A patatin-like phospholipase domain-containing protein 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96AD5]
EC 3.1.1.3;
Adipose triglyceride lipase;
Calcium-independent phospholipase A2;
Desnutrin;
IPLA2-zeta;
Pigment epithelium-derived factor;
TTS2.2;
Transport-secretion protein 2;
TTS2
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| atglistatin | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| lipoprotein lipase activity | molecular function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. [EC:3.1.1.34, GOC:bf] |
| phospholipase A2 activity | molecular function | Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801] |
| triglyceride lipase activity | molecular function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. [EC:3.1.1.3] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| acylglycerol O-acyltransferase activity | molecular function | Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. [GOC:ai] |
| retinyl-palmitate esterase activity | molecular function | Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. [RHEA:21508] |
| mono-olein transacylation activity | molecular function | Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. [GOC:ai, PMID:15364929] |
| diolein transacylation activity | molecular function | Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. [GOC:ai, PMID:15364929] |
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| diacylglycerol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. [GOC:curators] |
| negative regulation of sequestering of triglyceride | biological process | Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. [GOC:BHF, GOC:dph, GOC:tb] |
| positive regulation of triglyceride catabolic process | biological process | Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb] |
| triglyceride catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. [ISBN:0198506732] |
| lipid storage | biological process | The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] |
| intracellular triglyceride homeostasis | biological process | A homeostatic process involved in the maintenance of a steady state level of triglyceride within a cell. [GOC:BHF] |
| acylglycerol acyl-chain remodeling | biological process | Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains. [GOC:mw, PMID:15364929] |
| retinol metabolic process | biological process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] |
| lipid droplet disassembly | biological process | The disaggregation of a lipid particle into its constituent components. [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] |
| lipid homeostasis | biological process | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl] |