thioctic acid has been researched along with Insulin Resistance in 84 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 9.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
| "The aim of this retrospective study was to evaluate the effects of a long-term treatment with α-lipoic acid (ALA) combined with myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS)." | 7.96 | Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome. ( Fidecicchi, T; Fruzzetti, F; Gambacciani, M; Palla, G, 2020) |
| "To evaluate the effects of the combination of d-chiro inositol and alpha lipoic acid on menstrual cycles and insulin sensitivity in women with polycystic ovary syndrome (PCOS)." | 7.91 | Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndrome. ( Canu, A; Capozzi, A; Fruzzetti, F; Lello, S, 2019) |
| "The aim of our study was to investigate the effects of a combined treatment with alpha-lipoic acid (ALA) and myoinositol (MYO) on clinical, endocrine and metabolic features of women affected by polycystic ovary syndrome (PCOS)." | 7.85 | Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. ( Apa, R; De Cicco, S; Della Casa, S; Di Florio, C; Immediata, V; Lanzone, A; Policola, C; Romualdi, D; Scarinci, E; Tagliaferri, V; Tropea, A, 2017) |
| " The first experiment was conducted to determine the effects of lipoic acid (ALA; 200 mg/kg) on plasma lipids and insulin sensitivity of whole-body tissue in broilers treated with or without corticosterone (5 mg/kg)." | 7.73 | Effects of dietary lipoic acid on plasma lipid, in vivo insulin sensitivity, metabolic response to corticosterone and in vitro lipolysis in broiler chickens. ( Hamano, Y, 2006) |
| "Polycystic ovary syndrome is characterized by several endocrine impairments, insulin resistance and hyperinsulinemia." | 5.51 | Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. ( Genazzani, AD; Marchini, F; Napolitano, A; Petrillo, T; Prati, A; Simoncini, T, 2019) |
| "Patients treated with ALA at T1 and T2 showed a significant reduction in serum glucose, insulin, homeostatic model assessment-insulin resistance, and serum uric acid (P = 0." | 5.34 | α-lipoic acid in patients with autosomal dominant polycystic kidney disease. ( Amabile, MI; Ansuini, M; Carta, M; Cianci, R; D'Ambrosio, V; Galani, A; Lai, S; Letizia, C; Mazzaferro, S; Mitterhofer, AP; Molfino, A; Muscaritoli, M; Pasquali, M; Petramala, L; Ramaccini, C, 2020) |
| " The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM)." | 5.30 | Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid. ( Aslfalah, H; Jamilian, M; Khosrowbeygi, A, 2019) |
| "This new myo-inositol, monacolin K and lipoic acid association contains appropriate substances to contrast various etiopathogenic elements responsible for the onset of PCOS and the symptoms of hyperandrogenism and dyslipidemia related to it." | 5.20 | Polycystic ovary syndrome (PCOS) and hyperandrogenism: the role of a new natural association. ( Cappelli, V; De Leo, V; Di Sabatino, A; Massaro, MG; Morgante, G, 2015) |
| "Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 5.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
| "The aim of this retrospective study was to evaluate the effects of a long-term treatment with α-lipoic acid (ALA) combined with myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS)." | 3.96 | Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome. ( Fidecicchi, T; Fruzzetti, F; Gambacciani, M; Palla, G, 2020) |
