leucine and Insulin Resistance

leucine has been researched along with Insulin Resistance in 131 studies

Research

Studies (131)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (7.63)	18.7374
1990's	16 (12.21)	18.2507
2000's	22 (16.79)	29.6817
2010's	61 (46.56)	24.3611
2020's	22 (16.79)	2.80

Authors

Authors	Studies
Chen, S; Deng, J; Guo, F; Guo, Y; Hu, C; Jiang, X; Jiao, F; Li, Y; Niu, Y; Yin, H; Yuan, F; Zhai, Q	1
Rivera, CN; Rivera, ME; Vaughan, RA	1
Goh, HJ; Goh, JP; Govindharajulu, P; Henry, CJ; Leow, MK; Michael, N; Sadananthan, SA; Sun, L; Velan, SS; Verma, S	1
Bishop, CA; Grune, T; Henkel, J; Henning, T; Klaus, S; Machate, T; Püschel, G; Weber, D; Weitkunat, K	1
Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S	1
Barouki, R; Coumoul, X; De Bandt, JP	1
Bi, Y; Chen, Y; Kong, L; Li, M; Lu, J; Ning, G; Wang, T; Wang, W; Wang, Y; Xu, M; Xu, Y; Ye, C; Zhao, Z; Zheng, J	1
Ao, Q; Chen, C; Ding, H; Du, B; Feng, M; Huang, Y; Lei, Y; Li, X; Li, Y; Liang, N; Liao, S; Lu, C; Mo, J; Shi, Q; Tang, S; Tang, T; Wang, X; Wei, L; Wu, Y; Zhang, N; Zheng, Z	1
Becetti, I; Bredella, MA; Lauze, M; Lee, H; Misra, M; Singhal, V	1
Biolo, G; Di Girolamo, FG; Fiotti, N; Landolfo, M; Mangogna, A; Mearelli, F; Vinci, P	1
Johnson, MA; Lyon, ES; Rivera, ME; Vaughan, RA	1
Bezerra Pontes, EO; Carneiro, EM; Coelho de Souza, AN; D Avila, LSP; de Abreu, ES; de Carvalho, DP; de Oliveira, AC; de Oliveira, KA; Leal Cardoso, JH; Nascimento, JF; Rickli, S; Silveira, LR; Torres Leal, FL; Vasconcelos, RP	1
Holmes, E; Johnson, MR; Kanu, C; Li, JV; Maric, T; McDonald, JAK; Nicholson, JK; Savvidou, MD; West, KA	1
Chen, J; Hu, L; Ma, Q; Shan, A; Zhou, X; Zhu, J	1
Duan, Y; Guo, Q; Li, F; Wang, W; Yang, Y; Yin, Y; Zhang, L; Zhong, Y	1
Zemel, MB	1
Anderson, KA; Campbell, JE; Coakley, AJ; Hirschey, MD; Huynh, FK; Lin, Z; Llaguno, FMS; Newgard, CB; Nguyen, TN; Peterson, BS; Stephens, SB	1
de Ligt, M; Hesselink, MKC; Hoeks, J; Phielix, E; Schrauwen, P; Vanweert, F	1
Bongers, A; de Vogel-van den Bosch, J; Memelink, RG; Pasman, WJ; Tromp, W; Tump, A; van Ginkel, A; Verlaan, S; Weijs, PJM; Wopereis, S	1
Alizadeh, A; Hafezi, M; Hajitarkhani, S; Moini, A; Shahhoseini, M	1
Allen, SL; Breen, L; Edwards, SJ; Lavery, GG; Lord, JM; Marshall, RN	1
Guo, X; Hu, W; Jiang, X; Liang, Y; Wang, B; Zhang, Y; Zheng, J; Zheng, L	1
Anderson, KA; Backos, DS; Campbell, JE; Capra, JA; Douros, JD; Fisher-Wellman, K; Green, MF; Grimsrud, PA; Hirschey, MD; Huynh, FK; Ilkayeva, OR; Madsen, AS; Muoio, DM; Olsen, CA; Peterson, BS; Sivley, RM; Stevens, RD; Stuart, JD; Thompson, JW; Wagner, GR	1
Kolahian, S; Larki, NN; Sadri, H	1
Barceló, A; Esquinas, C; Fortuna, AM; Gasa, M; Mayos, M; Monasterio, C; Montserrat, JM; Morell-Garcia, D; Pérez, A; Pérez, G; Salord, N	1
Chao, T; Fan, W; Hao, L; Huang, J; Jin, Q; Li, H; Liu, R; Wu, Y; Yang, X	1
Auquier, J; Beauloye, C; Bertrand, L; Bultot, L; Daneault, C; Des Rosiers, C; Gélinas, R; Ginion, A; Horman, S; Hue, L; Renguet, E; Robillard Frayne, I; Vanoverschelde, JL	1
Hirschey, MD; Hu, X; Huynh, FK; Johnson, JD; Lin, Z	1
Coqueiro, AY; Lima, VBS; Martins, CEC; Ribeiro, HQT; Tirapegui, J	1
He, T; Ma, X; Nie, C; Zhang, G; Zhang, W	1
Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H	1
Chacko, S; Hsu, JW; Jahoor, F; Khoo, CM; Lai, OF; Tai, ES; Tan, HC; Yu, S	1
Gannon, NP; Johnson, MA; Lyon, ES; Schnuck, JK; Sunderland, KL; Vaughan, RA	1
Biebermann, H; Gong, M; Homuth, G; Jacobi, SF; Khajavi, N; Kleinau, G; Krude, H; Kühnen, P; Raile, K; Scheerer, P; Teumer, A; Völzke, H; Wiegand, S	1
Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J	1
Bruttomesso, D; Tessari, P	1
Chevalier, S; Jacob, KJ; Lamarche, M; Morais, JA	1
Cao, W; Guo, H; Hao, L; He, K; Li, X; Liu, L; Liu, R; Ma, Y; Sun, X; Wang, X; Yang, X; Yao, P	1
Bremner, DM; Calder, AG; Holtrop, G; Johnstone, AM; Lobley, GE; Milne, E	1
Boudreau, A; Feng, D; Gettys, TW; Ghosh, S; Hasek, BE; Hulver, M; Laque, A; Pessin, JE; Shin, J; Stewart, LK; Stone, KP; Van, NT; Wanders, D	1
André, C; Aubert, A; Belluomo, I; Bermúdez-Silva, FJ; Binder, E; Clark, S; Cota, D; Duchampt, A; Elie, M; Fanelli, F; Layé, S; Leste-Lasserre, T; Mezzullo, M; Mithieux, G; Pagotto, U; Romero-Zerbo, SY	1
Arthur, JS; English, G; Ibrahim, AF; McGuire, VA; Mitchell, FE; Poncet, N; Shi, YB; Taylor, PM	1
Guo, H; Hao, L; Li, X; Liu, H; Liu, L; Liu, R; Ma, Y; Wang, D; Wang, X; Xiong, Y; Yang, X; Yao, P	1
Han, S; Li, W; Qin, LQ; Tong, X; Xu, JY	1
Klein, S; Klein, SJ; Magkos, F; Mittendorfer, B; Reeds, DN; Smith, GI; Stromsdorfer, KL; Yoshino, J	1
Meininger, CJ; Wu, G; Wu, Z; Yang, Y	1
Hu, Z; Li, Q; Liu, Y; Qin, H; Ruan, C; Wang, Q; Wang, Z; Wu, B	1
Chevalier, S; Gougeon, R; Labonte, CC; Marliss, EB; Morais, JA	1
Chai, J; Chi, Y; Luo, H; Xu, C; Zhang, Q	1
Bruckbauer, A; Cao, Q; Cui, X; Fu, L; Li, F; Shi, H; Wu, R; Xue, B; Zemel, MB	1
Dioguardi, FS	1
Mittendorfer, B; Smith, GI	1
Chen, S; Deng, J; Guo, F; Guo, Y; Xiao, F; Yu, J	1
de la Garza, AL; Etxeberria, U; Martíinez, JA; Milagro, I	1
Fujita, S; Makanae, Y	1
Cho, US; Karin, M; Lee, JH	1
Adegoke, OA; Beatty, B; Moghei, M; Tavajohi-Fini, P	1
Davis, TA; Koo, SJ; Manjarín, R; Nguyen, HV; Orellana, RA; Suryawan, A; Wilson, FA	1
Darcos Wattimena, JL; de Rooij, FWM; Jainandunsing, S; Rietveld, T; Sijbrands, EJG; van Miert, JNI	1
Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X	1
Civantos, E; Egido, J; Mas, S; Peiró, C; Ruiz-Ortega, M; Sánchez, MS; Vázquez, C; Zhenyukh, O	1
Booker, C; Deger, SM; Ellis, CD; Fissell, R; Gore, JC; Ikizler, TA; Morse, JL; Sha, F; Siew, ED; Stewart, TG; Titze, J; Wang, P	1
Ando, F; Iguchi, A; Kuzuya, M; Shimokata, H	1
Andre, A; Bailhache, E; Briand, F; Krempf, M; Magot, T; Nguyen, P; Ouguerram, K	1
Benedini, S; Luzi, L; Mancuso, M; Ruffini, E; Terruzzi, I	1
Beelke, M; Benedini, S; Caumo, A; Cortelli, P; Lugaresi, E; Luzi, L; Montagna, P; Perseghin, G; Terruzzi, I	1
Bedu, M; Boirie, Y; Delcourt, I; Duche, P; Giraudet, C; Guillet, C; Rance, M; Walrand, S	1
Bidzińska-Speichert, B; Lenarcik, A; Tworowska-Bardzińska, U	1
Mensink, RP; Popeijus, HE; van Meijl, LE	1
Balage, M; Dardevet, D; Dupont, J; Mosoni, L; Mothe-Satney, I; Tesseraud, S	1
Brandon, AE; Deoliveira, R; Kraegen, EW; Lawson, E; Ruderman, NB; Saha, AK; Xu, XJ	1
Castillo, L; Coss-Bu, J; Joosten, KF; Schierbeek, H; van Goudoever, JB; Verbruggen, SC	1
Burgos, SA; Chevalier, S; Goulet, ED; Morais, JA; Wykes, LJ	1
Balage, M; Dardevet, D; Dupont, J; Hébuterne, X; Mothe-Satney, I; Schneider, SM; Zeanandin, G	1
Bång, AM; Beebe, K; Boucher, J; Emanuelli, B; Espinoza, DO; Gall, W; Kahn, CR; Macotela, Y	1
Brum, PC; Chaves, DF; da Luz, CR; Dardevet, D; de Moraes, WM; de Siqueira Filho, MA; Lancha, AH; Medeiros, A; Nicastro, H; Ramona, P; Zanchi, NE	1
Kuriyan, R; Kurpad, AV; Raj, T; Regan, MM; Sambashivaiah, S; Unni, US; Uthappa, S; Vaz, M	1
Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ	1
He, C; Lee, J; Li, H; Xie, Z; Xu, M	1
Millward, DJ	1
Campos-Ferraz, P; de Oliveira Carvalho, CR; Gabriel Camporez, JP; Guimarães-Ferreira, L; Lancha, AH; Nicastro, H; Seixas Chaves, DF; Siqueira-Filho, MA; Zanchi, NE	1
Ala-Korpela, M; Kähönen, M; Kangas, AJ; Lehtimäki, T; Raitakari, OT; Rönnemaa, T; Soininen, P; Viikari, JS; Würtz, P	1
Deger, SM; Egbert, P; Ellis, CD; Hung, AM; Ikizler, TA; Sha, F; Siew, ED; Sundell, MB	1
Bassil, MS; Gougeon, R	1
Candow, DG; Forbes, SC; Little, JP; Manders, RJ	1
Campbell, WW; Evans, WJ; Kirwan, JP; Krishnan, RK; Kullman, EL; Yarasheski, KE	1
Eller, LK; Reimer, RA; Saha, DC; Shearer, J	1
