Page last updated: 2024-08-21

pyrazines and Insulin Resistance

pyrazines has been researched along with Insulin Resistance in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (13.89)	18.2507
2000's	20 (27.78)	29.6817
2010's	39 (54.17)	24.3611
2020's	3 (4.17)	2.80

Authors

Authors	Studies
Aday, AW; Beckman, JA; Goldfine, AB; Gregory, JM	1
Alexopoulos, SJ; Beretta, M; Brandon, AE; Byrne, FL; Carrive, P; Chen, SY; Cooney, GJ; Garcia, CJ; Hargett, SR; Hoehn, KL; Lackner, C; Lawrence, RT; Lee, B; Olzomer, EM; Philp, A; Philp, AM; Salamoun, JM; Santos, WL; Shah, DP; Sligar, J; Tucker, SP; Turner, N	1
Liu, Y; Sun, X; Wang, X; Wang, Y; Xiang, Y; Xiao, F	1
Charidemou, E; Griffin, JL; Gudiksen, A; Hjelholt, AJ; Jessen, N; Jørgensen, JOL; Møller, N; Pedersen, SB; Pilegaard, H	1
Jessen, N; Johannsen, M; Jørgensen, JO; Møller, AB; Møller, N; Rittig, N; Thomsen, HH	1
Gribble, FM; Hjelholt, AJ; Holst, JJ; Jessen, N; Jørgensen, JOL; Kuhre, RE; Larraufie, P; Møller, N; Reimann, F; Vestergaard, ET	1
Lei, SY; Liu, Y; Ma, LQ; Mao, T; Qiao, Y; Sun, XL; Zhang, JC; Zheng, QX	1
Carbone, A; Cicero, AF; D'Angelo, A; Derosa, G; Fogari, E; Franzetti, IG; Maffioli, P; Piccinni, MN; Querci, F	2
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H	2
Defronzo, RA; Dubé, JJ; Espinoza, S; Liang, H; Mohan, S; Musi, N; Shanmugasundaram, K; Sriwijitkamol, A; Tantiwong, P	1
Akaslan, SB; Arslan, M; Cakir, N; Degertekin, CK; Toruner, FB; Yilmaz, G	1
Bae, JH; Cho, YM; Jung, HS; Kim, SY; Kim, YG; Oh, TJ; Park, KS	1
Du, Q; Liang, YY; Wang, YJ; Wu, B; Yang, S; Zhao, YY	1
Diamant, M; Heymans, MW; Mari, A; Muskiet, MH; Ouwens, DM; Pouwels, PJ; van Genugten, RE; van Raalte, DH	1
Abdul-Ghani, M; Clarke, GD; Daniele, G; DeFronzo, RA; Eldor, R; Merovci, A; Taranova, A; Tripathy, D; Xiong, J	1
Coric, J; Dizdarevic-Bostandzic, A; Djelilovic-Vranic, J; Izetbegovic, S; Karamehic, J; Macic-Dzankovic, A; Panjeta, M; Velija-Asimi, Z	1
Fukuda, I; Hizuka, N; Ichihara, A; Ishikawa, Y; Muraoka, T	1
Baldi, S; Casolaro, A; Cobb, J; Ferrannini, E; Frascerra, S; Gall, W; Mari, A; Muscelli, E	1
Coen, PM; Goodpaster, BH	1
Floettmann, E; Jones, HB; Lees, D; Seeliger, F	1
Al-Khalili, L; Cuesta, PG; de Castro Barbosa, T; Katayama, M; Massart, J; Nyström, AC; Oscarsson, J; Osler, ME; Ostling, J; Zierath, JR	1
Auwerx, J; Bierwagen, A; Bilet, L; Havekes, B; Hesselink, MK; Hwang, JH; Livingstone, R; Moullan, N; Nowotny, P; Paglialunga, S; Phielix, E; Pirinen, E; Roden, M; Ropelle, ER; Schrauwen, P; Schrauwen-Hinderling, VB; Sparks, LM; Szendroedi, J; van de Weijer, T; Williams, EG	1
Dai, X; Foretz, M; Liu, J; Liu, Z; Lu, Q; Ouyang, C; Song, P; Viollet, B; Wu, J; Wu, Y; Xie, Z; Yuan, Z; Zhang, W; Zhao, Z; Zhuo, X; Zou, MH	1
Abdul-Ghani, M; Daniele, G; DeFronzo, RA; Mari, A; Merovci, A; Solis-Herrera, C; Tripathy, D; Xiong, J	1
Chassin, LJ; Dunger, DB; Hill, N; Hovorka, R; Humphreys, SM; Lunn, DJ; Marcovecchio, ML; Salgin, B	1
Brooks, JS; Brooks, SC; Kim, SG; Lee, MG; Lee, WH	1
Acerini, CL; Bluck, LJ; Dunger, DB; Humphreys, SM; Jackson, SJ; Marcovecchio, ML; Salgin, B; Williams, RM	1
Cognard, E; Shepherd, PR; Smith, GC; Vickers, MH	1
Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Franzetti, IG; Gadaleta, G; Maffioli, P; Piccinni, MN; Querci, F; Ragonesi, PD; Salvadeo, SA	1
Aguila, MB; Cardoso-de-Lemos, FS; de Carvalho, L; Gregório, BM; Mandarim-de-Lacerda, CA; Souza-Mello, V	1
Bailey, CJ; Flatt, PR; Green, BD	1
Fernandes, R; Ferreira, L; Garrido, P; Mega, C; Melo, A; Nunes, S; Parada, B; Pinto, F; Pinto, R; Reis, F; Santos, P; Sereno, J; Teixeira, F; Teixeira-de-Lemos, E; Vala, H; Velada, I	1
Bergman, BC; Cobelli, C; Hunerdosse, DM; Man, CD; Perreault, L	1
Campbell, RK; Cobble, ME; Reid, TS; Shomali, ME	3
Chiang, Y; Fantus, IG; Foltz, W; Jin, T; Ling, W; Shao, W; Yu, Z; Zhang, Z	1
Bianchi, L; Bonaventura, A; Carbone, A; Cicero, AF; Derosa, G; Fogari, E; Franzetti, I; Maffioli, P; Querci, F; Romano, D	1
Borra, R; Iozzo, P; Knuuti, J; Lehto, HR; Lepomaki, V; Nuutila, P; Pärkkä, J; Parkkola, R; Tuunanen, H	1
Denison, H; Eriksson, JW; Karlsson, C; Knutsson, M; Kujacic, M; Löfgren, L; Nilsson, C	1
