| Assay ID | Title | Year | Journal | Article |
|---|
| AID204506 | Effect on triglyceride level in male Dawley rats at 24 hr r | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID8402 | Area under curve at 0-8 hr in IRC mice after peroral administration | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID199488 | Antagonistic efficacy against Retinoic acid receptor RXR-alpha was determined in vitro | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199314 | Binding affinity against retinoic acid receptor beta by [3H]ATRA displacement. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID199816 | Binding affinity against RXR gamma receptor using [3H]9-cis-RA as radioligand in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID220376 | Hypoglycemic activity in db/db mouse model after 7 days at 30 mg/kg/day oral dose | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199485 | Agonist activity against Retinoic acid receptor RXR-alpha expressed in CV-1 cell transcriptional activation assay | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID198894 | Binding affinity for Retinoic acid receptor gamma was determined by competing with 3[H]-ATRA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID47198 | Synergistic efficacy against RXR:PPAR-gamma heterodimer was determined in vitro | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199652 | Displacement of [3H]9-cis-RA from RXR beta receptor in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID199497 | Inhibition of 3[H]9-cis-retinoic acid binding to Retinoic acid receptor RXR-alpha expressed in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID199619 | In vitro transcriptional activation in CV-1 cells expressing RXR-alpha | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199325 | Antagonist activity for Retinoic X receptor alpha in CV1 cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID9602 | Cmax value in IRC mice | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID199194 | Binding affinity against retinoic acid receptor alpha by [3H]ATRA displacement. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID157284 | Binding affinity for Peroxisome proliferator activated receptor gamma was determined | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199352 | Binding affinity against RXR alpha receptor using [3H]9-cis-RA as radioligand in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID7828 | Tmax after oral administration at 30 mg/kg in ICR mouse | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID234577 | RXR:RAR synergy expressed as fold induction | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199487 | Antagonist activity against Retinoic acid receptor RXR-alpha expressed in CV-1 cell transcriptional activation assay | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID199623 | Binding affinity for Retinoic acid receptor RXR-alpha was determined by competing with 3[H]-9-cis-RA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID156458 | Binding affinity for Peroxisome proliferator activated receptor alpha was determined | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID55968 | In vivo hypoglycemic activity, as reduced plasma glucose in db/db mouse type II diabetes model | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID189944 | T4 level in rats at 24 hr r after 30 mg/kg oral dose | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199505 | Inhibition of Retinoic acid receptor RXR-alpha agonist activity in vitro; Not calculated | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID55969 | In vivo hypoglycemic activity compared to BRL-46953 as reduced plasma glucose in db/db mouse type II diabetes model | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID198734 | Binding affinity against Retinoic acid receptor gamma was determined in vitro by using [3H]ATRA as radioligand | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID167599 | Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assay | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID7842 | Tmax value in IRC mice | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID198194 | Binding affinity against RAR beta receptor using [3H]ATRA as radioligand in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID199648 | In vitro evaluation against RXR-alpha/PPAR-gamma in CV-1 cells by cotransfection assay. | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199647 | In vitro evaluation against RXR-alpha/PPAR-gamma in CV-1 cells by cotransfection assay was determined | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID234578 | Synergistic activation of retinoid acid receptor (RAR) transcriptional activation at 3 nM TTNPB | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID199322 | Transcriptional activation in CV-1 cells expressing Retinoic X receptor alpha | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID47191 | Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitro | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199486 | Agonistic efficacy against Retinoic acid receptor RXR-alpha was determined in vitro | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID204505 | Effect on T4 levels in male Dawley rats at 24 hr r | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199324 | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID198370 | Binding affinity for Retinoic acid receptor beta was determined by competing with 3[H]-ATRA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199956 | Binding affinity for Retinoic acid receptor RXR-gamma was determined by competing with 3[H]-9-cis-RA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199323 | In vitro agonist efficacy at human Retinoic X receptor alpha expressed in CV1 cells. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID199315 | Binding affinity against retinoic acid receptor gamma by [3H]ATRA displacement. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID199798 | Binding affinity for Retinoic acid receptor RXR-beta was determined by competing with 3[H]-9-cis-RA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199189 | Displacement of [3H]9-cis-RA from retinoic X receptor gamma | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID199646 | Binding affinity against Retinoic acid receptor RXR-alpha by [3H]9-cis-RA displacement. | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID199341 | In vitro synergistic elevation of transcriptional activation in CV-1 cells expressing RAR and RXR with 3 nm TTNBP | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID47180 | Transcriptional activation in CV-1 cells expressing RXR and LXR at 1 uM | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID197916 | Binding affinity for Retinoic acid receptor alpha was determined by competing with 3[H]-ATRA | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199650 | In vitro evaluation against RXR-alpha/PPAR-gamma in CV-1 cells by cotransfection assay was determined | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID198707 | Binding affinity against RAR gamma receptor using [3H]ATRA as radioligand in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID167600 | Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assay | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID198737 | Inhibition of 3[H]ATRA binding to retinoid acid receptor gamma expressed in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID8395 | AUC (0-6 hr) after oral administration at 30 mg/kg in ICR mouse | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID199494 | Binding affinity against Retinoic acid receptor RXR-alpha was determined in vitro by using [3H]9-cis-RA as radioligand | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199977 | Binding affinity against RAR alpha receptor using [3H]ATRA as radioligand in CV-1 cells | 2003 | Bioorganic & medicinal chemistry letters, Nov-17, Volume: 13, Issue:22
| Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
| AID199814 | Displacement of [3H]9-cis-RA from Retinoic X receptor beta | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
| AID9587 | Cmax after oral administration at 30 mg/kg in ICR mouse | 2003 | Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
| Design and synthesis of fluorinated RXR modulators. |
| AID191968 | Triglyceride level in rats 24 hr r after 30 mg/kg oral dose | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| AID199489 | Inhibitory activity against Retinoic acid receptor RXR-alpha antagonist was determined in vitro | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13
| Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
| AID199621 | In vitro transcriptional activation in CV-1 cells expressing RXR-alpha | 2003 | Journal of medicinal chemistry, Sep-11, Volume: 46, Issue:19
| Design, synthesis, and structure-activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |