Compounds > bavachin
Page last updated: 2024-11-12

bavachin

Description

bavachin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; do not confuse with bavachinin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PsoraleagenusA plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Psoralea corylifoliaspecies[no description available]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID14236566
CHEMBL ID469444
SCHEMBL ID4223610
MeSH IDM0430170

Synonyms (19)

Synonym
bavachin
CHEMBL469444
19879-32-4
S5469
SCHEMBL4223610
AC-34020
CS-6113
HY-N0233
mfcd11617359
AKOS032962062
coryfolin
(s)-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
4h-1-benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-, (2s)-
nsc-808860
nsc808860
CCG-267746
A879959
7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one
AS-75959

Research Excerpts

Overview

Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia. Bavachin exhibits anti-bacterial, anti-inflammatory, and anti-tumor and lipid-lowering activities.

ExcerptReferenceRelevance
"Bavachin is a dihydroflavonoid compound isolated from Psoralea corylifolia, and exhibits anti-bacterial, anti-inflammatory, anti-tumor and lipid-lowering activities. "( Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway.
Dou, J; Guan, L; Guo, M; Liu, C; Shen, J; Tian, B; Wang, M; Xu, S, 2023)		3.8
"Bavachin is a therapeutic phytoestrogen used to treat cancer, inflammation, and diabetes mellitus."( Bavachin suppresses human placental choriocarcinoma cells by targeting electron transport chain complexes and mitochondrial dysfunction.
Lee, JY; Lim, W; Song, G, 2020)		2.72
"Bavachin is a bioactive natural flavonoid with oestrogen-like activity. "( Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin-O-glucuronide in HeLa1A1 cells.
Gonzalez, FJ; Hu, L; Li, S; Li, Y; Qin, Z; Xu, C; Xu, J; Yao, X; Yao, Z, 2020)		2.22
"Bavachin is a natural product belonging to the flavonoid class."( Bavachin exerted anti-neuroinflammatory effects by regulation of A20 ubiquitin-editing complex.
Li, Z; Ren, Y; Wang, Q; Wang, Y; Yang, Z, 2021)		2.79
"Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. "( Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3.
Imano, M; Itoh, T; Kawashima, K; Nishida, S; Satou, T; Takeda, T; Tomonari, Y; Tsubaki, M, 2018)		3.37
"Bavachin is a natural product isolated from Psoralea corylifolia L. "( Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.
Chen, CS; Cheng, WC; Fang, SH; Huang, MY; Hung, YL; Li, CY; Liu, PL; Su, CC; Suzuki, K; Tu, HP; Wang, SC; Yeh, HC, 2019)		3.4

Treatment

ExcerptReferenceRelevance
"With bavachin treatment, chondrocytes survived for 21 d without cell proliferation, and the proteoglycan content and extracellular matrix increased."( Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes.
Cho, IA; Im, HJ; Kang, KR; Kim, CS; Kim, DK; Kim, JS; Kim, SG; Lee, GJ; Oh, JS; Seo, YS; Sohn, HM; You, JS; You, JW; Yu, SJ, 2015)		1.11

Pharmacokinetics

ExcerptReferenceRelevance
" The developed method was applied to evaluating the pharmacokinetic study of 13 bioactive compounds after oral administration of Psoraleae Fructus in rat of different genders."( Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics.
Cheng, LY; Song, L; Wu, YL; Yang, L; Yu, YL; Zhang, Y; Zhou, K; Zhou, ZX, 2020)		0.56

Compound-Compound Interactions

ExcerptReferenceRelevance
" Further integrative analysis indicated that bavachin combined with epimedin B affected genes that were not only related to immune system processes, but also to lipid metabolism."( Bavachin combined with epimedin B induce idiosyncratic liver injury under immunological stress conditions.
Cao, B; Li, C; Li, G; Li, Y; Lin, M; Xiao, X; Xu, J; Zhang, Y, 2023)		2.61
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID422532Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation2009Journal of natural products, Jan, Volume: 72, Issue:1
Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID354593Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation at 300 uM preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID421668Cytotoxicity against NHEM cells assessed as cell viability after 72 hrs by WST-8 assay2009Journal of natural products, Feb-27, Volume: 72, Issue:2
Melanin synthesis inhibitors from Lespedeza floribunda.
AID334647Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-nitroflorene-induced mutation at 300 ug/plate after 72 hrs
AID354592Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation at 300 uM preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID1352143Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by SRB assay2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID1225511Cytotoxicity against human A549 cells after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID334642Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of acetylaminofluorene-induced mutation at 150 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID334636Toxicity in Salmonella Typhimurium T98 at 150 ug/plate after 72 hrs by Ames assay in presence of Ames S-9 fraction
AID1225513Increase in SIRT1 (unknown origin) deacetylation activity at 10 uM2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID1352145Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by SRB assay2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID1352141Cytotoxicity against human MCF7 cells assessed as growth inhibition at 50 uM after 48 hrs by SRB assay relative to control2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID421667Inhibition of melanin synthesis in NHEM cells assessed as [14C]thiouracil incorporation after 72 hrs by liquid scintillation counting2009Journal of natural products, Feb-27, Volume: 72, Issue:2
Melanin synthesis inhibitors from Lespedeza floribunda.
AID1352138Cytotoxicity against human A549 cells assessed as growth inhibition at 50 uM after 48 hrs by SRB assay relative to control2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID334648Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-nitroflorene-induced mutation at 150 ug/plate after 72 hrs
AID1352142Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by SRB assay2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID1225512Cytotoxicity against human K562 cells after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID334637Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-aminoanthracene-induced mutation at 600 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID334641Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of acetylaminofluorene-induced mutation at 300 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID334644Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of benzo[a]pyrene-induced mutation at 300 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID1352144Cytotoxicity against human HCT116 cells assessed as growth inhibition after 48 hrs by SRB assay2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID334639Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-aminoanthracene-induced mutation at 150 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID334638Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-aminoanthracene-induced mutation at 300 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID1352139Cytotoxicity against human PC3 cells assessed as growth inhibition at 50 uM after 48 hrs by SRB assay relative to control2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID334635Toxicity in Salmonella Typhimurium T98 at 300 ug/plate after 72 hrs by Ames assay in presence of Ames S-9 fraction
AID357965Inhibition of aromatase from human placental microsomes2001Journal of natural products, Oct, Volume: 64, Issue:10
Aromatase inhibitors from Broussonetia papyrifera.
AID354591Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation at 300 uM preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID422533Cytotoxicity against NHEM cells assessed as cell viability 24 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID1352140Cytotoxicity against human HCT116 cells assessed as growth inhibition at 50 uM after 48 hrs by SRB assay relative to control2018European journal of medicinal chemistry, Feb-10, Volume: 145Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents.
AID334645Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of benzo[a]pyrene-induced mutation at 150 ug/plate after 72 hrs in presence of Ames S-9 fraction
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (44)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (4.55)18.2507
2000's8 (18.18)29.6817
2010's16 (36.36)24.3611
2020's18 (40.91)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.78 (24.57)
Research Supply Index3.83 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other45 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.1110hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
hydroquinone
[no description available]		2.7630benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
aminoglutethimide
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.. aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.		210dicarboximide;
piperidones;
substituted aniline		adrenergic agent;
anticonvulsant;
antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		1.9910benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		2.0710amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
ficusin
Ficusin: A naturally occurring furocoumarin, found in PSORALEA. After photoactivation with UV radiation, it binds DNA via single and double-stranded cross-linking.. psoralen : The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.		3.0440psoralensplant metabolite
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.2510naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure		2.1110dihydroxybenzaldehyde
angelicin
angelicin: used as tranquillizer; sedative; or anticonvulsant; structure		2.7930furanocoumarin
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.1710acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
nigericin
Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.		7.3110polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
baicalin
[no description available]		2.110dihydroxyflavone;
glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative		antiatherosclerotic agent;
antibacterial agent;
anticoronaviral agent;
antineoplastic agent;
antioxidant;
cardioprotective agent;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
ferroptosis inhibitor;
neuroprotective agent;
non-steroidal anti-inflammatory drug;
plant metabolite;
prodrug
loliolide
loliolide: RN given refers to (6S-cis)-isomer		210benzofuransmetabolite
cv 3988
CV 3988: platelet activating factor antagonist; structure given in first source		1.9910
liquiritigenin
liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.		2.05104',7-dihydroxyflavanonehormone agonist;
plant metabolite
phaseollidin
phaseollidin: from Erythrina burana; RN refers to (6aR-cis)-isomer; structure given in first source. phaseollidin : A member of the class of pterocarpans that is (6aR,11aR)-pterocarpan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 10.		2.0510pterocarpans
aromadedrin