| "To evaluate the effects of the combination of d-chiro inositol and alpha lipoic acid on menstrual cycles and insulin sensitivity in women with polycystic ovary syndrome (PCOS)." | 3.91 | Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndrome. ( Canu, A; Capozzi, A; Fruzzetti, F; Lello, S, 2019) |
| "The aim of our study was to investigate the effects of a combined treatment with alpha-lipoic acid (ALA) and myoinositol (MYO) on clinical, endocrine and metabolic features of women affected by polycystic ovary syndrome (PCOS)." | 3.85 | Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. ( Apa, R; De Cicco, S; Della Casa, S; Di Florio, C; Immediata, V; Lanzone, A; Policola, C; Romualdi, D; Scarinci, E; Tagliaferri, V; Tropea, A, 2017) |
| " In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose." | 3.79 | A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013) |
| "We studied the correlation between the effect of α-lipoic acid, emoxipin, reamberin, and mexidol on LPO in vitro and the action of these drugs on insulin sensitivity and tolerance to glucose load in vivo." | 3.77 | Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance. ( Astakhova, TV; Mester, KM; Miroshnichenko, IY; Novoselov, PN; Rassokhina, LM; Volchegorskii, IA, 2011) |
| "The advanced glycation end product inhibitor pyridoxamine (PYR) and the antioxidant alpha-lipoic acid (LA) interact to ameliorate insulin resistance in obese Zucker rats following short-term (6-week) treatment." | 3.75 | Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats. ( Diehl, CJ; Hasselwander, O; Henriksen, EJ; Lindborg, KA; Matuschek, M; Muellenbach, EM; Teachey, MK, 2009) |
| " Indeed, bimoclomol--a heat shock protein co-inducer being developed for treatment of diabetic neuropathy--and lipoic acid--suspected to be a heat shock protein inducer--have each demonstrated favorable effects on the insulin sensitivity of obese rodents, and parenteral lipoic acid is reported to improve the insulin sensitivity of type 2 diabetics." | 3.73 | Induction of heat shock proteins may combat insulin resistance. ( McCarty, MF, 2006) |
| " The first experiment was conducted to determine the effects of lipoic acid (ALA; 200 mg/kg) on plasma lipids and insulin sensitivity of whole-body tissue in broilers treated with or without corticosterone (5 mg/kg)." | 3.73 | Effects of dietary lipoic acid on plasma lipid, in vivo insulin sensitivity, metabolic response to corticosterone and in vitro lipolysis in broiler chickens. ( Hamano, Y, 2006) |
| "Critical illness is associated with oxidative stress and insulin resistance." | 2.87 | The Beneficial Effects of α-Lipoic Acid in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. ( Hejazi, N; Mazloom, Z; Nikandish, R; Rezaianzadeh, A; Zand, F, 2018) |
| "On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation." | 2.82 | Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review. ( Ghasemzadeh Rahbardar, M; Hosseinzadeh, H; Mehri, S; Najafi, N, 2022) |
| "The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease." | 2.78 | The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. ( Berry, EA; De Jong, SA; Manning, PJ; Ryalls, AR; Sutherland, WH; Walker, RJ; Williams, SM, 2013) |
| "placebo treatment on insulin sensitivity was compared." | 2.69 | Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. ( Augustin, HJ; Dietze, GJ; Hermann, R; Jacob, S; Maerker, E; Renn, W; Rett, K; Ruus, P; Tritschler, HJ, 1999) |
| "Insulin resistance is becoming an increasingly studied target for therapy, most evidence stemming from the time-honored metformin use." | 2.66 | Current treatment for polycystic ovary syndrome: focus on adolescence. ( Catellani, C; Cirillo, F; Dauriz, M; Lazzeroni, P; Moghetti, P; Sartori, C; Street, ME, 2020) |
