serine has been researched along with Insulin Resistance in 161 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we quantitated kaempferol in water extract from Cudrania tricuspidata leaves (CTL) and investigated its effects on endoplasmic reticulum (ER) stress-induced inflammation and insulin resistance in HepG2 cells." | 7.83 | Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells. ( Jun, W; Kim, OK; Lee, J, 2016) |
| " To test whether resveratrol, a polyphenol found in red wine, prevents FFA-induced insulin resistance, we used a hyperinsulinemic-euglycemic clamp with a tracer to assess hepatic and peripheral insulin sensitivity in overnight-fasted Wistar rats infused for 7 h with saline, Intralipid plus 20 U·mL(-1) heparin (IH; triglyceride emulsion that elevates FFA levels in vivo; 5." | 7.81 | Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo. ( Breen, DM; Faubert, B; Giacca, A; Kwan, D; Moore, J; Nahle, A; Oprescu, AI; Park, E; Pereira, S; Tsiani, E, 2015) |
| "5 cells either infected with HCV or ectopically expressing HCV NS5A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue (Ser(307)) followed by decreased phosphorylation of Akt Thr(308), Fox01 Ser(256) and GSK3β Ser(9), the downstream players of the insulin signaling pathway." | 7.81 | Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. ( Imran, M; Iqbal, J; Manzoor, S; Parvaiz, F; Sarkar-Dutta, M; Waris, G, 2015) |
| "Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and insulin resistance by transactivation of ErbB receptors." | 7.77 | p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. ( Barhod, E; Hemi, R; Kanety, H; Karasik, A; Kasher-Meron, M; Tirosh, A; Yochananov, Y, 2011) |
| "Phosphorylation of the insulin receptor substrates (Irs) on serine residues-typified by Ser307 of rodent Irs1-is thought to mediate insulin resistance." | 7.76 | Irs1 serine 307 promotes insulin sensitivity in mice. ( Copps, KD; Hancer, NJ; Opare-Ado, L; Qiu, W; Walsh, C; White, MF, 2010) |
| "Phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues has been recognized as a mechanism responsible for a diminution of insulin action and insulin resistance." | 7.75 | Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of pho ( Adochio, R; Draznin, B; Hedlund, R; Leitner, JW, 2009) |
| "To investigate the effects and molecular mechanisms of berberine on improving insulin resistance induced by free fatty acids (FFAs) in 3T3-L1 adipocytes." | 7.74 | Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. ( Chen, G; Dong, H; Lu, FE; Wang, KF; Xu, LJ; Yi, P, 2008) |
| "To investigate the effects of insulin receptor substrate (IRS)-1 and its serine (Ser)(307) phosphorylation and tyrosine (Tyr) phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis." | 7.73 | [Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats]. ( Li, JS; Li, N; Li, WQ; Wang, XD; Yan, XW, 2006) |
| "Obesity, a state of apparent "leptin resistance" is well known to be associated with insulin resistance." | 7.73 | Hepatic leptin signaling in obesity. ( Anderwald, C; Brabant, G; Horn, R; Müller, G; Nave, H; Roden, M, 2005) |
| "In an attempt to probe the effect of beta-endorphin on insulin resistance, we used Wistar rats that were fed fructose-rich chow to induce insulin resistance." | 7.72 | Infusion of beta-endorphin improves insulin resistance in fructose-fed rats. ( Chang, YY; Cheng, JT; Liu, IM; Lo, CY; Pai, HH; Su, CF, 2004) |
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 7.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| "Obesity is associated with the development of leptin resistance." | 7.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "Insulin resistance is characterized by a decrease in the insulin effect on glucose transport in muscle and adipose tissue." | 6.42 | Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. ( Barrès, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF, 2003) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide." | 5.91 | Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation. ( Dehury, B; Dogra, S; Jaswal, K; Mondal, P; Rawat, P; Thakur, S, 2023) |
| " Here, chronic administration of sulpiride (80 mg/kg, subcutaneously, once daily for 6 weeks) elevated fasting insulin concentration and the index of the homeostasis model assessment of insulin resistance in rats." | 5.48 | The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance. ( Huang, X; Li, Y; Ren, L; Wang, C; Yu, Z; Zhou, X, 2018) |
| "Insulin resistance is a critical component of T2DM pathogenesis." | 5.35 | Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. ( Ait-Goughoulte, M; Banerjee, S; Meyer, K; Ray, R; Ray, RB; Saito, K, 2008) |
| "Insulin resistance is a hallmark of late pregnancy both in human and rat." | 5.34 | Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy. ( Bocos, C; de Castro, J; Herrera, E; Ramos, MP; Sevillano, J, 2007) |
| "Preeclampsia is a severe complication of human pregnancy often associated with maternal risk factors." | 5.33 | Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2. ( Gumaa, K; Kunjara, S; Paine, MA; Rademacher, TW; Rodeck, CH; Scioscia, M; Selvaggi, LE, 2006) |
| "Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease." | 5.33 | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. ( Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P, 2005) |
| "Salicylic acid pretreatment completely reversed the effects of PMA and TNFalpha on both Akt and IRS1." | 5.32 | Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. ( Dallas-Yang, Q; Jiang, G; Liu, F; Moller, DE; Zhang, BB, 2003) |
| "Insulin resistance is defined as the decrease in the glucose disposal in response to insulin by the target tissues." | 5.32 | High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. ( Calderón, V; Reynoso, R; Salgado, LM, 2003) |
| "CR induces lipid insufficiency and stress, resulting in global physiological insulin resistance except muscle and enhances glycogen metabolism, culminating in the stability of blood glucose manifests in increased FBG, which compensates for insufficient blood ketones." | 4.12 | Calorie Restriction Enhanced Glycogen Metabolism to Compensate for Lipid Insufficiency. ( Gu, Y; Hu, L; Wei, L; Xia, X; Yin, J; Zong, Y, 2022) |
| " Exposure of L6 myotubes to 25 mmol/L glucose and 100 nmol/L insulin for 24 h, to mimic hyperglycemia and hyperinsulinemia, abolished the acute insulin-stimulated glucose uptake, increased the serine phosphorylation of IRS-1 and the phosphorylation/activation of mTOR and p70S6K." | 4.02 | Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance. ( MacPherson, REK; Shamshoum, H; Tsiani, E; Vlavcheski, F, 2021) |
| "Increased plasma levels of free fatty acids, including palmitic acid (PA), cause insulin resistance in endothelium characterized by a decreased synthesis of insulin-mediated vasodilator nitric oxide (NO), and by an increased production of the vasoconstrictor protein, endothelin-1." | 3.85 | Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors. ( Cimino, F; Ferrari, D; Fratantonio, D; Molonia, MS; Saija, A; Speciale, A; Virgili, F, 2017) |
| "In this study, we quantitated kaempferol in water extract from Cudrania tricuspidata leaves (CTL) and investigated its effects on endoplasmic reticulum (ER) stress-induced inflammation and insulin resistance in HepG2 cells." | 3.83 | Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells. ( Jun, W; Kim, OK; Lee, J, 2016) |
| " The results showed that amygdalin and cinnamic acid inhibit serine phosphorylation of IRS-1 through targeting JNK serine kinase and enhance insulin sensitivity." | 3.81 | Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance. ( Kim, MJ; Rangasamy, S; Shim, Y; Song, JM, 2015) |
| "5 cells either infected with HCV or ectopically expressing HCV NS5A alone have the potential to induce insulin resistance by the phosphorylation of IRS-1 at serine residue (Ser(307)) followed by decreased phosphorylation of Akt Thr(308), Fox01 Ser(256) and GSK3β Ser(9), the downstream players of the insulin signaling pathway." | 3.81 | Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. ( Imran, M; Iqbal, J; Manzoor, S; Parvaiz, F; Sarkar-Dutta, M; Waris, G, 2015) |
