melatonin has been researched along with Insulin Resistance in 82 studies
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the effect of melatonin supplementation on mental health parameters, metabolic and genetic parameters in women suffering from polycystic ovary syndrome (PCOS)." | 9.30 | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. ( Aghadavod, E; Asemi, Z; Eftekhar, T; Foroozanfard, F; Kavossian, E; Ostadmohammadi, V; Reiter, RJ; Shabani, A, 2019) |
| "To assess the effect of daily treatment with melatonin on fasting glucose, insulin, insulin sensitivity and haemoglobin A1c (HbA1c) levels." | 9.12 | Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis. ( Kampmann, U; Lauritzen, ES; Smedegaard, SB; Støy, J, 2021) |
| "The present results indicate that in aged women administration of 1 mg of melatonin reduces glucose tolerance and insulin sensitivity." | 9.09 | Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. ( Arangino, S; Cagnacci, A; Cagnacci, P; Melis, GB; Paoletti, AM; Renzi, A; Volpe, A, 2001) |
| "To analyse the effects of melatonin (ME) treatment on oxidative stress and insulin resistance (IR) in rats with apical periodontitis (AP) fed a high-fat diet (HFD)." | 8.31 | Melatonin decreases plasma TNF-α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high-fat diet. ( Belardi, BE; Bravo, LT; Chaves-Neto, AH; Chiba, FY; Cintra, LTA; Dos Santos, RM; Matsushita, DH; Mattera, MSLC; Tessarin, GWL; Tsosura, TVS, 2023) |
| "Melatonin attenuated weight gain, insulin resistance, adipocyte hypertrophy, inflammation, and hepatic steatosis induced by the HFD and increased energy expenditure." | 8.12 | Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet. ( Cai, S; Ding, C; Huang, Y; Jin, S; Li, D; Li, H; Shao, H; Wang, Y; Xu, L; Zhang, O; Zhu, Y, 2022) |
| "This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD)." | 7.88 | Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease. ( Belardi, BE; Chiba, FY; Marani, F; Mattera, MSLC; Pereira, RF; Pinheiro, BCES; Santos, RMD; Sumida, DH; Tessarin, GWL; Tsosura, TVS, 2018) |
| "Melatonin supplementation in combination with exercise behavior may ameliorate IR, hypertension and exercise performance or fatigue possibly by improving antioxidative activities, hyperlipidemia, inflammatory cytokines via up-regulation of GLUT4, PGC-1 α and mitochondrial biogenesis in T2DM rats." | 7.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "This study was undertaken to study the effects of melatonin on metabolic and reproductive aspects of polycystic ovary syndrome (PCOS) in rats." | 7.80 | Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. ( Majumdar, AS; Pai, SA, 2014) |
| "Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance." | 7.79 | Association of nocturnal melatonin secretion with insulin resistance in nondiabetic young women. ( Curhan, GC; Forman, JP; McMullan, CJ; Schernhammer, ES, 2013) |
| " Moreover, the aging process is also associated with obesity and reduction in melatonin synthesis from the pineal gland and other organs." | 7.79 | Melatonin improves insulin sensitivity independently of weight loss in old obese rats. ( Bacurau, RF; Bordin, S; Camporez, JP; Caperuto, LC; Carpinelli, AR; Carvalho, CR; Cipolla-Neto, J; do Amaral, FG; Hirata, E; Marçal, AC; Peliciari-Garcia, RA; Ribeiro, LM; Siqueira-Filho, MA; Zanuto, R, 2013) |
| "The aim of the present study was to investigate the effect of aging on several parameters related to glucose homeostasis and insulin resistance in pancreas and how melatonin administration could affect these parameters." | 7.79 | Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). ( Cuesta, S; García, C; Kireev, R; Rancan, L; Tresguerres, JA; Vara, E, 2013) |
| "In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats." | 7.78 | Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012) |
| "Seventeen male participants with type 2 diabetes completed (1) 3 months of daily melatonin treatment (10 mg) 1 h before bedtime (M) and (2) 3 months of placebo treatment 1 h before bedtime (P)." | 7.11 | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial. ( Christensen, LL; Jessen, N; Kampmann, U; Lauritzen, ES; Møller, N; Pedersen, MGB; Støy, J, 2022) |
| "We conclude that melatonin ameliorated hyperinsulinemia, insulin resistance, and insulin sensitivity, and the results are an update of a previous meta-analysis." | 6.72 | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Li, Y; Xu, Z, 2021) |
| " Supplementation dosage studies and more thorough clinical trials are needed to ascertain not only the relevance of such findings but also the efficacy of melatonin supplementation." | 6.72 | Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. ( Bueno, AA; Cipolla-Neto, J; Genario, R; Santos, HO, 2021) |
| "Melatonin has been suggested to be effective in improving MetS through its anti-hyperlipidemic action." | 6.49 | Metabolic syndrome, its pathophysiology and the role of melatonin. ( Espino, J; Mohamed, M; Ohta, Y; Pariente, JA; Rodriguez, AB; Srinivasan, V; Zakaria, R, 2013) |
| "Melatonin has been shown to have beneficial effects in cardiovascular disorders including ischaemic heart disease and hypertension." | 6.48 | Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? ( du Toit, EF; Lochner, A; Nduhirabandi, F, 2012) |
| "Melatonin has been proven to have antiarrhythmic potential; however, several studies have recently challenged this view." | 5.91 | Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload. ( Fan, J; Fu, Y; Jiang, T; Liu, B; Liu, P; Qin, X; Zhang, Y; Zheng, Q, 2023) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 5.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| "NAFLD is a still reversible phase but may evolve into steatohepatitis (NASH), cirrhosis and carcinoma." | 5.51 | Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. ( De Petro, G; García-Gómez, R; Grossi, I; Lavazza, A; Monsalve, M; Patel, GA; Rezzani, R; Salvi, A; Stacchiotti, A, 2019) |
| "Melatonin plays an important role in regulating circadian rhythms." | 5.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "Excess weight and obesity are severe public health threats worldwide." | 5.46 | Melatonin prevents obesity through modulation of gut microbiota in mice. ( Hong, F; Jia, L; Jin, X; Wang, J; Wang, S; Xu, P; Xue, T; Zhai, Y, 2017) |
| "Melatonin, which is an antioxidant phytochemical and synthesized by the pineal gland, has multiple functions in cellular responses such as apoptosis and survival against stress." | 5.46 | Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. ( Kim, OY; Song, J, 2017) |
| "Melatonin treatment alone improved circadian activity rhythms, attenuated induction of β-cell failure, and enhanced glucose tolerance." | 5.43 | Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats. ( Hoang, J; Matveyenko, AV; Nguyen, A; Rakshit, K; Thomas, AP; Vongbunyong, K, 2016) |
| "Melatonin has a number of beneficial metabolic actions and reduced levels of melatonin may contribute to type 2 diabetes." | 5.40 | Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle. ( Akira Uyemura, S; Alberici, LC; Amaral, FG; Araújo, MB; Baraldi, FG; Bomfim, LH; Carneiro, EM; Cipolla-Neto, J; Gomis, R; Lima, T; Passos, MA; Queiroz, AL; Sampaio, IH; Silveira, LR; Teodoro, BG; Vieira, E, 2014) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 5.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "The aim of this study was to evaluate the effect of melatonin supplementation on mental health parameters, metabolic and genetic parameters in women suffering from polycystic ovary syndrome (PCOS)." | 5.30 | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. ( Aghadavod, E; Asemi, Z; Eftekhar, T; Foroozanfard, F; Kavossian, E; Ostadmohammadi, V; Reiter, RJ; Shabani, A, 2019) |
| "Melatonin administration impaired glucose tolerance." | 5.19 | Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. ( Garaulet, M; Gómez-Abellán, P; Madrid, JA; Rubio-Sastre, P; Scheer, FA, 2014) |
| " We included randomized clinical trials investigating melatonin supplementation's effects, compared to placebo, on fasting blood glucose, insulin resistance, and glycated hemoglobin." | 5.12 | Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials. ( Delpino, FM; Figueiredo, LM; Nunes, BP, 2021) |
| "To assess the effect of daily treatment with melatonin on fasting glucose, insulin, insulin sensitivity and haemoglobin A1c (HbA1c) levels." | 5.12 | Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis. ( Kampmann, U; Lauritzen, ES; Smedegaard, SB; Støy, J, 2021) |
| "The present results indicate that in aged women administration of 1 mg of melatonin reduces glucose tolerance and insulin sensitivity." | 5.09 | Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. ( Arangino, S; Cagnacci, A; Cagnacci, P; Melis, GB; Paoletti, AM; Renzi, A; Volpe, A, 2001) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "To analyse the effects of melatonin (ME) treatment on oxidative stress and insulin resistance (IR) in rats with apical periodontitis (AP) fed a high-fat diet (HFD)." | 4.31 | Melatonin decreases plasma TNF-α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high-fat diet. ( Belardi, BE; Bravo, LT; Chaves-Neto, AH; Chiba, FY; Cintra, LTA; Dos Santos, RM; Matsushita, DH; Mattera, MSLC; Tessarin, GWL; Tsosura, TVS, 2023) |
| "Subjects with insulin resistance (n = 101) showed significantly lower nocturnal melatonin levels compared to those with unimpaired insulin secretion (p = 0." | 4.12 | Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity. ( Kalveram, L; Keller, T; Krude, H; Kühnen, P; Overberg, J; Wiegand, S, 2022) |
| "The pretreatment of hUC-MSCs with melatonin partly boosted cell efficiency and thereby alleviated impaired glycemic control and insulin resistance." | 4.12 | Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway. ( Aierken, A; Cheng, X; Du, X; Enkhbaatar, BB; He, X; Hua, J; Jia, W; Kou, Z; Li, B; Li, N; Liu, P; Peng, S; Shen, Q; Tan, N; Wang, C; Wang, R; Wu, X; Yu, S; Zhang, J; Zhang, M; Zhang, R, 2022) |
| "Melatonin attenuated weight gain, insulin resistance, adipocyte hypertrophy, inflammation, and hepatic steatosis induced by the HFD and increased energy expenditure." | 4.12 | Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet. ( Cai, S; Ding, C; Huang, Y; Jin, S; Li, D; Li, H; Shao, H; Wang, Y; Xu, L; Zhang, O; Zhu, Y, 2022) |
| "To verify the effects of melatonin supplementation on insulin sensitivity, plasma concentrations of inflammatory cytokines, insulin signalling and inflammatory pathways in the soleus (SM) and extensor digitorum longus (EDL) muscles of rats with apical periodontitis (AP)." | 4.02 | Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis. ( Belardi, BE; Chiba, FY; Cintra, LTA; Matsushita, DH; Mattera, MSLC; Santelli, JO; Silva, CC; Tavares, BS; Tsosura, TVS, 2021) |
| "Several novel animal studies have shown that intrauterine metabolic programming can be modified in the event of reduced melatonin synthesis during pregnancy, leading to glucose intolerance and insulin resistance in the offspring." | 3.91 | Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring. ( Amaral, F; Cipolla-Neto, J; Lowden, A; Moreno, CRC; Nehme, PA; Skene, DJ, 2019) |
| "This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD)." | 3.88 | Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease. ( Belardi, BE; Chiba, FY; Marani, F; Mattera, MSLC; Pereira, RF; Pinheiro, BCES; Santos, RMD; Sumida, DH; Tessarin, GWL; Tsosura, TVS, 2018) |
| "Melatonin supplementation in combination with exercise behavior may ameliorate IR, hypertension and exercise performance or fatigue possibly by improving antioxidative activities, hyperlipidemia, inflammatory cytokines via up-regulation of GLUT4, PGC-1 α and mitochondrial biogenesis in T2DM rats." | 3.85 | Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus. ( Go, HK; Kim, DH; Kim, MJ; Kwon, HS; Oak, MH; Rahman, MM, 2017) |
| "For the last decade melatonin has attracted attention as a neuroregulator in pathogenesis of obesity and metabolic syndrome." | 3.85 | [METABOLIC SECRETION IN REPRODUCTIVE AGE WOMEN WITH OBESITY]. ( Asatiani, K; Chkheidze, N; Malazonia, A; Vekua, N; Zerekidze, T, 2017) |
| "This study was undertaken to study the effects of melatonin on metabolic and reproductive aspects of polycystic ovary syndrome (PCOS) in rats." | 3.80 | Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats. ( Majumdar, AS; Pai, SA, 2014) |
| " Moreover, the aging process is also associated with obesity and reduction in melatonin synthesis from the pineal gland and other organs." | 3.79 | Melatonin improves insulin sensitivity independently of weight loss in old obese rats. ( Bacurau, RF; Bordin, S; Camporez, JP; Caperuto, LC; Carpinelli, AR; Carvalho, CR; Cipolla-Neto, J; do Amaral, FG; Hirata, E; Marçal, AC; Peliciari-Garcia, RA; Ribeiro, LM; Siqueira-Filho, MA; Zanuto, R, 2013) |
| "Exogenous melatonin ameliorates insulin resistance in animals, while among humans, polymorphisms in the melatonin receptor gene are associated with insulin resistance." | 3.79 | Association of nocturnal melatonin secretion with insulin resistance in nondiabetic young women. ( Curhan, GC; Forman, JP; McMullan, CJ; Schernhammer, ES, 2013) |
| "The aim of the present study was to investigate the effect of aging on several parameters related to glucose homeostasis and insulin resistance in pancreas and how melatonin administration could affect these parameters." | 3.79 | Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). ( Cuesta, S; García, C; Kireev, R; Rancan, L; Tresguerres, JA; Vara, E, 2013) |
| "In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats." | 3.78 | Melatonin improves metabolic syndrome induced by high fructose intake in rats. ( Kitagawa, A; Ohashi, K; Ohta, Y, 2012) |
| "During two years the influence of light regimens (standard lightning--LD, constant lightning--LL, natural lightning of the North-West of Russia--NL) and of melatonin on the development of metabolic syndrome of ageing LIO rats was studied." | 3.74 | [Effect of different light regimens on the development of metabolic syndrome of aging rats]. ( Vinogradova, IA, 2007) |
| "The present study aimed to investigate insulin sensitivity and GLUT4 expression protein in pinealectomized rats, as well as to determining the effects of melatonin and calorie restriction on the changes induced by pinealectomy." | 3.72 | Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane. ( Cipolla-Neto, J; Machado, UF; Seraphim, PM; Sumida, DH; Zanquetta, MM, 2003) |
| "Seventeen male participants with type 2 diabetes completed (1) 3 months of daily melatonin treatment (10 mg) 1 h before bedtime (M) and (2) 3 months of placebo treatment 1 h before bedtime (P)." | 3.11 | Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial. ( Christensen, LL; Jessen, N; Kampmann, U; Lauritzen, ES; Møller, N; Pedersen, MGB; Støy, J, 2022) |
| "We conclude that melatonin ameliorated hyperinsulinemia, insulin resistance, and insulin sensitivity, and the results are an update of a previous meta-analysis." | 2.72 | Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( Li, Y; Xu, Z, 2021) |
| " Supplementation dosage studies and more thorough clinical trials are needed to ascertain not only the relevance of such findings but also the efficacy of melatonin supplementation." | 2.72 | Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications. ( Bueno, AA; Cipolla-Neto, J; Genario, R; Santos, HO, 2021) |