Blachier, F; Bueno, C; Campos-Ferraz, P; de Oliveira Carvalho, CR; de Siqueira-Filho, MA; Felitti, V; Guimarães-Ferreira, L; Lancha, AH; Lira, FS; Naimo, MA; Nicastro, H; Nunes, MT; Seelaender, M; Zanchi, NE	1
Duvillard, L; Florentin, E; Gambert, P; Pont, F; Vergès, B	2
Battezzati, A; Benedini, S; Bertoli, S; Biolo, G; Fattorini, A; Lanzi, R; Losa, M; Luzi, L; Mortini, P; Testolin, G	1
KELLEY, VC; RUVALCABA, RH; SAMOLS, E	1
Epe, M; Fehmann, HC; Gross, U	1
Cucuianu, M; Dican, L	1
Adiels, M; Borén, J; Caslake, MJ; Olofsson, SO; Packard, C; Soro, A; Stewart, P; Taskinen, MR; Wennberg, B; Westerbacka, J	1
Burgess, SC; Chevalier, S; Gougeon, R; Malloy, CR; Marliss, EB; Morais, JA	1
Chevalier, S; Choong, N; Gougeon, R; Lamarche, M; Morais, JA	1
Cade, WT; Klein, S; Patterson, BW; Powderly, WG; Reeds, DN; Yarasheski, KE	1
Grefhorst, A; Havekes, LM; Janssen, GM; Korsheninnikova, E; Kuipers, F; Maassen, JA; Ouwens, DM; Reijngoud, DJ; Romijn, JA; van der Zon, GC; Voshol, PJ	1
Barroso, I; Cooper, C; Day, IN; Fawcett, KA; Luan, J; O'Rahilly, S; Sandhu, MS; Syddall, H; Wareham, NJ	1
Arslanian, SA; Danadian, K; Hannon, TS; Suprasongsin, C	1
Chevalier, S; Gougeon, R; Marliss, EB; Morais, JA; Pereira, S	1
Barazzoni, R; Bianco, F; Biolo, G; Guarnieri, G; Mengozzi, G; Panzetta, G; Stulle, M; Vasile, A	1
Barazzoni, R; Biolo, G; Dal Mas, V; De Cicco, M; Fantin, D; Guarnieri, G; Iapichino, G; Lorenzon, S; Paroni, R; Zanetti, M	1
Balba, Y; Donnelly, PV; Knutson, VP; Lopez-Reyes, M	1
Awata, T; Iwamoto, Y; Kadowaki, T; Kasuga, M; Matsumoto, C; Momomura, K; Odawara, M; Takahashi, Y	1
Egawa, K; Haruta, T; Imamura, T; Kobayashi, M; Sawa, T; Takada, Y; Takata, Y; Yang, GH	1
Awata, T; Goto, Y; Kadowaki, H; Kadowaki, T; Mori, Y; Sakura, H; Sakuta, R; Suzuki, Y; Tanabe, Y; Tobe, K	1
Amatruda, J; Barnard, R; Statt, M; Welle, S	1
Egawa, K; Haruta, T; Imamura, T; Ishibashi, O; Itazu, T; Iwanishi, M; Kobayashi, M; Naitou, K; Sasaoka, T; Takata, Y	1
Biolo, G; Inchiostro, S; Orlando, R; Sergi, G; Tessari, P; Vettore, M	1
Baker, C; Dobson, SP; Griffiths, MR; Hayward, AC; Krook, A; Maassen, JA; O'Rahilly, S; Ouwens, M; Sen, SK; Siddle, K; Tavaré, JM; Whitehead, JP	1
Hardin, DS; LeBlanc, A; Lukenbaugh, S; Para, L; Seilheimer, DK	1
Barrett, PH; Diffenderfer, MR; Falkner, B; Marsh, JB; Sumner, AE	1
Hardin, DS; Johnson, P; LeBlanc, A; Young, D	1
Devapatla, S; Kalhan, SC	1
Auwerx, J; Bac, P; Blanchard, SG; Champy, MF; Desreumaux, P; Dubuquoy, L; Gelman, L; Leesnitzer, LM; Moras, D; Picard, F; Plunket, KD; Potier, N; Renaud, JP; Rocchi, S; Vamecq, J; Zeyer, D	1
Alfieri, R; Colao, A; Faggiano, A; Filippella, M; Lombardi, G; Melis, D; Pivonello, R; Salvatore, F; Spagnuolo, G	1
Hudson, AJ; Tevaarwerk, GJ	1
Amatruda, JM; Barnard, RR; Statt, M; Welle, S	1
Klinkhamer, MP; Krans, HM; Maassen, JA; Möller, W; Van der Vorm, ER; Van der Zon, GC	1
Cheng, KN; Ford, GC; Halliday, D; Pacy, PJ	1
Caballero, B; Wurtman, RJ	1
Groen, NA; Klinkhamer, MP; Krans, HM; Lindhout, D; Maassen, JA; Möller, W; Sandkuyl, LA; van der Zon, GC	1
Haymond, MW; Horber, F; Rodriguez, N; Schwenk, WF; Zimmerman, T	1
Biolo, G; Boscarato, MT; Fantin, G; Inchiostro, S; Mantero, F; Marescotti, MC; Merola, G; Tessari, P; Tiengo, A	1
Herbertz, L; Langer, K; Schauder, P; Zavelberg, D	1
Atkinson, S; Caro, JF; Flickinger, EG; Meelheim, D; Pories, WJ; Sehgal, NS; Sinha, MK; Taylor, LG	1
Biolo, G; Crepaldi, G; De Kreutzenberg, SV; Duner, E; Inchiostro, S; Marescotti, MC; Nosadini, R; Tessari, P; Tiengo, A; Trevisan, R	1
Egdahl, DH; Egdahl, RH; George, BC; Ryan, NT	1
Cahill, GF; Felig, P; Marliss, E	1

Reviews

13 review(s) available for leucine and Insulin Resistance

Article	Year
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review. Ginekologia polska, 2022, Volume: 93, Issue:8 Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine	2022
Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity. Nutrients, 2022, Dec-23, Volume: 15, Issue:1 Topics: Amino Acids, Branched-Chain; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Insulin; Insulin Resistance; Leucine; Obesity	2022
Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites. Liver international : official journal of the International Association for the Study of the Liver, 2023, Volume: 43, Issue:4 Topics: Adult; Alanine; Birth Weight; Child; Genome-Wide Association Study; Humans; Insulin Resistance; Isoleucine; Leucine; Non-alcoholic Fatty Liver Disease; Pediatric Obesity; Polymorphism, Single Nucleotide; Valine	2023
Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis. Nutrients, 2020, May-02, Volume: 12, Issue:5 Topics: AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Energy Metabolism; Fatty Acids; Glucose Intolerance; Homeostasis; Humans; Insulin Resistance; Leucine; Lipid Metabolism; Lipolysis; Neurodegenerative Diseases; Nutritional Physiological Phenomena; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1	2020
Branched Chain Amino Acids: Beyond Nutrition Metabolism. International journal of molecular sciences, 2018, Mar-23, Volume: 19, Issue:4 Topics: Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Isoleucine; Leucine; Metabolic Diseases; Signal Transduction; Valine	2018
L-Leucine and NO-mediated cardiovascular function. Amino acids, 2015, Volume: 47, Issue:3 Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Leucine; Nitric Oxide; Nitrogenous Group Transferases; Obesity; TOR Serine-Threonine Kinases	2015
Role of Exercise and Nutrition in the Prevention of Sarcopenia. Journal of nutritional science and vitaminology, 2015, Volume: 61 Suppl Topics: Aging; Diet; Dietary Supplements; Humans; Insulin Resistance; Leucine; Muscle Proteins; Muscle, Skeletal; Nutritional Status; Protein Biosynthesis; Resistance Training; Sarcopenia	2015
Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Science signaling, 2016, 06-07, Volume: 9, Issue:431 Topics: AMP-Activated Protein Kinases; Animals; Heat-Shock Proteins; Humans; Insulin Resistance; Leucine; Lipid Metabolism; Lipids; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Models, Molecular; Nuclear Proteins; Protein Conformation; Signal Transduction	2016
Knowledge gained from studies of leucine consumption in animals and humans. The Journal of nutrition, 2012, Volume: 142, Issue:12 Topics: Animals; Body Weight; Genetic Code; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Knowledge; Leucine; Nitrogen; Nutritional Requirements; Proteins	2012
Muscle protein anabolism in type 2 diabetes. Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:1 Topics: Aged; Aging; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Male; Motor Activity; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Sarcopenia	2013
Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia. Nutrients, 2012, Nov-08, Volume: 4, Issue:11 Topics: Aging; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin Secretion; Leucine; Muscle Proteins; Muscle, Skeletal; Sarcopenia	2012
Coagulation factor XIII and atherothrombosis. A mini-review. Romanian journal of internal medicine = Revue roumaine de medecine interne, 2003, Volume: 41, Issue:4 Topics: Arteriosclerosis; Diabetes Mellitus, Type 2; Factor XIII; Fibrinolysis; Humans; Insulin Resistance; Leucine; Metabolic Syndrome; Polymorphism, Genetic; Valine	2003
Pregnancy, insulin resistance and nitrogen accretion. Current opinion in clinical nutrition and metabolic care, 1999, Volume: 2, Issue:5 Topics: Female; Humans; Insulin Resistance; Leucine; Nitrogen; Pregnancy; Urea	1999

