pyruvic acid has been researched along with Insulin Resistance in 45 studies
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pyruvate tolerance test and biochemical analysis coupled with the ex vivo siRNA knockdown and co-culture studies demonstrate that ilexgenin A suppresses inflammation-associated lipolysis in epididymal fat pad via 5'-AMP-activated protein kinase (AMPK) activation, thus inhibits diacylglycerol (DAG) accumulation and protein kinase C ε (PKCε) translocation in liver, leading to the improvement of insulin sensitivity and hepatic glucose production." | 7.85 | Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance. ( Li, LZ; Liu, B; Liu, K; Wang, L; Yang, L; Zhang, L; Zhang, T, 2017) |
| "Our previous findings clearly suggested the role of duration of exposure to monocrotophos (MCP) in the development of insulin resistance." | 7.83 | Adaptive response of rat pancreatic β-cells to insulin resistance induced by monocrotophos: Biochemical evidence. ( Nagaraju, R; Rajini, PS, 2016) |
| "Sodium nitrite significantly increased plasma glucose and insulin resistance." | 7.81 | Cod liver oil ameliorates sodium nitrite-induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway. ( Abbas, A; Al-Gayyar, MM; Alyoussef, A; Darweish, MM; El-Hawwary, AA; Hamdan, AM, 2015) |
| "Pioglitazone is effective in improving insulin resistance and liver histology in patients with nonalcoholic steatohepatitis (NASH)." | 3.88 | Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis. ( Abdo, K; Andrews, P; Bril, F; Cusi, K; Frye, RF; Garrett, TJ; Guingab, J; Jose, D; Kalavalapalli, S; Koelmel, JP; Li, WY; Sunny, NE; Yost, RA, 2018) |
| " Pyruvate tolerance test and biochemical analysis coupled with the ex vivo siRNA knockdown and co-culture studies demonstrate that ilexgenin A suppresses inflammation-associated lipolysis in epididymal fat pad via 5'-AMP-activated protein kinase (AMPK) activation, thus inhibits diacylglycerol (DAG) accumulation and protein kinase C ε (PKCε) translocation in liver, leading to the improvement of insulin sensitivity and hepatic glucose production." | 3.85 | Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance. ( Li, LZ; Liu, B; Liu, K; Wang, L; Yang, L; Zhang, L; Zhang, T, 2017) |
| "Our previous findings clearly suggested the role of duration of exposure to monocrotophos (MCP) in the development of insulin resistance." | 3.83 | Adaptive response of rat pancreatic β-cells to insulin resistance induced by monocrotophos: Biochemical evidence. ( Nagaraju, R; Rajini, PS, 2016) |
| "Sodium nitrite significantly increased plasma glucose and insulin resistance." | 3.81 | Cod liver oil ameliorates sodium nitrite-induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway. ( Abbas, A; Al-Gayyar, MM; Alyoussef, A; Darweish, MM; El-Hawwary, AA; Hamdan, AM, 2015) |
| " Characterization of overt hyperglycemia in insulin receptor mutant (Insr(P1195L/+)) mice exposed to HFD (Insr(P1195L/+)/HFD mice) revealed increased glucose-6-phosphatase (G6pc) expression in liver and increased gluconeogenesis from glycerol." | 3.81 | Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. ( Jiang, M; Lee, EY; Miki, T; Minokoshi, Y; Sakurai, K; Shirasawa, T; Tachibana, K; Tanaka, T; Toda, C; Vidal-Puig, A; Yokote, K; Zhang, X, 2015) |
| "Middle-age mice with pre-existing diet-induced obesity were provided with low concentration β-mercaptoethanol (BME) in drinking water for six months." | 3.80 | Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice. ( Corkey, BE; Guo, W; Hamilton, JA; Kirkland, JL; Schwanz, HA; Simmons, AL; Wong, S, 2014) |
| "Prediabetes is a major risk factor for type 2 diabetes and cardiovascular diseases." | 3.01 | A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes. ( Abumrad, NA; Bittel, AJ; Bittel, DC; Cade, WT; Mittendorfer, B; Okunade, AL; Patterson, BW; Reeds, DN, 2021) |
| " Such non-monotonic dose-response effects of iAs on glucose tolerance shed light on the complex interactions between iAs and the systemic glucose metabolism, which could potentially help reconcile some of the conflicting results in human epidemiological studies." | 1.51 | Non-monotonic dose-response effects of arsenic on glucose metabolism. ( Ding, G; Gong, Y; Li, X; Liu, J; Qian, J; Qian, S; Sun, Z; Xue, Y; Zhou, W; Zhuang, Z, 2019) |
| "Protection against fatty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside, a specific inhibitor of ANT." | 1.46 | Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. ( Cho, J; Choi, CS; Chun, SK; Han, C; Joseph, AM; Kalavalapalli, S; Kim, JS; Lee, HY; Lee, YJ; Mathews, CE; Morgan, D; Oh, SP; Park, HJ; Park, SY; Shiratsuchi, T; Someya, S; Sunny, NE; Terada, N; Wohlgemuth, SE; Zhang, Y, 2017) |
| "Although evidence that type 2 diabetes mellitus (T2DM) is accompanied by mitochondrial dysfunction in skeletal muscle has been accumulating, a causal link between mitochondrial dysfunction and the pathogenesis of the disease remains unclear." | 1.40 | Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat. ( Affolter, A; Clanachan, AS; Hersberger, M; Lemieux, H; Lou, PH; Lucchinetti, E; Warren, BE; Zaugg, M; Zhang, L, 2014) |
| "We find that rapamycin treatment leads to glucose intolerance in both young and old HET3 mice, but in contrast to the previously reported effect of injected rapamycin in C57BL/6 mice, HET3 mice treated with dietary rapamycin responded normally in an insulin tolerance test." | 1.39 | Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. ( Astle, CM; Baur, JA; Harrison, DE; Lamming, DW; Sabatini, DM; Ye, L, 2013) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| " Insulin dose-response curves revealed similar sensitivities and responsiveness." | 1.28 | Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM. ( Gavin, JR; Karl, IE; Levy, J, 1990) |
| "A change in insulin sensitivity is possibly involved." | 1.27 | Phenobarbital treatment enhances insulin mediated glucose metabolism in man. ( Lahtela, JT; Särkkä, P; Sotaniemi, EA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.67) | 18.7374 |
| 1990's | 5 (11.11) | 18.2507 |
| 2000's | 6 (13.33) | 29.6817 |
| 2010's | 26 (57.78) | 24.3611 |
| 2020's | 5 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Andrisse, S | 1 |
| Feng, M | 1 |
| Wang, Z | 1 |
| Awe, O | 1 |
| Yu, L | 1 |
| Zhang, H | 1 |
| Bi, S | 1 |
| Wang, H | 1 |
| Li, L | 1 |
| Joseph, S | 1 |
| Heller, N | 1 |
| Mauvais-Jarvis, F | 1 |
| Wong, GW | 1 |
| Segars, J | 1 |
| Wolfe, A | 1 |
| Divall, S | 1 |
| Ahima, R | 1 |
| Wu, S | 1 |
| Jevtovic, F | 1 |
| Zheng, D | 1 |
| Lopez, CA | 1 |
| Kern, K | 1 |
| Tanner, CJ | 1 |
| Jones, TE | 1 |
| Pories, WJ | 1 |
| Dohm, GL | 1 |
| Houmard, JA | 1 |
| May, LE | 1 |
| Broskey, NT | 1 |
| Mu, K | 1 |
| Sun, Y | 1 |
| Zhao, Y | 1 |
| Zhao, T | 1 |
| Li, Q | 1 |
| Zhang, M | 1 |
| Li, H | 1 |
| Zhang, R | 1 |
| Hu, C | 1 |
| Wang, C | 1 |
| Jia, W | 1 |
| Bittel, AJ | 1 |
| Bittel, DC | 1 |
| Mittendorfer, B | 1 |
| Patterson, BW | 1 |
| Okunade, AL | 1 |
| Abumrad, NA | 1 |
| Reeds, DN | 1 |
| Cade, WT | 1 |
| Park, JM | 1 |
| Josan, S | 1 |
| Hurd, RE | 1 |
| Graham, J | 1 |
| Havel, PJ | 1 |
| Bendahan, D | 1 |
| Mayer, D | 1 |
| Chung, Y | 1 |
| Spielman, DM | 1 |
| Jue, T | 1 |
| Gonzalez-Rellan, MJ | 1 |
| Fondevila, MF | 1 |
| Fernandez, U | 1 |
| Rodríguez, A | 1 |
| Varela-Rey, M | 1 |
| Veyrat-Durebex, C | 1 |
| Seoane, S | 1 |
| Bernardo, G | 1 |
| Lopitz-Otsoa, F | 1 |
| Fernández-Ramos, D | 1 |
| Bilbao, J | 1 |
| Iglesias, C | 1 |
| Novoa, E | 1 |
| Ameneiro, C | 1 |
| Senra, A | 1 |
| Beiroa, D | 1 |
| Cuñarro, J | 1 |
| Dp Chantada-Vazquez, M | 1 |
| Garcia-Vence, M | 1 |
| Bravo, SB | 1 |
| Da Silva Lima, N | 1 |
| Porteiro, B | 1 |
| Carneiro, C | 1 |
| Vidal, A | 1 |
| Tovar, S | 1 |
| Müller, TD | 1 |
| Ferno, J | 1 |
| Guallar, D | 1 |
| Fidalgo, M | 1 |
| Sabio, G | 1 |
| Herzig, S | 1 |
| Yang, WH | 1 |
| Cho, JW | 1 |
| Martinez-Chantar, ML | 1 |
| Perez-Fernandez, R | 1 |
| López, M | 1 |
| Dieguez, C | 1 |
| Mato, JM | 1 |
| Millet, O | 1 |
| Coppari, R | 1 |
| Woodhoo, A | 1 |
| Fruhbeck, G | 1 |
| Nogueiras, R | 1 |
| Li, LZ | 1 |
| Zhang, T | 1 |
| Yang, L | 1 |
| Zhang, L | 2 |
| Wang, L | 1 |
| Liu, B | 1 |
| Liu, K | 1 |
| Soto, M | 1 |
| Orliaguet, L | 1 |
| Reyzer, ML | 1 |
| Manier, ML | 1 |
| Caprioli, RM | 1 |
| Kahn, CR | 1 |
| Kalavalapalli, S | 2 |
| Bril, F | 1 |
| Koelmel, JP | 1 |
| Abdo, K | 1 |
| Guingab, J | 1 |
| Andrews, P | 1 |
| Li, WY | 1 |
| Jose, D | 1 |
| Yost, RA | 1 |
| Frye, RF | 1 |
| Garrett, TJ | 1 |
| Cusi, K | 1 |
| Sunny, NE | 2 |
| Min, BK | 1 |
| Park, S | 1 |
| Kang, HJ | 2 |
| Kim, DW | 1 |
| Ham, HJ | 2 |
| Ha, CM | 2 |
| Choi, BJ | 1 |
| Lee, JY | 1 |
| Oh, CJ | 1 |
| Yoo, EK | 1 |
| Kim, HE | 1 |
| Kim, BG | 2 |
| Jeon, JH | 2 |
| Hyeon, DY | 1 |
| Hwang, D | 1 |
| Kim, YH | 1 |
| Lee, CH | 2 |
| Lee, T | 1 |
| Kim, JW | 1 |
| Choi, YK | 2 |
| Park, KG | 2 |
| Chawla, A | 1 |
| Lee, J | 1 |
| Harris, RA | 2 |
| Lee, IK | 2 |
| Gong, Y | 1 |
| Liu, J | 1 |
| Xue, Y | 1 |
| Zhuang, Z | 1 |
| Qian, S | 1 |
| Zhou, W | 1 |
| Li, X | 1 |
| Qian, J | 1 |
| Ding, G | 1 |
| Sun, Z | 1 |
| Tsuneki, H | 1 |
| Tokai, E | 1 |
| Sugawara, C | 1 |
| Wada, T | 1 |
| Sakurai, T | 1 |
| Sasaoka, T | 1 |
| Lamming, DW | 1 |
| Ye, L | 1 |
| Astle, CM | 1 |
| Baur, JA | 1 |
| Sabatini, DM | 1 |
| Harrison, DE | 1 |
| Kennaway, DJ | 1 |
| Varcoe, TJ | 1 |
| Voultsios, A | 1 |
| Boden, MJ | 1 |
| Warren, BE | 1 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Clanachan, AS | 1 |
| Affolter, A | 1 |
| Hersberger, M | 1 |
| Zaugg, M | 1 |
| Lemieux, H | 1 |
| Van Sinderen, ML | 1 |
| Steinberg, GR | 1 |
| Jørgensen, SB | 1 |
| To, SQ | 1 |
| Knower, KC | 1 |
| Clyne, CD | 1 |
| Honeyman, J | 1 |
| Chow, JD | 1 |
| Herridge, KA | 1 |
| Jones, ME | 1 |
| Simpson, ER | 1 |
| Boon, WC | 1 |
| Cavalcanti, DM | 1 |
| Castro, LM | 1 |
| Rosa Neto, JC | 1 |
| Seelaender, M | 1 |
| Neves, RX | 1 |
| Oliveira, V | 1 |
| Forti, FL | 1 |
| Iwai, LK | 1 |
| Gozzo, FC | 1 |
| Todiras, M | 1 |
| Schadock, I | 1 |
| Barros, CC | 1 |
| Bader, M | 1 |
| Ferro, ES | 1 |
| Wong, S | 1 |
| Kirkland, JL | 1 |
| Schwanz, HA | 1 |
| Simmons, AL | 1 |
| Hamilton, JA | 1 |
| Corkey, BE | 2 |
| Guo, W | 1 |
| Motta, K | 1 |
| Barbosa, AM | 1 |
| Bobinski, F | 1 |
| Boschero, AC | 1 |
| Rafacho, A | 1 |
| Al-Gayyar, MM | 1 |
| Alyoussef, A | 1 |
| Hamdan, AM | 1 |
| Abbas, A | 1 |
| Darweish, MM | 1 |
| El-Hawwary, AA | 1 |
| Aroor, AR | 1 |
| Habibi, J | 1 |
| Ford, DA | 1 |
| Nistala, R | 1 |
| Lastra, G | 1 |
| Manrique, C | 1 |
| Dunham, MM | 1 |
| Ford, KD | 1 |
| Thyfault, JP | 1 |
| Parks, EJ | 1 |
| Sowers, JR | 1 |
| Rector, RS | 1 |
| Hagve, M | 1 |
| Gjessing, PF | 1 |
| Fuskevåg, OM | 1 |
| Larsen, TS | 1 |
| Irtun, Ø | 1 |
| Zhou, J | 1 |
| Xu, G | 1 |
| Bai, Z | 1 |
| Li, K | 1 |
| Yan, J | 1 |
| Li, F | 1 |
| Ma, S | 1 |
| Xu, H | 1 |
| Huang, K | 1 |
| Lee, EY | 1 |
| Sakurai, K | 1 |
| Zhang, X | 1 |
| Toda, C | 1 |
| Tanaka, T | 1 |
| Jiang, M | 1 |
| Shirasawa, T | 1 |
| Tachibana, K | 1 |
| Yokote, K | 1 |
| Vidal-Puig, A | 1 |
| Minokoshi, Y | 1 |
| Miki, T | 1 |
| Go, Y | 1 |
| Jeong, JY | 1 |
| Jeoung, NH | 1 |
| Park, BY | 1 |
| Lee, SJ | 1 |
| Park, SY | 2 |
| Choi, CS | 2 |
| Park, TS | 1 |
| Lee, WN | 1 |
| Nagaraju, R | 1 |
| Rajini, PS | 1 |
| Cho, J | 1 |
| Zhang, Y | 2 |
| Joseph, AM | 1 |
| Han, C | 1 |
| Park, HJ | 1 |
| Chun, SK | 1 |
| Morgan, D | 1 |
| Kim, JS | 1 |
| Someya, S | 1 |
| Mathews, CE | 1 |
| Lee, YJ | 1 |
| Wohlgemuth, SE | 1 |
| Lee, HY | 1 |
| Shiratsuchi, T | 1 |
| Oh, SP | 1 |
| Terada, N | 1 |
| Visinoni, S | 1 |
| Fam, BC | 1 |
| Blair, A | 1 |
| Rantzau, C | 1 |
| Lamont, BJ | 1 |
| Bouwman, R | 1 |
| Watt, MJ | 1 |
| Proietto, J | 1 |
| Favaloro, JM | 1 |
| Andrikopoulos, S | 2 |
| Nomura, M | 1 |
| Ishii, H | 1 |
| Kawakami, A | 1 |
| Yoshida, M | 1 |
| Saberi, M | 1 |
| Bjelica, D | 1 |
| Schenk, S | 1 |
| Imamura, T | 1 |
| Bandyopadhyay, G | 1 |
| Li, P | 1 |
| Jadhar, V | 1 |
| Vargeese, C | 1 |
| Wang, W | 1 |
| Bowman, K | 1 |
| Polisky, B | 1 |
| Olefsky, JM | 1 |
| Clementi, AH | 1 |
| Gaudy, AM | 1 |
| Zimmers, TA | 1 |
| Koniaris, LG | 1 |
| Mooney, RA | 1 |
| Konstantopoulos, N | 1 |
| Molero, JC | 1 |
| McGee, SL | 1 |
| Spolding, B | 1 |
| Connor, T | 1 |
| de Vries, M | 1 |
| Wanyonyi, S | 1 |
| Fahey, R | 1 |
| Morrison, S | 1 |
| Swinton, C | 1 |
| Jones, S | 1 |
| Cooper, A | 1 |
| Garcia-Guerra, L | 1 |
| Foletta, VC | 1 |
| Krippner, G | 1 |
| Walder, KR | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| Shirihai, O | 1 |
| Liu, YQ | 1 |
| Jetton, TL | 1 |
| Leahy, JL | 1 |
| Yao, XH | 1 |
| Chen, L | 1 |
| Nyomba, BL | 1 |
| Hamrin, K | 1 |
| Henriksson, J | 1 |
| Crettaz, M | 1 |
| Horton, ES | 1 |
| Wardzala, LJ | 1 |
| Horton, ED | 1 |
| Jeanrenaud, B | 1 |
| Lahtela, JT | 1 |
| Särkkä, P | 1 |
| Sotaniemi, EA | 1 |
| Ivy, JL | 2 |
| Cortez, MY | 1 |
| Chandler, RM | 1 |
| Byrne, HK | 1 |
| Miller, RH | 1 |
| Coppack, SW | 1 |
| Fisher, RM | 1 |
| Humphreys, SM | 1 |
| Clark, ML | 1 |
| Pointon, JJ | 1 |
| Frayn, KN | 1 |
| Heise, T | 1 |
| Heinemann, L | 1 |
| Starke, AA | 1 |
| Karl, IE | 1 |
| Gavin, JR | 1 |
| Levy, J | 1 |
| Rösen, P | 1 |
| Herberg, L | 1 |
| Reinauer, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyruvic acid and Insulin Resistance
| Article | Year |
|---|---|
Effect of pyruvate and dihydroxyacetone on metabolism and aerobic endurance capacity.
Topics: Animals; Cholesterol; Dihydroxyacetone; Exercise; Glycogen; Humans; Insulin Resistance; Muscle, Skel | 1998 |
1 trial available for pyruvic acid and Insulin Resistance
| Article | Year |
|---|---|
A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Cross-Over Studies; Diabetes Mellitus, Type 2; Glucos | 2021 |
43 other studies available for pyruvic acid and Insulin Resistance
| Article | Year |
|---|---|
Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females.
Topics: Androgens; Animals; Dihydrotestosterone; Female; Gluconeogenesis; Glucose; Hepatocytes; Homeostasis; | 2021 |
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs.
Topics: Carbon Dioxide; Glucose; Glycolysis; Humans; Insulin; Insulin Resistance; Lactic Acid; Mesenchymal S | 2023 |
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Topics: Adaptor Proteins, Signal Transducing; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; En | 2019 |
Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle.
Topics: Acetyl Coenzyme A; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Glucose; Insulin Resistance; Mag | 2021 |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Topics: Acetylglucosamine; Animals; Base Sequence; Caloric Restriction; Cell Line; Colforsin; Diabetes Melli | 2021 |
Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance.
Topics: Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Cyclic AMP; Cyclic AMP-Dependent Prot | 2017 |
Pyruvate induces torpor in obese mice.
Topics: Adenosine; Adipose Tissue, Brown; Animals; Brain; Insulin Resistance; Male; Mice, Inbred C57BL; Mice | 2018 |
Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.
Topics: Adipose Tissue; Amino Acids, Branched-Chain; Animals; Citric Acid Cycle; Diet; Female; Fructose; Hum | 2018 |
Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Topics: Acetyl Coenzyme A; Animals; Cytosol; Diet, High-Fat; Insulin Resistance; Macrophage Activation; Macr | 2019 |
Non-monotonic dose-response effects of arsenic on glucose metabolism.
Topics: Amino Acids; Animals; Arsenic; Dose-Response Relationship, Drug; Fatty Acids; Glucose; Glucose Clamp | 2019 |
Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice.
Topics: Animals; Blotting, Western; Corticosterone; Glucose; Glucose Tolerance Test; Homeostasis; Hypothalam | 2013 |
Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.
Topics: Age Factors; Animals; Blood Glucose; Diet; Female; Genetic Heterogeneity; Genotype; Glucose; Glucose | 2013 |
Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism.
Topics: Adipokines; Adipose Tissue; Animals; ARNTL Transcription Factors; Body Weight; Diet, High-Fat; Fatty | 2013 |
Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat.
Topics: Aconitate Hydratase; Animals; Carnitine; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease P | 2014 |
Hepatic glucose intolerance precedes hepatic steatosis in the male aromatase knockout (ArKO) mouse.
Topics: Adiponectin; Adipose Tissue; Animals; Aromatase; Blood Glucose; Body Weight; Estrogens; Gluconeogene | 2014 |
Neurolysin knockout mice generation and initial phenotype characterization.
Topics: Adipose Tissue; Animals; Blood Glucose; Blood Pressure; Genotype; Gluconeogenesis; Glucose Intoleran | 2014 |
Effects of thiol antioxidant β-mercaptoethanol on diet-induced obese mice.
Topics: Adipokines; Adipose Tissue; Animals; Antioxidants; Body Composition; C-Reactive Protein; Diet, High- | 2014 |
JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats.
Topics: Adipose Tissue; Animals; Body Weight; Cytokines; Dexamethasone; Epididymis; Glucocorticoids; Glycoge | 2015 |
Cod liver oil ameliorates sodium nitrite-induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway.
Topics: Animals; Body Weight; Cod Liver Oil; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fructose-Bisp | 2015 |
Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function.
Topics: Animals; Blotting, Western; Body Composition; Ceramides; Diet, Western; Dipeptidyl-Peptidase IV Inhi | 2015 |
Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS emission during surgery-induced acute insulin resistance.
Topics: Animals; Biomarkers; Crosses, Genetic; Glucose Clamp Technique; Insulin Resistance; Liver; Mitochond | 2015 |
Selenite exacerbates hepatic insulin resistance in mouse model of type 2 diabetes through oxidative stress-mediated JNK pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fasting; Gene E | 2015 |
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Bile Acids and Salts; Blood Gluco | 2015 |
Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
Topics: Animals; Citric Acid Cycle; Diet, High-Fat; Fatty Liver; Glucose; Insulin Resistance; Lipogenesis; L | 2016 |
Adaptive response of rat pancreatic β-cells to insulin resistance induced by monocrotophos: Biochemical evidence.
Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Glucose; In | 2016 |
Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance.
Topics: Adenine Nucleotide Translocator 2; Adenosine Triphosphate; Animals; Atractyloside; Diet, High-Fat; D | 2017 |
Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.
Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Eating; Fructose-Bisphosphatase; Gene Expression; | 2008 |
Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance.
Topics: Animals; Anticholesteremic Agents; Azetidines; Blotting, Western; Cells, Cultured; Cholesterol; DNA | 2009 |
Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.
Topics: Animals; Blood Glucose; Blotting, Western; Cells, Cultured; Chemistry, Pharmaceutical; Diabetes Mell | 2009 |
Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse.
Topics: Animals; Drug Resistance; Female; Gene Deletion; Insulin Resistance; Interleukin-6; Liver; Male; Mic | 2011 |
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.
Topics: Animals; Blood Glucose; Carbonic Anhydrase Inhibitors; Diabetes Mellitus, Experimental; Glucose Clam | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Metabolic master regulators: sharing information among multiple systems.
Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic A | 2012 |
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
Topics: Animals; Body Weight; Citric Acid; Dose-Response Relationship, Drug; Glucose; Glycerol; Insulin Resi | 2002 |
Adult rats prenatally exposed to ethanol have increased gluconeogenesis and impaired insulin response of hepatic gluconeogenic genes.
Topics: Age Factors; Animals; Blood Glucose; Central Nervous System Depressants; Diabetes Mellitus, Type 2; | 2006 |
Interstitial glucose concentration in insulin-resistant human skeletal muscle: influence of one bout of exercise and of local perfusion with insulin or vanadate.
Topics: Bicycling; Exercise; Extracellular Fluid; Glucose; Heart Rate; Humans; Hypoglycemic Agents; Infusion | 2008 |
Physical training of Zucker rats: lack of alleviation of muscle insulin resistance.
Topics: Animals; Blood Glucose; Glucose; Insulin; Insulin Resistance; Lactates; Lactic Acid; Muscles; Physic | 1983 |
Phenobarbital treatment enhances insulin mediated glucose metabolism in man.
Topics: Adult; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Lactates; Lactic Acid; Male; Meta | 1984 |
Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cholesterol; Energy Metabolism; Female; G | 1994 |
Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal.
Topics: Adipose Tissue; Adult; Female; Forearm; Glucose; Humans; Insulin; Insulin Resistance; Lactates; Lact | 1996 |
Simulated postaggression metabolism in healthy subjects: metabolic changes and insulin resistance.
Topics: Adult; Carbohydrate Metabolism; Fatty Acids, Nonesterified; Humans; Insulin Resistance; Lactic Acid; | 1998 |
Effect of insulin on glucose utilization in epitrochlearis muscle of rats with streptozocin-induced NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 1990 |
Different types of postinsulin receptor defects contribute to insulin resistance in hearts of obese Zucker rats.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Epoxy Compounds; Glucose; Insulin Resistance; Lacta | 1986 |