psi-baptigenin has been researched along with Insulin-Resistance* in 1 studies
1 other study(ies) available for psi-baptigenin and Insulin-Resistance
| Article | Year |
|---|---|
Flavonoids from Sophora alopecuroides L. improve palmitate-induced insulin resistance by inhibiting PTP1B activity in vitro.
Seventeen flavonoids (1-17) were isolated from Sophora alopecuroides L.. Compounds 1 and 2 were new compounds, and compounds 5, 8, 11, 12, and 17 were isolated from S. alopecuroides for the first time. The sources of compounds 1 and 2 were determined from the seeds of S. alopecuroides by UPLC-QE-Orbitrap-MS, and compounds 1, 2, 7, 13, 14, 15, 16, and 17 were proven to improve the insulin resistance of C2C12 myotubes and significantly increase glucose consumption levels. Among them, compounds 1, 2, 13, 14, 16, and 17 could bind to protein tyrosine phosphatase 1B (PTP1B), thereby significantly inhibiting the enzyme activity of PTP1B. Compound 2 had the strongest inhibitory effect, with an inhibition rate of 95.22% at 0.1 μg mL Topics: Animals; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Insulin Resistance; Mice; Molecular Structure; Palmitates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Sophora; Structure-Activity Relationship | 2021 |