| " To test whether resveratrol, a polyphenol found in red wine, prevents FFA-induced insulin resistance, we used a hyperinsulinemic-euglycemic clamp with a tracer to assess hepatic and peripheral insulin sensitivity in overnight-fasted Wistar rats infused for 7 h with saline, Intralipid plus 20 U·mL(-1) heparin (IH; triglyceride emulsion that elevates FFA levels in vivo; 5." | 3.81 | Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo. ( Breen, DM; Faubert, B; Giacca, A; Kwan, D; Moore, J; Nahle, A; Oprescu, AI; Park, E; Pereira, S; Tsiani, E, 2015) |
| "Evodiamine, an alkaloid extracted from the dried unripe fruit of the tree Evodia rutaecarpa Bentham (Rutaceae), reduces obesity and insulin resistance in obese/diabetic mice; however, the mechanism underlying the effect of evodiamine on insulin resistance is unknown." | 3.79 | Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. ( Kontani, Y; Kusudo, T; Mori, N; Okamatsu, Y; Saito, M; Takeuchi, T; Wang, T; Yamashita, H; Yamashita, Y, 2013) |
| "Results showed that E2 influenced on protein levels of insulin receptor substrate-1 (IRS-1) and impaired insulin-induced Ser308 phosphorylation of Akt/PKB and Ser9 phosphorylation of GSK3β in Huh7 cells, leading to an inhibition of glucose uptake and glycogen synthesis, respectively, and eventually insulin resistance." | 3.78 | Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes. ( Chen, TY; Chiou, HL; Hsieh, MJ; Lan, KP; Lin, YF; Liu, HY; Zhang, XZ, 2012) |
| "Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and insulin resistance by transactivation of ErbB receptors." | 3.77 | p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. ( Barhod, E; Hemi, R; Kanety, H; Karasik, A; Kasher-Meron, M; Tirosh, A; Yochananov, Y, 2011) |
| "IRS-1 serine phosphorylation is often elevated in insulin resistance models, but confirmation in vivo in humans is lacking." | 3.77 | Global IRS-1 phosphorylation analysis in insulin resistance. ( De Filippis, E; Finlayson, J; Langlais, P; Luo, M; Mandarino, LJ; Mapes, R; Mattern, M; Meyer, C; Plummer, E; Tongchinsub, P; Yi, Z, 2011) |
| "Phosphorylation of the insulin receptor substrates (Irs) on serine residues-typified by Ser307 of rodent Irs1-is thought to mediate insulin resistance." | 3.76 | Irs1 serine 307 promotes insulin sensitivity in mice. ( Copps, KD; Hancer, NJ; Opare-Ado, L; Qiu, W; Walsh, C; White, MF, 2010) |
| "Phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues has been recognized as a mechanism responsible for a diminution of insulin action and insulin resistance." | 3.75 | Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of pho ( Adochio, R; Draznin, B; Hedlund, R; Leitner, JW, 2009) |
| "The data demonstrated an interaction between testosterone and insulin on phosphorylation of intracellular signaling proteins, and suggests a link between a hyperandrogenic, hyperinsulinemic environment and the development of insulin resistance involving serine phosphorylation of IRS-1 Ser(636/639)." | 3.75 | Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance. ( Allemand, MC; Asmann, YW; Coddington, CC; Irving, BA; Klaus, KA; Nair, KS; Tatpati, L, 2009) |
| " On the other hand, the antioxidant, Taurine at 10mM concentrations was capable of reversing the oleate-induced insulin resistance in myocytes as manifested from the glucose uptake data." | 3.75 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways. ( Adeli, K; Fantus, IG; Medhat, AM; Ragheb, R; Seoudi, DM; Shanab, GM, 2009) |
| "To directly assess the role of serine phosphorylation in mediating fat-induced insulin resistance in skeletal muscle, we generated muscle-specific IRS-1 Ser(302), Ser(307), and Ser(612) mutated to alanine (Tg IRS-1 Ser-->Ala) and IRS-1 wild-type (Tg IRS-1 WT) transgenic mice and examined insulin signaling and insulin action in skeletal muscle in vivo." | 3.74 | Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. ( Bilz, S; Moore, I; Morino, K; Nagai, Y; Neschen, S; Philbrick, W; Reznick, RM; Samuel, V; Sebastian, D; Shulman, GI; Sono, S; Tsirigotis, D; White, M, 2008) |
| "To investigate the effects and molecular mechanisms of berberine on improving insulin resistance induced by free fatty acids (FFAs) in 3T3-L1 adipocytes." | 3.74 | Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. ( Chen, G; Dong, H; Lu, FE; Wang, KF; Xu, LJ; Yi, P, 2008) |
| "The activation of JNK elevates the level of IRS-1 phospho-serine 307 and might play a role in insulin resistance after burn in rats." | 3.74 | [Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn]. ( Ben, DF; Chen, XL; Ge, SD; Tang, HT; Wei, D; Xia, ZF, 2007) |
| " Cellular mechanisms responsible for the development of insulin resistance are unclear, though one proposed mechanism is that nutrient overload chronically increases available energy, over-activating the mammalian target of rapamycin (mTOR) and ribosomal S6 kinase 1 (S6K1) signaling pathway leading to increased phosphorylation of serine residues on insulin receptor substrate-1 (IRS-1)." | 3.74 | A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. ( DiCarlo, SE; Drummond, MJ; Glynn, EL; Kramer, VJ; Lujan, HL; Rasmussen, BB, 2008) |
| "Phosphorylation of insulin receptor substrate (IRS) proteins on serine residues is an important posttranslational modification that is linked to insulin resistance." | 3.73 | Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. ( Downes, CP; Gray, A; Jørgensen, CH; Nawaratne, R; Sethi, JK; Siddle, K, 2006) |
| "To investigate the effects of insulin receptor substrate (IRS)-1 and its serine (Ser)(307) phosphorylation and tyrosine (Tyr) phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis." | 3.73 | [Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats]. ( Li, JS; Li, N; Li, WQ; Wang, XD; Yan, XW, 2006) |
| "Increased serine/threonine phosphorylation of insulin receptor substrate-1 (IRS-1) is associated with cellular insulin resistance." | 3.73 | Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes. ( Fiedler, H; Häring, HU; Lehmann, R; Müssig, K; Schleicher, ED; Staiger, H; Weigert, C, 2005) |
| "Obesity, a state of apparent "leptin resistance" is well known to be associated with insulin resistance." | 3.73 | Hepatic leptin signaling in obesity. ( Anderwald, C; Brabant, G; Horn, R; Müller, G; Nave, H; Roden, M, 2005) |
| "Clinical evidence suggests a relationship between hypertension and insulin resistance, and cross-talk between angiotensin II (Ang II) and insulin signaling pathways may take place." | 3.73 | ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells. ( Ali, N; Ebina, Y; Fujita, Y; Ishizawa, K; Izawa, Y; Kanematsu, Y; Obata, T; Tamaki, T; Tomita, S; Tsuchiya, K; Yoshizumi, M, 2005) |
| "Dehydroepiandrosterone (DHEA) is an adrenal steroid and nutritional supplement that may improve insulin sensitivity." | 3.73 | Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. ( Chen, H; Consoli, A; Formoso, G; Kim, JA; Montagnani, M; Quon, MJ, 2006) |
| " In this study, we demonstrate that sepsis induces insulin resistance and that pretreatment with aspirin inhibits sepsis-induced insulin resistance." | 3.72 | Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats. ( Barreiro, GC; Caliseo, CT; Carvalheira, JB; Fugiwara, FY; Prada, PO; Prattali, RR; Saad, MJ; Ueno, M; Velloso, LA, 2004) |
| "In an attempt to probe the effect of beta-endorphin on insulin resistance, we used Wistar rats that were fed fructose-rich chow to induce insulin resistance." | 3.72 | Infusion of beta-endorphin improves insulin resistance in fructose-fed rats. ( Chang, YY; Cheng, JT; Liu, IM; Lo, CY; Pai, HH; Su, CF, 2004) |