| "Type 2 diabetes is a common metabolic disorder characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal." | 2.52 | Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle. ( Dirks-Naylor, AJ; Kouzi, SA; Nuzum, DS; Yang, S, 2015) |
| "Correlation between type 2 diabetes and other abnormalities such as obesity with redox balance disturbance was analyzed in many reports." | 1.72 | The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance. ( Chabowski, A; Dajnowicz-Brzezik, P; Maciejczyk, M; Zalewska, A; Żebrowska, E, 2022) |
| "Polycystic ovary syndrome is characterized by several endocrine impairments, insulin resistance and hyperinsulinemia." | 1.51 | Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. ( Genazzani, AD; Marchini, F; Napolitano, A; Petrillo, T; Prati, A; Simoncini, T, 2019) |
| "ALA integrative administration at a low dosage as 400 mg daily improved the metabolic impairment of all PCOS patients especially in those PCOS with familiar diabetes who have a higher grade of risk of NAFLD and predisposition to diabetes." | 1.48 | Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients. ( Della Casa, D; Despini, G; Genazzani, AD; Manzo, A; Napolitano, A; Prati, A; Shefer, K; Simoncini, T, 2018) |
| "Fatty liver is common in obese subjects with insulin resistance." | 1.35 | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. ( Choi, HS; Hwang, JS; Jang, BK; Kim, HS; Kim, JB; Kim, MO; Kim, YD; Koh, EH; Lee, IK; Lee, KU; Min, AK; Park, HS; Park, JY; Park, KG; Yoon, TS, 2008) |
| " Chronic administration of the hydrophobic/hydrophilic antioxidant alpha -lipoic-acid (ALA, 100 mg/kg, i." | 1.32 | Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. ( Al-Mulla, F; Al-Saleh, E; Bitar, MS; Pilcher, CW; Wahid, S, 2004) |
| "The development of insulin resistance has been shown to be an early step in the development of cardiovascular diseases in diabetic patients." | 1.32 | Cardiac lipids and antioxidant status in high fructose rats and the effect of alpha-lipoic acid. ( Anitha Nandhini, AT; Anuradha, CV; Thirunavukkarasu, V, 2004) |
| "Insulin resistance has been associated with people diagnosed with depression." | 1.31 | Alpha lipoic acid: a novel treatment for depression. ( Salazar, MR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (5.95) | 18.2507 |
| 2000's | 31 (36.90) | 29.6817 |
| 2010's | 35 (41.67) | 24.3611 |
| 2020's | 13 (15.48) | 2.80 |
| Authors | Studies |
|---|---|
| Najafi, N | 1 |
| Mehri, S | 1 |
| Ghasemzadeh Rahbardar, M | 1 |
| Hosseinzadeh, H | 1 |
| Laganà, AS | 1 |
| Monti, N | 1 |
| Fedeli, V | 1 |
| Gullo, G | 1 |
| Bizzarri, M | 1 |
| Dajnowicz-Brzezik, P | 1 |
| Żebrowska, E | 1 |
| Maciejczyk, M | 1 |
| Zalewska, A | 1 |
| Chabowski, A | 1 |
| Capece, U | 1 |
| Moffa, S | 1 |
| Improta, I | 1 |
| Di Giuseppe, G | 1 |
| Nista, EC | 1 |
| Cefalo, CMA | 1 |
| Cinti, F | 1 |
| Pontecorvi, A | 1 |
| Gasbarrini, A | 1 |
| Giaccari, A | 1 |
| Mezza, T | 1 |
| Guarano, A | 1 |
| Capozzi, A | 2 |
| Cristodoro, M | 1 |
| Di Simone, N | 1 |
| Lello, S | 2 |
| Aslanipour, B | 1 |
| Alan, M | 1 |
| Demir, I | 1 |
| Comhaire, F | 1 |
| Deslypere, JP | 1 |
| Lai, S | 1 |
| Petramala, L | 1 |
| Muscaritoli, M | 1 |
| Cianci, R | 1 |
| Mazzaferro, S | 1 |
| Mitterhofer, AP | 1 |
| Pasquali, M | 1 |
| D'Ambrosio, V | 1 |
| Carta, M | 1 |
| Ansuini, M | 1 |
| Ramaccini, C | 1 |
| Galani, A | 1 |
