| Assay ID | Title | Year | Journal | Article |
|---|
| AID1467529 | Inhibition of Streptococcus pneumoniae sialidase NanB using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
| Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans. |
| AID1405012 | Inhibition of recombinant His6-tagged human neuraminidase 1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID1418706 | Inhibition of Streptococcus pneumoniae NanA using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1418703 | Inhibition of Bifidobacterium longum subsp. infantis ATCC 15697 sialidase 2 (BiNanH2) using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID704188 | Inhibition of Influenza A virus sialidase N2 by fluorometric assay | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Exploring the interactions of unsaturated glucuronides with influenza virus sialidase. |
| AID1308298 | Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID728981 | Inhibition of human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate measured for every 30 seconds for 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID761715 | Inhibition of influenza A virus A/Paris/2590/2009 (pdm09 H1N1) N1 sialidase using fluorogenic substrate 4-methylumbelliferyl N-acetyl-alpha-D-neuraminide preincubated for 15 mins measured after 30 mins by spectrofluorometry | 2013 | Bioorganic & medicinal chemistry, Aug-15, Volume: 21, Issue:16
| Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop. |
| AID748618 | Inhibition of human NEU3 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate reader analysis | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. |
| AID729057 | Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate after 30 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID1415004 | Inhibition of MBP-fused human NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1490008 | Octanol-water partition coefficient, log D of compound at pH 7.4 at 10 uM after 2 hrs by LC-MS based shake flask analysis | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID1418715 | Inhibition of Streptococcus pneumoniae NanA using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID313830 | Inhibition of human NEU3 expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). |
| AID728980 | Inhibition of human neuraminidase 4 using 4MU-NANA as substrate measured for every 30 seconds for 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID1308302 | Inhibition of Influenza A virus (A/duck/Tsukuba/394/2005(H5N3)) neuraminidase N3 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID1418708 | Inhibition of Streptococcus pneumoniae sialidase NanC using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1418710 | Inhibition of Arthrobacter ureafaciens sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID526403 | Inhibition of influenza A nuraminidase N1 | 2010 | Journal of medicinal chemistry, Oct-28, Volume: 53, Issue:20
| Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles. |
| AID1490009 | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using GM3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID729053 | Selectivity ratio of IC50 for Vibrio cholerae neuraminidase to IC50 for human neuraminidase 1 | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID539787 | Inhibition of human neuraminidase 3 assessed as inhibition of 4-methylumbelliferyl-alpha-D-glucopyranoside hydrolysis | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
| Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid. |
| AID1415016 | Inhibition of NEU1 in C57BL6 mouse kidney homogenate at 150 uM using fluorogenic-4MU-NANA as substrate after 60 mins fluorescence-based assay relative to control | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1490012 | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID203525 | The compound was tested in vitro for the inhibitory concentration against influenza B/Mem/89 sialidase from whole virus by MUN assay | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. |
| AID1418719 | Inhibition of Arthrobacter ureafaciens sialidase using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID729055 | Inhibition of human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate after 30 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID1418711 | Inhibition of Clostridium perfringens sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1418707 | Inhibition of Streptococcus pneumoniae NanB using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID761716 | Inhibition of influenza A virus A/R1/5+/1957 (H2N2) N2 sialidase using fluorogenic substrate 4-methylumbelliferyl N-acetyl-alpha-D-neuraminide preincubated for 15 mins measured after 30 mins by spectrofluorometry | 2013 | Bioorganic & medicinal chemistry, Aug-15, Volume: 21, Issue:16
| Novel 3,4-disubstituted-Neu5Ac2en derivatives as probes to investigate flexibility of the influenza virus sialidase 150-loop. |
| AID729056 | Inhibition of human neuraminidase 1 using 4MU-NANA as substrate after 30 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID203520 | The compound was tested in vitro for the inhibitory concentration against influenza N2 sialidase from whole virus by fetuin assay | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. |
| AID313829 | Inhibition of human NEU2 expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). |
| AID1418700 | Inhibition of Vibrio cholerae sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1720574 | Inhibition of human NEU3 expressed in HEK293A cells as substrate incubated for 1 hr by spectrofluorometric analysis | 2020 | Bioorganic & medicinal chemistry, 07-15, Volume: 28, Issue:14
| 2β-3,4-Unsaturated sialic acid derivatives: Synthesis optimization, and biological evaluation as Newcastle disease virus hemagglutinin-neuraminidase inhibitors. |
| AID1415014 | Inhibition of NEU2/NEU3/NEU4 in NEU1 knockout C57BL6 mouse brain homogenate at 150 uM using fluorogenic-4MU-NANA as substrate after 60 mins fluorescence-based assay relative to control | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1889675 | Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-6GalbetapNP as substrate incubated for 30 mins | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID1415002 | Inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID147495 | Binding affinity against Neuraminidase | 2002 | Journal of medicinal chemistry, Jun-20, Volume: 45, Issue:13
| SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions. |
| AID748621 | Inhibition of human NEU1 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate reader analysis | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. |