| "Melatonin is a remarkable molecule with diverse biological and physiological actions and is involved in the regulation of various important functions such as circadian rhythm, energy metabolism, the reproductive system, the cardiovascular system, and the neuropsychiatric system." | 2.52 | Melatonin: a potential intervention for hepatic steatosis. ( Huang, FF; Qu, S; Sun, H, 2015) |
| "Melatonin has been suggested to be effective in improving MetS through its anti-hyperlipidemic action." | 2.49 | Metabolic syndrome, its pathophysiology and the role of melatonin. ( Espino, J; Mohamed, M; Ohta, Y; Pariente, JA; Rodriguez, AB; Srinivasan, V; Zakaria, R, 2013) |
| "Melatonin is a multifunctional indoleamine which counteracts several pathophysiologic steps and displays significant beneficial effects against hyperglycemia-induced cellular toxicity." | 2.48 | Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. ( Korkmaz, A; Ma, S; Reiter, RJ; Rosales-Corral, S; Tan, DX; Topal, T, 2012) |
| "Melatonin has been shown to have beneficial effects in cardiovascular disorders including ischaemic heart disease and hypertension." | 2.48 | Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities? ( du Toit, EF; Lochner, A; Nduhirabandi, F, 2012) |
| "Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD." | 2.40 | GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus. ( Das, UN, 1999) |
| "Melatonin has been proven to have antiarrhythmic potential; however, several studies have recently challenged this view." | 1.91 | Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload. ( Fan, J; Fu, Y; Jiang, T; Liu, B; Liu, P; Qin, X; Zhang, Y; Zheng, Q, 2023) |
| "Despite current treatments for polycystic ovary syndrome (PCOS), a considerable number of women with this syndrome do not reach the treatment goal, suggesting the presence of other probable misdiagnosed features of this syndrome that are not taken into account in the assessment and therefore in the therapeutical approach." | 1.91 | Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome. ( Barrea, L; Colao, A; de Alteriis, G; Docimo, A; Muscogiuri, G; Savastano, S; Verde, L; Vetrani, C, 2023) |
| "Melatonin is a chronobiotic substance that plays a main role in stabilizing bodily rhythm and has shown beneficial effects in protecting against obesity." | 1.56 | Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure. ( Guo, Y; Hong, F; Jia, L; Li, L; Pan, S; Qiao, X; Wang, J; Xu, P; Xue, T; Zhai, Y, 2020) |
| "NAFLD is a still reversible phase but may evolve into steatohepatitis (NASH), cirrhosis and carcinoma." | 1.51 | Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy. ( De Petro, G; García-Gómez, R; Grossi, I; Lavazza, A; Monsalve, M; Patel, GA; Rezzani, R; Salvi, A; Stacchiotti, A, 2019) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 1.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| "Melatonin plays an important role in regulating circadian rhythms." | 1.48 | Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ( Baik, SH; Choi, DS; Choi, KM; Heo, JI; Kim, NH; Kim, SG; Seo, JA; Yoo, HJ; Yoon, DW; Yu, JH, 2018) |
| "Excess weight and obesity are severe public health threats worldwide." | 1.46 | Melatonin prevents obesity through modulation of gut microbiota in mice. ( Hong, F; Jia, L; Jin, X; Wang, J; Wang, S; Xu, P; Xue, T; Zhai, Y, 2017) |
| "Melatonin, which is an antioxidant phytochemical and synthesized by the pineal gland, has multiple functions in cellular responses such as apoptosis and survival against stress." | 1.46 | Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition. ( Kim, OY; Song, J, 2017) |
| "Melatonin treatment alone improved circadian activity rhythms, attenuated induction of β-cell failure, and enhanced glucose tolerance." | 1.43 | Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats. ( Hoang, J; Matveyenko, AV; Nguyen, A; Rakshit, K; Thomas, AP; Vongbunyong, K, 2016) |
| "Reduced insulin sensitivity was compensated by an increased insulin response to glucose, which may reflect an initial physiological adaptation to maintain normal blood sugar levels during sleep loss." | 1.42 | Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. ( Depner, CM; Eckel, RH; Higgins, J; Markwald, RR; McHill, AW; Melanson, EL; Perreault, L; Smith, MR; Wright, KP, 2015) |
| "Melatonin has a number of beneficial metabolic actions and reduced levels of melatonin may contribute to type 2 diabetes." | 1.40 | Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle. ( Akira Uyemura, S; Alberici, LC; Amaral, FG; Araújo, MB; Baraldi, FG; Bomfim, LH; Carneiro, EM; Cipolla-Neto, J; Gomis, R; Lima, T; Passos, MA; Queiroz, AL; Sampaio, IH; Silveira, LR; Teodoro, BG; Vieira, E, 2014) |
