltransferase activityCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
carnitine O-palmitoyltransferase activityCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
protein bindingCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleoplasmCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
nucleolusCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
mitochondrial inner membraneCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
mitochondrial outer membraneCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
membraneCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
mitochondrial outer membraneCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
mitochondrionCarnitine O-palmitoyltransferase 1, muscle isoformHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (28)

Assay IDTitleYearJournalArticle
AID719683Reduction in HOMA index in NIDD patient at 450 mg/day, po for 15 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719662Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed as conversion of [14C]palmitic acid to [14C]palmitoylcarnitine by radiometric assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719639Reduction in glucose production in Sprague-Dawley rat at 5 to 25 pmol, icv administered as one or two single doses2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719644Reduction in water consumption in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719641Reduction in BHB level in po dosed 24 hrs fasted rat measured up to 12 hrs post dose2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719642Increase in circulating FFA level in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719646Reduction in liver glycogen level in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719672Cytotoxicity in human KB cells2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719661Inhibition of carnitine palmitoyltransferase in rat heart mitochondria assessed as conversion of [14C]palmitic acid to [14C]palmitoylcarnitine by radiometric assay2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID49186In vitro inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I of rat heart mitochondria2003Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2
Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.
AID719698Inhibition of rat CPT22011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719673Inhibition of human FAO2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719682Reduction in fasting insulin in NIDD patient at 450 mg/day, po for 15 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719671Inhibition of rat FAO2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719715Competitive inhibition of carnitine palmitoyltransferase using palmitoyl-CoA2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719637Inhibition of ketogenesis in fasted po dosed cynomolgus monkey2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719635Reduction in glucose level in db/db mouse at 80 mg/kgl/day, po for 12 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719640Reduction in blood glucose level in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719719Inhibition of human CPT1B2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719647Reduction in serum glucose in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719645Reduction in serum fructosamine level in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719643Increase in liver TG level in db/db mouse at 50 mg/kg, po bid for 45 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719684Half life in NIDD patient at 150 to 450 mg/day, po for 15 days2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719675Maximal inhibition of rat CPT1A2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719720Inhibition of human CPT1A2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID49183Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria2003Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2
Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.
AID719674Inhibition of human CPT22011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
AID719711Critical micelle concentration of compound2011Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]