longifolene and Insulin-Resistance

longifolene has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for longifolene and Insulin-Resistance

Article	Year
WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes. Bioscience, biotechnology, and biochemistry, 2017, Volume: 81, Issue:8 Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). The HMW adiponectin oligomers possess the most potent insulin-sensitizing activity. WSF-P-1(N-methyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4α-methanonaphthalen-7-amine) is derived from natural sesquiterpene longifolene by chemical modifications. We found that WSF-P-1 activates AMPK in both 3T3-L1 adipocytes and 293T cells in this study. Activation of AMPK by WSF-P-1 promotes the assembly of HMW adiponectin and increases the HMW/total ratio of adiponectin in 3T3-L1 adipocytes. We demonstrated that the Ca Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; AMP-Activated Protein Kinases; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Differentiation; Enzyme Activation; Enzyme Activators; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; HEK293 Cells; Humans; Insulin Resistance; Mice; Protein Multimerization; Sesquiterpenes; Signal Transduction	2017

Article

Year

WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes.

Bioscience, biotechnology, and biochemistry, 2017, Volume: 81, Issue:8

Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). The HMW adiponectin oligomers possess the most potent insulin-sensitizing activity. WSF-P-1(N-methyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4α-methanonaphthalen-7-amine) is derived from natural sesquiterpene longifolene by chemical modifications. We found that WSF-P-1 activates AMPK in both 3T3-L1 adipocytes and 293T cells in this study. Activation of AMPK by WSF-P-1 promotes the assembly of HMW adiponectin and increases the HMW/total ratio of adiponectin in 3T3-L1 adipocytes. We demonstrated that the Ca

Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; AMP-Activated Protein Kinases; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Differentiation; Enzyme Activation; Enzyme Activators; Gene Expression Regulation; Glucose; Glucose Transporter Type 1; HEK293 Cells; Humans; Insulin Resistance; Mice; Protein Multimerization; Sesquiterpenes; Signal Transduction

2017