| "Melatonin treatment reduced hyperglycemia, polydipsia, and polyphagia as well as improved insulin resistance as demonstrated by constant glucose disappearance rate and homeostasis model of assessment-insulin resistance." | 1.38 | Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment. ( Andreotti, S; Campaña, AB; Carpinelli, AR; Cipolla-Neto, J; de Oliveira, AC; de Proença, AR; de Souza, AH; Farias, Tda S; Lima, FB; Sertié, RA; Torres-Leal, FL, 2012) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 1.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "Although obesity has been reported to be associated with leptin "resistance," it is unclear whether obesity alters the cardiovascular and metabolic effects of chronic MC3/4-R activation." | 1.33 | Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation? ( Hall, JE; Kuo, JJ; Liu, J; Silva, AA; Tallam, LS, 2006) |
| "Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD." | 1.30 | GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity. ( Das, UN, 1999) |
| "Insulin sensitivity was defined as the hormone concentration capable of producing the half-maximal transport rate." | 1.29 | The regulation of insulin action in isolated adipocytes. Role of the periodicity of food intake, time of day and melatonin. ( Cipolla Neto, J; Dolnikoff, MS; Hell, NS; Lima, FB; Matsushita, DH; Okamoto, MM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.22) | 18.7374 |
| 1990's | 3 (3.66) | 18.2507 |
| 2000's | 7 (8.54) | 29.6817 |
| 2010's | 46 (56.10) | 24.3611 |
| 2020's | 25 (30.49) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 2 |
| Xu, Z | 1 |
| Albreiki, MS | 1 |
| Middleton, B | 1 |
| Hampton, SM | 1 |
| Li, X | 5 |
| He, J | 1 |
| Zhou, Y | 1 |
| Cai, S | 4 |
| Guo, R | 1 |
| Zheng, H | 1 |
| Li, Q | 1 |
| Qiu, X | 1 |
| Zhang, J | 4 |
| Cheng, Z | 1 |
| Overberg, J | 1 |
| Kalveram, L | 1 |
| Keller, T | 1 |
| Krude, H | 1 |
| Kühnen, P | 1 |
| Wiegand, S | 1 |
| Shen, S | 1 |
| Liao, Q | 1 |
| Wong, YK | 1 |
| Chen, X | 1 |
| Yang, C | 1 |
| Xu, C | 1 |
| Sun, J | 1 |
| Wang, J | 3 |
| Park, J | 1 |
| Kim, J | 1 |
| Yun, Y | 1 |
| Han, DH | 1 |
| Kim, K | 1 |
| Hong, J | 1 |
| Cho, S | 1 |
| Aierken, A | 1 |
| Li, B | 1 |
| Liu, P | 2 |
| Cheng, X | 1 |
| Kou, Z | 1 |
| Tan, N | 1 |
| Zhang, M | 1 |
| Yu, S | 1 |
| Shen, Q | 1 |
| Du, X | 1 |
| Enkhbaatar, BB | 1 |
| Zhang, R | 1 |
| Wu, X | 1 |
| Wang, R | 1 |
| He, X | 1 |
| Li, N | 1 |
| Peng, S | 1 |
| Jia, W | 1 |
| Wang, C | 1 |
| Hua, J | 1 |
| Lauritzen, ES | 3 |
| Kampmann, U | 3 |
| Pedersen, MGB | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Metabolic Effects of Melatonin Treatment[NCT03204877] | Phase 1/Phase 2 | 36 participants (Actual) | Interventional | 2017-08-22 | Completed | ||
| The Role of Gut Microbiota Metabolite, Trimethylamine N-oxide, in the Insulin Resistance Development[NCT05251207] | 60 participants (Anticipated) | Interventional | 2022-02-07 | Suspended (stopped due to PhD student responsible for the study has decided to terminate her education.) | |||
| Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls[NCT02157974] | Phase 2/Phase 3 | 92 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Investigating the Relationship Between Circadian Phase and Insulin Resistance in Obese Adolescents[NCT02585830] | 25 participants (Actual) | Observational | 2015-10-31 | Completed | |||
| A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP)[NCT03764020] | Phase 3 | 320 participants (Anticipated) | Interventional | 2019-06-01 | Not yet recruiting | ||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
~1mL saliva was collected at 30- to 60- minute intervals in dim light (<5 lux in the angle of gaze, approximately the light level of candlelight or civil twilight) from approximately 5pm until noon the next day. Dim light melatonin onset (DLMOn) was defined as the linear interpolated clock time at which evening salivary melatonin concentrations increased and remained above a threshold of 3pg/mL. Melatonin offset (DLMOff) was the linear interpolated clock time at which salivary melatonin concentrations fell below this threshold. Later DLMOn and DLMOff are indicative of a later circadian rhythm. (NCT02585830)
Timeframe: 1 day
| Intervention | decimal hours (Mean) | |
|---|---|---|
| Dim Light Melatonin Onset | Dim Light Melatonin Offset | |
| Observation | 21.33 | 8.32 |
After an overnight fast, participants completed an oral glucose tolerance test (OGTT) in the morning. Participants consumed a 75g dextrose drink and serum for glucose and insulin concentrations were collected at baseline and every 30 minutes for 3 hours. The homeostatic model assessment for insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/ml) x fasting glucose (mmol/l)] / 22.5); lower HOMA-IR indicates better insulin sensitivity. The Matsuda Index was calculated as √10,000 / [[fasting insulin (μU/ml) x fasting glucose (mmol/l)] x [mean OSTT insulin (μU/ml) x mean OSTT glucose (mmol/l)]]; high Matsuda Index indicates better insulin sensitivity. (NCT02585830)
Timeframe: 3 hours
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Homeostatic Model Assessment (HOMA-IR) | Matsuda Index | |
| Observation | 2.9 | 4.93 |
18 reviews available for melatonin and Insulin Resistance
| Article | Year |
|---|---|
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperinsulinism; Insulin; Insu | 2021 |
The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Type 2; Humans; Inflam | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications.
