Page last updated: 2024-11-07

rubiadin 1-methyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Rubiadin 1-methyl ether is a natural product isolated from various plant species, including Rubia tinctorum. It exhibits a range of biological activities, including antioxidant, anti-inflammatory, and anti-cancer properties. Research has shown its potential as a therapeutic agent for treating conditions like cancer and inflammatory diseases. Its unique chemical structure, characterized by a quinone moiety and a methoxy group, contributes to its biological activity. Studies have explored its synthesis through various methods, including chemical and enzymatic approaches, to understand its structure-activity relationship and develop synthetic analogs with enhanced properties.'
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rubiadin 1-methyl ether: structure given in first source; isolated from the stem bark and roots of Morinda lucida [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
MorindagenusA plant genus of the family RUBIACEAE. Members contain iridoid glycosides and ANTHRAQUINONES.[MeSH]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]
Morinda lucidaspecies[no description available]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]

Cross-References

ID SourceID
PubMed CID96191
CHEMBL ID3921530
SCHEMBL ID16227041
MeSH IDM0211999

Synonyms (28)

Synonym
rubiadin-1-methyl ether
3-hydroxy-1-methoxy-2-methyl-anthraquinone
3-hydroxy-1-methoxy-2-methyl-anthracene-9,10-dione
nsc-59063
7460-43-7
nsc59063
NCIOPEN2_002551
rubiadin 1-methyl ether
3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione
unii-mk2ixh6aue
nsc 59063
9,10-anthracenedione, 3-hydroxy-1-methoxy-2-methyl-
mk2ixh6aue ,
AKOS015897180
DTXSID80225572
AC-34253
FT-0698923
SCHEMBL16227041
1-methoxy-2-methyl-3-hydroxy-anthrachinon
3-hydroxy-1-methoxy-2-methylanthraquinone
CHEMBL3921530
CS-0018274
HY-N1956
F17682
mfcd12031637
anthraquinone, 3-hydroxy-1-methoxy-2-methyl-
3-hydroxy-1-methoxy-2-methyl-9,10-anthracenedione
MS-23789
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1328320Cytotoxicity against human MDA-MB-231 cells after 72 hrs by alamar blue assay2016Journal of natural products, 09-23, Volume: 79, Issue:9
Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei.
AID1332109Activation of AMPK in mouse 3T3L1 adipocytes assessed as increase in 2-NBDG uptake at 10 uM after 90 mins by fluorescence assay2017Bioorganic & medicinal chemistry letters, 01-01, Volume: 27, Issue:1
Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.75

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.75 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.75)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]