| Amabile, MI | 1 |
| Molfino, A | 1 |
| Letizia, C | 1 |
| Street, ME | 1 |
| Cirillo, F | 1 |
| Catellani, C | 1 |
| Dauriz, M | 1 |
| Lazzeroni, P | 1 |
| Sartori, C | 1 |
| Moghetti, P | 1 |
| Mahmoudi-Nezhad, M | 1 |
| Vajdi, M | 1 |
| Farhangi, MA | 1 |
| Zeng, M | 1 |
| Xu, J | 1 |
| Zhang, Z | 2 |
| Zou, X | 1 |
| Wang, X | 1 |
| Cao, K | 1 |
| Lv, W | 1 |
| Cui, Y | 1 |
| Long, J | 1 |
| Feng, Z | 1 |
| Liu, J | 2 |
| Behl, T | 1 |
| Gupta, A | 1 |
| Sehgal, A | 1 |
| Sharma, S | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Diaconu, CC | 1 |
| Rahdar, A | 1 |
| Hafeez, A | 1 |
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Bungau, S | 1 |
| De Cicco, S | 1 |
| Immediata, V | 1 |
| Romualdi, D | 1 |
| Policola, C | 1 |
| Tropea, A | 1 |
| Di Florio, C | 1 |
| Tagliaferri, V | 1 |
| Scarinci, E | 1 |
| Della Casa, S | 1 |
| Lanzone, A | 1 |
| Apa, R | 1 |
| Liu, Z | 1 |
| Patil, I | 1 |
| Sancheti, H | 1 |
| Yin, F | 1 |
| Cadenas, E | 1 |
| Cavestro, C | 1 |
| Bedogni, G | 1 |
| Molinari, F | 1 |
| Mandrino, S | 1 |
| Rota, E | 1 |
| Frigeri, MC | 1 |
| Genazzani, AD | 2 |
| Shefer, K | 1 |
| Della Casa, D | 1 |
| Prati, A | 2 |
| Napolitano, A | 2 |
| Manzo, A | 1 |
| Despini, G | 1 |
| Simoncini, T | 2 |
| Hejazi, N | 2 |
| Mazloom, Z | 2 |
| Zand, F | 1 |
| Rezaianzadeh, A | 1 |
| Nikandish, R | 1 |
| Aslfalah, H | 1 |
| Jamilian, M | 1 |
| Khosrowbeygi, A | 1 |
| Fruzzetti, F | 2 |
| Canu, A | 1 |
| Ahuja, S | 1 |
| Uniyal, A | 1 |
| Akhtar, A | 1 |
| Sah, SP | 1 |
| Marchini, F | 1 |
| Petrillo, T | 1 |
| Fidecicchi, T | 1 |
| Palla, G | 1 |
| Gambacciani, M | 1 |
| Rhoads, RP | 1 |
| Baumgard, LH | 1 |
| Suagee, JK | 1 |
| Sanders, SR | 1 |
| Ishiki, M | 1 |
| Nishida, Y | 1 |
| Ishibashi, H | 1 |
| Wada, T | 1 |
| Fujisaka, S | 1 |
| Takikawa, A | 1 |
| Urakaze, M | 1 |
| Sasaoka, T | 1 |
| Usui, I | 1 |
| Tobe, K | 1 |
| Capasso, I | 1 |
| Esposito, E | 1 |
| Maurea, N | 1 |
| Montella, M | 1 |
| Crispo, A | 1 |
| De Laurentiis, M | 1 |
| D'Aiuto, M | 1 |
| Frasci, G | 1 |
| Botti, G | 1 |
| Grimaldi, M | 1 |
| Cavalcanti, E | 1 |
| Esposito, G | 1 |
| Fucito, A | 1 |
| Brillante, G | 1 |
| D'Aiuto, G | 1 |
| Ciliberto, G | 1 |
| Cappelli, V | 2 |
| Di Sabatino, A | 2 |
| Musacchio, MC | 1 |
| De Leo, V | 2 |
| Kathirvel, E | 1 |
| Morgan, K | 1 |
| French, SW | 1 |
| Morgan, TR | 1 |
| Yang, Y | 2 |
| Li, W | 1 |
| Liu, Y | 3 |
| Li, Y | 3 |
| Gao, L | 1 |
| Zhao, JJ | 1 |
| Kouzi, SA | 1 |
| Yang, S | 1 |
| Nuzum, DS | 1 |
| Dirks-Naylor, AJ | 1 |
| Yan, H | 1 |
| Zhang, G | 1 |
| Sun, Y | 1 |
| Yu, P | 1 |
| Wang, Y | 1 |
| Xu, L | 1 |
| Castro, MC | 2 |
| Massa, ML | 2 |
| Arbeláez, LG | 1 |
| Schinella, G | 2 |
| Gagliardino, JJ | 2 |
| Francini, F | 2 |
| Morgante, G | 1 |
| Massaro, MG | 1 |
| Lei, L | 1 |
| Zhu, Y | 1 |
| Gao, W | 1 |
| Du, X | 1 |
| Zhang, M | 2 |
| Peng, Z | 1 |
| Fu, S | 1 |
| Li, X | 3 |
| Zhe, W | 1 |
| Liu, G | 1 |
| Derosa, G | 1 |
| D'Angelo, A | 1 |
| Romano, D | 1 |
| Maffioli, P | 1 |
| Ghibu, S | 1 |
| Richard, C | 1 |
| Delemasure, S | 1 |
| Vergely, C | 1 |
| Mogosan, C | 1 |
| Muresan, A | 1 |
| Muellenbach, EA | 1 |
| Diehl, CJ | 2 |
| Teachey, MK | 2 |
| Lindborg, KA | 2 |
| Archuleta, TL | 1 |
| Harrell, NB | 1 |
| Andersen, G | 1 |
| Somoza, V | 1 |
| Hasselwander, O | 2 |
| Matuschek, M | 2 |
| Henriksen, EJ | 9 |
| Hatzitolios, A | 1 |
| Iliadis, F | 1 |
| Katsiki, N | 1 |
| Baltatzi, M | 1 |
| Park, KG | 1 |
| Min, AK | 1 |
| Koh, EH | 2 |
| Kim, HS | 2 |
| Kim, MO | 1 |
| Park, HS | 2 |
| Kim, YD | 1 |
| Yoon, TS | 1 |
| Jang, BK | 1 |
| Hwang, JS | 1 |
| Kim, JB | 1 |
| Choi, HS | 1 |
| Park, JY | 2 |
| Lee, IK | 1 |
| Lee, KU | 2 |
| Muellenbach, EM | 1 |
| Poh, ZX | 1 |
| Goh, KP | 1 |
| Cummings, BP | 1 |
| Stanhope, KL | 1 |
| Graham, JL | 1 |
| Evans, JL | 2 |
| Baskin, DG | 1 |
| Griffen, SC | 1 |
| Havel, PJ | 1 |
| Volchegorskii, IA | 1 |
| Rassokhina, LM | 1 |
| Miroshnichenko, IY | 1 |
| Mester, KM | 1 |
| Novoselov, PN | 1 |
| Astakhova, TV | 1 |
| Zhang, Y | 1 |
| Han, P | 1 |
| Wu, N | 1 |
| He, B | 1 |
| Lu, Y | 1 |
| Li, S | 1 |
| Zhao, S | 1 |
| Liu, L | 1 |
| Ansar, H | 1 |
| Kazemi, F | 1 |
| Xiao, C | 1 |
| Giacca, A | 1 |
| Lewis, GF | 1 |
| Deiuliis, JA | 1 |
| Kampfrath, T | 1 |
| Ying, Z | 1 |
| Maiseyeu, A | 1 |
| Rajagopalan, S | 1 |
| El Midaoui, A | 4 |
| Lungu, C | 1 |
| Wang, H | 1 |
| Wu, L | 3 |
| Robillard, C | 1 |
| Deblois, D | 1 |
| Couture, R | 2 |
| Moreno, JA | 1 |
| Hong, E | 1 |
| Manning, PJ | 1 |
| Sutherland, WH | 1 |
| Williams, SM | 1 |
| Walker, RJ | 1 |
| Berry, EA | 1 |
| De Jong, SA | 1 |
| Ryalls, AR | 1 |
| Wang, YM | 2 |
| Lin, XF | 1 |
| Shi, CM | 1 |
| Lu, L | 1 |
| Qin, ZY | 2 |
| Zhu, GZ | 2 |
| Cao, XG | 2 |
| Ji, CB | 1 |
| Qiu, J | 2 |
| Guo, XR | 2 |
| Wang, W | 1 |
| Guo, T | 1 |
| Chen, P | 1 |
| Ma, K | 1 |
| Zhou, C | 1 |
| Prieto-Hontoria, PL | 1 |
| Pérez-Matute, P | 1 |
| Fernández-Galilea, M | 1 |
| Alfredo Martínez, J | 1 |
| Moreno-Aliaga, MJ | 1 |
| Ni, YH | 1 |
| Zhao, YP | 1 |
| Kou, CZ | 1 |
| Qin, R | 1 |
| Abiko, T | 1 |
| Abiko, A | 1 |
| Clermont, AC | 1 |
| Shoelson, B | 1 |
| Horio, N | 1 |
| Takahashi, J | 1 |
| Adamis, AP | 1 |
| King, GL | 1 |
| Bursell, SE | 1 |
| Midaoui, AE | 1 |
| Elimadi, A | 1 |
| Haddad, PS | 1 |
| de Champlain, J | 4 |
| Saengsirisuwan, V | 1 |
| Potashnik, R | 1 |
| Bloch-Damti, A | 1 |
| Bashan, N | 1 |
| Rudich, A | 1 |
| Thirunavukkarasu, V | 4 |
| Anitha Nandhini, AT | 3 |
| Anuradha, CV | 4 |
| Bitar, MS | 1 |
| Wahid, S | 1 |
| Pilcher, CW | 1 |
| Al-Saleh, E | 1 |
| Al-Mulla, F | 1 |
| Lee, WJ | 1 |
| Song, KH | 1 |
| Won, JC | 1 |
| Kim, MS | 1 |
| Kim, SW | 1 |
| Ongali, B | 1 |
| Petcu, M | 1 |
| Rodi, D | 1 |
| Neugebauer, W | 1 |
| McCarty, MF | 1 |
| Vasdev, S | 1 |
| Gill, V | 1 |
| Parai, S | 1 |
| Gadag, V | 1 |
| Wang, R | 1 |
| Hamano, Y | 1 |
| Chittiboyina, AG | 1 |
| Venkatraman, MS | 1 |
| Mizuno, CS | 1 |
| Desai, PV | 1 |
| Patny, A | 1 |
| Benson, SC | 1 |
| Ho, CI | 1 |
| Kurtz, TW | 1 |
| Pershadsingh, HA | 1 |
| Avery, MA | 1 |
| Shen, W | 1 |
| Liu, K | 1 |
| Tian, C | 1 |
| Yang, L | 1 |
| Ren, J | 1 |
| Packer, L | 1 |
| Cotman, CW | 1 |
| Kim, E | 1 |
| Park, DW | 1 |
| Choi, SH | 1 |
| Kim, JJ | 1 |
| Cho, HS | 1 |
| Jacob, S | 4 |
| Schiemann, AL | 1 |
| Simon, I | 1 |
| Clancy, DE | 1 |
| Tritschler, HJ | 6 |
| Jung, WI | 1 |
| Augustin, HJ | 2 |
| Dietze, GJ | 3 |
| Streeper, RS | 2 |
| Fogt, DL | 2 |
| Hokama, JY | 2 |
| Black, K | 1 |
| Qu, X | 1 |
| Seale, JP | 1 |
| Donnelly, R | 1 |
| Ruus, P | 1 |
| Hermann, R | 1 |
| Maerker, E | 1 |
| Renn, W | 1 |
| Rett, K | 1 |
| Peth, JA | 1 |
| Kinnick, TR | 1 |
| Youngblood, EB | 1 |
| Salazar, MR | 1 |
| Weinstein, RB | 1 |
| Maddux, BA | 1 |
| See, W | 1 |
| Lawrence, JC | 1 |
| Goldfine, AL | 1 |
| Goldfine, ID | 1 |
| Greene, EL | 1 |
| Nelson, BA | 1 |
| Robinson, KA | 1 |
| Buse, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for thioctic acid and Insulin Resistance
| Article | Year |
|---|---|
Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review.