Topics: Adipose Tissue; Animals; Antioxidants; Dietary Supplements; Glucose; Humans; Insulin Resistance; Lip | 2021 |
Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Dietary Supplements; Fasting; Female; Glycated Hemoglobin; | 2021 |
Effects of daily administration of melatonin before bedtime on fasting insulin, glucose and insulin sensitivity in healthy adults and patients with metabolic diseases. A systematic review and meta-analysis.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Glucose; Glycated Hemoglobin; Humans; Insu | 2021 |
The role of melatonin in the onset and progression of type 3 diabetes.
Topics: Animals; Blood-Brain Barrier; Diabetes Mellitus; Disease Progression; Humans; Insulin Resistance; Me | 2017 |
The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Blood Glucose; Diabetes Mellitus; Dietary Supplements; Humans; Insulin Resistance; Melatonin; Random | 2018 |
Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes.
Topics: Adipose Tissue, Beige; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Diabetes Mellitus, Typ | 2019 |
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Topics: Aging; Animals; Autophagy; Brain; Caloric Restriction; Circadian Rhythm; Diabetes Mellitus; Energy M | 2014 |
Melatonin: a potential intervention for hepatic steatosis.
Topics: Adiposity; Animals; Antioxidants; Fatty Liver; Humans; Insulin Resistance; Lipid Metabolism; Melaton | 2015 |
Elevated heart rate and nondipping heart rate as potential targets for melatonin: a review.
Topics: Animals; Endothelium, Vascular; Heart Rate; Humans; Hypertension; Insulin Resistance; Melatonin; Pin | 2016 |
Melatonin and the pathologies of weakened or dysregulated circadian oscillators.
Topics: Animals; Biological Clocks; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; | 2017 |
Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state.
Topics: Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Diabetes Mellitus, Type | 2012 |
Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities?
Topics: Body Weight; Energy Metabolism; Humans; Insulin Resistance; Melatonin; Metabolic Syndrome; Obesity | 2012 |
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity.
Topics: Adiponectin; Appetite; Diabetes Mellitus; Energy Metabolism; Female; Ghrelin; Glucose; Humans; Insul | 2012 |
Metabolic syndrome, its pathophysiology and the role of melatonin.
Topics: Animals; Antioxidants; Dyslipidemias; Humans; Insulin Resistance; Melatonin; Metabolic Syndrome; Pat | 2013 |
GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus.
Topics: Caenorhabditis elegans Proteins; Diabetes Mellitus, Type 2; Fatty Acids, Essential; Glucose; Glucose | 1999 |
11 trials available for melatonin and Insulin Resistance
| Article | Year |
|---|---|
The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males.
Topics: Circadian Rhythm; Cross-Over Studies; Glucose; Humans; Insulin Resistance; Lipids; Male; Meals; Mela | 2021 |
Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized placebo-controlled crossover trial.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose; Humans; | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
The Effects of Melatonin Supplementation on Parameters of Mental Health, Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress in Diabetic Hemodialysis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Biomarkers; Blood Glucose; Cardiovascular | 2020 |
Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.
Topics: Adolescent; Adult; Blood Pressure; Calorimetry, Indirect; Child; Child, Preschool; Cross-Over Studie | 2021 |
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD | 2019 |
Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Blood Glucose; Dietary Supplements; Double-Blind Method; Female; Gene Expression; | 2019 |
A double-blind, placebo-controlled trial related to the effects of melatonin on oxidative stress and inflammatory parameters of obese women.
Topics: Adult; C-Reactive Protein; Double-Blind Method; Female; Humans; Inflammation; Insulin Resistance; In | 2015 |
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening.