Trials

16 trial(s) available for leucine and Insulin Resistance

Article	Year
Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE). Scientific reports, 2022, 03-07, Volume: 12, Issue:1 Topics: Adipose Tissue, Brown; Amino Acids, Branched-Chain; Fluorodeoxyglucose F18; Humans; Hyperthyroidism; Insulin; Insulin Resistance; Isoleucine; Leucine; Valine	2022
High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women. Clinical nutrition (Edinburgh, Scotland), 2023, Volume: 42, Issue:12 Topics: Amino Acids, Branched-Chain; Blood Glucose; Diet; Diet, High-Protein; Female; Humans; Insulin; Insulin Resistance; Leucine	2023
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. Journal of medicinal food, 2020, Volume: 23, Issue:11 Topics: AMP-Activated Protein Kinases; Animals; Humans; Insulin Resistance; Leucine; Longevity; Mice, Obese; Prediabetic State; Resveratrol; Sirtuin 1; Stilbenes	2020
Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT. Nutrients, 2020, Dec-28, Volume: 13, Issue:1 Topics: Absorptiometry, Photon; Aged; Anthropometry; Body Composition; Diabetes Mellitus, Type 2; Dietary Proteins; Double-Blind Method; Exercise; Female; Glucose Tolerance Test; Glycemic Control; Humans; Insulin Resistance; Leucine; Life Style; Male; Middle Aged; Muscle Strength; Muscles; Obesity; Overweight; Proteins; Vitamin D; Weight Loss	2020
A randomized controlled trial: branched-chain amino acid levels and glucose metabolism in patients with obesity and sleep apnea. Journal of sleep research, 2017, Volume: 26, Issue:6 Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Continuous Positive Airway Pressure; Fasting; Female; Glucose Intolerance; Glycated Hemoglobin; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Middle Aged; Obesity, Morbid; Prospective Studies; Sleep Apnea, Obstructive	2017
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial. Diabetic medicine : a journal of the British Diabetic Association, 2018, Volume: 35, Issue:7 Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine	2018
A High-Fiber Diet Decreases Postabsorptive Protein Turnover but Does Not Alter Insulin Sensitivity in Men with Type 1 Diabetes Mellitus. The Journal of nutrition, 2019, 04-01, Volume: 149, Issue:4 Topics: Adult; Diabetes Mellitus, Type 1; Dietary Fiber; Dietary Proteins; Humans; Insulin Resistance; Leucine; Male; Young Adult	2019
Leucine Supplementation Does Not Alter Insulin Sensitivity in Prefrail and Frail Older Women following a Resistance Training Protocol. The Journal of nutrition, 2019, 06-01, Volume: 149, Issue:6 Topics: Aged; Aged, 80 and over; Dietary Supplements; Double-Blind Method; Female; Frail Elderly; Frailty; Humans; Insulin Resistance; Leucine; Resistance Training	2019
Impact of short term consumption of diets high in either non-starch polysaccharides or resistant starch in comparison with moderate weight loss on indices of insulin sensitivity in subjects with metabolic syndrome. Nutrients, 2013, Jun-10, Volume: 5, Issue:6 Topics: Blood Glucose; C-Peptide; Carbohydrate Metabolism; Cross-Over Studies; Diet, Reducing; Dietary Proteins; Energy Intake; Energy Metabolism; Fasting; Homeostasis; Humans; Insulin; Insulin Resistance; Leucine; Male; Metabolic Syndrome; Models, Biological; Obesity; Polysaccharides; Starch; Weight Loss	2013
Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation. Diabetes, 2015, Volume: 64, Issue:5 Topics: Aged; Amino Acids; Blood Glucose; Dietary Proteins; Female; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Leucine; Middle Aged; Milk Proteins; Muscle, Skeletal; Signal Transduction; TOR Serine-Threonine Kinases; Whey Proteins	2015
Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin. Clinical nutrition (Edinburgh, Scotland), 2011, Volume: 30, Issue:4 Topics: Adolescent; Albumins; Amino Acids; Blood Glucose; Critical Illness; Cross-Over Studies; Female; Glucose; Homeostasis; Humans; Hyperinsulinism; Infant; Insulin; Insulin Resistance; Intensive Care Units, Pediatric; Leucine; Male; Parenteral Nutrition, Total; Sepsis	2011
The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men. Clinical nutrition (Edinburgh, Scotland), 2012, Volume: 31, Issue:6 Topics: Adolescent; Adult; Anthropometry; Body Composition; Diet; Dietary Supplements; Humans; Insulin Resistance; Leucine; Lysine; Male; Muscle Strength; Muscle, Skeletal; Nutritional Requirements; Young Adult	2012
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:8 Topics: Adult; Apolipoproteins B; Blood Glucose; Cholesterol, HDL; Cholesterol, VLDL; Deuterium; Diabetes Mellitus, Type 2; Dyslipidemias; Glycerol; Humans; Hyperglycemia; Insulin Resistance; Leucine; Male; Triglycerides	2005
Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:3 Topics: Aged; Carnitine; Double-Blind Method; Female; Glucose; Humans; Injections, Intravenous; Insulin; Insulin Resistance; Kidney Failure, Chronic; Leucine; Male; Middle Aged; Proteins; Renal Dialysis	2008
Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery. Critical care medicine, 2008, Volume: 36, Issue:6 Topics: Abdominal Neoplasms; Amino Acids; Arginine; Blood Glucose; Cancer Care Facilities; Combined Modality Therapy; Critical Care; Cross-Over Studies; Energy Metabolism; Female; Glutamine; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Middle Aged; Muscle Proteins; Muscle, Skeletal; Overweight; Parenteral Nutrition, Total; Phenylalanine; Postoperative Complications; Radiotherapy, Adjuvant	2008
A study of the metabolism of apolipoprotein B100 in relation to insulin resistance in African American males. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1999, Volume: 221, Issue:4 Topics: Adult; Apolipoprotein B-100; Apolipoproteins B; Black People; Body Mass Index; Cholesterol; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Kinetics; Leucine; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged	1999

Other Studies

102 other study(ies) available for leucine and Insulin Resistance

Article	Year
Intermittent Leucine Deprivation Produces Long-lasting Improvement in Insulin Sensitivity by Increasing Hepatic Gcn2 Expression. Diabetes, 2022, 02-01, Volume: 71, Issue:2 Topics: Animals; Cells, Cultured; Epigenesis, Genetic; Female; Gene Expression Regulation, Enzymologic; Insulin; Insulin Resistance; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Serine-Threonine Kinases; Signal Transduction	2022
Excess branched-chain amino acids alter myotube metabolism and substrate preference which is worsened by concurrent insulin resistance. Endocrine, 2022, Volume: 76, Issue:1 Topics: Amino Acids, Branched-Chain; Humans; Insulin; Insulin Resistance; Leucine; Muscle Fibers, Skeletal	2022
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle. Nutrition & diabetes, 2022, 04-13, Volume: 12, Issue:1 Topics: Amino Acids, Branched-Chain; Animals; Glucose; Insulin Resistance; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Valine	2022
Hepatic leucine carboxyl methyltransferase 1 (LCMT1) contributes to high fat diet-induced glucose intolerance through regulation of glycogen metabolism. The Journal of nutritional biochemistry, 2023, Volume: 117 Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Glucose Intolerance; Glycogen; Insulin Resistance; Leucine; Liver; Methyltransferases; Mice; Protein O-Methyltransferase	2023
Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance. Nutrients, 2023, Aug-30, Volume: 15, Issue:17 Topics: Adolescent; Adult; Amino Acids, Branched-Chain; Female; Gastrectomy; Glucose; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Leucine; Meals; Obesity; Young Adult	2023
Leucine increases mitochondrial metabolism and lipid content without altering insulin signaling in myotubes. Biochimie, 2020, Volume: 168 Topics: Animals; Cell Line; Insulin; Insulin Resistance; Leucine; Lipid Metabolism; Mitochondria; Muscle Fibers, Skeletal; Organelle Biogenesis	2020
Hypoglycaemic effect of resveratrol in streptozotocin-induced diabetic rats is impaired when supplemented in association with leucine. International journal of food sciences and nutrition, 2020, Volume: 71, Issue:5 Topics: Adipocytes; Adipose Tissue; Adipose Tissue, White; Adiposity; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Supplements; Drug Interactions; Fruit; Hypoglycemic Agents; Insulin; Insulin Resistance; Leucine; Male; Phytotherapy; Rats; Resveratrol	2020
Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery. Gut, 2020, Volume: 69, Issue:8 Topics: 3-Hydroxybutyric Acid; Adult; Amino Acids; Birth Weight; Body Mass Index; Clostridiales; Creatinine; Cresols; Enterococcus; Escherichia; Feces; Female; Fetal Development; Gastric Bypass; Gastrointestinal Microbiome; Gastroplasty; Glutamine; Hemiterpenes; Humans; Indican; Infant, Newborn; Insulin Resistance; Isobutyrates; Isoleucine; Keto Acids; Leucine; Metabolomics; Micrococcaceae; Phenotype; Phenylacetates; Pregnancy; Streptococcus; Sulfuric Acid Esters; Young Adult	2020
Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice. Food & function, 2020, Mar-26, Volume: 11, Issue:3 Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cecum; Diet, High-Fat; Insulin Resistance; Isoleucine; Leucine; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Obese	2020
β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American journal of physiology. Endocrinology and metabolism, 2020, 10-01, Volume: 319, Issue:4 Topics: Animals; Glucose; Glucose Intolerance; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Leucine; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Nutrients; Protein Processing, Post-Translational; Sirtuins	2020
Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes-Related Metabolic Disturbances. The Journal of clinical endocrinology and metabolism, 2021, 03-25, Volume: 106, Issue:4 Topics: Adult; Aged; Amino Acids, Branched-Chain; Case-Control Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Leucine; Male; Metabolic Diseases; Middle Aged; Mitochondria; Oxidation-Reduction	2021
Differences in gene expression of enzymes involved in branched-chain amino acid metabolism of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS. Taiwanese journal of obstetrics & gynecology, 2021, Volume: 60, Issue:2 Topics: Adult; Amino Acids, Branched-Chain; Body Mass Index; Female; Gene Expression; Humans; Insulin Resistance; Isoleucine; Leucine; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Subcutaneous Fat, Abdominal; Valine	2021
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging. American journal of physiology. Cell physiology, 2021, 07-01, Volume: 321, Issue:1 Topics: Adult; Aged; Aging; Animals; C-Reactive Protein; Cell Line; Culture Media; Humans; Insulin Resistance; Interleukin-6; Leucine; Male; Mice; Models, Biological; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Peptide Elongation Factor 2; Protein Biosynthesis; Proteolysis; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction	2021
Different Effects of Leucine Supplementation and/or Exercise on Systemic Insulin Sensitivity in Mice. Frontiers in endocrinology, 2021, Volume: 12 Topics: Adiponectin; Adipose Tissue; Adiposity; AMP-Activated Protein Kinases; Animals; Diet, Fat-Restricted; Diet, High-Fat; Dietary Supplements; Dyslipidemias; Glucose Tolerance Test; Inflammation; Insulin; Insulin Resistance; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Physical Conditioning, Animal	2021
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell metabolism, 2017, Apr-04, Volume: 25, Issue:4 Topics: Amidohydrolases; Amino Acid Sequence; Animals; Carbon-Carbon Ligases; Glucose; HEK293 Cells; Homeostasis; Humans; Insulin; Insulin Resistance; Insulin Secretion; Leucine; Lysine; Metabolic Flux Analysis; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Models, Molecular; Phylogeny; Sirtuins	2017
Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes. Biological trace element research, 2017, Volume: 180, Issue:2 Topics: Animals; Blood Glucose; Chromium; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dietary Supplements; Glyburide; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Leucine; Lipids; Male; Random Allocation; Rats, Wistar; Streptozocin; Zinc	2017
Leucine Supplementation Differently Modulates Branched-Chain Amino Acid Catabolism, Mitochondrial Function and Metabolic Profiles at the Different Stage of Insulin Resistance in Rats on High-Fat Diet. Nutrients, 2017, Jun-02, Volume: 9, Issue:6 Topics: Amino Acids, Branched-Chain; Animals; Caloric Restriction; Diet, High-Fat; Dietary Supplements; Hyperglycemia; Insulin Resistance; Leucine; Lipid Metabolism; Male; Mitochondria; Muscle, Skeletal; Rats; Rats, Sprague-Dawley	2017
Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake. American journal of physiology. Heart and circulatory physiology, 2017, Aug-01, Volume: 313, Issue:2 Topics: Acetylation; Animals; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Energy Metabolism; Glucose; Glucose Transporter Type 4; Insulin Resistance; Isolated Heart Preparation; Keto Acids; Ketone Bodies; Leucine; Male; Myocytes, Cardiac; Protein Transport; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Time Factors; TOR Serine-Threonine Kinases	2017
Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. Journal of inherited metabolic disease, 2018, Volume: 41, Issue:1 Topics: Age Factors; Animals; Biomarkers; Blood Glucose; Female; Genetic Predisposition to Disease; In Vitro Techniques; Insulin; Insulin Resistance; Leucine; Lipid Metabolism; Lysine; Male; Metabolism, Inborn Errors; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Phenotype; Protein Processing, Post-Translational; Sirtuins; Up-Regulation	2018
Leucine and resistance training improve hyperglycemia, white adipose tissue loss, and inflammatory parameters in an experimental model of type 1 diabetes. Nutrition and health, 2018, Volume: 24, Issue:1 Topics: Adiponectin; Adipose Tissue, White; Adiposity; Animals; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therapy; Diabetes Mellitus, Type 1; Dietary Supplements; Gene Expression Regulation; Hyperglycemia; Inflammation Mediators; Insulin Resistance; Intra-Abdominal Fat; Leptin; Leucine; Male; Random Allocation; Rats, Wistar; Resistance Training; Weight Loss	2018
Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men. The American journal of clinical nutrition, 2018, 12-01, Volume: 108, Issue:6 Topics: Adult; Amino Acids, Branched-Chain; Asian People; Blood Glucose; Carbon Isotopes; Fatty Acids, Nonesterified; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Leucine; Male; Oxidation-Reduction; Palmitic Acid	2018
Leucine, Palmitate, or Leucine/Palmitate Cotreatment Enhances Myotube Lipid Content and Oxidative Preference. Lipids, 2018, Volume: 53, Issue:11-12 Topics: Amino Acids, Branched-Chain; Animals; Cell Line; Cell Survival; Dietary Fats; Insulin Resistance; Leucine; Mice; Muscle Fibers, Skeletal; Oxidation-Reduction; Palmitates; Real-Time Polymerase Chain Reaction	2018
Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes. Diabetes, obesity & metabolism, 2019, Volume: 21, Issue:5 Topics: Adolescent; Age of Onset; Amino Acid Substitution; Animals; Arginine; Child; Chlorocebus aethiops; Cohort Studies; COS Cells; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genome-Wide Association Study; Germany; Homozygote; Humans; Insulin Resistance; Leucine; Male; Pediatric Obesity; Polymorphism, Single Nucleotide; Receptors, Gastrointestinal Hormone	2019
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men. Diabetes, 2019, Volume: 68, Issue:6 Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine	2019
Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues. Molecular nutrition & food research, 2013, Volume: 57, Issue:6 Topics: Adipose Tissue; Animals; Body Weight; Cytokines; Diet, High-Fat; Dietary Supplements; Energy Intake; Gluconeogenesis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leucine; Liver; Male; Muscle, Skeletal; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Tyrosine	2013
Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes, 2013, Volume: 62, Issue:10 Topics: Adipose Tissue, White; Animals; Biomarkers; Blotting, Western; Diet; Down-Regulation; Eating; Energy Metabolism; Fatty Acids; Gene Expression; Insulin Resistance; Leucine; Lipid Metabolism; Liver; Male; Methionine; Mitochondria; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction	2013
Leucine supplementation protects from insulin resistance by regulating adiposity levels. PloS one, 2013, Volume: 8, Issue:9 Topics: Adiposity; Animals; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Fatty Acids; Glucose; Homeostasis; Insulin; Insulin Resistance; Leucine; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Oxidation-Reduction; Phenotype; Weight Gain	2013
The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PloS one, 2014, Volume: 9, Issue:2 Topics: Animals; Blotting, Western; Cells, Cultured; Dietary Proteins; Glucose Tolerance Test; Insulin; Insulin Resistance; Integrases; Large Neutral Amino Acid-Transporter 1; Leucine; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Phosphorylation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases	2014
Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2. Amino acids, 2014, Volume: 46, Issue:8 Topics: Androstadienes; Animals; Biological Transport; Carrier Proteins; Cells, Cultured; Glucose; Insulin; Insulin Antagonists; Insulin Resistance; Leucine; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rapamycin-Insensitive Companion of mTOR Protein; Rats; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin	2014
Effects of whey protein and leucine supplementation on insulin resistance in non-obese insulin-resistant model rats. Nutrition (Burbank, Los Angeles County, Calif.), 2014, Volume: 30, Issue:9 Topics: Animals; Antioxidants; Area Under Curve; Blood Glucose; Cholesterol, HDL; Dietary Supplements; Disease Models, Animal; Fasting; Glucose Tolerance Test; Glutathione; Insulin; Insulin Resistance; Leucine; Male; Malondialdehyde; Milk Proteins; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Whey Proteins	2014
Preoperative oral carbohydrate improved postoperative insulin resistance in rats through the PI3K/AKT/mTOR pathway. Medical science monitor : international medical journal of experimental and clinical research, 2015, Jan-01, Volume: 21 Topics: Animals; Blood Glucose; Blotting, Western; Dietary Carbohydrates; Digestive System Surgical Procedures; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intestine, Small; Leucine; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Postoperative Period; Preoperative Care; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; TOR Serine-Threonine Kinases	2015
Effect of 10% dietary protein intake on whole body protein kinetics in type 2 diabetic adults. Clinical nutrition (Edinburgh, Scotland), 2015, Volume: 34, Issue:6 Topics: Amino Acids; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Diet, Protein-Restricted; Dietary Proteins; Energy Intake; Female; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Male; Mental Recall; Middle Aged; Obesity; Sex Factors; Waist Circumference	2015
Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats. Surgery, 2015, Volume: 157, Issue:6 Topics: Analysis of Variance; Animals; Apelin; Binding Sites; Burns; Carrier Proteins; Cytokines; Cytoskeletal Proteins; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glucose Tolerance Test; Inflammasomes; Injury Severity Score; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Leucine; Male; NG-Nitroarginine Methyl Ester; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrin; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate	2015
Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. Metabolism: clinical and experimental, 2015, Volume: 64, Issue:7 Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Fasting; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Metformin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Signal Transduction; Sirtuin 1	2015
Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. Diabetes 2015;64:1555-1563. Diabetes, 2015, Volume: 64, Issue:6 Topics: Dietary Proteins; Female; Humans; Insulin Resistance; Leucine; Milk Proteins; Muscle, Skeletal; TOR Serine-Threonine Kinases	2015
Response to Comment on Smith et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. Diabetes 2015;64:1555-1563. Diabetes, 2015, Volume: 64, Issue:6 Topics: Dietary Proteins; Female; Humans; Insulin Resistance; Leucine; Milk Proteins; Muscle, Skeletal; TOR Serine-Threonine Kinases	2015
A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:1 Topics: Animals; Cells, Cultured; HEK293 Cells; Hep G2 Cells; Humans; Insulin; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Leucine; Liver; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Receptors, Leptin; Receptors, Retinoic Acid; Second Messenger Systems	2016
Biocompounds Attenuating the Development of Obesity and Insulin Resistance Produced by a High-fat Sucrose Diet. Natural product communications, 2015, Volume: 10, Issue:8 Topics: Animals; Blood Glucose; Chlorogenic Acid; Coumaric Acids; Curcumin; Diet, High-Fat; Dietary Fats; Dietary Supplements; Flavanones; Humans; Insulin Resistance; Leucine; Male; Obesity; Rats; Rats, Wistar; Sucrose	2015
Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner. American journal of physiology. Cell physiology, 2016, 09-01, Volume: 311, Issue:3 Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Glucose; Insulin; Insulin Resistance; Keto Acids; Leucine; Mechanistic Target of Rapamycin Complex 1; Membrane Transport Proteins; Mitochondrial Proteins; Monocarboxylic Acid Transporters; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle, Skeletal; Rats; TOR Serine-Threonine Kinases; Transaminases	2016
Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs. Pediatric research, 2016, Volume: 80, Issue:5 Topics: Amino Acids, Branched-Chain; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Glucose; Glucose Clamp Technique; Insulin; Insulin Resistance; Leucine; Muscle, Skeletal; Peritonitis; Phosphorylation; Signal Transduction; Sirtuin 1; Sus scrofa; Swine; Transcription Factors	2016
A stable isotope method for in vivo assessment of human insulin synthesis and secretion. Acta diabetologica, 2016, Volume: 53, Issue:6 Topics: Adult; Blood Glucose; C-Peptide; Chromatography, Affinity; Feasibility Studies; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Isotope Labeling; Leucine; Male; Reproducibility of Results	2016
Tryptophan Predicts the Risk for Future Type 2 Diabetes. PloS one, 2016, Volume: 11, Issue:9 Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine	2016
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation. Free radical biology & medicine, 2017, Volume: 104 Topics: Amino Acids, Branched-Chain; Cell Movement; Humans; Inflammation; Insulin Resistance; Interleukin-6; Isoleucine; Leucine; Leukocytes, Mononuclear; Mechanistic Target of Rapamycin Complex 1; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Valine	2017
Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients. Journal of cachexia, sarcopenia and muscle, 2017, Volume: 8, Issue:3 Topics: Adult; Biomarkers; Blood Glucose; Body Composition; Female; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Muscle, Skeletal; Organ Specificity; Renal Dialysis; Skin; Sodium	2017
Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. The American journal of clinical nutrition, 2008, Volume: 87, Issue:6 Topics: Adipose Tissue; Adult; Aged; Amino Acid Substitution; Body Size; Cohort Studies; DNA Primers; Female; Gene Frequency; Genetic Variation; Genotype; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Insulin Resistance; Japan; Leucine; Longevity; Longitudinal Studies; Male; Metabolic Syndrome; Middle Aged; Polymorphism, Single Nucleotide; Proline; Sex Characteristics	2008
The hyperenergetic-fed obese dog, a model of disturbance of apolipoprotein B-100 metabolism associated with insulin resistance: kinetic study using stable isotopes. Metabolism: clinical and experimental, 2008, Volume: 57, Issue:7 Topics: Animals; Apolipoprotein B-100; Blood Glucose; Cholesterol; Diet; Dogs; Energy Intake; Gas Chromatography-Mass Spectrometry; Insulin; Insulin Resistance; Kinetics; Leucine; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity	2008
Glucose and leucine metabolism in lung tranplanted patients on low dose of steroids for immunosuppressive therapy. Transplantation proceedings, 2008, Volume: 40, Issue:5 Topics: Adult; Aged; Azathioprine; Blood Glucose; Cyclosporine; Fatty Acids, Nonesterified; Female; Glucocorticoids; Hormones; Humans; Immunosuppressive Agents; Insulin Resistance; Leucine; Lung Transplantation; Male; Middle Aged; Prednisone; Tacrolimus	2008
Insulin resistance to both glucose and aminoacid metabolism in a patient with Fatal Familial Insomnia. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2008, Volume: 18, Issue:9 Topics: Glucose; Humans; Insomnia, Fatal Familial; Insulin Resistance; Leucine; Male; Middle Aged	2008
Changes in basal and insulin and amino acid response of whole body and skeletal muscle proteins in obese men. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:8 Topics: Adult; Amino Acids; Body Composition; Fatty Acids, Nonesterified; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Obesity	2009
The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2010, Volume: 26, Issue:9 Topics: Adult; Amino Acid Substitution; Aryldialkylphosphatase; Case-Control Studies; Chronic Disease; Female; Glucose Tolerance Test; Humans; Inflammation; Insulin Resistance; Leucine; Methionine; Polycystic Ovary Syndrome; Polymorphism, Single Nucleotide; Testosterone; Young Adult	2010
Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells. Molecular nutrition & food research, 2010, Volume: 54, Issue:11 Topics: Glutamine; Hep G2 Cells; Humans; Insulin; Insulin Resistance; Interleukin-1beta; Interleukin-8; Leucine; Models, Biological; NF-kappa B; Phosphorylation; Proline; Proto-Oncogene Proteins c-akt; Signal Transduction; Tumor Necrosis Factor-alpha	2010
Leucine supplementation in rats induced a delay in muscle IR/PI3K signaling pathway associated with overall impaired glucose tolerance. The Journal of nutritional biochemistry, 2011, Volume: 22, Issue:3 Topics: Adipose Tissue; Animals; Dietary Supplements; Glucose; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leucine; Linear Models; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Rats; Rats, Wistar; Receptor, Insulin; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2011
Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes, 2010, Volume: 59, Issue:10 Topics: Adenylate Kinase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Dose-Response Relationship, Drug; Down-Regulation; Glucose; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Kinetics; Lactates; Leucine; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvates; Rats; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases	2010
Protein anabolic responses to a fed steady state in healthy aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Volume: 66, Issue:6 Topics: Adult; Aged; Aging; Exercise; Female; Glucose; Humans; Insulin Resistance; Leucine; Muscle Proteins; Phosphorylation; Proteins; Sarcopenia	2011
Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach. Age (Dordrecht, Netherlands), 2012, Volume: 34, Issue:2 Topics: Adipose Tissue; Aging; Animals; Biological Transport; Blotting, Western; Dietary Supplements; Disease Models, Animal; Follow-Up Studies; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Muscle, Skeletal; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA; Sarcopenia; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases	2012
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism. PloS one, 2011, Volume: 6, Issue:6 Topics: Adenylate Kinase; Adipose Tissue; Adiposity; Animals; Body Weight; Diet; Dietary Fats; Dietary Supplements; Fatty Liver; Feeding Behavior; Glucose Tolerance Test; Inflammation; Insulin; Insulin Resistance; Leucine; Liver; Metabolomics; Mice; Muscles; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction	2011
Effects of leucine supplementation and resistance exercise on dexamethasone-induced muscle atrophy and insulin resistance in rats. Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:4 Topics: Animals; Blood Glucose; Dexamethasone; Dietary Supplements; Glucose Transporter Type 4; Hyperglycemia; Insulin Resistance; Leucine; Male; Movement; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Wistar; Resistance Training; Ribosomal Protein S6 Kinases, 70-kDa	2012
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatric obesity, 2013, Volume: 8, Issue:1 Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine	2013
Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. American journal of physiology. Endocrinology and metabolism, 2012, Nov-15, Volume: 303, Issue:10 Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Cell Cycle Proteins; Cytokines; Dietary Supplements; DNA, Mitochondrial; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Glucose Clamp Technique; Insulin Resistance; Leucine; Male; Mice; Mice, Inbred C57BL; Mitochondrial Turnover; Nicotinamide Phosphoribosyltransferase; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Sirtuin 1; Trans-Activators; Transcription Factors	2012
The possible role of leucine in modulating glucose homeostasis under distinct catabolic conditions. Medical hypotheses, 2012, Volume: 79, Issue:6 Topics: Dexamethasone; Dietary Proteins; Glucose; Homeostasis; Humans; Insulin Resistance; Leucine; Models, Theoretical	2012
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults. Diabetes care, 2013, Volume: 36, Issue:3 Topics: Adult; Amino Acids; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Phenylalanine; Tyrosine; Valine; Young Adult	2013
Insulin resistance and protein metabolism in chronic hemodialysis patients. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2013, Volume: 23, Issue:3 Topics: Adult; Aged; Amino Acids; Black or African American; Blood Glucose; Body Composition; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Male; Middle Aged; Proteins; Renal Dialysis; Sarcopenia; Sensitivity and Specificity	2013
Age attenuates leucine oxidation after eccentric exercise. International journal of sports medicine, 2013, Volume: 34, Issue:8 Topics: Age Factors; Aged; Aging; Exercise; Exercise Test; Glucose Clamp Technique; Humans; Hyperglycemia; Insulin Resistance; Leucine; Male; Middle Aged; Oxidation-Reduction; Time Factors; Young Adult	2013
Dietary leucine improves whole-body insulin sensitivity independent of body fat in diet-induced obese Sprague-Dawley rats. The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:7 Topics: Adipose Tissue; Animals; Dairy Products; Diet; Gene Expression; Insulin Resistance; Leucine; Liver; Muscle, Skeletal; Obesity; Rats; Rats, Sprague-Dawley	2013
Dose and latency effects of leucine supplementation in modulating glucose homeostasis: opposite effects in healthy and glucocorticoid-induced insulin-resistance states. Nutrients, 2012, Nov-27, Volume: 4, Issue:12 Topics: Animals; Blood Glucose; Dexamethasone; Dietary Supplements; Dose-Response Relationship, Drug; Drug Administration Routes; Glucocorticoids; Homeostasis; Insulin; Insulin Resistance; Leucine; Male; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar	2012
High-density lipoprotein apolipoprotein A-I kinetics in obese insulin resistant patients. An in vivo stable isotope study. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2002, Volume: 26, Issue:9 Topics: Adult; Apolipoprotein A-I; Female; Gas Chromatography-Mass Spectrometry; Humans; Insulin Resistance; Isotopes; Kinetics; Leucine; Lipoproteins, HDL; Models, Statistical; Obesity; Time Factors	2002
Early kinetic abnormalities of apoB-containing lipoproteins in insulin-resistant women with abdominal obesity. Arteriosclerosis, thrombosis, and vascular biology, 2002, Oct-01, Volume: 22, Issue:10 Topics: Abdomen; Adult; Apolipoproteins B; Body Mass Index; Carbon Isotopes; Fasting; Female; Humans; Injections, Intravenous; Insulin Resistance; Kinetics; Leucine; Lipids; Lipoproteins; Lipoproteins, IDL; Lipoproteins, LDL; Lipoproteins, VLDL; Obesity; Triglycerides	2002
Insulin action on protein metabolism in acromegalic patients. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:4 Topics: Acromegaly; Adult; Amino Acids; Body Composition; Female; Glucose; Glutamine; Human Growth Hormone; Humans; Insulin; Insulin Resistance; Keto Acids; Leucine; Male; Middle Aged; Proteins	2003
LIPOATROPHIC DIABETES. I. STUDIES CONCERNING ENDOCRINE FUNCTION AND CARBOHYDRATE METABOLISM. American journal of diseases of children (1960), 1965, Volume: 109 Topics: Adolescent; Carbohydrate Metabolism; Diabetes Mellitus, Lipoatrophic; Diabetes Mellitus, Type 1; Drug Tolerance; Epinephrine; Fatty Acids; Glucagon; Glucose Tolerance Test; Hepatomegaly; Humans; Infant; Insulin; Insulin Resistance; L-Lactate Dehydrogenase; Leucine; Lipids; Lipodystrophy; Liver; Liver Cirrhosis; Liver Function Tests; Metyrapone; Pharmacology; Pituitary-Adrenal Function Tests; Radiography; Tolbutamide; Transaminases; Urine	1965
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2004, Volume: 112, Issue:2 Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Homozygote; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Mutation; Nuclear Proteins; Proline; Serine; Transcription Factors	2004
The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism. Diabetes, 2006, Volume: 55, Issue:3 Topics: Adult; Female; Gluconeogenesis; Glucose; Glycogenolysis; Humans; Insulin Resistance; Leucine; Liver; Male; Obesity; Proteins	2006
Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:2 Topics: Adiposity; Adult; Aged; Aging; Female; Humans; Insulin; Insulin Resistance; Leucine; Male; Protein Biosynthesis; Proteins	2006
Whole-body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes, 2006, Volume: 55, Issue:10 Topics: Adult; Anti-Retroviral Agents; Blood Glucose; Female; Glucose Intolerance; HIV Infections; Humans; Insulin Resistance; Leucine; Male; Middle Aged; Proteins	2006
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia, 2006, Volume: 49, Issue:12 Topics: Animals; Blood Glucose; Dietary Fats; DNA, Mitochondrial; Electron Transport Complex IV; Fatty Acids; Fatty Liver; Insulin; Insulin Resistance; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Ribosomal Proteins; TOR Serine-Threonine Kinases	2006
PARL Leu262Val is not associated with fasting insulin levels in UK populations. Diabetologia, 2006, Volume: 49, Issue:11 Topics: Aged; Amino Acid Substitution; Body Mass Index; Cohort Studies; Fasting; Genotype; Humans; Insulin; Insulin Resistance; Leucine; Male; Metalloproteases; Middle Aged; Mitochondrial Proteins; Models, Genetic; United Kingdom; Valine	2006
Growth hormone treatment in adolescent males with idiopathic short stature: changes in body composition, protein, fat, and glucose metabolism. The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:8 Topics: Absorptiometry, Photon; Adipose Tissue; Adolescent; Body Composition; Body Height; Calorimetry, Indirect; Child; Fats; Glucose; Glycerol; Growth Hormone; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Leucine; Liver; Male; Proteins	2007
Insulin resistance of protein metabolism in type 2 diabetes. Diabetes, 2008, Volume: 57, Issue:1 Topics: Adult; Amino Acids; Blood Chemical Analysis; Body Mass Index; Diabetes Mellitus, Type 2; Female; Follicular Phase; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Male; Middle Aged; Proteins; Reference Values	2008
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor. The Journal of biological chemistry, 1995, Oct-20, Volume: 270, Issue:42 Topics: 3T3 Cells; Adipocytes; Animals; Female; Glycogen; Insulin; Insulin Resistance; Leucine; Mice; Obesity; Peptide Fragments; Phosphorylation; Rats; Rats, Zucker; Receptor, Insulin; Triglycerides	1995
A 3-basepair in-frame deletion (delta Leu999) in exon 17 of the insulin receptor gene in a family with insulin resistance. The Journal of clinical endocrinology and metabolism, 1994, Volume: 79, Issue:6 Topics: Acanthosis Nigricans; Adolescent; Adult; Base Sequence; Cell Line, Transformed; Child; Exons; Female; Gene Deletion; Glucose Tolerance Test; Herpesvirus 4, Human; Humans; Insulin; Insulin Resistance; Japan; Leucine; Lymphocytes; Male; Molecular Sequence Data; Phosphorylation; Receptor, Insulin; Transfection	1994
Leu 193 mutation in the cysteine rich region of the insulin receptor inhibits the cleavage of the insulin receptor precursor but not insulin binding. Biochemical and biophysical research communications, 1994, Sep-15, Volume: 203, Issue:2 Topics: Animals; Base Sequence; Blotting, Western; Cell Line; Cysteine; Fibroblasts; Gene Expression; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Precursors; Rats; Receptor, Insulin; Structure-Activity Relationship; Transfection	1994
A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. The New England journal of medicine, 1994, Apr-07, Volume: 330, Issue:14 Topics: Adolescent; Adult; Aged; Base Sequence; Child; Child, Preschool; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Female; Humans; Insulin Resistance; Leucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree	1994
