Page last updated: 2024-11-10

sodium aescinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

sodium aescinate: extracted from dry mature fruit of Aesculus Wilsonii Rehd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AesculusgenusA plant genus of the family HIPPOCASTANACEAE (or SAPINDACEAE by some) that contains antimicrobial protein 1 and escin. A. hippocastanum is used in folk medicine for treating chronic venous insufficiency.[MeSH]SapindaceaeThe soapberry plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida. Some members contain SAPONINS.[MeSH]

Cross-References

ID SourceID
PubMed CID102004407
MeSH IDM0589413

Synonyms (2)

Synonym
20977-05-3
sodium aescinate

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" To date, no toxicity or adverse events in SA have been reported, by using routine models (in vivo or in vitro), which are insufficient to predict all aspects of its pharmacological and toxicological actions."( In Vivo Cardiotoxicity Induced by Sodium Aescinate in Zebrafish Larvae.
Efferth, T; Huang, Y; Jin, W; Li, C; Li, H; Liang, J; Liu, H; Shan, L; Shan, X, 2016
)
0.43
" When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored."( Adverse event due to a likely interaction between sodium aescinate and ginkgo biloba extract: a case report.
Ji, H; Yue, F; Zhang, G; Zhou, X, 2017
)
0.46

Dosage Studied

ExcerptRelevanceReference
"High dosage of SA treatment improved the morphological features of the ovaries in PCOS rats, and also induced significant decrease in serum expression of testosterone and LH/FSH ratio and significant decrease in the expression of p-PI3K, p-Akt and p-Gsk-3β."( Effect of sodium aescinate treatment on PCOS rat model with insulin resistance.
Chen, L; Hu, LM; Huang, XY; Sun, HX; Wang, YF; Yang, HY; Zhou, W, 2017
)
0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (73.68)24.3611
2020's5 (26.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (5.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (95.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]