BRCA1-associated RING domain protein 1

A BRCA1-associated RING domain protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99728]

Synonyms

BARD-1;
EC 2.3.2.27;
RING-type E3 ubiquitin transferase BARD1

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
beta-thujaplicin	Homo sapiens (human)	IC50	3.8900	1	0

Enables

This protein enables 7 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
ubiquitin-protein transferase activity	molecular function	Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. [GOC:BioGRID, GOC:jh2, PMID:9635407]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase binding	molecular function	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nuclear speck	cellular component	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]
cytoplasmic ribonucleoprotein granule	cellular component	A ribonucleoprotein granule located in the cytoplasm. [GOC:bf, GOC:PARL, PMID:15121898]

Part Of

This protein is part of 6 target(s):

Target	Category	Definition
nuclear ubiquitin ligase complex	cellular component	A ubiquitin ligase complex found in the nucleus. [GOC:mah]
BRCA1-BARD1 complex	cellular component	A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage. [PMID:12787778]
BRCA1-A complex	cellular component	A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. [GOC:mah, PMID:19261749]
BRCA1-B complex	cellular component	A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites. [GOC:mah, PMID:16391231]
BRCA1-C complex	cellular component	A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. [GOC:mah, PMID:15485915, PMID:16391231]
ubiquitin ligase complex	cellular component	A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. [GOC:jh2, PMID:9529603]

Involved In

This protein is involved in 19 target(s):

Target	Category	Definition
tissue homeostasis	biological process	A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:isa_complete]
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
regulation of DNA repair	biological process	Any process that modulates the frequency, rate or extent of DNA repair. [GOC:go_curators]
DNA damage response	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
protein ubiquitination	biological process	The process in which one or more ubiquitin groups are added to a protein. [GOC:ai]
negative regulation of mRNA 3'-end processing	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing. [GOC:mah]
homologous recombination	biological process	A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules. [GOC:mah, PMID:11139492, PMID:17304215]
regulation of phosphorylation	biological process	Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. [GOC:jl]
positive regulation of apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
mitotic G2/M transition checkpoint	biological process	A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. [GOC:mtg_cell_cycle]
positive regulation of protein catabolic process	biological process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators]
negative regulation of cell cycle	biological process	Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
negative regulation of protein export from nucleus	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. [GOC:bf]
regulation of cell cycle	biological process	Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]
cellular response to ionizing radiation	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. [GOC:mah]
protein K6-linked ubiquitination	biological process	A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair. [GOC:sp]
DNA strand resection involved in replication fork processing	biological process	The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing. [GOC:mah, PMID:28475874]
regulation of DNA damage checkpoint	biological process	Any process that modulates the frequency, rate or extent of a DNA damage checkpoint. [GOC:obol]

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