| " Tumor necrosis factor (TNF)-alpha caused insulin resistance on glucose uptake and GLUT4 translocation by impairing insulin stimulation of insulin receptor (IR) and IR substrate (IRS)-1 and IRS-2 tyrosine phosphorylation, IRS-associated phosphatidylinositol 3-kinase activation, and Akt phosphorylation." | 3.72 | Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. ( de Alvaro, C; Hernandez, R; Lorenzo, M; Teruel, T, 2004) |
| "Obesity is associated with the development of leptin resistance." | 3.72 | Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity. ( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004) |
| "Inhibitory serine phosphorylation is a potential molecular mechanism for insulin resistance." | 3.72 | Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. ( Hansen, L; Lee, J; Shoelson, SE; Werner, ED; Yuan, M, 2004) |
| "A promising approach for treating type 2 diabetes mellitus (T2DM) is to target the Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates the expression of proteins critical for T2DM." | 2.72 | The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes. ( Bruning, JB; Frkic, RL; Richter, K, 2021) |
| "Insulin resistance is characterized by a decrease in the insulin effect on glucose transport in muscle and adipose tissue." | 2.42 | Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. ( Barrès, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF, 2003) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide." | 1.91 | Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation. ( Dehury, B; Dogra, S; Jaswal, K; Mondal, P; Rawat, P; Thakur, S, 2023) |
| "Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis." | 1.72 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. ( Butte, NF; Cole, SA; Comuzzie, AG; Haack, K; Hou, R; Krupenko, SA; Laston, S; Mehta, NR; Voruganti, VS, 2022) |
| "NAFLD is viewed as a hepatic manifestation of metabolic syndrome, with humans and animal models presenting dyslipidemia, hypertension, and diabetes." | 1.72 | Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice. ( Araujo, LCC; Carvalho, CRO; Matos, SL; Moreira, GV; Murata, GM, 2022) |
| " Here, chronic administration of sulpiride (80 mg/kg, subcutaneously, once daily for 6 weeks) elevated fasting insulin concentration and the index of the homeostasis model assessment of insulin resistance in rats." | 1.48 | The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance. ( Huang, X; Li, Y; Ren, L; Wang, C; Yu, Z; Zhou, X, 2018) |
| " It is well established that reduced vascular endothelial nitric oxide (NO) bioavailability promotes arterial inflammation; however, the role of NO in modulating inflammation in AT remains disputed." | 1.43 | Ablation of eNOS does not promote adipose tissue inflammation. ( Gastecki, ML; Jurrissen, TJ; Padilla, J; Rector, RS; Sheldon, RD; Vieira-Potter, VJ; Woodford, ML; Zidon, TM, 2016) |
| "Insulin sensitivity was measured by hyperinsulinemic euglycemic clamp (HEC) in mature female sheep (n = 7)." | 1.42 | Acute exercise increases insulin sensitivity in adult sheep: a new preclinical model. ( Falcão-Tebas, F; Gatford, KL; Hong, YH; Kaur, G; McConell, GK, 2015) |
| "In the present study, a rodent model of critical illness diabetes was used to determine whether adipose tissue becomes acutely insulin resistant and how insulin signaling pathways are being affected." | 1.38 | Injury-induced insulin resistance in adipose tissue. ( Franklin, JL; Hardy, RW; Martin, RE; Messina, JL; Williams, VL, 2012) |
| "Obesity is a health hazard that is associated with a number of diseases and metabolic abnormalities, such as type-2 diabetes, hypertension, dyslipidemia, and coronary heart disease." | 1.38 | Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. ( Cho, JH; Kim, CH; Kim, GS; Kim, MK; Ko, YG; Koh, PO; Min, W; Park, HJ; Won, CK; Woo, JH, 2012) |
| "The rapidly increasing prevalence of gestational diabetes mellitus (GDM) globally places a growing population at risk for developing type 2 diabetes mellitus (T2DM), particularly those with persistent impaired glucose tolerance (IGT) postpartum." | 1.37 | Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. ( Barbour, LA; Friedman, JE; Hernandez, TL; McCurdy, CE, 2011) |
| "Obesity is associated with resistance to IGF-I at a whole-body level and in the endothelium." | 1.35 | Vascular insulin-like growth factor-I resistance and diet-induced obesity. ( Abbas, A; Ajjan, R; Cubbon, RM; Duncan, ER; Ezzat, VA; Gage, M; Grant, PJ; Imrie, H; Kahn, M; Kearney, MT; Rajwani, A; Viswambharan, H; Wheatcroft, SB, 2009) |
| "Insulin resistance is a critical component of T2DM pathogenesis." | 1.35 | Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. ( Ait-Goughoulte, M; Banerjee, S; Meyer, K; Ray, R; Ray, RB; Saito, K, 2008) |
| "Insulin resistance is a hallmark of late pregnancy both in human and rat." | 1.34 | Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy. ( Bocos, C; de Castro, J; Herrera, E; Ramos, MP; Sevillano, J, 2007) |
| "Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease." | 1.33 | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. ( Danielsson, A; Nystrom, FH; Ost, A; Strålfors, P, 2005) |
| "Preeclampsia is a severe complication of human pregnancy often associated with maternal risk factors." | 1.33 | Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2. ( Gumaa, K; Kunjara, S; Paine, MA; Rademacher, TW; Rodeck, CH; Scioscia, M; Selvaggi, LE, 2006) |
| "Recently we found that trauma and hemorrhage acutely induced hepatic insulin resistance in the rat." | 1.32 | Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. ( Chaudry, IH; Holland, LT; Keeton, AB; Ma, Y; Messina, JL; Toth, B, 2004) |
| "Insulin resistance is defined as the decrease in the glucose disposal in response to insulin by the target tissues." | 1.32 | High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. ( Calderón, V; Reynoso, R; Salgado, LM, 2003) |
| "Salicylic acid pretreatment completely reversed the effects of PMA and TNFalpha on both Akt and IRS1." | 1.32 | Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. ( Dallas-Yang, Q; Jiang, G; Liu, F; Moller, DE; Zhang, BB, 2003) |
| "Insulin resistance was estimated using the homeostasis model assessment (HOMA) index." | 1.31 | Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus. ( Groop, L; Klannemark, M; Orho-Melander, M; Suurinkeroinen, L; Taskinen, MR, 2000) |
| "Insulin resistance is a key pathophysiologic feature of obesity and type 2 diabetes and is associated with other human diseases, including atherosclerosis, hypertension, hyperlipidemia, and polycystic ovarian disease." | 1.31 | In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. ( Jetton, TL; Qiao, LY; Sun, XJ; Zhande, R; Zhou, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.24) | 18.7374 |
| 1990's | 9 (5.59) | 18.2507 |
| 2000's | 77 (47.83) | 29.6817 |
| 2010's | 56 (34.78) | 24.3611 |
| 2020's | 17 (10.56) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 5 |
| Chen, X | 1 |
| Chen, Y | 2 |
| Yu, D | 1 |
| Jiang, R | 1 |
| Kou, X | 1 |
| Sheng, L | 1 |
| Liu, Y | 3 |
| Song, Y | 1 |
| Krupenko, SA | 1 |
| Cole, SA | 1 |
| Hou, R | 1 |
| Haack, K | 1 |
| Laston, S | 1 |
| Mehta, NR | 1 |
| Comuzzie, AG | 1 |
| Butte, NF | 1 |
| Voruganti, VS | 1 |
| Du, M | 1 |
| Li, X | 2 |
| Xiao, F | 1 |
| Fu, Y | 1 |
| Shi, Y | 1 |
| Guo, S | 2 |
| Chen, L | 1 |
| Shen, L | 1 |
| Wang, L | 2 |
| Cheng, H | 1 |
| Li, H | 1 |
| Xie, A | 1 |
| Zhou, Y | 2 |
| Yang, K | 1 |
| Fang, H | 1 |
| Lyu, J | 1 |
| Zhao, Q | 1 |
| Rousseau, M | 2 |
| Denhez, B | 2 |
| Spino, C | 2 |
| Lizotte, F | 2 |
| Guay, A | 2 |
| Côté, AM | 1 |
| Burger, D | 1 |
| Geraldes, P | 2 |
| Hu, L | 1 |
| Xia, X | 1 |
| Zong, Y | 1 |
| Gu, Y | 1 |
| Wei, L | 2 |
| Yin, J | 1 |
| Duarte, JMN | 1 |
| Moreira, GV | 1 |
| Araujo, LCC | 1 |
| Murata, GM | 1 |
| Matos, SL | 1 |
| Carvalho, CRO | 1 |
| Park, JE | 1 |
| Han, JS | 1 |
| Ortiz-Huidobro, RI | 1 |
| Larqué, C | 1 |
| Velasco, M | 1 |
| Chávez-Maldonado, JP | 1 |
| Sabido, J | 1 |
| Sanchez-Zamora, YI | 1 |
| Hiriart, M | 1 |