| AID1420835 | Inhibition of recombinant Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate after 10 mins in presence of [D-glucose-1-14C]lactose by liquid scintillation counting method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | The synthesis and kinetic evaluation of aryl α-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase. |
| AID729058 | Inhibition of Vibrio cholerae neuraminidase | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID729050 | Selectivity ratio of IC50 for Vibrio cholerae neuraminidase to IC50 for human neuraminidase 4 | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID595827 | Inhibition of human NEU3 using 4MU-NA as substrate after 1 hr by fluorescence assay | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes. |
| AID1415001 | Inhibition of human His6-tagged NEU1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID94523 | Inhibitory activity against KDN-sialidase from Crassostrea virginica at a concentration of 1 mM | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition. |
| AID1415008 | Non-competitive inhibition of N-terminal MBP-fused human NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated with substrate for 15 mins and measured every min for 30 mins by Lineweaver-Burk plot analysis | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1405015 | Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID1415005 | Competitive inhibition of human His6-tagged NEU1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated with substrate for 15 mins and measured every min for 30 mins by Lineweaver-Burk plot analysis | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID748615 | Inhibition of human NEU4 using GM3 as substrate preincubated for 30 mins before substrate addition measured after 1 hr by fluorescence plate reader analysis | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. |
| AID1416512 | Inhibition of Influenza virus NA | 2017 | MedChemComm, Jul-01, Volume: 8, Issue:7
| Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their |
| AID1308297 | Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID1308296 | Inhibition of human Neu1 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID1490014 | Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID427114 | Inhibition of human NEU1 transiently transfected in HEK293T cells by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. |
| AID1308299 | Inhibition of Influenza A virus (A/duck/Tsukuba/67/2005(H1N1)) neuraminidase N1 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID722347 | Inhibition of Influenza A virus H5N1 neuraminidase | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
| Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors. |
| AID1415003 | Inhibition of N-terminal MBP-fused human NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by fluorescence assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1490010 | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using GM3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID203364 | Inhibitory activity against sialidase of influenza A | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4
| Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase. |
| AID203375 | Inhibitory activity against sialidase of influenza B | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4
| Synthesis of tetrasubstituted bicyclo[3.2.1]octenes as potential inhibitors of influenza virus sialidase. |
| AID1889677 | Inhibition of human NEU2 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID532109 | Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID1418720 | Inhibition of Clostridium perfringens sialidase using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1490016 | Inhibition of human N-terminal MBP-fused NEU3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID1889674 | Inhibition of NEU2 (unknown origin) using Neu5Acalpha2-3GalbetapNP as substrate incubated for 30 mins | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID306105 | Inhibition of sialidase in Human parainfluenza virus 3 C243 | 2007 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
| Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity. |
| AID147491 | In vitro inhibitory activity against neuraminidase | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21
| Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 2. Computational titration and pH effects in molecular models of neuraminidase-inhibitor complexes. |
| AID1418722 | Inhibition of Pasteurella multocida sialyltransferase 1 using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID532106 | Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID384920 | Inhibition of influenza virus neuraminidase | 2008 | European journal of medicinal chemistry, Mar, Volume: 43, Issue:3
| QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network. |
| AID1490018 | Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID729054 | Inhibition of human neuraminidase 4 using 4MU-NANA as substrate after 30 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID1418713 | Inhibition of Pasteurella multocida sialyltransferase 1 using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID474369 | Inhibition of Trypanosoma cruzi recombinant trans-sialidase at 1 mM after 10 mins by MUNANA continuous fluorimetric assay | 2010 | Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
| 'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase. |
| AID1418712 | Inhibition of Bifidobacterium longum subsp. infantis ATCC 15697 sialidase 2 (BiNanH2) using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID591599 | Inhibition of Human parainfluenza virus 1 sialidase using N-acetyl-alpha-neuramic acid by fluorometric assay | 2011 | Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
| Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1. |
| AID532113 | Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID1405017 | Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID1418697 | Inhibition of Streptococcus pneumoniae NanA using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1418698 | Inhibition of Streptococcus pneumoniae NanB using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1490015 | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID1418714 | Inhibition of recombinant human cytosolic sialidase NEU2 using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID729052 | Selectivity ratio of IC50 for Vibrio cholerae neuraminidase to IC50 for human neuraminidase 3 | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID670430 | Inhibition of influenza B virus neuraminidase | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
| Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity. |
