Page last updated: 2024-12-06
englitazone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
englitazone: structure given in first source; RN given refers to (+-)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 60303 |
| CHEMBL ID | 55977 |
| SCHEMBL ID | 37697 |
| MeSH ID | M0181307 |
Synonyms (5)
| Synonym |
|---|
| englitazone |
| CHEMBL55977 |
| SCHEMBL37697 |
| DTXSID80883191 |
| Q5378714 |
Research Excerpts
Actions
| Excerpt | Reference | Relevance |
|---|---|---|
| "Englitazone did not increase IR, IRS-1/IRS-2, pp60, or MAPK phosphorylation, nor did it enhance insulin's stimulation of these parameters." | ( Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis. Andrews, KM; Genereux, PE; Gibbs, EM; Kreutter, DK; Stevenson, RW, 1998) | 1.02 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (12)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID131961 | In vitro fold stimulation of glucose transporter protein in 3T3-L1 adipocytes at a concentration of 10 uM | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID169109 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 30 uM | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID123048 | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 10 mg/kg. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Novel thiazolidine-2,4-diones as potent euglycemic agents. |
| AID131971 | In vivo percent glucose normalization in mice at a concentration of 25 mg/kg | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID131962 | In vitro fold stimulation of glucose transporter protein in 3T3-L1 adipocytes at a concentration of 30 uM | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID123169 | In vivo euglycemic activity of the compound (administered by oral gavage) in C57/6J-ob/ob mice is measured by normalization of blood glucose levels at a dose of 25(mg/kg) | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Novel thiazolidine-2,4-diones as potent euglycemic agents. |
| AID131970 | Compound was evaluated for in vivo for % glucose normalization in mice at a concentration of 2.5 mg/kg. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID131972 | Compound was evaluated for in vivo for % glucose normalization in mice at a concentration of 5 mg/kg. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID169108 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 3 uM | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID131969 | Compound was evaluated for in vivo for % glucose normalization in mice at a concentration of 10 mg/kg. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| AID123170 | In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice measured by normalization of blood glucose levels at a dose of 5 mg/kg. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Novel thiazolidine-2,4-diones as potent euglycemic agents. |
| AID169107 | In vitro stimulation of 2-Deoxyglucose uptake in L6 myocytes from rat skeletal myoblasts at a concentration of 10 uM | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1 | Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (25)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (80.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.21
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.21) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (4.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 24 (96.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||