sodium aescinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

sodium aescinate: extracted from dry mature fruit of Aesculus Wilsonii Rehd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Aesculus	genus	A plant genus of the family HIPPOCASTANACEAE (or SAPINDACEAE by some) that contains antimicrobial protein 1 and escin. A. hippocastanum is used in folk medicine for treating chronic venous insufficiency.[MeSH]	Sapindaceae	The soapberry plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Some members contain SAPONINS.[MeSH]

Cross-References

ID Source	ID
PubMed CID	102004407
MeSH ID	M0589413

Synonyms (2)

Synonym
20977-05-3
sodium aescinate

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions."	( In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae. Efferth, T; Huang, Y; Jin, W; Li, C; Li, H; Liang, J; Liu, H; Shan, L; Shan, X, 2016)	0.43
" When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored."	( Adverse event due to a likely interaction between sodium aescinate and ginkgo biloba extract: a case report. Ji, H; Yue, F; Zhang, G; Zhou, X, 2017)	0.46

Dosage Studied

Excerpt	Relevance	Reference
"High dosage of SA treatment improved the morphological features of the ovaries in PCOS rats, and also induced significant decrease in serum expression of testosterone and LH/FSH ratio and significant decrease in the expression of p-PI3K, p-Akt and p-Gsk-3β."	( Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Chen, L; Hu, LM; Huang, XY; Sun, HX; Wang, YF; Yang, HY; Zhou, W, 2017)	0.46

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	14 (73.68)	24.3611
2020's	5 (26.32)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (5.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.1	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	7.25	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	2.25	1	iditol	fungal metabolite
glycidyl nitrate glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.	2.11	1
chalcone trans-chalcone : The trans-isomer of chalcone.	2.25	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
flavokawain a flavokawain A: from kava extract, induces apoptosis in bladder cancer cells; structure in first source	2.25	1	chalcones
beta-escin [no description available]	4.4	18
veliparib [no description available]	2.17	1	benzimidazoles	EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor

Condition	Relationship Strength	Studies
Acute Post-Traumatic Stress Disorder [description not available]	2.6	1
Stress Disorders, Post-Traumatic A class of traumatic stress disorders with symptoms that last more than one month.	2.6	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.21	1
Hepatocellular Carcinoma [description not available]	7.21	1
Cancer of Liver [description not available]	2.21	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.21	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.21	1
Encephalopathy, Traumatic [description not available]	2.25	1
Acute Brain Injuries [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.84	3
Brain Injuries, Traumatic A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.	2.25	1
Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.	2.25	1
Adhesions, Tissue [description not available]	2.25	1
Peritoneal Diseases Pathological processes involving the PERITONEUM.	2.25	1
Complication, Postoperative [description not available]	2.25	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	2.25	1
Insulin Sensitivity [description not available]	2.15	1
Polycystic Ovarian Syndrome [description not available]	2.15	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	7.15	1
Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.	2.15	1
ALS - Amyotrophic Lateral Sclerosis [description not available]	2.17	1
Amyotrophic Lateral Sclerosis A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)	2.17	1
Cancer of Stomach [description not available]	2.13	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.13	1
Alloxan Diabetes [description not available]	2.11	1
Middle Ear Inflammation [description not available]	2.11	1
Otitis Media Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	2.11	1
Breast Cancer [description not available]	7.11	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.11	1
Cardiac Toxicity [description not available]	2.13	1
Abnormality, Heart [description not available]	2.13	1
Bleeding [description not available]	2.13	1
Blood Clot [description not available]	2.13	1
Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.	2.13	1
Hemorrhage Bleeding or escape of blood from a vessel.	2.13	1
Thrombosis Formation and development of a thrombus or blood clot in the blood vessel.	2.13	1
Cardiotoxicity Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	7.13	1
Injuries, Spinal Cord [description not available]	2.13	1
Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	2.13	1
Acute Kidney Failure [description not available]	2.15	1
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	2.15	1

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