Differential effect of insulin on whole-body proteolysis and glucose metabolism in normal-weight, obese, and reduced-obese women. Metabolism: clinical and experimental, 1994, Volume: 43, Issue:4 Topics: Adult; Blood Glucose; Body Composition; Body Weight; Female; Humans; Hydrolysis; Insulin; Insulin Resistance; Kinetics; Leucine; Middle Aged; Obesity; Proteins; Weight Loss	1994
A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance. Diabetologia, 1993, Volume: 36, Issue:5 Topics: Adult; Alleles; Amino Acid Sequence; Aminoisobutyric Acids; Base Sequence; Biological Transport; Blood Glucose; Cell Division; Cell Line, Transformed; Cells, Cultured; Consanguinity; DNA; Exons; Female; Fibroblasts; Herpesvirus 4, Human; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Leucine; Lymphocytes; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Pedigree; Point Mutation; Protein-Tyrosine Kinases; Receptor, Insulin; Reference Values; Syndrome; Thymidine; Tryptophan	1993
Leucine and phenylalanine kinetics in compensated liver cirrhosis: effects of insulin. Gastroenterology, 1993, Volume: 104, Issue:6 Topics: Adult; Humans; Insulin; Insulin Resistance; Leucine; Liver Cirrhosis; Male; Middle Aged; Phenylalanine	1993
Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects. The Journal of biological chemistry, 1997, Nov-28, Volume: 272, Issue:48 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; CHO Cells; Cricetinae; Enzyme Activation; Female; Glutamine; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leucine; Mutation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Proteins; Receptor, Insulin; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Structure-Activity Relationship	1997
Proteolysis associated with insulin resistance in cystic fibrosis. Pediatrics, 1998, Volume: 101, Issue:3 Pt 1 Topics: Adolescent; Adult; Case-Control Studies; Cystic Fibrosis; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Insulin Resistance; Leucine; Male; Proteins	1998
Increased leucine turnover and insulin resistance in men with advanced HIV infection. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1999, Volume: 47, Issue:8 Topics: Adult; Body Mass Index; Energy Metabolism; Glucose; HIV; HIV Infections; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Leucine; Liver; Male; RNA, Viral; Viral Load	1999
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Molecular cell, 2001, Volume: 8, Issue:4 Topics: Adipocytes; Amino Acids; Animals; Binding Sites; Blood Glucose; Body Weight; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Fluorenes; Gene Expression Regulation; Genes, Reporter; Hypoglycemic Agents; Insulin Resistance; Leucine; Ligands; Male; Mice; Mice, Inbred Strains; Molecular Structure; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Spectrometry, Mass, Electrospray Ionization; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tyrosine	2001
Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease. Journal of endocrinological investigation, 2002, Volume: 25, Issue:2 Topics: Adult; Alanine; Amino Acids; Blood Glucose; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Creatinine; Cushing Syndrome; Cystine; Cystinuria; Fasting; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Insulin Resistance; Isoleucine; Kidney; Leucine; Male; Middle Aged; Valine	2002
Carbohydrate metabolism and insulin resistance in myotonia dystrophica. The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:3 Topics: Adult; Aged; Arginine; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Galactose; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Leucine; Male; Middle Aged; Myotonic Dystrophy; Sorbitol; Tolbutamide; Xylose	1977
Increased protein turnover in obese women. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:9 Topics: Abdomen; Adult; Body Mass Index; Body Weight; Female; Glucose Tolerance Test; Hip; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Resistance; Leucine; Magnetic Resonance Imaging; Middle Aged; Obesity; Proteins	1992
A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface. Biochemistry, 1991, Nov-05, Volume: 30, Issue:44 Topics: Animals; Biological Transport; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Gene Expression; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Kinetics; Leucine; Mutation; Phosphorylation; Proline; Protein Precursors; Receptor, Insulin; Transfection	1991
Influence of glucagon on protein and leucine metabolism: a study in fasting man with induced insulin resistance. The British journal of surgery, 1990, Volume: 77, Issue:7 Topics: Adult; Fasting; Female; Forearm; Glucagon; Humans; Insulin Resistance; Leucine; Male; Muscles; Proteins; Somatostatin	1990
Differential effects of insulin resistance on leucine and glucose kinetics in obesity. Metabolism: clinical and experimental, 1991, Volume: 40, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Carbon Isotopes; Female; Glucose; Humans; Hyperinsulinism; Insulin Resistance; Kinetics; Leucine; Obesity	1991
A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance. The EMBO journal, 1989, Volume: 8, Issue:9 Topics: Cells, Cultured; Cloning, Molecular; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; Fibroblasts; Genotype; Humans; Insulin Resistance; Leucine; Male; Mutation; Pedigree; Proline; Radioligand Assay; Receptor, Insulin	1989
Contribution of insulin resistance to catabolic effect of prednisone on leucine metabolism in humans. Diabetes, 1989, Volume: 38, Issue:10 Topics: Adult; Basal Metabolism; Glucagon; Glucose; Growth Hormone; Humans; Insulin; Insulin Infusion Systems; Insulin Resistance; Kinetics; Leucine; Models, Theoretical; Oxidation-Reduction; Prednisone; Reference Values; Somatostatin	1989
Leucine kinetics and the effects of hyperinsulinemia in patients with Cushing's syndrome. The Journal of clinical endocrinology and metabolism, 1989, Volume: 68, Issue:2 Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Cushing Syndrome; Female; Humans; Insulin; Insulin Resistance; Keto Acids; Kinetics; Leucine; Male; Middle Aged	1989
Sex-specific differences in plasma branched-chain keto acid levels in obesity. The American journal of clinical nutrition, 1987, Volume: 46, Issue:1 Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine	1987
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes. The Journal of clinical investigation, 1987, Volume: 80, Issue:4 Topics: Adipose Tissue; Adult; Binding, Competitive; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Insulin; Insulin Resistance; Leucine; Male; Obesity	1987
Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. The Journal of clinical investigation, 1986, Volume: 77, Issue:6 Topics: Adult; Amino Acids; Blood Glucose; Carbon; Diabetes Mellitus, Type 1; Humans; Insulin; Insulin Resistance; Keto Acids; Leucine; Male; Oxidation-Reduction	1986
Chronic tissue insulin resistance following hemorrhagic shock. Annals of surgery, 1974, Volume: 180, Issue:4 Topics: Adipose Tissue; Amino Acids; Animals; Carbon Dioxide; Carbon Radioisotopes; Female; Glucose; Insulin; Insulin Resistance; Leucine; Male; Muscles; Rabbits; Shock, Hemorrhagic; Time Factors	1974
Plasma amino acid levels and insulin secretion in obesity. The New England journal of medicine, 1969, Oct-09, Volume: 281, Issue:15 Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine	1969