Topics: Adult; Area Under Curve; Blood Glucose; Body Mass Index; Female; Glucose Intolerance; Glucose Tolera | 2014 |
The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis.
Topics: Adult; Antioxidants; Cytokines; Fatty Liver; Female; gamma-Glutamyltransferase; Hepatocytes; Humans; | 2010 |
Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women.
Topics: Analysis of Variance; Area Under Curve; Blood Glucose; C-Peptide; Estradiol; Estrogen Replacement Th | 2001 |
54 other studies available for melatonin and Insulin Resistance
| Article | Year |
|---|---|
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, | 2021 |
Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome.
Topics: Female; Granulosa Cells; Humans; Insulin Resistance; Melatonin; Phosphatidylinositol 3-Kinases; Poly | 2022 |
Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity.
Topics: Adolescent; Child; Circadian Rhythm; Cross-Sectional Studies; Humans; Insulin Resistance; Melatonin; | 2022 |
Daily injection of melatonin inhibits insulin resistance induced by chronic mealtime shift.
Topics: Animals; Diabetes Mellitus, Type 2; Insulin Resistance; Meals; Melatonin; Mice; Reactive Oxygen Spec | 2022 |
Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.
Topics: Animals; bcl-2-Associated X Protein; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Melatoni | 2022 |
Agomelatine, a structural analog of melatonin, improves kidney dysfunction through regulating the AMPK/mTOR signaling pathway to promote autophagy in obese rats.
Topics: Acetamides; AMP-Activated Protein Kinases; Animals; Autophagy; Insulin Resistance; Kidney; Male; Mel | 2022 |
Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet.
Topics: Adipose Tissue, Brown; AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Energy Metabolism; In | 2022 |
Melatonin decreases plasma TNF-α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high-fat diet.
Topics: Animals; Antioxidants; Diet, High-Fat; Glutathione; Insulin Resistance; Melatonin; Oxidative Stress; | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome.
Topics: Case-Control Studies; Chronotype; Female; Humans; Insulin; Insulin Resistance; Melatonin; Obesity; P | 2023 |
Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload.
Topics: Animals; Atrial Fibrillation; Insulin Resistance; Lipids; Melatonin; Mice; Mice, Obese; Obesity; Pro | 2023 |
A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucose; Hypo | 2023 |
Reduced melatonin synthesis in pregnant night workers: Metabolic implications for offspring.
Topics: Circadian Rhythm; Energy Metabolism; Female; Fetus; Glucose Intolerance; Humans; Insulin Resistance; | 2019 |
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy.
Topics: Animals; Autophagy; Diet, High-Fat; Inflammation; Insulin Resistance; Liver; Male; Melatonin; Mice; | 2019 |
Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glyco | 2019 |
Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure.
Topics: Animals; Cell Line; Circadian Clocks; Circadian Rhythm; Dysbiosis; Gastrointestinal Microbiome; Hepa | 2020 |
Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis.
Topics: Animals; Insulin; Insulin Resistance; Melatonin; Periapical Periodontitis; Rats; Rats, Wistar | 2021 |
Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway.
Topics: Adult; Animals; Antioxidants; Autophagy; Case-Control Studies; Female; Gene Expression Regulation; H | 2021 |
Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
Topics: Animals; Aromatase Inhibitors; Blood Glucose; Cell Proliferation; Cricetinae; Disease Models, Animal | 2021 |
Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Fatigue; Hypertension; I | 2017 |
Melatonin Modulates Neuronal Cell Death Induced by Endoplasmic Reticulum Stress under Insulin Resistance Condition.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Gene Expressio | 2017 |
[METABOLIC SECRETION IN REPRODUCTIVE AGE WOMEN WITH OBESITY].
Topics: Adult; Case-Control Studies; Dyslipidemias; Female; Humans; Insulin Resistance; Lipid Metabolism; Me | 2017 |
Four days of simulated shift work reduces insulin sensitivity in humans.
Topics: Adult; Biological Clocks; Blood Glucose; Circadian Rhythm; Female; Gene Expression; Humans; Insulin | 2018 |
Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
Topics: alpha-2-HS-Glycoprotein; Animals; Dietary Fats; Endoplasmic Reticulum Stress; Fatty Liver; Hep G2 Ce | 2018 |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease.
Topics: Animals; Blood Glucose; Cytokines; Insulin; Insulin Resistance; Lipids; Male; Melatonin; Periodontal | 2018 |
Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity.
Topics: Actigraphy; Adolescent; Body Mass Index; Circadian Rhythm; Female; Follow-Up Studies; Humans; Insuli | 2019 |
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin | 2019 |
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin | 2019 |
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin | 2019 |
Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Topics: Actigraphy; Adolescent; Circadian Rhythm; Cross-Sectional Studies; Fasting; Female; Humans; Insulin | 2019 |
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet.
Topics: Aging; Animals; Cholinergic Neurons; Cognitive Dysfunction; Dietary Fats; Female; Hippocampus; Insul | 2019 |
Melatonin improves insulin sensitivity independently of weight loss in old obese rats.
Topics: Aging; Animals; Antioxidants; Dietary Supplements; Drug Evaluation, Preclinical; Glucose Metabolism | 2013 |
Association of nocturnal melatonin secretion with insulin resistance in nondiabetic young women.
Topics: Adult; Biomarkers; Circadian Rhythm; Cross-Sectional Studies; Female; Health Surveys; Humans; Insuli | 2013 |
Neu-p11 reduces clock/apelin expression in insulin-resistant mouse adipocyte model.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Apelin; CLOCK Proteins; Glucose; Hypoglycemic Agents; | 2013 |
Melatonin rescues 3T3-L1 adipocytes from FFA-induced insulin resistance by inhibiting phosphorylation of IRS-1 on Ser307.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Gene Expression Regulation; Glucose; Glucos | 2014 |
Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle.
Topics: Animals; Cells, Cultured; Citric Acid Cycle; Glucose Tolerance Test; Insulin Resistance; Male; Melat | 2014 |
Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Disease Models, Animal; Female; Glucose Tolerance Test; Insulin Resistance; Lipid Metabolis | 2014 |
The investigation of melatonin effect on liver antioxidant and oxidant levels in fructose-mediated metabolic syndrome model.
Topics: Animals; Antioxidants; Disease Models, Animal; Fructose; Insulin Resistance; Liver; Male; Melatonin; | 2015 |
Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity.
Topics: Adolescent; Adult; Circadian Rhythm; Female; Glucose; Humans; Insulin; Insulin Resistance; Male; Mel | 2015 |
Role of Neu-p11/luzindole in the regulation of insulin signaling pathways and insulin resistance.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Glycogen Synthase Kinase 3 beta; Indoles; Insulin; Insulin Recept | 2016 |
Administration of Melatonin and Metformin Prevents Deleterious Effects of Circadian Disruption and Obesity in Male Rats.
Topics: Adiposity; Animals; Central Nervous System Depressants; Circadian Rhythm; Glucose Intolerance; Hypog | 2016 |
Melatonin prevents obesity through modulation of gut microbiota in mice.
Topics: Animals; Bacteroidetes; Blotting, Western; Central Nervous System Depressants; Diet, High-Fat; Fatty | 2017 |
Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Glucose Clamp Technique; Hemodynamics; Hyp | 2009 |
Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Deoxyglucose; Dietary Fats; Endothelium, Vascular; Glu | 2009 |
Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response.
Topics: Adiposity; Animals; Body Weight; Circadian Rhythm; Eating; Gluconeogenesis; Immunoblotting; Insulin | 2011 |
Pentoxifylline and melatonin in combination with pioglitazone ameliorate experimental non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Body Weight; C | 2011 |
Melatonin supplementation therapy as a potent alternative to ERT in ovariectomized rats.
Topics: Analysis of Variance; Animals; Area Under Curve; Blood Glucose; Estradiol; Estrogen Replacement Ther | 2012 |
Melatonin improves metabolic syndrome induced by high fructose intake in rats.
Topics: Adipokines; Analysis of Variance; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Di | 2012 |
Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Ins | 2012 |
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8).
Topics: Aging; Animals; Antioxidants; Follow-Up Studies; Gene Expression Regulation, Developmental; Glucagon | 2013 |
Maternal melatonin programs the daily pattern of energy metabolism in adult offspring.
Topics: Animals; Energy Metabolism; Female; Glucose Tolerance Test; Insulin; Insulin Resistance; Melatonin; | 2012 |
Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane.
Topics: Animals; Caloric Restriction; Cell Membrane; Glucose Transporter Type 4; Insulin Resistance; Male; M | 2003 |
Light/dark cycle-dependent metabolic changes in adipose tissue of pinealectomized rats.
Topics: Adipocytes; Adipose Tissue; Analysis of Variance; Animals; Blood Glucose; Body Weight; Circadian Rhy | 2004 |
Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation?
Topics: Animals; Blood Pressure; Diet; Energy Intake; Injections, Intraventricular; Insulin; Insulin Resista | 2006 |
[Effect of different light regimens on the development of metabolic syndrome of aging rats].
Topics: Aging; Animals; Antioxidants; Blood Glucose; Cholesterol; Eating; Insulin Resistance; Light; Lipopro | 2007 |
The regulation of insulin action in isolated adipocytes. Role of the periodicity of food intake, time of day and melatonin.
Topics: Adipocytes; Animals; Deoxyglucose; Eating; Insulin; Insulin Resistance; Melatonin; Periodicity; Rats | 1994 |
GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity.
Topics: Diabetes Mellitus, Type 2; Fatty Acids, Essential; Glucose; Glucose Transporter Type 4; Humans; Insu | 1999 |
Melatonin state in Mendenhall's syndrome.
Topics: Diabetes Mellitus, Type 1; Humans; Hypoglycemia; Infant, Newborn; Insulin Resistance; Male; Melatoni | 1988 |