Topics: AMP-Activated Protein Kinases; Cholesterol; Humans; Insulin Resistance; Lipoproteins, LDL; Metabolic | 2022 |
Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features.
Topics: Antioxidants; Autoimmune Diseases; Diabetic Neuropathies; Female; Glucose; Humans; Insulin Resistanc | 2022 |
Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?
Topics: Antioxidants; Diabetes Mellitus, Type 2; Female; Humans; Inositol; Insulin; Insulin Resistance; Metf | 2023 |
Current treatment for polycystic ovary syndrome: focus on adolescence.
Topics: Adolescent; Contraceptives, Oral, Hormonal; Female; Gene-Environment Interaction; Humans; Hypoglycem | 2020 |
An updated systematic review and dose-response meta-analysis of the effects of α-lipoic acid supplementation on glycemic markers in adults.
Topics: Adult; Biomarkers; Blood Glucose; Dietary Supplements; Glycated Hemoglobin; Humans; Insulin Resistan | 2021 |
A spotlight on underlying the mechanism of AMPK in diabetes complications.
Topics: AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Complications; Diabetes Mellitus, Type 2 | 2021 |
Nutritional interventions to alleviate the negative consequences of heat stress.
Topics: Animal Husbandry; Animals; Animals, Domestic; Antioxidants; Blood Glucose; Body Temperature Regulati | 2013 |
Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle.
Topics: Biotin; Cinnamomum zeylanicum; Diabetes Mellitus, Type 2; Dietary Supplements; Glucose; Humans; Insu | 2015 |
[An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases].
Topics: 8,11,14-Eicosatrienoic Acid; Animal Experimentation; Animals; Antioxidants; Cardiovascular Diseases; | 2008 |
Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review.
Topics: Aldehydes; Animals; Ascorbic Acid; Dietary Supplements; Evidence-Based Medicine; Glucose Intolerance | 2008 |
A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
Topics: Antioxidants; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Neuropath | 2009 |
Exercise training and antioxidants: relief from oxidative stress and insulin resistance.
Topics: Diabetes Mellitus; Exercise; Glucose; Homeostasis; Humans; Insulin Resistance; Models, Animal; Molec | 2003 |
Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Exercise Therapy; Humans; Insulin Resistance; Musc | 2006 |
16 trials available for thioctic acid and Insulin Resistance
| Article | Year |
|---|---|
News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments.
Topics: Adult; Animals; Antiviral Agents; Autoimmune Diseases; Comorbidity; Dichloroacetic Acid; Dietary Sup | 2020 |
α-lipoic acid in patients with autosomal dominant polycystic kidney disease.
Topics: Adult; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Blood Glucose; C-Reactive Protein; Caroti | 2020 |
Alpha-Lipoic Acid Shows Promise to Improve Migraine in Patients with Insulin Resistance: A 6-Month Exploratory Study.
Topics: Adult; Antioxidants; Biomarkers; Blood Glucose; Cohort Studies; Combined Modality Therapy; Female; F | 2018 |
The Beneficial Effects of α-Lipoic Acid in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Aged; Blood Glucose; Critical Illness; Double-Blind Method; Female; Humans; Insulin Resistanc | 2018 |
Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-lipoic acid.
Topics: Adiponectin; Adult; Antioxidants; Blood Glucose; Diabetes, Gestational; Dietary Supplements; Double- | 2019 |
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial.
Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Breast Neoplasms; Caloric Restriction; Cholesterol | 2013 |
[Evaluation of a new association between insulin-sensitizers and α-lipoic acid in obese women affected by PCOS].
Topics: Adult; Antioxidants; Blood Glucose; Body Mass Index; Drug Therapy, Combination; Electron Transport; | 2013 |
Polycystic ovary syndrome (PCOS) and hyperandrogenism: the role of a new natural association.
Topics: Adult; Antioxidants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyslipidemias; Fem | 2015 |
A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients.
Topics: Adult; Biomarkers; Blood Glucose; Body Mass Index; Body Weight; C-Reactive Protein; Carnosine; Diabe | 2016 |
Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Glucose Intolerance; Humans; | 2011 |
Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.
Topics: Adult; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glutathione Peroxidase; Human | 2011 |
Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men.
Topics: Administration, Oral; Adult; Fatty Acids, Nonesterified; Glucose; Homeostasis; Humans; Insulin Resis | 2011 |
The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Antioxidants; Blood Glucose; Dietary Supplements; Doubl | 2013 |
A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.
Topics: Adult; Antioxidants; Antipsychotic Agents; Appetite; Blood Glucose; Body Mass Index; Brief Psychiatr | 2008 |
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
Topics: Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; | 1995 |
Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial.
Topics: Administration, Oral; Anthropometry; Diabetes Mellitus, Type 2; Female; Free Radical Scavengers; Glu | 1999 |
55 other studies available for thioctic acid and Insulin Resistance
| Article | Year |
|---|---|
Does Alpha-lipoic acid improve effects on polycystic ovary syndrome?
Topics: Female; Humans; Inositol; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Thioctic Acid | 2022 |
The Effect of α-Lipoic Acid on Oxidative Stress in Adipose Tissue of Rats with Obesity-Induced Insulin Resistance.
Topics: Adipose Tissue; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Insul | 2022 |
Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome.
Topics: Adult; Antimicrobial Cationic Peptides; Blood Glucose; Blood Proteins; C-Reactive Protein; Case-Cont | 2020 |
Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Insulin; Insulin Resistance; Mice; Mitochondria; Thioctic Acid | 2021 |
Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action.
Topics: Adolescent; Adult; Androstenedione; Body Mass Index; Dehydroepiandrosterone Sulfate; Drug Therapy, C | 2017 |
Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and
Topics: Animals; Anti-Obesity Agents; Antioxidants; Astrocytes; Biological Transport; Brain; Brain Chemistry | 2017 |
Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients.
Topics: Adult; Antioxidants; Body Mass Index; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Insulin | 2018 |
Treatment with d-chiro-inositol and alpha lipoic acid in the management of polycystic ovary syndrome.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Drug Therapy, Combination; Estradiol; Female; Folli | 2019 |
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Disease Models, Animal; Insulin; Insulin Res | 2019 |
Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both.
Topics: Adult; Androstenedione; Drug Therapy, Combination; Estradiol; Female; Follicle Stimulating Hormone; | 2019 |
Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome.
Topics: Adult; Body Mass Index; Female; Hirsutism; Humans; Inositol; Insulin Resistance; Organ Size; Ovary; | 2020 |
Impact of divergent effects of astaxanthin on insulin signaling in L6 cells.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blotting, Western; Cell Line; Deoxyglucose; Glucose Transpo | 2013 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe | 2013 |
Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Diet, High-Fat; Down-Regulatio | 2014 |
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.
Topics: Andrographis; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpenes; Dose- | 2015 |
Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid.
Topics: Animals; Antioxidants; Blood Glucose; Cyclooxygenase 2; Dietary Supplements; Fructose; Gene Expressi | 2015 |
Alpha-lipoic acid attenuates endoplasmic reticulum stress-induced insulin resistance by improving mitochondrial function in HepG2 cells.
Topics: Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; Inositol 1,4,5-Trisphosphate Receptors; Insulin; | 2016 |
Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat.
Topics: Animals; Antioxidants; Blood Glucose; Drug Interactions; Fatty Acids, Nonesterified; Female; Glucose | 2008 |
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.
Topics: AMP-Activated Protein Kinases; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Fatty | 2008 |
Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats.
Topics: Animals; Antioxidants; Blood Glucose; Drug Synergism; Female; Glucose Tolerance Test; Glycation End | 2009 |
Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid.
Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Dyslipide | 2010 |
Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.
Topics: Animals; Antioxidants; Blood Glucose; Brain; In Vitro Techniques; Insulin Resistance; Lipid Peroxida | 2011 |
Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Blood Glucose; Blood Vessels; Body Weight; | 2011 |
Impact of α-lipoic acid on liver peroxisome proliferator-activated receptor-α, vascular remodeling, and oxidative stress in insulin-resistant rats.