Bianchi, L; Bonaventura, A; Cicero, AF; Derosa, G; Fogari, E; Maffioli, P; Ragonesi, PD; Romano, D	1
Fowler, MB; Keu, KV; Quon, A; Tavana, H; Witteles, RM	1
Carbone, A; Cicero, AF; D'Angelo, A; Derosa, G; Fogari, E; Maffioli, P; Querci, F	1
Ahrén, B; Alsalim, W; Carr, RD; Mari, A; Ohlsson, L; Pacini, G; Tura, A	1
Aliabadi, N; Breu, J; Grinspoon, S; Hadigan, C; Meininger, G; Rabe, J	1
Christiansen, JS; Jørgensen, JO; Møller, N; Nielsen, S; Nørrelund, H	1
Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ	1
Christiansen, JS; Hansen, TK; Jorgensen, JO; Moller, N; Nielsen, S; Vestergaard, ET	1
Braun, EJ; McMurtry, JP; Sweazea, KL	1
Andersen, R; Grinspoon, S; Hadigan, C; Liebau, J; Torriani, M	1
Bajaj, M; DeFronzo, RA; Mandarino, LJ; Medina-Navarro, R; Meyer, C; Suraamornkul, S	1
Winkler, G	1
Herman, GA; Stein, PP; Thornberry, NA; Wagner, JA	1
Bae, EJ; Kim, JW; Kim, SG; Yang, YM	1
Borra, R; Iozzo, P; Kankaanpaa, M; Knuuti, J; Lehto, HR; Någren, K; Naum, AG; Nuutila, P; Parkkola, R; Rigazio, S; Simi, C; Tuunanen, H	1
Kim, JY; Kim, YW; Lee, SK	1
Aguirre, C; Araya, V; Contreras, P; Zura, ML	1
Jéquier, E; Nicod, P; Paquot, N; Randin, D; Scherrer, U; Schneiter, P; Tappy, L; Vollenweider, L; Vollenweider, P	1
Ekstrand, A; Franssila-Kallunki, A; Groop, L; Saloranta, C; Taskinen, MR	1
Groop, L; Saloranta, C	1
Boden, G; Rocha, DM; Santomauro, AT; Santos, RF; Silva, ME; Strassmann, PG; Ursich, MJ; Wajchenberg, BL	1
Bolscher, E; Casanueva, FF; de Vries, WR; Dieguez, C; Koppeschaar, HP; Niesink, M; Smid, HE; Van Dam, PS; Waasdorp, EJ	1
Choong, B; Cooney, GJ; Cooper, GJ; Iglesias, MA; Kraegen, EW; Lim-Fraser, M; Watson, DG; Ye, JM	1
Ackermans, MT; Endert, E; Romijn, JA; Sauerwein, HP; Sprangers, F	1
Belosi, C; Cento, RM; Ciampelli, M; Lanzone, A; Leoni, F; Muzj, G; Romualdi, D	1
Bramnert, M; Groop, LC; Laurila, E; Manhem, P; Segerlantz, M	1
Beck-Nielsen, H; Vaag, AA	1
Alberti, KG; Farrer, M; Fulcher, GR; Johnson, AJ; Record, CO	1
Ahonen, J; Ekstrand, A; Grönhagen-Riska, C; Groop, LC; Saloranta, C	1
Brady, EJ; Chapin, EW; Saperstein, R; Slater, EE	1

Reviews

6 review(s) available for pyrazines and Insulin Resistance

Article	Year
Comparative effects of sitagliptin and metformin in patients with type 2 diabetes mellitus: a meta-analysis. Current medical research and opinion, 2013, Volume: 29, Issue:11 Topics: Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Secreting Cells; Metformin; Pyrazines; Sitagliptin Phosphate; Triazoles	2013
Therapeutic potential of dithiolethiones for hepatic diseases. Pharmacology & therapeutics, 2009, Volume: 124, Issue:1 Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Fatty Liver; Glutathione Transferase; Humans; Inactivation, Metabolic; Insulin Resistance; Liver; Liver Cirrhosis; Liver Diseases; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Protein Kinases; Pyrazines; Receptors, Aryl Hydrocarbon; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thiones; Thiophenes; TOR Serine-Threonine Kinases	2009
Fixed-dose combination therapy for type 2 diabetes: sitagliptin plus pioglitazone. Expert opinion on investigational drugs, 2010, Volume: 19, Issue:8 Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles	2010
[Incretin enhancers, incretin mimetics: from therapeutic concept to clinical application]. Orvosi hetilap, 2007, Apr-01, Volume: 148, Issue:13 Topics: Adamantane; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon-Like Peptide 1; Glycoproteins; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Mucosa; Nitriles; Peptide Hormones; Peptides; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin	2007
Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin. Clinical pharmacology and therapeutics, 2007, Volume: 81, Issue:5 Topics: Animals; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin Resistance; Protease Inhibitors; Pyrazines; Sitagliptin Phosphate; Triazoles	2007
Interactions between glucose and FFA metabolism in man. Diabetes/metabolism reviews, 1996, Volume: 12, Issue:1 Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipolysis; Models, Biological; Niacin; Obesity; Pyrazines	1996

