sapropterin has been researched along with Insulin Resistance in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aldámiz-Echevarría, L; Correcher, P; Couce, ML; De Castro, MJ; Fernández-Marmiesse, A; Hermida, A; Leis, R; Martínez-Olmos, M; Roca, I; Sánchez-Pintos, P; Vitoria, I | 1 |
| Geddawy, A; Imamura, T; Iwasaki, H; Masada, M; Okamura, T; Shimosato, T; Shinozaki, K; Shintaku, H; Tawa, M; Yoshida, Y | 1 |
| Antoniades, C; Koutsogiannis, M; Papageorgiou, N; Siasos, G; Stefanadis, C; Tousoulis, D; Tsiamis, E | 1 |
| Busija, DW; Katakam, PV; Snipes, JA; Steed, MM | 1 |
| Benedito, S; Climent, B; Contreras, C; García-Sacristán, A; Hernández, M; Martínez, MP; Prieto, D; Sánchez, A | 1 |
| Kashiwagi, A; Masada, M; Okamura, T; Shinozaki, K | 1 |
| Kurabayashi, M; Morita, H; Nagai, R; Nakamura, T; Saito, Y | 1 |
| Nygren, A; Nyström, T; Sjöholm, A | 1 |
| Ren, J; Wu, S | 1 |
| Ayajiki, K; Kashiwagi, A; Koya, D; Masada, M; Nishio, Y; Okamura, T; Shinozaki, K; Yoshida, Y | 1 |
| Duncan, ER; Kahn, M; Kearney, MT; Wheatcroft, SB | 1 |
| Kashiwagi, A; Kikkawa, R; Masada, M; Nishio, Y; Okamura, T; Shinozaki, K; Toda, N; Yoshida, Y | 1 |
| Brunner, F; Pfeiffer, S; Russell, JC; Wascher, TC; Wölkart, G | 1 |
| Anderson, TJ; Dumont, AS; Maitland, A; Verma, S | 1 |
| Kashiwagi, A; Kikkawa, R; Kojima, H; Maegawa, H; Masada, M; Nishio, Y; Okamura, T; Shinozaki, K; Toda, N; Yoshida, Y | 1 |
| Hirayama, A; Kashiwagi, A; Kikkawa, R; Kodama, K; Masada, M; Nishio, Y; Ohtani, T; Okamura, T; Shinozaki, K; Yoshida, Y | 1 |
5 review(s) available for sapropterin and Insulin Resistance
| Article | Year |
|---|---|
Endothelial dysfunction: potential clinical implications.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Atherosclerosis; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Folic Acid; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Nitric Oxide; Risk Factors | 2010 |
Stress and vascular responses: oxidative stress and endothelial dysfunction in the insulin-resistant state.
Topics: Administration, Oral; Animals; Antioxidants; Biopterins; Cardiovascular Diseases; Endothelium, Vascular; Humans; Insulin; Insulin Resistance; Muscle Relaxation; Nitric Oxide Synthase; Oxidative Stress; Pteridines | 2003 |
[Involvement of homocysteine in the pathogenesis of hypertension and hypertensive target-organ damage].
Topics: Arginine; Arteriosclerosis; Biopterins; Cell Division; Endothelium, Vascular; Folic Acid; Homocysteine; Humans; Hypertension; Insulin Resistance; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Risk Factors | 2004 |
A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction?
Topics: Animals; Biopterins; Cytokines; Diabetes Mellitus; Endothelin-1; Heart Diseases; Humans; Inflammation; Insulin Resistance; Myocardium; Nitric Oxide; Sepsis; Shock, Septic; Systemic Inflammatory Response Syndrome; Toll-Like Receptors | 2006 |
Insulin resistance and endothelial cell dysfunction: studies in mammalian models.
Topics: Animals; Atherosclerosis; Biological Availability; Biopterins; Calcium; Endothelial Cells; Humans; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Reactive Oxygen Species; Vascular Diseases | 2008 |
1 trial(s) available for sapropterin and Insulin Resistance
| Article | Year |
|---|---|
Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.
Topics: Biopterins; Blood Glucose; Coenzymes; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Matched-Pair Analysis; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Reference Values; Vasodilation | 2004 |
10 other study(ies) available for sapropterin and Insulin Resistance
| Article | Year |
|---|---|
Carbohydrate status in patients with phenylketonuria.
Topics: Adolescent; Adult; Amino Acids; Biopterins; Body Mass Index; Carbohydrate Metabolism; Child; Child, Preschool; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Insulin Resistance; Male; Middle Aged; Multicenter Studies as Topic; Phenylalanine; Phenylketonurias; Postprandial Period; Young Adult | 2018 |
Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.
Topics: Amlodipine; Animals; Atorvastatin; Biopterins; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Fructose; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin Resistance; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Vasoconstriction; Vasodilation | 2014 |
Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats.
Topics: Animals; Biopterins; Cerebral Arteries; Cerebrovascular Circulation; Gene Expression Regulation, Enzymologic; GTP Cyclohydrolase; Hypoglycemic Agents; Insulin; Insulin Resistance; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type I; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rats, Zucker; Reactive Oxygen Species; Vasodilation | 2012 |
Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.
Topics: Acetophenones; Animals; Arginine; Arteries; Biopterins; Calcium; Electric Stimulation; Endothelium, Vascular; Erectile Dysfunction; GTP Cyclohydrolase; Insulin Resistance; Male; Metabolic Syndrome; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Obesity; Oxidative Stress; Penis; Rats; Rats, Zucker; Signal Transduction; Superoxides; Vasodilation | 2012 |
Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.
Topics: Adipose Tissue; Animals; Aorta; Biopterins; Blood Pressure; DNA, Complementary; Endothelial Cells; Endothelium, Vascular; Gene Transfer Techniques; GTP Cyclohydrolase; In Vitro Techniques; Injections, Intramuscular; Insulin Resistance; Male; Nitric Oxide Synthase Type III; Plasmids; Rats; Rats, Zucker; Superoxides; Vasodilation | 2005 |
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Ascorbic Acid; Biopterins; Blood Glucose; Blood Pressure; Calcimycin; Endothelium, Vascular; Fructose; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Resistance; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides; Transcription, Genetic; Vasodilation | 1999 |
Vascular dysfunction and myocardial contractility in the JCR:LA-corpulent rat.
Topics: Animals; Antioxidants; Aorta, Thoracic; Biopterins; Bradykinin; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Insulin Resistance; Ionophores; Male; Microcirculation; Myocardial Contraction; Nitric Oxide Synthase; Nitroarginine; Obesity; Perfusion; Rats; Rats, Inbred Strains | 2000 |
Endothelial function of bypass grafts: role of endothelin and tetrahydrobiopterin.
Topics: Biopterins; Coronary Artery Bypass; Endothelin-1; Endothelium, Vascular; Graft Occlusion, Vascular; Humans; Insulin Resistance; Vascular Resistance | 2000 |
Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats.
Topics: Administration, Oral; Animals; Antioxidants; Aorta; Biopterins; Endothelium, Vascular; Humans; Insulin Resistance; Male; Muscle Relaxation; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2000 |
Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.
Topics: Acetylcholine; Aged; Biopterins; Coronary Circulation; Coronary Disease; Dihydropteridine Reductase; Endothelium, Vascular; Erythrocytes; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Lipid Peroxides; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Reference Values; Risk Factors | 2001 |