2-keto-4-methylvalerate has been researched along with Insulin Resistance in 8 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In summary, in IDDM: (a) Peripheral hyperinsulinemia is required to normalize both fasting leucine metabolism and blood glucose concentrations." | 5.27 | Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. ( Biolo, G; Crepaldi, G; De Kreutzenberg, SV; Duner, E; Inchiostro, S; Marescotti, MC; Nosadini, R; Tessari, P; Tiengo, A; Trevisan, R, 1986) |
| "Although leucine has many positive effects on metabolism in multiple tissues, elevated levels of this amino acid and the other branched-chain amino acids (BCAAs) and their metabolites are implicated in obesity and insulin resistance." | 3.83 | Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner. ( Adegoke, OA; Beatty, B; Moghei, M; Tavajohi-Fini, P, 2016) |
| "Most patients at risk for developing type 2 diabetes are hyperinsulinemic." | 1.33 | Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005) |
| "Obesity was associated with a significant increase in postabsorptive plasma concentrations of the branched-chain keto acids in men but not in women matched for body-mass index and age." | 1.27 | Sex-specific differences in plasma branched-chain keto acid levels in obesity. ( Herbertz, L; Langer, K; Schauder, P; Zavelberg, D, 1987) |
| "In summary, in IDDM: (a) Peripheral hyperinsulinemia is required to normalize both fasting leucine metabolism and blood glucose concentrations." | 1.27 | Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. ( Biolo, G; Crepaldi, G; De Kreutzenberg, SV; Duner, E; Inchiostro, S; Marescotti, MC; Nosadini, R; Tessari, P; Tiengo, A; Trevisan, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Park, TJ | 1 |
| Park, SY | 1 |
| Lee, HJ | 1 |
| Abd El-Aty, AM | 1 |
| Jeong, JH | 1 |
| Jung, TW | 1 |
| Renguet, E | 1 |
| Ginion, A | 1 |
| Gélinas, R | 1 |
| Bultot, L | 1 |
| Auquier, J | 1 |
| Robillard Frayne, I | 1 |
| Daneault, C | 1 |
| Vanoverschelde, JL | 1 |
| Des Rosiers, C | 1 |
| Hue, L | 1 |
| Horman, S | 1 |
| Beauloye, C | 1 |
| Bertrand, L | 1 |
| Moghei, M | 1 |
| Tavajohi-Fini, P | 1 |
| Beatty, B | 1 |
| Adegoke, OA | 1 |
| Rabaglia, ME | 1 |
| Gray-Keller, MP | 1 |
| Frey, BL | 1 |
| Shortreed, MR | 1 |
| Smith, LM | 1 |
| Attie, AD | 1 |
| Fex, M | 1 |
| Nitert, MD | 1 |
| Wierup, N | 1 |
| Sundler, F | 1 |
| Ling, C | 1 |
| Mulder, H | 1 |
| Tessari, P | 2 |
| Inchiostro, S | 2 |
| Biolo, G | 2 |
| Marescotti, MC | 2 |
| Fantin, G | 1 |
| Boscarato, MT | 1 |
| Merola, G | 1 |
| Mantero, F | 1 |
| Tiengo, A | 2 |
| Schauder, P | 1 |
| Zavelberg, D | 1 |
| Langer, K | 1 |
| Herbertz, L | 1 |
| Nosadini, R | 1 |
| Trevisan, R | 1 |
| De Kreutzenberg, SV | 1 |
| Duner, E | 1 |
| Crepaldi, G | 1 |
8 other studies available for 2-keto-4-methylvalerate and Insulin Resistance
| Article | Year |
|---|---|
α-ketoisocaproic acid promotes ER stress through impairment of autophagy, thereby provoking lipid accumulation and insulin resistance in murine preadipocytes.
Topics: Animals; Autophagy; Endoplasmic Reticulum Stress; Insulin Resistance; Keto Acids; Lipid Metabolism; | 2022 |
Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake.
Topics: Acetylation; Animals; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Energ | 2017 |
Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner.
Topics: Amino Acids; Animals; Biological Transport; Cells, Cultured; Glucose; Insulin; Insulin Resistance; K | 2016 |
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase | 2005 |
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Body Weight; Dietary Fats; Female; Glutamine; Ins | 2007 |
Leucine kinetics and the effects of hyperinsulinemia in patients with Cushing's syndrome.
Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Cushing Syndrome; Female; Humans; Insulin; Insulin Re | 1989 |
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleuci | 1987 |
Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism.
Topics: Adult; Amino Acids; Blood Glucose; Carbon; Diabetes Mellitus, Type 1; Humans; Insulin; Insulin Resis | 1986 |