| AID1490017 | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID1418718 | Inhibition of Vibrio cholerae sialidase using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1418716 | Inhibition of Streptococcus pneumoniae NanB using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1405019 | Inhibition of MBP-fused recombinant human neuraminidase 4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID532111 | Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID147488 | Inhibitory concentration of compound against influenza viral coat protein neuraminidase | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations. |
| AID203380 | Inhibitory activity against influenza virus A(N9) sialidase | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition. |
| AID203526 | The compound was tested in vitro for the inhibitory concentration against influenza B/Mem/89 sialidase from whole virus by fetuin assay | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. |
| AID539786 | Inhibition of human neuraminidase 3 assessed as inhibition of GM3 hydrolysis | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
| Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid. |
| AID313828 | Inhibition of human NEU1 expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). |
| AID1490011 | Inhibition of human N-terminal MBP-fused NEU4 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID427116 | Inhibition of human NEU3 transiently transfected in HEK293T cells by fluorimetric high-performance liquid chromatography | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. |
| AID1405013 | Inhibition of MBP-fused recombinant human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID1467530 | Inhibition of Streptococcus pneumoniae sialidase NanA using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid as substrate after 60 mins by FRET assay | 2017 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
| Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans. |
| AID1405014 | Inhibition of MBP-fused recombinant human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID1889676 | Inhibition of human NEU1 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID1490007 | Effective permeability of compound at pH 7.4 after 16 hrs by PAMPA | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID203365 | Inhibitory activity against sialidase of influenza A | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4
| Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase. |
| AID1857995 | Inhibition of influenza virus neuraminidase | 2022 | Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20
| Sialidase Inhibitors with Different Mechanisms. |
| AID532110 | Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID748619 | Inhibition of human NEU4 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate reader analysis | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. |
| AID1418717 | Inhibition of Streptococcus pneumoniae sialidase NanC using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID722348 | Inhibition of Influenza A virus Mississippi/1/85(H3N2) neuraminidase | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
| Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors. |
| AID1418721 | Inhibition of Bifidobacterium longum subsp. infantis ATCC 15697 sialidase 2 (BiNanH2) using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID203508 | Inhibitory activity against Vibrio cholerae sialidase | 1999 | Bioorganic & medicinal chemistry letters, Jul-19, Volume: 9, Issue:14
| Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition. |
| AID1418701 | Inhibition of Arthrobacter ureafaciens sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID313831 | Inhibition of human NEU4 expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). |
| AID704187 | Inhibition of Influenza A virus sialidase N2 | 2012 | Journal of medicinal chemistry, Oct-25, Volume: 55, Issue:20
| Exploring the interactions of unsaturated glucuronides with influenza virus sialidase. |
| AID1418723 | Inhibition of recombinant human cytosolic sialidase NEU2 using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID748620 | Inhibition of human NEU2 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate reader analysis | 2013 | ACS medicinal chemistry letters, Jun-13, Volume: 4, Issue:6
| Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4. |
| AID1415013 | Inhibition of NEU1 in C57BL6 mouse brain homogenate at 150 uM using fluorogenic-4MU-NANA as substrate after 60 mins fluorescence-based assay relative to control | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID203528 | Compound was tested for inhibitory concentration against Influenza sialidase type A | 1998 | Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
| Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. |
| AID1308294 | Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID1418709 | Inhibition of Vibrio cholerae sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 0.1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1308295 | Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID1308301 | Inhibition of Influenza A virus (A/duck/Tsukuba/28/2005(H6N2)) neuraminidase N2 activity using 4MU-Neu5Ac as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by fluorescence analysis | 2016 | Journal of medicinal chemistry, 05-26, Volume: 59, Issue:10
| A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions. |
| AID532112 | Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID539788 | Inhibition of human neuraminidase 3 assessed as inhibition of 4-methylumbelliferyl-alpha-D-glucopyranoside hydrolysis by fluorescence assay | 2010 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
| Inhibition of human neuraminidase 3 (NEU3) by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic acid. |
| AID532107 | Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID1418704 | Inhibition of Pasteurella multocida sialyltransferase 1 using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID728982 | Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate measured for every 30 seconds for 60 mins by fluorescence assay | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID670429 | Inhibition of influenza A virus neuraminidase | 2012 | Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14
| Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity. |
| AID473065 | Inhibition of human neuraminidase 2 | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| Complexity in influenza virus targeted drug design: interaction with human sialidases. |
| AID1418699 | Inhibition of Streptococcus pneumoniae sialidase NanC using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID722346 | Inhibition of Influenza A virus Brazilll/78(H1N1) neuraminidase | 2013 | Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
| Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors. |
| AID595828 | Inhibition of human NEU4 using 4MU-NA as substrate after 1 hr by fluorescence assay | 2011 | Bioorganic & medicinal chemistry, May-01, Volume: 19, Issue:9
| Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes. |
| AID1720575 | Inhibition of Newcastle disease virus neuraminidase using 4-MUNeu5Ac as substrate incubated for 15 mins by spectrofluorometric analysis | 2020 | Bioorganic & medicinal chemistry, 07-15, Volume: 28, Issue:14
| 2β-3,4-Unsaturated sialic acid derivatives: Synthesis optimization, and biological evaluation as Newcastle disease virus hemagglutinin-neuraminidase inhibitors. |
| AID427115 | Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. |
| AID729051 | Selectivity ratio of IC50 for Vibrio cholerae neuraminidase to IC50 for human neuraminidase 2 | 2013 | Journal of medicinal chemistry, Apr-11, Volume: 56, Issue:7
| Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. |
| AID368571 | Inhibition of Trypanosoma cruzi trans-Sialidase | 2009 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
| Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening. |
| AID532108 | Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Limited inhibitory effects of oseltamivir and zanamivir on human sialidases. |
| AID1405018 | Inhibition of MBP-fused recombinant human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID203519 | The compound was tested in vitro for the inhibitory concentration against influenza N2 sialidase from whole virus by MUN assay | 1995 | Journal of medicinal chemistry, Aug-18, Volume: 38, Issue:17
| Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. |
| AID1418705 | Inhibition of recombinant human cytosolic sialidase NEU2 using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID343957 | Inhibition of hPIV1 sialidase | 2008 | Bioorganic & medicinal chemistry, Jul-15, Volume: 16, Issue:14
| 2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogs structurally modified by thiocarbamoylalkyl groups at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1. |
| AID203529 | Compound was tested for inhibitory concentration against Influenza sialidase type B | 1998 | Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
| Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. |
| AID1405016 | Inhibition of recombinant His6-tagged human neuraminidase 1 expressed in HEK293 cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every 1 min for 30 mins by fluorescence analysis | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity. |
| AID427117 | Inhibition of human NEU4 transiently transfected in HEK293T cells by fluorimetric analysis | 2009 | Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
| Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids. |
| AID1418702 | Inhibition of Clostridium perfringens sialidase using Neu5Acalpha2-3GalbetapNP as substrate at 1 mM after 30 mins by colorimetric assay | 2018 | Bioorganic & medicinal chemistry, 11-15, Volume: 26, Issue:21
| Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. |
| AID1889678 | Inhibition of human NEU3 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID1415015 | Inhibition of NEU1 in NEU3/NEU4 double knockout C57BL6 mouse brain homogenate at 150 uM using 4MU-NANA as substrate after 60 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Selective Inhibitors of Human Neuraminidase 1 (NEU1). |
| AID1889679 | Inhibition of human NEU4 | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Human Neuraminidases: Structures and Stereoselective Inhibitors. |
| AID147346 | inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza A virus | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19
| BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. |
| AID1490013 | Inhibition of human N-terminal MBP-fused NEU2 expressed in Escherichia coli using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured every minute for 30 mins by fluorescence based assay | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Selective Inhibitors of Human Neuraminidase 3. |
| AID203376 | Inhibitory activity against sialidase of influenza B | 1999 | Bioorganic & medicinal chemistry letters, Feb-22, Volume: 9, Issue:4
| Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase. |
| AID488376 | Inhibition of Influenza A virus A/Vienna/83/58(H2N2) neuraminidase | 2010 | Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
| Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses. |
| AID1802683 | Sialidase Assay from Article 10.1186/1471-2091-13-19: \\Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.\\ | 2012 | BMC biochemistry, Oct-02, Volume: 13 | Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases. |
| AID1795674 | Neuraminidase Inhibition Assay from Article 10.1021/jm970479e: \\Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design.\\ | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2003 | Journal of molecular biology, Jan-24, Volume: 325, Issue:4
| The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2003 | Journal of molecular biology, Jan-24, Volume: 325, Issue:4
| The high resolution structures of free and inhibitor-bound Trypanosoma rangeli sialidase and its comparison with T. cruzi trans-sialidase. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1998 | Structure (London, England : 1993), Jun-15, Volume: 6, Issue:6
| Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1998 | Structure (London, England : 1993), Jun-15, Volume: 6, Issue:6
| Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 2001 | Protein science : a publication of the Protein Society, Apr, Volume: 10, Issue:4
| Analysis of inhibitor binding in influenza virus neuraminidase. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 2001 | Protein science : a publication of the Protein Society, Apr, Volume: 10, Issue:4
| Analysis of inhibitor binding in influenza virus neuraminidase. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1993 | Journal of molecular biology, Aug-20, Volume: 232, Issue:4
| Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1993 | Journal of molecular biology, Aug-20, Volume: 232, Issue:4
| Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1996 | Journal of molecular biology, Jun-07, Volume: 259, Issue:2
| The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1996 | Journal of molecular biology, Jun-07, Volume: 259, Issue:2
| The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |