16-hydroxydehydroepiandrosterone sulfate profile

## 16-Hydroxydehydroepiandrosterone Sulfate (16OH-DHEA-S)

**16-Hydroxydehydroepiandrosterone sulfate (16OH-DHEA-S)** is a steroid hormone that is a derivative of dehydroepiandrosterone (DHEA). It's important to note that it's **not** the same as DHEA-S, which is the sulfate conjugate of DHEA.

**Here's why 16OH-DHEA-S is important for research:**

* **Potential Role in Neurological Disorders:** Research suggests that 16OH-DHEA-S may play a role in neuroprotection and cognitive function. Some studies have shown that it can protect against neuronal damage induced by toxins and oxidative stress. This makes it a potential target for the development of new treatments for neurological disorders like Alzheimer's disease and Parkinson's disease.
* **Influence on Endocrine System:** 16OH-DHEA-S is involved in the regulation of the endocrine system, particularly the adrenal glands, which produce DHEA and other steroid hormones. This makes it an interesting target for research into adrenal function and hormone regulation.
* **Marker for Disease:** 16OH-DHEA-S levels in the body may be used as a marker for certain diseases. For example, studies have linked elevated levels of 16OH-DHEA-S to conditions like polycystic ovary syndrome (PCOS).
* **Potential Therapeutic Applications:** Due to its various biological effects, 16OH-DHEA-S is being investigated for its potential therapeutic applications in conditions like depression, anxiety, and chronic fatigue syndrome.

**However, it's crucial to note that research on 16OH-DHEA-S is still in its early stages.** More studies are needed to fully understand its role in health and disease.

**Key Research Areas:**

* Understanding the precise mechanisms by which 16OH-DHEA-S exerts its effects on the body.
* Exploring the potential therapeutic applications of 16OH-DHEA-S in different diseases.
* Investigating the safety and efficacy of 16OH-DHEA-S as a therapeutic agent.

Overall, 16OH-DHEA-S is a promising molecule with potential therapeutic applications in various areas of health and disease. Further research is crucial to unlock its full potential.

16-hydroxydehydroepiandrosterone sulfate: RN given refers to cpd with unspecified sulfate ester linkage locant & (3 beta,16 beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	168847
MeSH ID	M0082588

Synonym
28905-55-7
16-hydroxydehydroepiandrosterone sulfate
16beta-hydroxydehydroepiandrosterone sulfate
androst-5-en-17-one, 3,16-dihydroxy-, mono(hydrogen sulfate), (3beta,16beta)-
16 alpha-oh-dhea-sulfate
DTXSID10951539
3-hydroxy-17-oxoandrost-5-en-16-yl hydrogen sulfate

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (53.85)	18.7374
1990's	3 (23.08)	18.2507
2000's	2 (15.38)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
sulfobromophthalein Sulfobromophthalein: A phenolphthalein that is used as a diagnostic aid in hepatic function determination.	2.11	1	2-benzofurans; organobromine compound; organosulfonic acid; phenols	dye
estriol hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.	4.47	7	16alpha-hydroxy steroid; 17beta-hydroxy steroid; 3-hydroxy steroid	estrogen; human metabolite; human xenobiotic metabolite; mouse metabolite
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	2.11	1	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
androsterone [no description available]	2.05	1	17-oxo steroid; 3alpha-hydroxy steroid; androstanoid; C19-steroid	androgen; anticonvulsant; human blood serum metabolite; human metabolite; human urinary metabolite; mouse metabolite; pheromone
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	5.53	13	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	2	1	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
dehydroepiandrosterone sulfate Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.. dehydroepiandrosterone sulfate : A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.	4.17	5	17-oxo steroid; steroid sulfate	EC 2.7.1.33 (pantothenate kinase) inhibitor; human metabolite; mouse metabolite
estriol 3-sulfate estriol 3-sulfate: estriol conjugate; RN given refers to (16alpha,17beta)-isomer	2.38	2
17-alpha-hydroxypregnenolone 17-alpha-Hydroxypregnenolone: A 21-carbon steroid that is converted from PREGNENOLONE by STEROID 17-ALPHA-HYDROXYLASE. It is an intermediate in the delta-5 pathway of biosynthesis of GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.. 17alpha-hydroxypregnenolone : A hydroxypregnenolone carrying an alpha-hydroxy group at position 17.	1.97	1	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; hydroxypregnenolone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
16-hydroxydehydroepiandrosterone 16-hydroxydehydroepiandrosterone: RN refers to (3beta,16alpha)-isomer	1.96	1	16alpha-hydroxy steroid; 17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid; secondary alpha-hydroxy ketone	human metabolite; mouse metabolite
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	1.97	1	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
estrone sulfate estrone sulfate: sulfoconjugated estrone; RN given refers to parent cpd	2.11	1	17-oxo steroid; steroid sulfate	human metabolite; mouse metabolite
11 beta-hydroxyandrosterone 11 beta-hydroxyandrosterone: RN given refers to (3alpha,5alpha,11beta)-isomer; structure	2.05	1	3-hydroxy steroid	androgen

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	4.4	8
7-Dehydrocholesterol Reductase Deficiency [description not available]	2.05	1
Ichthyosis, Sex-Linked [description not available]	2.05	1
Smith-Lemli-Opitz Syndrome An autosomal recessive disorder of CHOLESTEROL metabolism. It is caused by a deficiency of 7-dehydrocholesterol reductase, the enzyme that converts 7-dehydrocholesterol to cholesterol, leading to an abnormally low plasma cholesterol. This syndrome is characterized by multiple CONGENITAL ABNORMALITIES, growth deficiency, and INTELLECTUAL DISABILITY.	2.05	1
Xeroderma [description not available]	2.87	1
Ichthyosis Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.	2.87	1
Blood Pressure, High [description not available]	1.95	1
Adrenal Gland Diseases Pathological processes of the ADRENAL GLANDS.	1.95	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	1.95	1
Insulin Sensitivity [description not available]	2.91	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.91	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.91	1
Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.	2.91	1
Adenosis of Breast [description not available]	2.38	2
Fibrocystic Breast Disease A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.	2.38	2
Fetal Death Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.	1.97	1

16-hydroxydehydroepiandrosterone sulfate

Description

Cross-References

Synonyms (7)

Research

Studies (13)

Market Indicators

Research Demand Index: 11.47

Study Types