2,4-dinitrophenol has been researched along with Insulin Resistance in 5 studies
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed)
dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.
2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined whether a functionally liver-targeted derivative of 2,4-dinitrophenol (DNP), DNP-methyl ether (DNPME), could safely decrease hypertriglyceridemia, NAFLD, and insulin resistance without systemic toxicities." | 3.79 | Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. ( Cline, GW; Jurczak, MJ; Kim, T; Lee, HY; Perry, RJ; Pesta, D; Popov, VB; Rahimi, Y; Shulman, GI; Spiegel, DA; Zhang, D; Zhang, XM, 2013) |
| "Previous studies show that naringenin promotes insulin sensitivity in fructose-fed rats." | 3.76 | Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats. ( Anuradha, CV; Kannappan, S; Palanisamy, N, 2010) |
| "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol)." | 3.74 | Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. ( Gaster, M, 2007) |
| "Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH)." | 1.42 | Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. ( Boyer, JL; Perry, RJ; Shulman, GI; Zhang, D; Zhang, XM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perry, RJ | 3 |
| Kim, T | 1 |
| Zhang, XM | 2 |
| Lee, HY | 1 |
| Pesta, D | 1 |
| Popov, VB | 1 |
| Zhang, D | 2 |
| Rahimi, Y | 1 |
| Jurczak, MJ | 1 |
| Cline, GW | 1 |
| Spiegel, DA | 1 |
| Shulman, GI | 3 |
| Boyer, JL | 1 |
| Kannappan, S | 1 |
| Palanisamy, N | 1 |
| Anuradha, CV | 1 |
| Gaster, M | 1 |
5 other studies available for 2,4-dinitrophenol and Insulin Resistance
| Article | Year |
|---|---|
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler.
Topics: 2,4-Dinitrophenol; Animals; Diet, High-Fat; Ethers; Fatty Liver; Hypertriglyceridemia; Insulin Resis | 2013 |
Treating fatty liver and insulin resistance.
Topics: 2,4-Dinitrophenol; Animals; Fatty Liver; Insulin Resistance | 2013 |
Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.
Topics: 2,4-Dinitrophenol; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; G | 2015 |
Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats.
Topics: 2,4-Dinitrophenol; Aldehydes; Animals; Antioxidants; Apoptosis; Blood Glucose; Diet; Flavanones; Fru | 2010 |
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes.
Topics: 2,4-Dinitrophenol; Antimycin A; Case-Control Studies; Cells, Cultured; Diabetes Mellitus, Type 2; Gl | 2007 |