Topics: Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Dietary Supplements; Fatty Acids, Nonest | 2011 |
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc | 2013 |
α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carrier Proteins; Glucose Transporter Type 4; Insulin Receptor Su | 2012 |
α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Line; Cell Prolif | 2012 |
Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats.
Topics: Adiponectin; Adipose Tissue, Brown; Adipose Tissue, White; Adiposity; AMP-Activated Protein Kinases; | 2013 |
α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.
Topics: 3T3-L1 Cells; Animals; Antioxidants; Apoptosis Regulatory Proteins; Gene Expression; Glucose; Glucos | 2012 |
Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Diet; Fructose; Gene Expression Regulation; Insuli | 2013 |
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabe | 2003 |
Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glycat | 2003 |
IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.
Topics: 3T3 Cells; Animals; Antioxidants; Biomarkers; Cycloheximide; Cysteine Endopeptidases; Glucose Oxidas | 2003 |
Lipoic acid restores antioxidant system in tissues of hyperinsulinaemic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Fructose; Insulin; Insulin Resistance; Kidney; Li | 2003 |
Influence of alpha-lipoic acid on lipid peroxidation and antioxidant defence system in blood of insulin-resistant rats.
Topics: Animals; Antioxidants; Blood Glucose; Diet; Erythrocytes; Fructose; Glucose Tolerance Test; Insulin; | 2004 |
Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats.
Topics: Animals; Antioxidants; Biological Transport; Diabetes Mellitus, Type 2; Glucose; Insulin; Insulin Re | 2004 |
Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats.
Topics: Animals; Biological Transport; Blood Glucose; Blood Pressure; Calcium-Transporting ATPases; Creatine | 2004 |
Cardiac lipids and antioxidant status in high fructose rats and the effect of alpha-lipoic acid.
Topics: Animals; Antioxidants; Blood Glucose; Fructose; Insulin; Insulin Resistance; Lipid Peroxidation; Mal | 2004 |
Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activation; Fatty Acids; G | 2005 |
Increases of spinal kinin receptor binding sites in two rat models of insulin resistance.
Topics: Animals; Binding Sites; Blood Glucose; Blood Pressure; Body Weight; Glucose; Insulin; Insulin Resist | 2005 |
Induction of heat shock proteins may combat insulin resistance.
Topics: Diabetes Mellitus, Type 2; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP72 | 2006 |
Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats.
Topics: Aldehydes; Animals; Antioxidants; Blood Glucose; Blood Platelets; Blood Pressure; Calcium; Dietary S | 2005 |
Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Cells, Cultured; Gene Expression Regulation; Glucose; | 2006 |
Effects of dietary lipoic acid on plasma lipid, in vivo insulin sensitivity, metabolic response to corticosterone and in vitro lipolysis in broiler chickens.
Topics: Adipose Tissue; Animals; Blood Glucose; Chickens; Corticosterone; Fatty Acids, Nonesterified; Female | 2006 |
Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.
Topics: Adipocytes; Adipogenesis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; C | 2006 |
R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylcarnitine; Adipocytes; Animals; Carnitine O-Palmitoyltransferase; DNA, Mitochond | 2008 |
The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle.
Topics: Animals; Antioxidants; Biological Transport; Body Weight; Female; Glucose; Glycogen; Insulin; Insuli | 1996 |
Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle.
Topics: Animals; Antioxidants; Biological Transport; Blood Glucose; Deoxyglucose; Fatty Acids, Nonesterified | 1997 |
Metabolic effects of thioctic acid in rodent models of insulin resistance and diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models, Animal; Fructose; Glucose; H | 1998 |
Effects of a unique conjugate of alpha-lipoic acid and gamma-linolenic acid on insulin action in obese Zucker rats.
Topics: Animals; Biological Transport; Blood Glucose; Drug Combinations; Fatty Acids, Nonesterified; Female; | 2000 |
Alpha lipoic acid: a novel treatment for depression.
Topics: Antidepressive Agents; Depression; Humans; Insulin; Insulin Resistance; Serotonin; Thioctic Acid | 2000 |
Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.
Topics: Animals; Biological Transport; Female; Free Radicals; Glucose; In Vitro Techniques; Insulin; Insulin | 2001 |
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.
Topics: Animals; Cell Death; Cell Line; Enzyme Activation; Glucose; Glucose Oxidase; Glucose Transporter Typ | 2001 |
alpha-Lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation.
Topics: 3T3 Cells; Acetylcysteine; Adipocytes; Animals; Antioxidants; Biological Transport; Culture Media, C | 2001 |
Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid.
Topics: Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Glucose; Glutathione Peroxidase; Hyperte | 2002 |