| Sakaguchi, M | 1 |
| Okagawa, S | 1 |
| Okubo, Y | 1 |
| Otsuka, Y | 1 |
| Fukuda, K | 1 |
| Igata, M | 1 |
| Kondo, T | 1 |
| Sato, Y | 1 |
| Yoshizawa, T | 1 |
| Fukuda, T | 1 |
| Yamagata, K | 1 |
| Cai, W | 1 |
| Tseng, YH | 1 |
| Sakaguchi, N | 1 |
| Kahn, CR | 1 |
| Araki, E | 1 |
| Ng, SP | 1 |
| Nomura, W | 1 |
| Takahashi, H | 1 |
| Inoue, K | 1 |
| Kawada, T | 1 |
| Goto, T | 1 |
| Inoue, Y | 1 |
| Tang, P | 2 |
| Tang, Y | 2 |
| He, B | 2 |
| Shen, X | 2 |
| Zhang, ZJ | 2 |
| Qin, DL | 2 |
| Tian, J | 2 |
| Rawat, P | 1 |
| Thakur, S | 1 |
| Dogra, S | 1 |
| Jaswal, K | 1 |
| Dehury, B | 1 |
| Mondal, P | 1 |
| Dancosst, DA | 1 |
| Dumas, MÈ | 1 |
| Dias, MMG | 1 |
| Batista, FAH | 1 |
| Tittanegro, TH | 1 |
| de Oliveira, AG | 1 |
| Le Maire, A | 1 |
| Torres, FR | 1 |
| Filho, HVR | 1 |
| Silveira, LR | 1 |
| Figueira, ACM | 1 |
| Shamshoum, H | 1 |
| Vlavcheski, F | 1 |
| MacPherson, REK | 1 |
| Tsiani, E | 2 |
| Frkic, RL | 1 |
| Richter, K | 1 |
| Bruning, JB | 1 |
| Vandenbeek, R | 1 |
| Khan, NP | 1 |
| Estall, JL | 1 |
| He, S | 1 |
| Peng, WB | 1 |
| Zhou, HL | 1 |
| Zhou, X | 2 |
| Ren, L | 1 |
| Yu, Z | 2 |
| Huang, X | 1 |
| Wang, C | 1 |
| Jin, X | 1 |
| Qiao, A | 1 |
| Moskophidis, D | 1 |
| Mivechi, NF | 1 |
| Suwandhi, L | 1 |
| Hausmann, S | 1 |
| Braun, A | 1 |
| Gruber, T | 1 |
| Heinzmann, SS | 1 |
| Gálvez, EJC | 1 |
| Buck, A | 1 |
| Legutko, B | 1 |
| Israel, A | 1 |
| Feuchtinger, A | 1 |
| Haythorne, E | 1 |
| Staiger, H | 2 |
| Heni, M | 1 |
| Häring, HU | 4 |
| Schmitt-Kopplin, P | 1 |
| Walch, A | 1 |
| Cáceres, CG | 1 |
| Tschöp, MH | 1 |
| Rutter, GA | 1 |
| Strowig, T | 1 |
| Elsner, M | 1 |
| Ussar, S | 1 |
| Takaguri, A | 2 |
| Sim, WC | 1 |
| Kim, DG | 1 |
| Lee, W | 1 |
| Sim, H | 1 |
| Choi, YJ | 1 |
| Lee, BH | 1 |
| Zhang, K | 1 |
| Guo, X | 1 |
| Yan, H | 1 |
| Wu, Y | 2 |
| Pan, Q | 1 |
| Shen, JZ | 1 |
| Li, L | 1 |
| Qi, Y | 1 |
| Xu, Z | 1 |
| Xie, W | 2 |
| Zhang, W | 2 |
| Threadgill, D | 1 |
| He, L | 1 |
| Villarreal, D | 1 |
| Sun, Y | 1 |
| White, MF | 10 |
| Zheng, H | 1 |
| Kobayashi, M | 2 |
| Matsuda, Y | 1 |
| Iwai, H | 1 |
| Hiramitsu, M | 1 |
| Inoue, T | 1 |
| Katagiri, T | 1 |
| Yamashita, Y | 2 |
| Ashida, H | 1 |
| Murai, A | 1 |
| Horio, F | 1 |
| Obanda, DN | 1 |
| Cefalu, WT | 1 |
| Astolphi, RD | 1 |
| Curbete, MM | 1 |
| Colombo, NH | 1 |
| Shirakashi, DJ | 1 |
| Chiba, FY | 1 |
| Prieto, AK | 1 |
| Cintra, LT | 1 |
| Bomfim, SR | 1 |
| Ervolino, E | 1 |
| Sumida, DH | 1 |
| Shibata, T | 1 |
| Ichihara, K | 1 |
| Satoh, K | 1 |
| Park, K | 1 |
| Li, Q | 4 |
| Rask-Madsen, C | 1 |
| Mima, A | 1 |
| Mizutani, K | 1 |
| Winnay, J | 1 |
| Maeda, Y | 1 |
| D'Aquino, K | 1 |
| Feener, EP | 1 |
| King, GL | 1 |
| Thewissen, MM | 1 |
| van de Gaar, J | 1 |
| den Boer, AT | 1 |
| Munsters, MJ | 1 |
| Blaak, EE | 1 |
| Duijvestijn, A | 1 |
| Herrema, H | 1 |
| Lee, J | 3 |
| Copps, KD | 3 |
| Ozcan, U | 1 |
| Wang, T | 1 |
| Kusudo, T | 1 |
| Takeuchi, T | 1 |
| Kontani, Y | 1 |
| Okamatsu, Y | 1 |
| Saito, M | 1 |
| Mori, N | 1 |
| Yamashita, H | 1 |
| She, M | 1 |
| Hou, H | 1 |
| Wang, Z | 1 |
| Zhang, C | 1 |
| Laudon, M | 1 |
| Yin, W | 1 |
| Xie, X | 1 |
| Chen, W | 1 |
| Long, L | 1 |
| Li, W | 1 |
| Yang, X | 2 |
| Li, S | 1 |
| Jiang, Y | 1 |
| Biswas, SK | 1 |
| Steinle, JJ | 1 |
| McConell, GK | 1 |
| Kaur, G | 1 |
| Falcão-Tebas, F | 1 |
| Hong, YH | 1 |
| Gatford, KL | 1 |
| Kim, MJ | 1 |
| Rangasamy, S | 1 |
| Shim, Y | 1 |
| Song, JM | 1 |
| Bhattacharyya, S | 1 |
| Feferman, L | 1 |
| Tobacman, JK | 1 |
| Song, P | 1 |
| Liu, J | 1 |
| Dai, X | 1 |
| Liu, Z | 1 |
| Lu, Q | 1 |
| Ouyang, C | 1 |
| Xie, Z | 1 |
| Zhao, Z | 1 |
| Zhuo, X | 1 |
| Viollet, B | 1 |
| Foretz, M | 1 |
| Wu, J | 1 |
| Yuan, Z | 1 |
| Zou, MH | 1 |
| Pereira, S | 1 |
| Park, E | 2 |
| Moore, J | 1 |
| Faubert, B | 1 |
| Breen, DM | 1 |
| Oprescu, AI | 2 |
| Nahle, A | 1 |
| Kwan, D | 1 |
| Giacca, A | 2 |
| Parvaiz, F | 1 |
| Manzoor, S | 1 |
| Iqbal, J | 1 |
| Sarkar-Dutta, M | 1 |
| Imran, M | 1 |
| Waris, G | 1 |
| Kim, OK | 1 |
| Jun, W | 1 |
| Jurrissen, TJ | 1 |
| Sheldon, RD | 1 |
| Gastecki, ML | 1 |
| Woodford, ML | 1 |
| Zidon, TM | 1 |
| Rector, RS | 1 |
| Vieira-Potter, VJ | 1 |
| Padilla, J | 1 |
| Wang, H | 1 |
| Liu, L | 1 |
| Lin, JZ | 1 |
| Aprahamian, TR | 1 |
| Farmer, SR | 1 |
| Fratantonio, D | 1 |
| Cimino, F | 1 |
| Molonia, MS | 1 |
| Ferrari, D | 1 |
| Saija, A | 1 |
| Virgili, F | 1 |
| Speciale, A | 1 |
| Mullins, RJ | 1 |
| Mustapic, M | 1 |
| Goetzl, EJ | 1 |
| Kapogiannis, D | 1 |
| Mack, E | 1 |
| Ziv, E | 1 |
| Reuveni, H | 1 |
| Kalman, R | 1 |
| Niv, MY | 1 |
| Jörns, A | 1 |
| Lenzen, S | 1 |
| Shafrir, E | 1 |
| Morino, K | 2 |
| Neschen, S | 2 |
| Bilz, S | 2 |
| Sono, S | 2 |
| Tsirigotis, D | 1 |
| Reznick, RM | 1 |
| Moore, I | 1 |
| Nagai, Y | 1 |
| Samuel, V | 1 |
| Sebastian, D | 1 |
| White, M | 1 |
| Philbrick, W | 1 |
| Shulman, GI | 4 |
| Morris, JK | 1 |
| Zhang, H | 1 |
| Gupte, AA | 1 |
| Bomhoff, GL | 1 |
| Stanford, JA | 1 |
| Geiger, PC | 1 |
| Adochio, R | 2 |
| Leitner, JW | 1 |
| Hedlund, R | 1 |
| Draznin, B | 2 |
| Kim, T | 1 |
| Wayne Leitner, J | 1 |
| Zhang, Z | 1 |
| Zhao, M | 1 |
| Zhao, H | 1 |
| Wang, J | 1 |
| Allemand, MC | 1 |
| Irving, BA | 1 |
| Asmann, YW | 1 |
| Klaus, KA | 1 |
| Tatpati, L | 1 |
| Coddington, CC | 1 |
| Nair, KS | 1 |
| Muñoz, MC | 2 |
| Giani, JF | 1 |
| Mayer, MA | 1 |
| Toblli, JE | 2 |
| Turyn, D | 2 |
| Dominici, FP | 2 |
| Imrie, H | 1 |
| Abbas, A | 1 |
| Viswambharan, H | 1 |
| Rajwani, A | 1 |
| Cubbon, RM | 1 |
| Gage, M | 1 |
| Kahn, M | 1 |
| Ezzat, VA | 1 |
| Duncan, ER | 1 |
| Grant, PJ | 1 |
| Ajjan, R | 1 |
| Wheatcroft, SB | 1 |
| Kearney, MT | 1 |
| Ragheb, R | 1 |
| Shanab, GM | 1 |
| Medhat, AM | 1 |
| Seoudi, DM | 1 |
| Adeli, K | 1 |
| Fantus, IG | 1 |
| Zhang, ZF | 1 |
| Liang, J | 1 |
| Dai, XQ | 1 |
| Ding, Y | 1 |
| Wang, JB | 1 |
| Arellano-Plancarte, A | 1 |
| Hernandez-Aranda, J | 1 |
| Catt, KJ | 1 |
| Olivares-Reyes, JA | 1 |
| Bourron, O | 1 |
| Daval, M | 1 |
| Hainault, I | 1 |
| Hajduch, E | 1 |
| Servant, JM | 1 |
| Gautier, JF | 1 |
| Ferré, P | 1 |
| Foufelle, F | 1 |
| Hancer, NJ | 1 |
| Opare-Ado, L | 1 |
| Qiu, W | 1 |
| Walsh, C | 1 |
| Nascimento, EB | 1 |
| Snel, M | 1 |
| Guigas, B | 1 |
| van der Zon, GC | 1 |
| Kriek, J | 1 |
| Maassen, JA | 1 |
| Jazet, IM | 1 |
| Diamant, M | 1 |
| Ouwens, DM | 1 |
| Pauli, JR | 2 |
| Ropelle, ER | 2 |
| Cintra, DE | 2 |
| De Souza, CT | 3 |
| da Silva, AS | 1 |
| Moraes, JC | 1 |
| Prada, PO | 3 |
| de Almeida Leme, JA | 1 |
| Luciano, E | 1 |
| Velloso, LA | 5 |
| Carvalheira, JB | 4 |
| Saad, MJ | 5 |
| Elks, CM | 1 |
| Francis, J | 1 |
| Uebi, T | 1 |
| Tamura, M | 1 |
| Horike, N | 2 |
| Hashimoto, YK | 1 |
| Takemori, H | 2 |
| Xin-Long, C | 1 |
| Zhao-Fan, X | 1 |
| Dao-Feng, B | 1 |
| Wei, D | 2 |
| Jin, T | 1 |
| Barbour, LA | 1 |
| McCurdy, CE | 1 |
| Hernandez, TL | 1 |
| Friedman, JE | 1 |
| Hemi, R | 3 |
| Yochananov, Y | 1 |
| Barhod, E | 1 |
| Kasher-Meron, M | 1 |
| Karasik, A | 3 |
| Tirosh, A | 1 |
| Kanety, H | 3 |
| Kiilerich, K | 1 |
| Ringholm, S | 1 |
| Biensø, RS | 1 |
| Fisher, JP | 1 |
| Iversen, N | 1 |
| van Hall, G | 1 |
| Wojtaszewski, JF | 1 |
| Saltin, B | 1 |
| Lundby, C | 1 |
| Calbet, JA | 1 |
| Pilegaard, H | 1 |
| Langlais, P | 1 |
| Yi, Z | 1 |
| Finlayson, J | 1 |
| Luo, M | 1 |
| Mapes, R | 1 |
| De Filippis, E | 1 |
| Meyer, C | 1 |
| Plummer, E | 1 |
| Tongchinsub, P | 1 |
| Mattern, M | 1 |
| Mandarino, LJ | 1 |
| Kurtz, B | 1 |
| Thibault, HB | 1 |
| Raher, MJ | 1 |
| Popovich, JR | 1 |
| Cawley, S | 1 |
| Atochin, DN | 2 |
| Hayton, S | 1 |
| Shakartzi, HR | 1 |
| Huang, PL | 2 |
| Bloch, KD | 1 |
| Buys, E | 1 |
| Scherrer-Crosbie, M | 1 |
| Deng, YT | 1 |
| Chang, TW | 1 |
| Lee, MS | 1 |
| Lin, JK | 1 |
| Kim, GS | 1 |
| Park, HJ | 1 |
| Woo, JH | 1 |
| Kim, MK | 1 |
| Koh, PO | 1 |
| Min, W | 1 |
| Ko, YG | 1 |
| Kim, CH | 2 |
| Won, CK | 1 |
| Cho, JH | 1 |
| Williams, VL | 1 |
| Martin, RE | 1 |
| Franklin, JL | 1 |
| Hardy, RW | 1 |
| Messina, JL | 2 |
| Katta, A | 1 |
| Kakarla, SK | 1 |
| Manne, ND | 1 |
| Wu, M | 1 |
| Kundla, S | 1 |
| Kolli, MB | 1 |
| Nalabotu, SK | 1 |
| Blough, ER | 1 |
| Liu, M | 1 |
| Zhou, L | 1 |
| Villarreal, R | 1 |
| Hu, D | 1 |
| Riojas, RA | 1 |
| Holmes, BM | 1 |
| Langlais, PR | 1 |
| Lee, H | 1 |
| Dong, LQ | 1 |
| Hsieh, MJ | 1 |
| Lan, KP | 1 |
| Liu, HY | 1 |
| Zhang, XZ | 1 |
| Lin, YF | 1 |
| Chen, TY | 1 |
| Chiou, HL | 1 |
| Arunkumar, E | 1 |
| Anuradha, CV | 2 |
| Bhuvaneswari, S | 1 |
| Kashiwagi, S | 1 |
| Schleicher, M | 1 |
| Pong, T | 1 |
| Sessa, WC | 1 |
| Wood, AR | 1 |
| Lyssenko, V | 1 |
| Weedon, MN | 1 |
| Knowles, JW | 1 |
| Alkayyali, S | 1 |
| Assimes, TL | 1 |
| Quertermous, T | 1 |
| Abbasi, F | 1 |
| Paananen, J | 1 |
| Häring, H | 2 |
| Hansen, T | 1 |
| Pedersen, O | 1 |
| Smith, U | 1 |
| Laakso, M | 1 |
| Dekker, JM | 1 |
| Nolan, JJ | 1 |
| Groop, L | 2 |
| Ferrannini, E | 1 |
| Adam, KP | 1 |
| Gall, WE | 1 |
| Frayling, TM | 1 |
| Walker, M | 1 |
| Jiang, G | 1 |
| Dallas-Yang, Q | 1 |
| Liu, F | 1 |
| Moller, DE | 2 |
| Zhang, BB | 1 |
| Katoh, Y | 1 |
| Doi, J | 1 |
| Min, L | 1 |
| Asano, T | 1 |
| Sun, XJ | 3 |
| Yamamoto, H | 1 |
| Kasayama, S | 1 |
| Muraoka, M | 1 |
| Nonaka, Y | 1 |
| Okamoto, M | 1 |
| Torsoni, MA | 1 |
| Pereira-Da-Silva, M | 1 |
| de Carvalho-Filho, MA | 1 |
| Gao, Z | 1 |
| Zuberi, A | 1 |
| Quon, MJ | 3 |
| Dong, Z | 1 |
| Ye, J | 1 |
| Gual, P | 3 |
| Gonzalez, T | 2 |
| Grémeaux, T | 2 |
| Barres, R | 2 |
| Le Marchand-Brustel, Y | 3 |
| Tanti, JF | 3 |
| Potashnik, R | 1 |
| Bloch-Damti, A | 1 |
| Bashan, N | 1 |
| Rudich, A | 1 |
| Reynoso, R | 1 |
| Salgado, LM | 1 |
| Calderón, V | 1 |
| Rangwala, SM | 1 |
| Rhoades, B | 1 |
| Shapiro, JS | 1 |
| Rich, AS | 1 |
| Kim, JK | 2 |
| Kaestner, KH | 1 |
| Lazar, MA | 1 |
| Schmitz-Peiffer, C | 1 |
| Whitehead, JP | 1 |
| de Alvaro, C | 1 |
| Teruel, T | 2 |
| Hernandez, R | 1 |
| Lorenzo, M | 2 |
| Huang, W | 1 |
| Dedousis, N | 1 |
| Bhatt, BA | 1 |
| O'Doherty, RM | 1 |
| Fehmann, HC | 1 |
| Gross, U | 1 |
| Epe, M | 1 |
| Werner, ED | 1 |
| Hansen, L | 1 |
| Yuan, M | 1 |
| Shoelson, SE | 1 |
| Barreiro, GC | 1 |
| Prattali, RR | 1 |
| Caliseo, CT | 1 |
| Fugiwara, FY | 1 |
| Ueno, M | 2 |
| Ma, Y | 1 |
| Toth, B | 1 |
| Keeton, AB | 1 |
| Holland, LT | 1 |
| Chaudry, IH | 1 |
| Su, CF | 1 |
| Chang, YY | 1 |
| Pai, HH | 1 |
| Liu, IM | 1 |
| Lo, CY | 1 |
| Cheng, JT | 1 |
| Coba, MP | 1 |
| Peña, C | 1 |
| Bartke, A | 1 |
| Liu, YF | 2 |
| Herschkovitz, A | 2 |
| Boura-Halfon, S | 2 |
| Ronen, D | 3 |
| Paz, K | 2 |
| Leroith, D | 1 |
| Zick, Y | 5 |
| Sugita, H | 2 |
| Kaneki, M | 2 |
| Sugita, M | 1 |
| Yasukawa, T | 2 |
| Yasuhara, S | 1 |
| Martyn, JA | 2 |
| Araújo, EP | 1 |
| Gasparetti, AL | 1 |
| Boschero, AC | 1 |
| Khamzina, L | 1 |
| Veilleux, A | 1 |
| Bergeron, S | 1 |
| Marette, A | 2 |
| Tokunaga, E | 1 |
| Ota, H | 1 |
| Brabant, G | 1 |
| Müller, G | 1 |
| Horn, R | 1 |
| Anderwald, C | 1 |
| Roden, M | 2 |
| Nave, H | 1 |
| Izawa, Y | 1 |
| Yoshizumi, M | 1 |
| Fujita, Y | 1 |
| Ali, N | 1 |
| Kanematsu, Y | 1 |
| Ishizawa, K | 1 |
| Tsuchiya, K | 1 |
| Obata, T | 1 |
| Ebina, Y | 1 |
| Tomita, S | 1 |
| Tamaki, T | 1 |
| Usui, I | 2 |
| Imamura, T | 1 |
| Babendure, JL | 1 |
| Satoh, H | 1 |
| Lu, JC | 1 |
| Hupfeld, CJ | 1 |
| Olefsky, JM | 1 |
| Müssig, K | 1 |
| Fiedler, H | 1 |
| Weigert, C | 1 |
| Lehmann, R | 1 |
| Schleicher, ED | 1 |
| Danielsson, A | 2 |
| Ost, A | 1 |
| Nystrom, FH | 2 |
| Strålfors, P | 2 |
| He, J | 1 |
| Ishizuka, K | 1 |
| Kanatani, Y | 1 |
| Hiratani, K | 1 |
| Iwata, M | 1 |
| Bukhari, A | 1 |
| Haruta, T | 1 |
| Sasaoka, T | 1 |
| Pandolfi, A | 1 |
| Solini, A | 1 |
| Pellegrini, G | 1 |
| Mincione, G | 1 |
| Di Silvestre, S | 1 |
| Chiozzi, P | 1 |
| Giardinelli, A | 1 |
| Di Marcantonio, MC | 1 |
| Piccirelli, A | 1 |
| Capani, F | 1 |
| Consoli, A | 2 |
| Southgate, RJ | 1 |
| Bruce, CR | 1 |
| Carey, AL | 1 |
| Steinberg, GR | 1 |
| Walder, K | 1 |
| Monks, R | 1 |
| Watt, MJ | 1 |
| Hawley, JA | 1 |
| Birnbaum, MJ | 1 |
| Febbraio, MA | 1 |
| Petersen, KF | 1 |
| Dufour, S | 1 |
| Befroy, D | 1 |
| Frattini, J | 1 |
| Shatzkes, N | 1 |
| Pypaert, M | 1 |
| Scioscia, M | 1 |
| Gumaa, K | 1 |
| Kunjara, S | 1 |
| Paine, MA | 1 |
| Selvaggi, LE | 1 |
| Rodeck, CH | 1 |
| Rademacher, TW | 1 |
| Formoso, G | 1 |
| Chen, H | 1 |
| Kim, JA | 1 |
| Montagnani, M | 1 |
| Fanelli, M | 1 |
| Filippi, E | 1 |
| Sentinelli, F | 1 |
| Romeo, S | 1 |
| Fallarino, M | 1 |
| Buzzetti, R | 1 |
| Leonetti, F | 1 |
| Baroni, MG | 1 |
| Sutton, GM | 1 |
| Trevaskis, JL | 1 |
| Hulver, MW | 1 |
| McMillan, RP | 1 |
| Markward, NJ | 1 |
| Babin, MJ | 1 |
| Meyer, EA | 1 |
| Butler, AA | 1 |
| Bouzakri, K | 1 |
| Karlsson, HK | 1 |
| Vestergaard, H | 1 |
| Madsbad, S | 1 |
| Christiansen, E | 1 |
| Zierath, JR | 1 |
| Nawaratne, R | 1 |
| Gray, A | 1 |
| Jørgensen, CH | 1 |
| Downes, CP | 1 |
| Siddle, K | 2 |
| Sethi, JK | 1 |
| Picardi, PK | 1 |
| Faria, MC | 1 |
| Fernandes, MF | 1 |
| Flores, MB | 1 |
| Seow, KM | 1 |
| Juan, CC | 1 |
| Hsu, YP | 1 |
| Hwang, JL | 1 |
| Huang, LW | 1 |
| Ho, LT | 1 |
| Yan, XW | 1 |
| Li, WQ | 1 |
| Wang, XD | 1 |
| Li, JS | 1 |
| Li, N | 1 |
| Chen, XL | 1 |
| Xia, ZF | 1 |
| Ben, DF | 1 |
| Tang, HT | 1 |
| Ge, SD | 1 |
| Ilan, E | 1 |
| Jin, UH | 1 |
| Kang, YJ | 1 |
| Chang, YC | 1 |
| Tremblay, F | 1 |
| Brûlé, S | 1 |
| Hee Um, S | 1 |
| Masuda, K | 1 |
| Krebs, M | 1 |
| Polakiewicz, RD | 1 |
| Thomas, G | 1 |
| Levkovitz, Y | 1 |
| Ben-Shushan, G | 1 |
| Hershkovitz, A | 1 |
| Isaac, R | 1 |
| Gil-Ad, I | 1 |
| Shvartsman, D | 1 |
| Weizman, A | 1 |
| Sevillano, J | 1 |
| de Castro, J | 1 |
| Bocos, C | 1 |
| Herrera, E | 1 |
| Ramos, MP | 1 |
| Wong, V | 1 |
| Guan, X | 1 |
| Banerjee, S | 1 |
| Saito, K | 1 |
| Ait-Goughoulte, M | 1 |
| Meyer, K | 1 |
| Ray, RB | 1 |
| Ray, R | 1 |
| Yi, P | 1 |
| Lu, FE | 1 |
| Xu, LJ | 1 |
| Chen, G | 1 |
| Dong, H | 1 |
| Wang, KF | 1 |
| Glynn, EL | 1 |
| Lujan, HL | 1 |
| Kramer, VJ | 1 |
| Drummond, MJ | 1 |
| DiCarlo, SE | 1 |
| Rasmussen, BB | 1 |
| Bremer, AA | 1 |
| Miller, WL | 2 |
| Vinayagamoorthi, R | 1 |
| Bobby, Z | 1 |
| Sridhar, MG | 1 |
| Hörl, WH | 1 |
| Heidland, A | 1 |
| Zhang, LH | 1 |
| Rodriguez, H | 1 |
| Ohno, S | 1 |
| Feinstein, R | 1 |
| Papa, MZ | 1 |
| Kellerer, M | 2 |
| Coghlan, M | 1 |
| Capp, E | 1 |
| Mühlhöfer, A | 1 |
| Kroder, G | 1 |
| Mosthaf, L | 1 |
| Galante, P | 1 |
| Orho, M | 1 |
| Nikula-Ijäs, P | 1 |
| Schalin-Jäntti, C | 1 |
| Permutt, MA | 1 |
| Groop, LC | 1 |
| Cama, A | 1 |
| Sierra, ML | 1 |
| Kadowaki, T | 1 |
| Kadowaki, H | 1 |
| Rüdiger, HW | 1 |
| Dreyer, M | 1 |
| Taylor, SI | 1 |
| Hotamisligil, GS | 1 |
| Peraldi, P | 1 |
| Budavari, A | 1 |
| Ellis, R | 1 |
| Spiegelman, BM | 1 |
| Valverde, AM | 1 |
| Benito, M | 1 |
| Aguirre, V | 2 |
| Uchida, T | 1 |
| Yenush, L | 1 |
| Davis, R | 1 |
| Strack, V | 1 |
| Hennige, AM | 1 |
| Krützfeldt, J | 1 |
| Bossenmaier, B | 1 |
| Klein, HH | 1 |
| Lammers, R | 1 |
| Klannemark, M | 1 |
| Suurinkeroinen, L | 1 |
| Orho-Melander, M | 1 |
| Taskinen, MR | 1 |
| Yang, DQ | 1 |
| Kastan, MB | 1 |
| Rui, L | 1 |
| Lee, A | 1 |
| Corbould, A | 1 |
| Dunaif, A | 1 |
| Sykiotis, GP | 1 |
| Papavassiliou, AG | 1 |
| Siani, A | 1 |
| Iacone, R | 1 |
| Russo, O | 1 |
| Barba, G | 1 |
| Russo, P | 1 |
| Cappuccio, FP | 1 |
| Galletti, F | 1 |
| Strazzullo, P | 1 |
| Stumvoll, M | 1 |
| Wahl, HG | 1 |
| Jacob, S | 1 |
| Rettig, A | 1 |
| Machicao, F | 1 |
| Wertheim, N | 1 |
| Terruzzi, I | 1 |
| Allibardi, S | 1 |
| Bendinelli, P | 1 |
| Maroni, P | 1 |
| Piccoletti, R | 1 |
| Vesco, F | 1 |
| Samaja, M | 1 |
| Luzi, L | 1 |
| Qiao, LY | 1 |
| Zhande, R | 1 |
| Jetton, TL | 1 |
| Zhou, G | 1 |
| Yokota, A | 1 |
| Ginsberg-Fellner, F | 1 |
| Flier, JS | 1 |
| Hari, J | 1 |
| Yokono, K | 1 |
| Kasuga, M | 1 |
| Magré, J | 1 |
| Grigorescu, F | 1 |
| Reynet, C | 1 |
| Caron, M | 1 |
| Capony, JP | 1 |
| Picard, J | 1 |
| Mirouze, J | 1 |
| Capeau, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| New Electrophoretic Approaches in Studies of Obesity and Diabetes[NCT03189732] | 10 participants (Actual) | Interventional | 2015-10-01 | Completed | |||
| Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in Pulmonary Arterial Hypertension[NCT03979482] | 30 participants (Actual) | Observational | 2019-06-01 | Completed | |||
| Nutritional and Contractile Regulation of Muscle Growth (Cycle 2)[NCT00891696] | Phase 1 | 144 participants (Actual) | Interventional | 2009-04-30 | Completed | ||
| Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224] | Phase 2/Phase 3 | 90 participants (Anticipated) | Interventional | 2018-07-07 | Recruiting | ||
| Phase 4 Study of the Effects of Pravastatin on Cholesterol Levels, Inflammation and Cognition in Schizophrenia[NCT01082588] | Phase 4 | 60 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Status of the Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis in Relation to Growth Failure, Body Weight and Neuroprotection in Children With Ataxia Telangiectasia[NCT01052623] | Phase 4 | 24 participants (Anticipated) | Interventional | 2010-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/L (Mean) |
|---|---|
| Pravastatin | 0.8063 |
| Placebo | -0.5136 |
(NCT01082588)
Timeframe: Baseline, week 12
| Intervention | mg/dl (Mean) |
|---|---|
| Pravastatin | -25.565 |
| Placebo | -2.913 |
"The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery measures cognitive functioning within 7 domains: speed of processing, attention/vigilance, working memory (non verbal and verbal), verbal learning, visual learning, reasoning and problem solving and social cognition.~The composite score is calculated by the MATRICS computer program, which equally weights each of the 7 domain scores. The range of composite scores is 20-80. Higher scores indicate higher levels or cognitive functioning, while lower scores indicate lower levels of cognitive functioning." (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | 4.0417 |
| Placebo | 4.125 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 15-105. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -5.625 |
| Placebo | -3.76 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -0.83 |
| Placebo | -0.28 |
This is a subscale of the Positive and Negative Syndrome Scale (PANSS). The range for this subscale is 7-49. All items are summed to calculate the total score. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -2.9583 |
| Placebo | -2.44 |
The Positive and Negative Syndrome Scale (PANSS) is a scale used to rate severity of schizophrenia. All items are summed to calculate the total score. The scale range is 30-210. Better outcomes have lower numbers and worse outcomes have higher numbers. (NCT01082588)
Timeframe: Baseline, week 12
| Intervention | Scores on a scale (Mean) |
|---|---|
| Pravastatin | -9.416 |
| Placebo | -6.48 |
11 reviews available for serine and Insulin Resistance
| Article | Year |
|---|---|
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Ligands; Phosphorylation; PPAR gamma; Protein | 2021 |
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea | 2018 |
[Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction].
Topics: Adipocytes; AMP-Activated Protein Kinases; Animals; Atorvastatin; Diabetes Mellitus; Dual-Specificit | 2018 |
Central adiposity, systemic inflammation, and the metabolic syndrome.
Topics: Abdominal Fat; Adipokines; Adiponectin; Adiposity; C-Reactive Protein; Cytokines; Diet; Humans; Infl | 2010 |
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Topics: Animals; Diabetes Mellitus; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; M | 2012 |
IRS-1 regulation in health and disease.
Topics: Animals; Cysteine Endopeptidases; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Ins | 2003 |
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling.
Topics: Animals; Fatty Acids; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Osm | 2003 |
Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance.
Topics: Animals; Binding Sites; Humans; Insulin; Insulin Resistance; Models, Biological; Phosphorylation; Se | 2004 |
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Topics: AMP-Activated Protein Kinases; Animals; Fatty Acids, Nonesterified; Gene Expression Regulation; Huma | 2005 |
The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance.
Topics: Androgens; Female; Gonadotropins; Humans; Insulin Resistance; Phosphorylation; Polycystic Ovary Synd | 2008 |
Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance.
Topics: Animals; Drug Design; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Phosphoprotei | 2001 |
150 other studies available for serine and Insulin Resistance
| Article | Year |
|---|---|
Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway.
Topics: Berberine; Humans; Insulin; Insulin Resistance; Isoquinolines; MAP Kinase Signaling System; Mitogen- | 2022 |
Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
Topics: Child; Genome-Wide Association Study; Glycine; Glycine Dehydrogenase (Decarboxylating); Hispanic or | 2022 |
Serine active site containing protein 1 depletion alters lipid metabolism and protects against high fat diet-induced obesity in mice.
Topics: Animals; Catalytic Domain; Cholesterol; Diet, High-Fat; Insulin Resistance; Lipid Metabolism; Liver; | 2022 |
Reduction of DUSP4 contributes to podocytes oxidative stress, insulin resistance and diabetic nephropathy.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Insulin; Insul | 2022 |
Calorie Restriction Enhanced Glycogen Metabolism to Compensate for Lipid Insufficiency.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Caloric Restriction; Corticosterone; Fatty Acids, Non | 2022 |
Serine racemase modulation for improving brain insulin resistance: An Editorial Highlight for "Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers": An Editorial Highlight for "Deletion of serine racemase reve
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Hippocampus; Humans; Insulin; Insulin Resistance; R | 2022 |
Kombucha tea improves glucose tolerance and reduces hepatic steatosis in obese mice.
Topics: Animals; Bile Acids and Salts; Carbohydrates; Citrate (si)-Synthase; Collagen; Diet, High-Fat; Farne | 2022 |
HM-Chromanone, a Major Homoisoflavonoid in
Topics: Glucose; Glucose Transporter Type 4; Glycogen; Glycogen Synthase Kinase 3; Humans; I-kappa B Kinase; | 2022 |
Sexual dimorphism in the molecular mechanisms of insulin resistance during a critical developmental window in Wistar rats.
Topics: Animals; Blood Glucose; Female; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resis | 2022 |
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Homeostasis; Insulin; Insulin Resistance; Male; Mice | 2022 |
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
Topics: Adipocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mechanistic Ta | 2022 |
Quercetin-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3β Pathway.
Topics: Eucommiaceae; Glucose; Glycogen; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Insulin; Ins | 2023 |
Quercetin-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3β Pathway.
Topics: Eucommiaceae; Glucose; Glycogen; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Insulin; Ins | 2023 |
Quercetin-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3β Pathway.
Topics: Eucommiaceae; Glucose; Glycogen; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Insulin; Ins | 2023 |
Quercetin-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3β Pathway.
Topics: Eucommiaceae; Glucose; Glycogen; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Insulin; Ins | 2023 |
Diet-induced induction of hepatic serine/threonine kinase STK38 triggers proinflammation and hepatic lipid accumulation.
Topics: Animals; Diet, High-Fat; Inflammation; Insulin Resistance; Lipids; Lipogenesis; Liver; Mice; Mice, I | 2023 |
Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1.
Topics: Animals; Diabetic Nephropathies; Fatty Acids; I-kappa B Kinase; Insulin; Insulin Receptor Substrate | 2020 |
PPARγ S273 Phosphorylation Modifies the Dynamics of Coregulator Proteins Recruitment.
Topics: 3T3 Cells; Adipocytes; Animals; Chlorocebus aethiops; COS Cells; Cyclin-Dependent Kinase 5; HEK293 C | 2020 |
Rosemary extract activates AMPK, inhibits mTOR and attenuates the high glucose and high insulin-induced muscle cell insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cells, Cultured; Deoxyglucose; Disease Models | 2021 |
Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes.
Topics: Cell Survival; Glucose; Glycogen; Hep G2 Cells; Humans; Insulin Resistance; Liver; Oncogene Protein | 2018 |
The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance.
Topics: Adipose Tissue; Animals; Antipsychotic Agents; Fatty Liver; Insulin Receptor Substrate Proteins; Ins | 2018 |
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance.
Topics: Aging; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Female; Gene Knock | 2018 |
Chronic d-serine supplementation impairs insulin secretion.
Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Dietary Supplements; Energy Metabolism; Glucose | 2018 |
Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA C-Acyltransferase; Acetylation; AMP-Activated Protein K | 2019 |
Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice.
Topics: Alanine; Animals; Blood Glucose; Forkhead Box Protein O1; Glucagon; Glucose; Homeostasis; Insulin; I | 2019 |
Coffee improves insulin-stimulated Akt phosphorylation in liver and skeletal muscle in diabetic KK-A(y) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Coffee; Diabetes Mellitus, Experimental; Hyperg | 2012 |
Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.
Topics: Animals; Cells, Cultured; Ceramides; Diglycerides; Fatty Acids, Nonesterified; Glycogen; Insulin Res | 2013 |
Periapical lesions decrease insulin signal and cause insulin resistance.
Topics: Adipose Tissue, White; Animals; Dental Pulp Exposure; Dental Pulp Necrosis; Insulin; Insulin Recepto | 2013 |
Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR.
Topics: 3T3-L1 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; D | 2013 |
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Topics: Angiotensin II; Animals; Cattle; Cell Line; Endothelial Cells; Enzyme Activation; Insulin; Insulin R | 2013 |
Monocytes, but not T cells, respond to insulin with Akt(S473) phosphorylation independent of the donor glucometabolic state.
Topics: Aged; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Female; Glu | 2014 |
IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.
Topics: Animals; Blood Glucose; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Mechanistic | 2014 |
Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Diabetes Me | 2013 |
Melatonin rescues 3T3-L1 adipocytes from FFA-induced insulin resistance by inhibiting phosphorylation of IRS-1 on Ser307.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Gene Expression Regulation; Glucose; Glucos | 2014 |
L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation.
Topics: 3T3-L1 Cells; Adipose Tissue, White; Animals; Binding, Competitive; Blotting, Western; Cyclin-Depend | 2015 |
Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-α signaling in the rMC-1 cell line.
Topics: Alanine; Amino Acid Substitution; Animals; Caspase 3; Cell Line; Ependymoglial Cells; Feedback, Phys | 2014 |
Acute exercise increases insulin sensitivity in adult sheep: a new preclinical model.
Topics: Age Factors; Animals; Biopsy; Blood Glucose; Female; Glucose Clamp Technique; Insulin; Insulin Resis | 2015 |
Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Aspirin; Cinnamates; Forkhead Box Protein O1; F | 2015 |
Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.
Topics: Animals; Carrageenan; GATA2 Transcription Factor; Gene Expression; GRB10 Adaptor Protein; Hep G2 Cel | 2015 |
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
Topics: Adipocytes; Adiposity; AMP-Activated Protein Kinases; Animals; Body Composition; Body Weight; Dual S | 2015 |
Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo.
Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Dyslipidemias; Emulsions; Fatty Acids, N | 2015 |
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Forkhead Box Protein O1; Forkhead Transcription Factors | 2015 |
Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells.
Topics: CCAAT-Enhancer-Binding Protein-alpha; Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; Inflammati | 2016 |
Ablation of eNOS does not promote adipose tissue inflammation.
Topics: Adipose Tissue, Brown; Adiposity; Animals; Diet, High-Fat; Disease Models, Animal; Genetic Predispos | 2016 |
Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diet; Energy Metabolism; Flow Cyt | 2016 |
Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors.
Topics: Anthocyanins; Antioxidants; Cells, Cultured; Endothelium, Vascular; Glucosides; Human Umbilical Vein | 2017 |
Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Atrophy; Brain; Exosomes; Female; | 2017 |
Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.
Topics: Animals; Catalytic Domain; Diabetes Mellitus, Experimental; Female; Gerbillinae; Insulin Receptor Su | 2008 |
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Topics: Alanine; Amino Acid Substitution; Animals; Blotting, Western; Dietary Fats; Female; Glucose Clamp Te | 2008 |
Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Blotting, Western; Chromatography, High Pressure Liquid; | 2008 |
Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of pho
Topics: 3T3-L1 Cells; Adipocytes; Animals; Genetic Therapy; Insulin Receptor Substrate Proteins; Insulin Res | 2009 |
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Deoxyglucose; | 2009 |
Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.
Topics: Acetylcarnitine; AMP-Activated Protein Kinases; Animals; Cell Line; Glucose; Insulin; Insulin Recept | 2009 |
Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance.
Topics: Animals; Cell Differentiation; Female; Insulin; Insulin Resistance; Muscle Fibers, Skeletal; Muscle, | 2009 |
TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance.
Topics: Animals; Diabetes Mellitus, Experimental; Inflammation; Insulin Resistance; Liver; Male; Mice; Mice, | 2009 |
Vascular insulin-like growth factor-I resistance and diet-induced obesity.
Topics: Animals; Aorta; Dietary Fats; Endothelium, Vascular; Enzyme Activation; Humans; In Vitro Techniques; | 2009 |
Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways.
Topics: Animals; Antioxidants; Cell Line; Enzyme Activation; Fatty Acids, Nonesterified; Glucose; Insulin; I | 2009 |
Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition.
Topics: AMP-Activated Protein Kinases; Animals; Biological Transport; Camellia sinensis; Catechin; Cell Line | 2010 |
Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.
Topics: Angiotensin II; Animals; Cell Line; Enzyme Inhibitors; ErbB Receptors; Hepatocytes; Insulin; Insulin | 2010 |
Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylate Kinase; Adipocytes; Adipose Tissue; Adren | 2010 |
Irs1 serine 307 promotes insulin sensitivity in mice.
Topics: Amino Acid Substitution; Animals; Dietary Fats; Gene Knock-In Techniques; Insulin; Insulin Receptor | 2010 |
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Cell Line; Enzyme Inhibitors; Humans; | 2010 |
Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle.
Topics: Aging; Animals; I-kappa B Proteins; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance | 2010 |
Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP Response Element-Binding Protein; Cyclosporine; | 2010 |
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Burns; C-Peptide; Disease Models, Animal; Glucose | 2011 |
Extracellular high dosages of adenosine triphosphate induce inflammatory response and insulin resistance in rat adipocytes.
Topics: Adenosine Triphosphate; Adipocytes; Animals; Cells, Cultured; Glucose; Inflammation; Insulin; Insuli | 2010 |
Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.
Topics: Adult; Biomarkers; Blood Glucose; Blotting, Western; Diabetes, Gestational; Female; Glucose Intolera | 2011 |
p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance.
Topics: Animals; Anisomycin; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hep G | 2011 |
Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest.
Topics: Adult; Bed Rest; Biopsy; Blood Glucose; Enzyme Activation; Exercise; Exercise Test; Gene Expression | 2011 |
Global IRS-1 phosphorylation analysis in insulin resistance.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2011 |
Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance.
Topics: Adenosine Triphosphate; Animals; Dietary Fats; Disease Models, Animal; Energy Metabolism; Enzyme Inh | 2011 |
Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.
Topics: Animals; Catechin; Cell Line; Curcumin; Enzyme Activation; Fatty Acids, Nonesterified; Insulin Recep | 2012 |
Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Protein | 2012 |
Injury-induced insulin resistance in adipose tissue.
Topics: Adipose Tissue; Animals; Critical Illness; Diabetes Mellitus; Disease Models, Animal; Glycogen Synth | 2012 |
Diminished muscle growth in the obese Zucker rat following overload is associated with hyperphosphorylation of AMPK and dsRNA-dependent protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; eIF-2 Kinase; Extracellular Signal-Regulated MAP Kinases; In | 2012 |
Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Endoplasmic Reticulum Stress; Enzyme Activ | 2012 |
Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes.
Topics: Cell Line; Diabetes Mellitus, Type 2; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycogen Syntha | 2012 |
Genistein promotes insulin action through adenosine monophosphate-activated protein kinase activation and p70 ribosomal protein S6 kinase 1 inhibition in the skeletal muscle of mice fed a high energy diet.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Down-Regulation; Energy Intake; Fructose; Ge | 2012 |
Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice.
Topics: Animals; Antioxidants; Dietary Supplements; Hyperglycemia; Hypoglycemic Agents; Insulin Receptor Sub | 2012 |
eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity.
Topics: Adiposity; Animals; Blood Pressure; Gene Knock-In Techniques; Glucose; Insulin Resistance; Male; Mic | 2013 |
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Topics: Adult; Betaine; Diabetes Mellitus, Type 2; Female; Glycine; Humans; Insulin Resistance; Male; Middle | 2013 |
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Topics: Animals; Anthracenes; Cell Line; Enzyme Activation; Humans; I-kappa B Kinase; Insulin Receptor Subst | 2003 |
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
Topics: 3T3 Cells; Adipocytes; Adipose Tissue; Amino Acid Sequence; Animals; Blotting, Northern; Cell Differ | 2003 |
Molecular and functional resistance to insulin in hypothalamus of rats exposed to cold.
Topics: Animals; Blood Glucose; Cold Temperature; Eating; Fatty Acids, Nonesterified; Hormones; Hypoglycemic | 2003 |
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.
Topics: 3T3 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Insulin Receptor Subst | 2003 |
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Membrane; Enzyme Activation; Insulin; Insulin Receptor Substrat | 2003 |
IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.
Topics: 3T3 Cells; Animals; Antioxidants; Biomarkers; Cycloheximide; Cysteine Endopeptidases; Glucose Oxidas | 2003 |
High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.
Topics: Animals; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinas | 2003 |
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Topics: Adiponectin; Adipose Tissue; Adipose Tissue, Brown; Alanine; Amino Acid Substitution; Animals; Blood | 2003 |
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.
Topics: Animals; Biological Transport; Blotting, Western; Cell Membrane; Cells, Cultured; Enzyme Activation; | 2004 |
Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.
Topics: Androstadienes; Animals; Chromones; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insul | 2004 |
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha
Topics: Adolescent; Aged; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Exons; Female; Hepatocyte Nuclear | 2004 |
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.
Topics: Animals; Hyperinsulinism; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Obese | 2004 |
Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats.
Topics: Adipose Tissue; Animals; Aspirin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mus | 2004 |
Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha.
Topics: Abdomen; Acute Disease; Animals; Hemorrhage; Insulin Receptor Substrate Proteins; Insulin Resistance | 2004 |
Infusion of beta-endorphin improves insulin resistance in fructose-fed rats.
Topics: Animals; beta-Endorphin; Diet; Fructose; Glucose; Glucose Transporter Type 4; Insulin; Insulin Recep | 2004 |
Increased in vivo phosphorylation of insulin receptor at serine 994 in the liver of obese insulin-resistant Zucker rats.
Topics: Animals; Cattle; Growth Hormone; Immunoblotting; Insulin Resistance; Liver; Male; Mice; Mice, Transg | 2004 |
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
Topics: Adenoviridae; Animals; Binding Sites; Cell Line; Cricetinae; Enzyme Activation; Gene Expression Regu | 2004 |
Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle.
Topics: Animals; Blood Glucose; Burns; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Immunobl | 2005 |
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
Topics: Adipose Tissue; Animals; Body Weight; Epididymis; Glucose; Glucose Clamp Technique; Glucose Toleranc | 2005 |
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Activation; Food Deprivation; Humans; Immunoblott | 2005 |
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Cell Line, Tumor; Cells, Cultured; COS Cells; Cysteine; Diabetes Mel | 2005 |
Hepatic leptin signaling in obesity.
Topics: AMP-Activated Protein Kinases; Animals; Dietary Fats; Drug Resistance; Gene Expression; Glycogen Syn | 2005 |
ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Blood Vessels; Cell Membrane; Cytoplasm; Enzyme Activation; Enzyme Inhibito | 2005 |
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antibodies; Endothelin-1; Glucose Transporter Type 4; GTP-Binding | 2005 |
Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.
Topics: Animals; Cell Line; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resista | 2005 |
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Topics: Adipocytes; Aged; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Electrophoresis, Gel, | 2005 |
Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; | 2006 |
Selective insulin resistance affecting nitric oxide release but not plasminogen activator inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals.
Topics: Adult; Atherosclerosis; Cells, Cultured; Culture Media; Female; Fibroblasts; Glucose; Glycogen; Huma | 2005 |
PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.
Topics: Animals; Biopsy; Cell Nucleus; Cells, Cultured; Down-Regulation; Forkhead Box Protein O1; Forkhead T | 2005 |
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Topics: Biopsy; Blood Glucose; Blotting, Western; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; D | 2005 |
Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2.
Topics: Adult; Blotting, Western; Cross-Sectional Studies; Enzyme Activation; Female; Humans; Inositol Phosp | 2006 |
Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.
Topics: Animals; Cattle; Cells, Cultured; Dehydroepiandrosterone; Endothelin-1; Endothelium, Vascular; Enzym | 2006 |
The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.
Topics: Adult; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Glucose Intolerance; Glyc | 2005 |
Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.
Topics: Adipose Tissue; Animal Feed; Animals; Calorimetry; Cell Proliferation; Diet; Energy Metabolism; Fatt | 2006 |
IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.
Topics: Adult; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Nonesterified; Female; Glucose; Huma | 2006 |
Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes.
Topics: Adipocytes; Adult; Aged; Binding Sites; Cells, Cultured; Feedback; Female; Humans; Insulin; Insulin | 2006 |
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.
Topics: 3T3-L1 Cells; Animals; Blood Proteins; Catalytic Domain; Ceramides; Humans; Insulin; Insulin Recepto | 2006 |
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.
Topics: Animals; Dietary Fats; Dose-Response Relationship, Drug; I-kappa B Proteins; Insulin; Insulin Recept | 2006 |
Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery.
Topics: Body Mass Index; Electrocoagulation; Female; Glucose Tolerance Test; Humans; Insulin Receptor Substr | 2007 |
[Effects of insulin receptor substrate-1 and its serine phosphorylation and tyrosine phosphorylation on insulin resistance in skeletal muscle cells in the state of sepsis: experiment with rats].
Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Insulin Receptor Substrate Proteins; I | 2006 |
[Role of c-Jun NH (2)-terminal kinase in insulin resistance after burn].
Topics: Adaptor Proteins, Signal Transducing; Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; | 2007 |
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Topics: Animals; Fatty Acids, Nonesterified; Hepatocytes; Humans; I-kappa B Kinase; Insulin; Insulin Recepto | 2007 |
Secretion of atherogenic risk factor apolipoprotein B-100 is increased by a potential mechanism of JNK/PKC-mediated insulin resistance in liver cells.
Topics: Adaptor Proteins, Signal Transducing; Apolipoprotein B-100; Carrier Proteins; Cells, Cultured; Enzym | 2008 |
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.
Topics: Animals; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Nutritional Status; | 2007 |
Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus; Enzyme Activation; Insulin; Insulin Receptor Substrate | 2007 |
Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adaptor Proteins, Signal Transducing; Adiponectin; Adi | 2007 |
Salicylate prevents hepatic insulin resistance caused by short-term elevation of free fatty acids in vivo.
Topics: Animals; Drug Combinations; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Female; Glucose; | 2007 |
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Glucose; Hepatitis C Antigens; Hepatocytes; Humans; | 2008 |
Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta.
Topics: 3T3-L1 Cells; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adipocytes; Anim | 2008 |
A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blood Glucose; Blotting, Western; Citrate (si)-Syntha | 2008 |
Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance.
Topics: Animals; Antioxidants; Body Weight; Cells, Cultured; Dietary Fats; Hydrogen Peroxide; Insulin; Insul | 2008 |
Glycogen metabolism in muscle in uremia.
Topics: Acute Disease; Animals; Dietary Proteins; Enzyme Activation; Fasting; Glycogen; Glycogen Synthase; I | 1980 |
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.
Topics: Adrenal Cortex; Age Factors; Aldehyde-Lyases; Amino Acids; Cyclic AMP-Dependent Protein Kinases; Cyt | 1995 |
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1.
Topics: Alkaloids; Animals; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin | 1995 |
Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.
Topics: Aged; Aged, 80 and over; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Middle Aged | 1995 |
Isolation and characterization of the human muscle glycogen synthase gene.
Topics: Adult; Amino Acid Sequence; Animals; Base Sequence; Deoxyribonucleases, Type II Site-Specific; Diabe | 1995 |
Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.
Topics: Alleles; Amino Acid Sequence; Asparagine; Base Sequence; Exons; Female; Genotype; Humans; Hydrogen-I | 1995 |
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Cells, Cultured; Insulin; Insulin Receptor Substrate Proteins; | 1996 |
Alterations in the insulin signaling pathway induced by immortalization and H-ras transformation of brown adipocytes.
Topics: Adipocytes; Adipose Tissue, Brown; Alkaline Phosphatase; Animals; Blotting, Western; Cell Line, Tran | 1997 |
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
Topics: Amino Acid Sequence; Animals; Anisomycin; CHO Cells; Cricetinae; Humans; Insulin; Insulin Receptor S | 2000 |
Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta.
Topics: Adenosine Triphosphate; Alanine; Cell Line; Humans; Insulin Resistance; Isoenzymes; Phosphorylation; | 2000 |
Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.
Topics: Aged; Amino Acid Substitution; Apolipoproteins; Asparagine; Blood Pressure; Cholesterol; Cholesterol | 2000 |
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Ataxia Telangiectasia; Ataxia Telangiectas | 2000 |
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
Topics: Animals; Anisomycin; CHO Cells; Cricetinae; Insulin; Insulin Antagonists; Insulin Resistance; Insuli | 2001 |
Gly40Ser polymorphism of the glucagon receptor gene is associated with central adiposity in men.
Topics: Adipose Tissue; Adult; Aged; Body Composition; Body Constitution; Body Mass Index; Energy Metabolism | 2001 |
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
Topics: Adult; Alleles; Aspartic Acid; Blood Glucose; Exons; Fatty Acids, Nonesterified; Female; Glucose Cla | 2001 |
Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins.
Topics: Anisomycin; Cycloheximide; Genes, erbB; Genes, erbB-2; Humans; Insulin; Insulin Receptor Substrate P | 2002 |
Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms.
Topics: Amino Acids; Animals; Biological Transport; Glucose; Glycogen Synthase Kinase 3; Heart; In Vitro Tec | 2002 |
In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Glycogen | 2002 |
Functional properties of a naturally occurring Trp1200----Ser1200 mutation of the insulin receptor.
Topics: Animals; Base Sequence; Cell Line; Cricetinae; DNA; Female; Humans; Insulin; Insulin Resistance; Mol | 1990 |
[Insulin receptors in sugar metabolism system].
Topics: Binding Sites; Humans; Insulin; Insulin Resistance; Molecular Structure; Phosphorylation; Protein-Ty | 1990 |
Tyrosine-kinase defect of the insulin receptor in cultured fibroblasts from patients with lipoatropic diabetes.
Topics: Adolescent; Adult; Autoradiography; Binding Sites; Binding, Competitive; Cells, Cultured; Child; Chi | 1989 |