Page last updated: 2024-11-04

sulforaphane and Insulin Resistance

sulforaphane has been researched along with Insulin Resistance in 8 studies

sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats."7.91Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats. ( Gameil, NM; Shawky, NM; Shehatou, GSG; Suddek, GM, 2019)
"Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance."7.91Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. ( Du, M; Lei, X; Li, Y; Ren, F; Teng, W; Xie, S, 2019)
" Nevertheless, the vasoprotective role of SFN has not been examined in the setting of obesity characterized by hyperleptinemia and insulin resistance."7.83Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice. ( Gameil, NM; Jun, JY; Pichavaram, P; Segar, L; Shawky, NM; Shehatou, GS; Suddek, GM, 2016)
"Sulforaphane (SFN) is a natural antioxidant extracted from the cruciferous vegetables."5.72Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. ( Gao, Y; Liu, J; Ma, X; Thring, RW; Tong, H; Wu, M; Wu, Q; Zhang, Y; Zhang, Z; Zhu, J, 2022)
"Nonalcoholic fatty liver disease (NAFLD) is characterized by lipotoxicity and ectopic lipid deposition within hepatocytes."5.62Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. ( Li, J; Teng, W; Xie, S, 2021)
"The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats."3.91Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats. ( Gameil, NM; Shawky, NM; Shehatou, GSG; Suddek, GM, 2019)
"Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance."3.91Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. ( Du, M; Lei, X; Li, Y; Ren, F; Teng, W; Xie, S, 2019)
" Nevertheless, the vasoprotective role of SFN has not been examined in the setting of obesity characterized by hyperleptinemia and insulin resistance."3.83Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice. ( Gameil, NM; Jun, JY; Pichavaram, P; Segar, L; Shawky, NM; Shehatou, GS; Suddek, GM, 2016)
"Sulforaphane (SFN) is a natural antioxidant extracted from the cruciferous vegetables."1.72Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. ( Gao, Y; Liu, J; Ma, X; Thring, RW; Tong, H; Wu, M; Wu, Q; Zhang, Y; Zhang, Z; Zhu, J, 2022)
"Nonalcoholic fatty liver disease (NAFLD) is characterized by lipotoxicity and ectopic lipid deposition within hepatocytes."1.62Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis. ( Li, J; Teng, W; Xie, S, 2021)
"Obesity and insulin resistance are the key factors underlying the etiology of major health problems such as hypertension, diabetes and stroke."1.39Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet. ( Brum, LM; de Assis, AM; Hansen, F; Moreira, JD; Perry, ML; Riboldi, BP; Souza, CG; Souza, DG; Souza, DO, 2013)
"Sulforaphane (SFN) is a compound which is found in cruciferous vegetables and that acts as both a potent antioxidant and regulator of gene expression."1.38Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats. ( de Assis, AM; de Souza, CG; Perry, ML; Rech, A; Sattler, JA; Souza, DO, 2012)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (75.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Li, J1
Xie, S2
Teng, W2
Zhang, Y2
Wu, Q1
Liu, J1
Zhang, Z1
Ma, X1
Zhu, J1
Thring, RW1
Wu, M1
Gao, Y1
Tong, H1
Shawky, NM2
Shehatou, GSG1
Suddek, GM2
Gameil, NM2
Li, Y1
Du, M1
Lei, X1
Ren, F1
Souza, CG1
Riboldi, BP1
Hansen, F1
Moreira, JD1
Souza, DG1
de Assis, AM2
Brum, LM1
Perry, ML2
Souza, DO2
Pichavaram, P1
Shehatou, GS1
Jun, JY1
Segar, L1
Bahadoran, Z1
Tohidi, M1
Nazeri, P1
Mehran, M1
Azizi, F1
Mirmiran, P1
de Souza, CG1
Sattler, JA1
Rech, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Consumption of a Lyophilized Nasturtium (Tropaeolum Majus L), on the Insulin Response, Lipid Profile, Antioxidant Capacity and Gene Expression in Pre-diabetic Subjects: Bogotá-Colombia[NCT05346978]10 participants (Actual)Interventional2018-06-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for sulforaphane and Insulin Resistance

ArticleYear
Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
    International journal of food sciences and nutrition, 2012, Volume: 63, Issue:7

    Topics: Adult; Antioxidants; Blood Glucose; Brassica; Diabetes Mellitus, Type 2; Dietary Supplements; Double

2012

Other Studies

7 other studies available for sulforaphane and Insulin Resistance

ArticleYear
Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis.
    Nutrients, 2021, Dec-24, Volume: 14, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Ceramides; Diet, High-Fat; Hep G2 Cells; Humans;

2021
Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet, High-Fat; Ins

2022
Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats.
    Environmental toxicology and pharmacology, 2019, Volume: 66

    Topics: Animals; Aorta, Thoracic; Blood Glucose; Body Weight; C-Reactive Protein; Dyslipidemias; Fatty Liver

2019
Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.
    Nutrients, 2019, May-27, Volume: 11, Issue:5

    Topics: Animals; Ceramides; Enzyme Inhibitors; Glucose; Glycogen; Hep G2 Cells; Hepatocytes; Humans; Insulin

2019
Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet.
    Food & function, 2013, Volume: 4, Issue:8

    Topics: Animals; Blood Glucose; Cerebral Cortex; Glucose Transporter Type 3; Humans; Hypothalamus; Insulin R

2013
Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice.
    The Journal of nutritional biochemistry, 2016, Volume: 32

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Anticarcinogenic Agents; Anti

2016
Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats.
    Journal of medicinal food, 2012, Volume: 15, Issue:9

    Topics: Animals; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dietary Supplements; Gluco

2012