Trials

31 trial(s) available for pyrazines and Insulin Resistance

Article	Year
Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial. Obesity (Silver Spring, Md.), 2019, Volume: 27, Issue:11 Topics: Adult; Aged; Blood Glucose; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Fatty Acids, Nonesterified; Female; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Male; Metabolic Syndrome; Middle Aged; Pyrazines; Vasodilation	2019
Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals. Diabetologia, 2020, Volume: 63, Issue:12 Topics: Calorimetry, Indirect; Ceramides; Diglycerides; Electrophoresis, Capillary; Growth Hormone; Humans; Insulin Resistance; Lipid Metabolism; Lipolysis; Male; Muscle, Skeletal; Polymerase Chain Reaction; Pyrazines; Pyruvate Dehydrogenase Complex	2020
Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies. The American journal of clinical nutrition, 2018, 10-01, Volume: 108, Issue:4 Topics: 3-Hydroxybutyric Acid; Adult; Biomarkers; Blotting, Western; Fatty Acids, Nonesterified; Glucose Clamp Technique; Humans; Hypolipidemic Agents; Inflammation; Insulin Resistance; Ketone Bodies; Kinetics; Lipopolysaccharides; Male; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; Proteolysis; Pyrazines; Ribosomal Protein S6 Kinases; Signal Transduction; Young Adult	2018
Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. The Journal of clinical endocrinology and metabolism, 2019, 07-01, Volume: 104, Issue:7 Topics: Adult; Animals; Blood Glucose; Cells, Cultured; Cross-Over Studies; Enteroendocrine Cells; Fatty Acids, Nonesterified; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypolipidemic Agents; Hypopituitarism; Insulin Resistance; Intestinal Mucosa; Lipolysis; Male; Middle Aged; Overweight; Pilot Projects; Primary Cell Culture; Pyrazines; Rats	2019
A comparison between sitagliptin or glibenclamide in addition to metformin + pioglitazone on glycaemic control and β-cell function: the triple oral therapy. Diabetic medicine : a journal of the British Diabetic Association, 2013, Volume: 30, Issue:7 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glucose Clamp Technique; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Triazoles	2013
A randomized, double-blind, comparative therapy evaluating sitagliptin versus glibenclamide in type 2 diabetes patients already treated with pioglitazone and metformin: a 3-year study. Diabetes technology & therapeutics, 2013, Volume: 15, Issue:3 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Obesity; Pioglitazone; Pyrazines; Sitagliptin Phosphate; Thiazolidinediones; Treatment Outcome; Triazoles	2013
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. European journal of endocrinology, 2014, Volume: 170, Issue:3 Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Fasting; Glucocorticoids; Glucose Intolerance; Humans; Insulin Resistance; Islets of Langerhans; Male; Metabolic Syndrome; Middle Aged; Postprandial Period; Prednisolone; Pyrazines; Sitagliptin Phosphate; Triazoles	2014
The effects of dipeptidyl peptidase-4 inhibitors in treatment of obese patients with type 2 diabetes. Medical archives (Sarajevo, Bosnia and Herzegovina), 2013, Volume: 67, Issue:5 Topics: Adult; Aged; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Obesity; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles; Triglycerides	2013
The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment. Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:11 Topics: Adult; Aged; Amino Acids; Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Fasting; Female; Humans; Hydroxybutyrates; Insulin; Insulin Resistance; Male; Meals; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles	2014
Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes, 2015, Volume: 64, Issue:4 Topics: Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypolipidemic Agents; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; Pyrazines	2015
Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males. The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:3 Topics: Adult; Aged; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Tolerance Test; Glucosides; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Middle Aged; Pyrazines; Young Adult	2016
Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects. American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:3 Topics: Adult; Fasting; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Human Growth Hormone; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Lipolysis; Male; Pyrazines; Young Adult	2009
Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:9 Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Female; Human Growth Hormone; Humans; Insulin Resistance; Male; Pyrazines	2009
Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients. Metabolism: clinical and experimental, 2010, Volume: 59, Issue:6 Topics: Adiponectin; Blood Glucose; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Diet; Double-Blind Method; Drug Therapy, Combination; Exercise; Female; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Pioglitazone; Pyrazines; Resistin; Sitagliptin Phosphate; Thiazolidinediones; Triazoles; Tumor Necrosis Factor-alpha	2010
Incretin action maintains insulin secretion, but not hepatic insulin action, in people with impaired fasting glucose. Diabetes research and clinical practice, 2010, Volume: 90, Issue:1 Topics: Aged; Blood Glucose; Body Mass Index; C-Peptide; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Hyperglycemia; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Liver; Male; Middle Aged; Pyrazines; Severity of Illness Index; Sitagliptin Phosphate; Triazoles	2010
Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients. Diabetes research and clinical practice, 2012, Volume: 98, Issue:1 Topics: Blood Glucose; C-Peptide; C-Reactive Protein; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Exercise; Fasting; Female; Glucagon; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Secreting Cells; Italy; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles	2012
Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study. Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:2 Topics: Acetates; Adult; Area Under Curve; Cohort Studies; Diabetes Mellitus, Type 2; Diacylglycerol O-Acyltransferase; Diglycerides; Dose-Response Relationship, Drug; Humans; Insulin Resistance; Intestinal Absorption; Male; Mass Spectrometry; Postprandial Period; Pyrazines; Treatment Outcome; Triglycerides	2013
Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation. Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:2 Topics: Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Italy; Lipids; Male; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles	2014
A randomized, double-blind, placebo-controlled trial evaluating sitagliptin action on insulin resistance parameters and β-cell function. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:17 Topics: Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles	2012
Inhibition of lipolysis improves insulin sensitivity in protease inhibitor-treated HIV-infected men with fat redistribution. The American journal of clinical nutrition, 2003, Volume: 77, Issue:2 Topics: Adipose Tissue; Adult; Area Under Curve; Fasting; Fatty Acids; Glucose Tolerance Test; HIV Infections; Humans; Hyperinsulinism; Hypolipidemic Agents; Insulin Resistance; Lipodystrophy; Lipolysis; Male; Middle Aged; Protease Inhibitors; Pyrazines; Viscera	2003
Effects of GH replacement therapy in adults on serum levels of leptin and ghrelin: the role of lipolysis. European journal of endocrinology, 2005, Volume: 153, Issue:4 Topics: Adult; Drug Combinations; Fasting; Fatty Acids, Nonesterified; Female; Ghrelin; Growth Hormone; Hormone Replacement Therapy; Human Growth Hormone; Humans; Hypolipidemic Agents; Insulin Resistance; Leptin; Lipolysis; Male; Middle Aged; Peptide Hormones; Pyrazines; Steroid Metabolism, Inborn Errors; Sterol Esterase	2005
Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia. The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:11 Topics: Adult; Body Composition; Double-Blind Method; Fatty Acids, Nonesterified; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Placebos; Pyrazines; Triglycerides	2006
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration. Diabetes, 2007, Volume: 56, Issue:3 Topics: Adult; Fatty Acids, Nonesterified; Female; Free Radical Scavengers; Gene Expression Profiling; Gene Expression Regulation; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Pyrazines; RNA, Messenger	2007
The effect of an antilipolytic agent (acipimox) on the insulin resistance of lipid and glucose metabolism in hypertriglyceridaemic patients. Acta diabetologica, 1994, Volume: 31, Issue:1 Topics: Fatty Acids, Nonesterified; Glucose; Glucose Clamp Technique; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Lipolysis; Male; Middle Aged; Oxidation-Reduction; Palmitates; Pyrazines	1994
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes, 1999, Volume: 48, Issue:9 Topics: Adult; Basal Metabolism; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hypolipidemic Agents; Insulin Resistance; Male; Obesity; Oxidation-Reduction; Pyrazines	1999
Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men. The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:12 Topics: Aged; Area Under Curve; Blood Glucose; Fatty Acids, Nonesterified; Female; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Insulin-Like Growth Factor Binding Protein 1; Male; Obesity; Oligopeptides; Pyrazines	2000
The role of free fatty acids (FFA) in the regulation of intrahepatic fluxes of glucose and glycogen metabolism during short-term starvation in healthy volunteers. Clinical nutrition (Edinburgh, Scotland), 2001, Volume: 20, Issue:2 Topics: Cross-Over Studies; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids, Nonesterified; Food Deprivation; Gluconeogenesis; Glucose; Glycogen; Humans; Hypolipidemic Agents; Insulin Resistance; Liver; Male; Pyrazines	2001
Metabolic and endocrine consequences of acute suppression of FFAs by acipimox in polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:11 Topics: Adult; Area Under Curve; Body Mass Index; C-Peptide; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipids; Obesity; Polycystic Ovary Syndrome; Pyrazines	2001
Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:12 Topics: Adult; Blood Glucose; Double-Blind Method; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucose; Growth Hormone; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Oxidation-Reduction; Pyrazines	2001
Effects of prolonged Acipimox treatment on glucose and lipid metabolism and on in vivo insulin sensitivity in patients with non-insulin dependent diabetes mellitus. Acta endocrinologica, 1992, Volume: 127, Issue:4 Topics: Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metabolism; Female; Glucose; Glucose Clamp Technique; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Male; Middle Aged; Pyrazines; Time Factors	1992
Effect of acute inhibition of lipolysis on operation of the glucose-fatty acid cycle in hepatic cirrhosis. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:5 Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Fatty Acids; Fatty Acids, Nonesterified; Glucose Tolerance Test; Glycerol; Humans; Hydroxybutyrates; Hypolipidemic Agents; Insulin Resistance; Lipolysis; Liver Cirrhosis; Male; Middle Aged; Pyrazines; Reference Values	1992

Other Studies

35 other study(ies) available for pyrazines and Insulin Resistance

Article	Year
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nature communications, 2020, 05-14, Volume: 11, Issue:1 Topics: Adipose Tissue; Administration, Oral; Animals; Blood Glucose; Body Temperature; Body Weight; Diamines; Diet, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Clamp Technique; Humans; Insulin Resistance; Liver; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Obesity; Oxadiazoles; Oxidative Stress; Pyrazines	2020
2,3,5,6-Tetramethylpyrazine improves diet-induced whole-body insulin resistance via suppressing white adipose tissue lipolysis in mice. Biochemical and biophysical research communications, 2020, 11-19, Volume: 532, Issue:4 Topics: Adipose Tissue, White; Animals; Diet, High-Fat; Fatty Liver; Glucose; Insulin Resistance; Lipolysis; Male; Mice; Muscle, Skeletal; Pyrazines	2020
[Intervention effects and mechanism of Chinese herbal medicine of supplementing Qi and activating blood circulation on chronic intermittent hypoxia composite insulin resistance ApoE~(-/-) mice model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019, Volume: 44, Issue:1 Topics: Animals; Atherosclerosis; Blood Circulation; Drugs, Chinese Herbal; Ginsenosides; Hypoxia; Insulin Resistance; Mice; Mice, Knockout, ApoE; Pyrazines; Qi; Random Allocation	2019
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. British journal of pharmacology, 2013, Volume: 169, Issue:5 Topics: Adamantane; Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiotonic Agents; Cholesterol; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Heart; Heart Rate; Insulin; Insulin Resistance; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Heart; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects. The Journal of physiology, 2013, Jun-01, Volume: 591, Issue:11 Topics: Administration, Oral; Adult; Case-Control Studies; Ceramides; Chemokine CCL2; Diabetes Mellitus, Type 2; Diglycerides; Fatty Acids, Nonesterified; Female; Glucose; Humans; Hypolipidemic Agents; I-kappa B Kinase; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Muscle, Skeletal; Obesity; Pyrazines; Signal Transduction; Toll-Like Receptor 4	2013
Effects of sitagliptin on nonalcoholic fatty liver disease in diet-induced obese rats. Metabolic syndrome and related disorders, 2013, Volume: 11, Issue:4 Topics: Alanine Transaminase; Animals; Blood Glucose; Cholesterol; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Fatty Liver; Female; Insulin; Insulin Resistance; Liver; Non-alcoholic Fatty Liver Disease; Obesity; Pyrazines; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Triglycerides	2013
DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. The Journal of endocrinology, 2013, Volume: 218, Issue:1 Topics: Adamantane; Animals; Behavior, Animal; Brain; Cognition Disorders; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Hippocampus; Insulin Resistance; Male; Maze Learning; Memory; Memory Disorders; Mitochondria; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
Clinical characteristics of the responders to dipeptidyl peptidase-4 inhibitors in Korean subjects with type 2 diabetes. Journal of Korean medical science, 2013, Volume: 28, Issue:6 Topics: Adamantane; Blood Glucose; Body Mass Index; C-Peptide; Creatinine; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Nitriles; Pyrazines; Pyrrolidines; Retrospective Studies; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals. Diabetes, 2014, Volume: 63, Issue:8 Topics: Adult; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Glucose; Humans; Hypolipidemic Agents; Insulin Resistance; Liver; Male; Middle Aged; Mitochondria; Obesity; Pyrazines; Reactive Oxygen Species	2014
Mechanism of repression of 11β-hydroxysteroid dehydrogenase type 1 by growth hormone in 3T3-L1 adipocytes. Endocrine journal, 2014, Volume: 61, Issue:7 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3T3-L1 Cells; Adipocytes, White; Animals; Carbohydrate Dehydrogenases; Enzyme Repression; Growth Hormone; Imidazoles; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Mice; Phosphorylation; Phthalazines; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrazines; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Signal Transduction	2014
Improved mitochondrial function is linked with improved insulin sensitivity through reductions in FFA. Diabetes, 2014, Volume: 63, Issue:8 Topics: Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Humans; Insulin Resistance; Male; Mitochondria; Obesity; Pyrazines	2014
Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse. Toxicologic pathology, 2015, Volume: 43, Issue:3 Topics: Acetates; Alopecia; Animals; Diacylglycerol O-Acyltransferase; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Insulin Resistance; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Pyrazines; Sebaceous Glands; Skin	2015
Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. American journal of physiology. Cell physiology, 2014, Nov-01, Volume: 307, Issue:9 Topics: Boronic Acids; Bortezomib; Cells, Cultured; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose; Glycogen; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Muscle, Skeletal; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Carbonylation; Proteome; Pyrazines; RNA Interference; Signal Transduction	2014
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nature medicine, 2015, Volume: 21, Issue:4 Topics: Adipocytes; Adiposity; AMP-Activated Protein Kinases; Animals; Body Composition; Body Weight; Dual Specificity Phosphatase 1; Enzyme Activation; HEK293 Cells; Homeostasis; Humans; Hypolipidemic Agents; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Phosphorylation; Pyrazines; Rats; Serine; Smoking	2015
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour. Schizophrenia research, 2009, Volume: 115, Issue:1 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Composition; Body Weight; Clozapine; Dibenzothiazepines; Dietary Fats; Disease Models, Animal; Eating; Exenatide; Food Preferences; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Peptides; Pyrazines; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Venoms	2009
Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet. Clinical science (London, England : 1979), 2010, Jun-08, Volume: 119, Issue:6 Topics: Adipocytes; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Dietary Fats; Dipeptidyl-Peptidase IV Inhibitors; Drug Evaluation, Preclinical; Drug Therapy, Combination; Energy Intake; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Metabolic Syndrome; Metformin; Mice; Mice, Inbred C57BL; Obesity; Pancreas; Pyrazines; Sitagliptin Phosphate; Telmisartan; Triazoles	2010
Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat). Mediators of inflammation, 2010, Volume: 2010 Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glycated Hemoglobin; Insulin; Insulin Resistance; Interleukin-1beta; Lipids; Male; Oxidative Stress; Pancreas; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles	2010
Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms	2010
Distinguishing among incretin-based therapies. Patient education and self-management. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Patient Education as Topic; Peptides; Pyrazines; Receptors, Glucagon; Self Care; Sitagliptin Phosphate; Triazoles; Venoms	2010
Distinguishing among incretin-based therapies. Introduction. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Administration Schedule; Exenatide; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Insulin-Secreting Cells; Liraglutide; Metformin; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms	2010
Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice. Diabetologia, 2011, Volume: 54, Issue:4 Topics: Animals; Antioxidants; Blotting, Western; Dietary Fats; Hep G2 Cells; Humans; Insulin Resistance; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Thiones; Thiophenes	2011
Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:9 Topics: Adipokines; Adiponectin; Adult; Aged; Fatty Acids, Nonesterified; Female; Heart; Heart Function Tests; Hemodynamics; Humans; Hypolipidemic Agents; Insulin Resistance; Lipid Metabolism; Magnetic Resonance Imaging; Male; Middle Aged; Muscle, Skeletal; Myocardium; Pyrazines; Stroke Volume; Ventricular Function, Left	2012
Dipeptidyl peptidase 4 inhibition increases myocardial glucose uptake in nonischemic cardiomyopathy. Journal of cardiac failure, 2012, Volume: 18, Issue:10 Topics: Adult; Blood Glucose; Cardiomyopathy, Dilated; Dipeptidyl-Peptidase IV Inhibitors; Female; Fluorodeoxyglucose F18; Humans; Insulin Resistance; Male; Middle Aged; Myocardium; Pyrazines; Sitagliptin Phosphate; Statistics as Topic; Statistics, Nonparametric; Triazoles	2012
Glucose-lowering effect of the DPP-4 inhibitor sitagliptin after glucose and non-glucose macronutrient ingestion in non-diabetic subjects. Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:6 Topics: Adult; Blood Glucose; Dietary Fats; Dietary Proteins; Dipeptidyl-Peptidase IV Inhibitors; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Micronutrients; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles	2013
Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting. European journal of endocrinology, 2004, Volume: 150, Issue:6 Topics: Adult; Amino Acids; Blood Flow Velocity; Blood Glucose; Calorimetry, Indirect; Fasting; Fatty Acids, Nonesterified; Forearm; Glucagon; Glucose Clamp Technique; Glycerol; Human Growth Hormone; Humans; Insulin; Insulin Resistance; Lactic Acid; Lipolysis; Male; Microdialysis; Plethysmography; Pyrazines; Somatostatin	2004
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2003, Volume: 28, Issue:12 Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2003
Inhibition of lipolysis does not affect insulin sensitivity to glucose uptake in the mourning dove. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2006, Volume: 144, Issue:3 Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Columbidae; Fatty Acids; Female; Insulin; Insulin Resistance; Lipolysis; Male; Pyrazines; Tissue Distribution	2006
Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway. Hepatology (Baltimore, Md.), 2007, Volume: 46, Issue:3 Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Glucose; Hypoglycemia; Insulin; Insulin Resistance; Leptin; Liver; Mice; Mice, Mutant Strains; Multienzyme Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Pyrazines; Ribosomal Protein S6 Kinases, 70-kDa; Thiones; Thiophenes; Transfection; Transforming Growth Factor alpha	2007
The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:2 Topics: Alanine Transaminase; Fatty Acids, Nonesterified; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipolysis; Liver; Magnetic Resonance Spectroscopy; Middle Aged; Positron-Emission Tomography; Pyrazines; Triglycerides	2008
Effects of phlorizin and acipimox on insulin resistance in STZ-diabetic rats. Journal of Korean medical science, 1995, Volume: 10, Issue:1 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Hypolipidemic Agents; Insulin Resistance; Phlorhizin; Pyrazines; Rats; Rats, Sprague-Dawley; Streptozocin	1995
[Improvement of insulin sensitivity associated with the prolonged use of Acipimox in ++a morbid obese patient]. Revista medica de Chile, 1994, Volume: 122, Issue:11 Topics: Adult; Blood Glucose; Fatty Acids, Nonesterified; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Male; Obesity, Morbid; Pyrazines; Time Factors	1994
Mechanisms of dexamethasone-induced insulin resistance in healthy humans. The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:4 Topics: Adult; Blood Glucose; Dexamethasone; Female; Glucose; Glucose Clamp Technique; Humans; Hypolipidemic Agents; Insulin; Insulin Resistance; Leg; Male; Oxidation-Reduction; Pyrazines; Regional Blood Flow	1994
Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance. American journal of physiology. Endocrinology and metabolism, 2001, Volume: 280, Issue:4 Topics: Amyloid; Animals; Blood Glucose; Hypolipidemic Agents; Insulin; Insulin Resistance; Islet Amyloid Polypeptide; Lactic Acid; Lipids; Lipolysis; Liver; Male; Muscle, Skeletal; Peptide Fragments; Pyrazines; Rats; Rats, Wistar; Triglycerides	2001
Reversal of steroid-induced insulin resistance by a nicotinic-acid derivative in man. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:7 Topics: Adrenal Cortex Hormones; Adult; Energy Metabolism; Fatty Acids, Nonesterified; Glucose; Humans; Hypolipidemic Agents; Insulin Resistance; Middle Aged; Pyrazines	1992
Effects of an alpha 2-adrenoceptor antagonist on glucose tolerance in the genetically obese mouse (C57BL/6J ob/ob). Metabolism: clinical and experimental, 1990, Volume: 39, Issue:5 Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Clonidine; Diaphragm; Glucose Tolerance Test; Glycogen; Insulin; Insulin Resistance; Male; Mice; Mice, Obese; Piperazines; Pyrazines; Somatostatin	1990