aromadedrin: inhibits protein kinase C; the dihydro makes it a flavone rather than a flavonol. (+)-dihydrokaempferol : A tetrahydroxyflavanone having hydroxy groupa at the 3-, 4'-, 5- and 7-positions.		2104'-hydroxyflavanones;
dihydroflavonols;
secondary alpha-hydroxy ketone;
tetrahydroxyflavanone		metabolite
moracin m
moracin M: has been isolated from Morus alba L.; structure in first source		210benzofurans
isobavachin
isobavachin: RN given for (S)-isomer; structure in first source		2.7530flavanones
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.4920
marmesin
marmesin: RN given refers to (S)-isomer; nodakenetin is the (R)-isomer		210marmesin
taurochenodeoxycholic acid
Taurochenodeoxycholic Acid: A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.. taurochenodeoxycholate : An organosulfonate oxoanion that is the conjugate base of taurochenodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3.. taurochenodeoxycholic acid : A bile acid taurine conjugate of chenodeoxycholic acid.		2.1710bile acid taurine conjugatehuman metabolite;
mouse metabolite
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.4320(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		2.4520beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		210resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
glycosides
[no description available]		2.0310
chalcone
trans-chalcone : The trans-isomer of chalcone.		2.0110chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
xanthoangelol
xanthoangelol: from Angelica keiskei; structure given in first source; RN given refers to (E,E)-isomer		2.0510
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone: a mitochondrial division inhibitor		2.610
leachianone g
leachianone G: structure in first source. leachianone G : A tetrahydroxyflavanone having the hydroxy groups at the 2'-, 4'-, 5- and 7-positions and a prenyl group at 8-position.		2.0510(2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone
bilirubin
[no description available]		2.1110biladienes;
dicarboxylic acid		antioxidant;
human metabolite;
mouse metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.5520prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
genistein
[no description available]		2.45207-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		4130chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
baicalein
[no description available]		2.110trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
chrysin
chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.		2.1107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
psoralidin
psoralidin : A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.		2.4920coumestans;
delta-lactone;
polyphenol		estrogen receptor agonist;
plant metabolite
broussonin a
broussonin A: has antiviral activity; isolated from Anemarrhena asphodeloides; structure in first source		210
broussonin b
broussonin B: structure in first source		210
corylin
corylin: from Psoralea corylifolia (Leguminosae), has osteoblastic proliferation stimulating activity; structure in first source		2.9640
Isolicoflavonol
[no description available]		210flavones
neobavaisoflavone
neobavaisoflavone: isolated from Psoralea corylifolia; structure in first source. neobavaisoflavone : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone with an additonal hydroxy group at position 4' and a prenyl group at position 3'. Isolated from seeds of Psoralea corylifolia, it exhibits inhibitory activity against DNA polymerase and platelet aggregation.		3.32607-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
plant metabolite;
platelet aggregation inhibitor
bakuchiol
bakuchiol: chief component of Psoralea corylifolia Linn; structure		8.4370
isowighteone
isowighteone : A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 3'. It has been isolated from Ficus mucuso.		2.11107-hydroxyisoflavonesplant metabolite
epimedin b
epimedin B: structure given in first source; from Epimedium sp.		7.610flavonoids;
glycoside
broussochalcone a
broussochalcone A: RN given for (E)-isomer; inhibits neutrophil respiratory burst; structure in first source		210
bavachalcone
bavachalcone: structure in first source		2.7730chalcones
ursodoxicoltaurine
tauroursodeoxycholate : An organosulfonate oxoanion that is the conjugate base of tauroursodeoxycholic acid arising from deprotonation of the sulfonate OH group; major species at pH 7.3.. tauroursodeoxycholic acid : A bile acid taurine conjugate derived from ursoodeoxycholic acid.		2.1710bile acid taurine conjugateanti-inflammatory agent;
apoptosis inhibitor;
bone density conservation agent;
cardioprotective agent;
human metabolite;
neuroprotective agent
morachalcone a
morachalcone A: tyrosinase inhibitor from the wood of Artocarpus heterophyllus; structure in first source		210chalcones
2,4,2',4'-Tetrahydroxychalcone
[no description available]		210chalcones
bavachinin
bavachinin: do not confuse with bavachin		3.3560flavanones
psoralenoside
psoralenoside: structure in first source		2.0310
isopsoralenoside
isopsoralenoside: structure in first source		2.0310
corylifol a
corylifol A: isolated from Psoralea corylifolia; structure in first source		2.8130
mulberrofuran g
mulberrofuran G: from Mulberry tree; Diels-Alder type adduct; structure given in first source		210
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.4920benzenes;
hydroxycoumarin;
methyl ketone
phytoestrogens
Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.		2.4820
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.4620
Bone Cancer
[description not available]		02.3110
Osteogenic Sarcoma
[description not available]		02.3110
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.		02.3110
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)		07.3110
Asthma, Bronchial
[description not available]		02.4110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5920
Innate Inflammatory Response
[description not available]		02.6920
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		07.4110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.6920
Infections, Staphylococcal
[description not available]		02.4110
Staphylococcal Pneumonia
[description not available]		02.4110
Pneumonia, Staphylococcal
Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.		02.4110
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.4110
Colorectal Cancer
[description not available]		07.610
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.610
Fatty Liver, Nonalcoholic
[description not available]		02.610
Insulin Sensitivity
[description not available]		02.610
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		02.610
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).		07.610
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION.		02.610
Diabetic Glomerulosclerosis
[description not available]		02.610
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.		02.610
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.		02.610
Acute Liver Injury, Drug-Induced
[description not available]		03.1740
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		03.1740
Choriocarcinoma
A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).		07.2510
Kahler Disease
[description not available]		02.1710
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.		07.1710
Fish Diseases
Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).		02.1710
Infections, Rhabdoviridae
[description not available]		02.1710
Arthritis, Degenerative
[description not available]		02.1110
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.		02.1110
Age-Related Osteoporosis
[description not available]		02.1110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.1110
Diabetes Mellitus, Adult-Onset
[description not available]		02.1310
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.1310
B16 Melanoma
[description not available]		02.0510
Extravascular Hemolysis
[description not available]		02.0110
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.0110
chemdatabank.com