Compounds > (2E-4E)-N-isobutyl-2-4-dodecadienamide

(2E-4E)-N-isobutyl-2-4-dodecadienamide and Insulin-Resistance

(2E-4E)-N-isobutyl-2-4-dodecadienamide has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for (2E-4E)-N-isobutyl-2-4-dodecadienamide and Insulin-Resistance

Article	Year
Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea). Journal of natural products, 2009, May-22, Volume: 72, Issue:5 Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes. Topics: 3T3-L1 Cells; Animals; Denmark; Diabetes Mellitus, Type 2; Echinacea; Fatty Acids, Unsaturated; Flowers; Glucose; Insulin Resistance; Mice; Plants, Medicinal; PPAR gamma	2009

Article

Year

Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).

Journal of natural products, 2009, May-22, Volume: 72, Issue:5

Thiazolidinediones are insulin sensitizing drugs that target the peroxisome proliferator-activated receptor (PPAR) gamma. An n-hexane extract of the flowers of Echinacea purpurea was found to activate PPARgamma without stimulating adipocyte differentiation. Bioassay-guided fractionations yielded five alkamides, of which one was new, and three fatty acids that all activated PPARgamma. The new alkamide hexadeca-2E,9Z,12Z,14E-tetraenoic acid isobutylamide (5) was identified by analysis of spectroscopic data and found to activate PPARgamma with no concurrent stimulation of adipocyte differentiation. Compound 5 was further shown to increase insulin-stimulated glucose uptake. The data suggest that flowers of E. purpurea contain compounds with potential to manage insulin resistance and type 2 diabetes.

Topics: 3T3-L1 Cells; Animals; Denmark; Diabetes Mellitus, Type 2; Echinacea; Fatty Acids, Unsaturated; Flowers; Glucose; Insulin Resistance; Mice; Plants, Medicinal; PPAR gamma

2009