2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Insulin Resistance in 26 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effect of conditioned media for rat bone marrow mesenchymal stem cells (BMSCs-CM) on palmitic acid (PA)-induced insulin resistance (IR) in HepG2 cells and its underlying molecular mechanisms." | 7.81 | [Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells]. ( Han, W; Hao, H; Mu, Y; Sun, X, 2015) |
| "Obesity is associated with the development of leptin resistance." | 7.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "To study the effect of conditioned media for rat bone marrow mesenchymal stem cells (BMSCs-CM) on palmitic acid (PA)-induced insulin resistance (IR) in HepG2 cells and its underlying molecular mechanisms." | 3.81 | [Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells]. ( Han, W; Hao, H; Mu, Y; Sun, X, 2015) |
| "Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes, a high-risk population for the development of a diffuse and extensive pattern of arteriosclerosis." | 3.72 | C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro. ( Aleksic, M; Bach, H; Grüb, M; Hombach, V; Homma, S; Libby, P; Marx, N; Raichle, C; Strong, J; Walcher, D; Zieske, A, 2004) |
| "Obesity is associated with the development of leptin resistance." | 3.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "The anti-obesity agent sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNRI), has been shown to reduce insulin resistance and improve glycaemic control in obese-diabetic ob/ob mice and overweight type 2 diabetic patients." | 3.71 | Sibutramine metabolites increase glucose transport by cultured rat muscle cells. ( Bailey, CJ; Bates, SH; Jones, RB; Turner, SL, 2001) |
| "Hepatic insulin resistance was induced by palmitic acid (PA) in the HepG2 cells, which were then treated with EPO (5 or 10 U/ml) or specific phosphoinositide 3‑kinase (PI3K) inhibitors, wortmannin or LY294002." | 1.46 | Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells. ( Bi, Y; Ge, Z; Meng, R; Tang, S; Zhang, H; Zhu, D, 2017) |
| "Insulin resistance was induced by glucosamine (GlcN) or palmitate in human hepatocellular carcinoma (HepG2) cells and mouse primary hepatocytes." | 1.42 | Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. ( Chen, Q; Ding, L; Gao, R; Kang, YM; Li, YH; Liu, TY; Shi, CX; Sun, HJ; Wang, JJ; Xiong, XQ; Zhu, GQ, 2015) |
| "Type 2 diabetes mellitus is thought to be a significant risk factor for Alzheimer's disease." | 1.38 | Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. ( Kasahara, R; Matsubara, T; Naruse, K; Sato, T; Sobue, K; Suzuki, K; Tanida, M; Taniura, H; Yamamoto, N, 2012) |
| "Insulin resistance is frequently associated with hypertension, but the mechanism underlying this association remains speculative." | 1.33 | Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. ( Endo, Y; Fujita, T; Horita, S; Kadowaki, T; Kunimi, M; Li, Y; Sakamoto, K; Seki, G; Terauchi, Y; Tobe, K; Yamada, H; Zheng, Y, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 11 (42.31) | 29.6817 |
| 2010's | 14 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Ge, Z | 1 |
| Tang, S | 1 |
| Meng, R | 1 |
| Bi, Y | 1 |
| Zhu, D | 1 |
| Nazarians-Armavil, A | 1 |
| Menchella, JA | 1 |
| Belsham, DD | 1 |
| Cheng, J | 1 |
| Song, ZY | 1 |
| Pu, L | 1 |
| Yang, H | 1 |
| Zheng, JM | 1 |
| Zhang, ZY | 1 |
| Shi, XE | 1 |
| Yang, GS | 1 |
| Sun, X | 1 |
| Hao, H | 1 |
| Han, W | 1 |
| Mu, Y | 1 |
| Liu, TY | 1 |
| Shi, CX | 1 |
| Gao, R | 1 |
| Sun, HJ | 1 |
| Xiong, XQ | 1 |
| Ding, L | 1 |
| Chen, Q | 1 |
| Li, YH | 1 |
| Wang, JJ | 1 |
| Kang, YM | 1 |
| Zhu, GQ | 1 |
| Yang, M | 1 |
| Ren, Y | 1 |
| Lin, Z | 1 |
| Tang, C | 1 |
| Jia, Y | 1 |
| Lai, Y | 1 |
| Zhou, T | 1 |
| Wu, S | 1 |
| Liu, H | 1 |
| Yang, G | 1 |
| Li, L | 1 |
| Peterson, SJ | 1 |
| Kim, DH | 1 |
| Li, M | 1 |
| Positano, V | 1 |
| Vanella, L | 1 |
| Rodella, LF | 1 |
| Piccolomini, F | 1 |
| Puri, N | 1 |
| Gastaldelli, A | 1 |
| Kusmic, C | 1 |
| L'Abbate, A | 1 |
| Abraham, NG | 1 |
| Gao, D | 1 |
| Griffiths, HR | 1 |
| Bailey, CJ | 2 |
| Yue, P | 1 |
| Jin, H | 1 |
| Aillaud, M | 1 |
| Deng, AC | 1 |
| Azuma, J | 1 |
| Asagami, T | 1 |
| Kundu, RK | 1 |
| Reaven, GM | 1 |
| Quertermous, T | 1 |
| Tsao, PS | 1 |
| Morgan, DA | 1 |
| Rahmouni, K | 1 |
| Cao, C | 1 |
| Chen, Y | 1 |
| Wang, W | 2 |
| Liu, Y | 2 |
| Liu, G | 1 |
| Kim, B | 1 |
| Sullivan, KA | 1 |
| Backus, C | 1 |
| Feldman, EL | 1 |
| Keuper, M | 1 |
| Blüher, M | 1 |
| Schön, MR | 1 |
| Möller, P | 1 |
| Dzyakanchuk, A | 1 |
| Amrein, K | 1 |
| Debatin, KM | 1 |
| Wabitsch, M | 1 |
| Fischer-Posovszky, P | 1 |
| Ning, J | 1 |
| Hong, T | 1 |
| Yang, X | 1 |
| Mei, S | 1 |
| Liu, Z | 1 |
| Liu, HY | 1 |
| Cao, W | 1 |
| Yamamoto, N | 1 |
| Matsubara, T | 1 |
| Sobue, K | 1 |
| Tanida, M | 1 |
| Kasahara, R | 1 |
| Naruse, K | 1 |
| Taniura, H | 1 |
| Sato, T | 1 |
| Suzuki, K | 1 |
| Yang, Y | 1 |
| Guo, T | 1 |
| Chen, P | 1 |
| Ma, K | 1 |
| Zhou, C | 1 |
| Marx, N | 1 |
| Walcher, D | 1 |
| Raichle, C | 1 |
| Aleksic, M | 1 |
| Bach, H | 1 |
| Grüb, M | 1 |
| Hombach, V | 1 |
| Libby, P | 1 |
| Zieske, A | 1 |
| Homma, S | 1 |
| Strong, J | 1 |
| Liang, CP | 1 |
| Han, S | 1 |
| Okamoto, H | 1 |
| Carnemolla, R | 1 |
| Tabas, I | 1 |
| Accili, D | 1 |
| Tall, AR | 1 |
| Huang, W | 1 |
| Dedousis, N | 1 |
| Bhatt, BA | 1 |
| O'Doherty, RM | 1 |
| Nadeau, KJ | 1 |
| Leitner, JW | 1 |
| Gurerich, I | 1 |
| Draznin, B | 1 |
| Kamon, J | 1 |
| Yamauchi, T | 1 |
| Muto, S | 1 |
| Takekawa, S | 1 |
| Ito, Y | 1 |
| Hada, Y | 1 |
| Ogawa, W | 1 |
| Itai, A | 1 |
| Kasuga, M | 1 |
| Tobe, K | 2 |
| Kadowaki, T | 2 |
| Collier, JJ | 1 |
| White, SM | 1 |
| Dick, GM | 1 |
| Scott, DK | 1 |
| Zheng, Y | 1 |
| Yamada, H | 1 |
| Sakamoto, K | 1 |
| Horita, S | 1 |
| Kunimi, M | 1 |
| Endo, Y | 1 |
| Li, Y | 1 |
| Terauchi, Y | 1 |
| Seki, G | 1 |
| Fujita, T | 1 |
| Huang, TT | 1 |
| Du, ML | 1 |
| Ma, HM | 1 |
| Su, Z | 1 |
| Gu, YF | 1 |
| Grzelkowska, K | 1 |
| Dardevet, D | 1 |
| Balage, M | 1 |
| Grizard, J | 1 |
| Turner, SL | 1 |
| Bates, SH | 1 |
| Jones, RB | 1 |
26 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Insulin Resistance
| Article | Year |
|---|---|
Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells.
