Assay ID | Title | Year | Journal | Article |
AID719683 | Reduction in HOMA index in NIDD patient at 450 mg/day, po for 15 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719662 | Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed as conversion of [14C]palmitic acid to [14C]palmitoylcarnitine by radiometric assay | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719639 | Reduction in glucose production in Sprague-Dawley rat at 5 to 25 pmol, icv administered as one or two single doses | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719644 | Reduction in water consumption in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719641 | Reduction in BHB level in po dosed 24 hrs fasted rat measured up to 12 hrs post dose | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719642 | Increase in circulating FFA level in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719646 | Reduction in liver glycogen level in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719672 | Cytotoxicity in human KB cells | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719661 | Inhibition of carnitine palmitoyltransferase in rat heart mitochondria assessed as conversion of [14C]palmitic acid to [14C]palmitoylcarnitine by radiometric assay | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID49186 | In vitro inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I of rat heart mitochondria | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2
| Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity. |
AID719698 | Inhibition of rat CPT2 | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719673 | Inhibition of human FAO | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719682 | Reduction in fasting insulin in NIDD patient at 450 mg/day, po for 15 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719671 | Inhibition of rat FAO | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719715 | Competitive inhibition of carnitine palmitoyltransferase using palmitoyl-CoA | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719637 | Inhibition of ketogenesis in fasted po dosed cynomolgus monkey | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719635 | Reduction in glucose level in db/db mouse at 80 mg/kgl/day, po for 12 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719640 | Reduction in blood glucose level in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719719 | Inhibition of human CPT1B | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719647 | Reduction in serum glucose in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719645 | Reduction in serum fructosamine level in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719643 | Increase in liver TG level in db/db mouse at 50 mg/kg, po bid for 45 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719684 | Half life in NIDD patient at 150 to 450 mg/day, po for 15 days | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719675 | Maximal inhibition of rat CPT1A | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719720 | Inhibition of human CPT1A | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID49183 | Inhibition of [14C]palmitoyl-CoA and carnitine binding to carnitine palmitoyltransferase I from rat liver mitochondria | 2003 | Journal of medicinal chemistry, Jan-16, Volume: 46, Issue:2
| Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity. |
AID719674 | Inhibition of human CPT2 | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
AID719711 | Critical micelle concentration of compound | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |