Compounds > 2-3-5-4--tetrahydroxystilbene-2-o-glucopyranoside

2-3-5-4--tetrahydroxystilbene-2-o-glucopyranoside and Insulin-Resistance

2-3-5-4--tetrahydroxystilbene-2-o-glucopyranoside has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for 2-3-5-4--tetrahydroxystilbene-2-o-glucopyranoside and Insulin-Resistance

Article	Year
Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance. International journal of biological macromolecules, 2020, Dec-01, Volume: 164 Total polysaccharide from Polygonum multiflorum (PS) and 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could relieve high-fat and high-sugar diet (HF-HSD) induced rats' insulin resistance (IR) by gut microbiota and host regulation. We found that PS and TSG significantly reversed the increase of fasting blood glucose and the decrease of glucose tolerance in HF-HSD induced IR rats. PS and TSG effectively reversed the imbalance of Firmicutes/Bacteroides caused by an HF-HSD, and significantly reduced the relative abundance of Proteobacteria. It also affected the functional genes of gut microbiota and regulated short-chain fatty acids (SCFAs) and its downstream signal protein molecules. Together, these results indicated that PS and TSG alleviated HF-HSD induced IR by promoting gut microbiota and host function. Thus, PS and TSG may be promising lead substances for developing IR inhibitors that could regulate gut microbiota and its molecular messenger SCFAs to remedy IR. Topics: AMP-Activated Protein Kinases; Animals; Fallopia multiflora; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Glucosides; Insulin; Insulin Resistance; Liver; Male; Metagenomics; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Ribosomal, 16S; Signal Transduction; Stilbenes	2020

Article

Year

Pharmacological and metagenomics evidence of polysaccharide from Polygonum multiflorum in the alleviation of insulin resistance.

International journal of biological macromolecules, 2020, Dec-01, Volume: 164

Total polysaccharide from Polygonum multiflorum (PS) and 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (TSG) could relieve high-fat and high-sugar diet (HF-HSD) induced rats' insulin resistance (IR) by gut microbiota and host regulation. We found that PS and TSG significantly reversed the increase of fasting blood glucose and the decrease of glucose tolerance in HF-HSD induced IR rats. PS and TSG effectively reversed the imbalance of Firmicutes/Bacteroides caused by an HF-HSD, and significantly reduced the relative abundance of Proteobacteria. It also affected the functional genes of gut microbiota and regulated short-chain fatty acids (SCFAs) and its downstream signal protein molecules. Together, these results indicated that PS and TSG alleviated HF-HSD induced IR by promoting gut microbiota and host function. Thus, PS and TSG may be promising lead substances for developing IR inhibitors that could regulate gut microbiota and its molecular messenger SCFAs to remedy IR.

Topics: AMP-Activated Protein Kinases; Animals; Fallopia multiflora; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Glucosides; Insulin; Insulin Resistance; Liver; Male; Metagenomics; Polysaccharides; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Ribosomal, 16S; Signal Transduction; Stilbenes

2020