Topics: Androstadienes; Chemokine CCL2; Chromones; Epoetin Alfa; Forkhead Box Protein O1; Glucose; Glycogen | 2017 |
Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinases; Gen | 2013 |
Retinol binding protein 4 affects the adipogenesis of porcine preadipocytes through insulin signaling pathways.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Differentiation; Chromones; Dexamethasone; G | 2013 |
[Effects of conditioned media for rat bone marrow-derived mesenchymal stem cells on palmitic acid-induced insulin resistance in HepG2 cells].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromones; Culture Media, Conditioned; Glucose; Hep G2 Cell | 2015 |
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Class I Phosphatidylinositol 3-Kinases; Diab | 2015 |
Krüppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway.
Topics: Adipose Tissue; Animals; Antigens, CD; Biological Transport; Cell Line, Tumor; Chromones; Diabetes M | 2015 |
The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice.
Topics: Adipocytes; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Body Weight; Chromones; Diabetes | 2009 |
Oleate protects against palmitate-induced insulin resistance in L6 myotubes.
Topics: Androstadienes; Animals; Cell Membrane; Cell Survival; Cells, Cultured; Chromones; Deoxyglucose; Dos | 2009 |
Apelin is necessary for the maintenance of insulin sensitivity.
Topics: Adipokines; AMP-Activated Protein Kinases; Animals; Apelin; Carrier Proteins; Cells, Cultured; Chrom | 2010 |
Differential effects of insulin on sympathetic nerve activity in agouti obese mice.
Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Enzyme Inhibitors; Injections, Intraventr | 2010 |
Ghrelin inhibits insulin resistance induced by glucotoxicity and lipotoxicity in cardiomyocyte.
Topics: AMP-Activated Protein Kinases; Animals; Cell Shape; Cells, Cultured; Chromones; Deoxyglucose; Enzyme | 2011 |
Cortical neurons develop insulin resistance and blunted Akt signaling: a potential mechanism contributing to enhanced ischemic injury in diabetes.
Topics: Animals; Blotting, Western; Butadienes; Cells, Cultured; Cerebral Cortex; Chromones; Enzyme Inhibito | 2011 |
An inflammatory micro-environment promotes human adipocyte apoptosis.
Topics: Adipocytes; Adipose Tissue; Adult; Aged; Aged, 80 and over; Apoptosis; CD11c Antigen; Cells, Culture | 2011 |
Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Adipose Tissue; Animals; Carcinoma, | 2011 |
Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes.
Topics: Aging; Amyloid beta-Peptides; Animals; Blotting, Western; Brain Chemistry; Cell Separation; Cells, C | 2012 |
α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Line; Cell Prolif | 2012 |
C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro.
Topics: Adolescent; Adult; Androstadienes; Aorta, Thoracic; Aortic Diseases; Arteriosclerosis; C-Peptide; Ce | 2004 |
Increased CD36 protein as a response to defective insulin signaling in macrophages.
Topics: Animals; Blotting, Northern; Blotting, Western; CD36 Antigens; Chromones; Electrophoresis, Polyacryl | 2004 |
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.
Topics: Androstadienes; Animals; Chromones; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insul | 2004 |
Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein | 2004 |
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Benzamides; Blood Glucose; Body Weight; Chromones; D | 2004 |
Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells.
Topics: Action Potentials; Androstadienes; Animals; Calcium; Cell Line, Tumor; Chromones; Dose-Response Rela | 2004 |
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
Topics: Absorption; Androstadienes; Animals; Bicarbonates; Chromones; Crosses, Genetic; Dose-Response Relati | 2005 |
[Correlation between growth hormone/insulin-like growth factor-1 resistance and insulin resistance in non catch-up growth rats born small for gestational age].
Topics: Animals; Animals, Newborn; Birth Weight; Blood Glucose; Body Weight; Chromones; Female; Gestational | 2007 |
Involvement of the rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Chromones; Diabetes Mellitus, Experimental; Enzyme | 1999 |
Sibutramine metabolites increase glucose transport by cultured rat muscle cells.
Topics: Animals; Appetite Depressants; Area Under Curve; Biological Transport; Cells, Cultured; Chromones; C | 2001 |