Page last updated: 2024-12-06

diisodecyl phthalate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Diisodecyl phthalate (DIDP) is a synthetic plasticizer widely used in various industries due to its excellent properties such as flexibility, durability, and low cost. It is commonly used in polyvinyl chloride (PVC) products, including flooring, wall coverings, clothing, and toys. DIDP is synthesized by reacting phthalic anhydride with isodecyl alcohol. However, concerns have been raised regarding its potential health effects, particularly its endocrine disrupting properties and potential for developmental and reproductive toxicity. Studies have shown that DIDP can disrupt the endocrine system, potentially interfering with hormone production and signaling pathways. It can also accumulate in the body, leading to long-term health risks. These concerns have led to increased scrutiny and regulatory measures aimed at reducing its use and exposure. Ongoing research focuses on understanding the mechanisms of its action and exploring safer alternatives to replace DIDP in consumer products.'

monodesmethylisoproturon: a metabolite of isoproturon; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID33599
CHEMBL ID3183266
CHEBI ID34709
SCHEMBL ID22307
MeSH IDM0124485

Synonyms (73)

Synonym
BIDD:ER0436
phthalic acid, diisodecyl ester
1,2-benzenedicarboxylic acid, diisodecyl ester
einecs 271-091-4
26761-40-0
diisodecyl phthalate
hsdb 930
px 120
vestinol dz
sicol 184
ccris 6194
didp (plasticizer)
bis(isodecyl)phthalate
di(i-decyl) phthalate
plasticized ddp
palatinol z
brn 2171889
di-''isodecyl'' phthalate
phthalic acid, bis(8-methylnonyl) ester
bis(isodecyl) phthalate
einecs 247-977-1
68515-49-1
di-isodecyl phthalate
diisodecylphthalate
19269-67-1
di-iso-decyl phthalate
bis(8-methylnonyl) benzene-1,2-dicarboxylate
FT-0667183
FT-0667182
phthalic acid diisodecyl ester
P0299
NCGC00248087-02
NCGC00248087-01
ec 271-091-4
dsstox_cid_8666
cas-68515-49-1
tox21_300530
dsstox_rid_78654
dsstox_gsid_28666
NCGC00254318-01
89-16-7
einecs 201-884-2
bis(8-methylnonyl) phthalate
1,2-benzenedicarboxylic acid, 4,4'-carbonylbis-, 1,1',2,2'-tetraisodecyl ester
1,2-benzenedicarboxylic acid, 1,2-diisodecyl ester
unii-wf93t741qi
wf93t741qi ,
FT-0606278
AKOS015888325
SCHEMBL22307
1,2-benzenedicarboxylic acid, bis(8-methylnonyl) ester
diisodecyl phthalate [hsdb]
1,2-benzenedicarboxylic acid diisodecyl ester
di(isodecyl) phthalate
CHEBI:34709 ,
CHEMBL3183266
monodesmethylisoproturon
FT-0696778
bis-(8-methylnonyl)phthalate
diisodecyl phthalate, selectophore(tm), >=99.0%
DTXSID50274032
mfcd00048389
bis(8-methylnonyl) phthalate, analytical standard
J-016536
1,2-benzenedicarboxylic acid, bis(8-methylnonyl) ester (9ci); phthalic acid, bis(8-methylnonyl) ester (8ci); diisodecyl phthalate
phthalic acid, bis-8-methylnonyl ester
bis(8-methylnonyl)phthalate
Q904337
D97452
1,2-benzenedicarboxylicacid,bis(8-methylnonyl)ester
CS-W013841
?diisodecyl phthalate
1,2-benzenedicarboxylicacid,di-c9-11-branchedalkylesters,c10-rich

Research Excerpts

Overview

Diisodecyl phthalate is used in the coating of pharmaceutical pills and in plastic food wrappers. It is an isomeric mixture of phthalates with predominantly 10-carbon branched-dialkyl chains, widely used as a plasticizer for polyvinyl chloride.

ExcerptReferenceRelevance
"Diisodecyl phthalate (DIDP) is a new type of phthalate used in the coating of pharmaceutical pills and in plastic food wrappers. "( Diisodecyl phthalate aggravates the formaldehyde-exposure-induced learning and memory impairment in mice.
Chen, M; Chen, Y; Ge, S; Huang, J; Ma, P; Shen, D; Wu, Y; Yan, B; Yang, X, 2019
)
3.4
"Diisodecyl phthalate (DiDP) is an isomeric mixture of phthalates with predominantly 10-carbon branched-dialkyl chains, widely used as a plasticizer for polyvinyl chloride. "( Urinary metabolites of diisodecyl phthalate in rats.
Calafat, AM; Gray, LE; Kato, K; Needham, LL; Silva, MJ; Wolf, C, 2007
)
2.09

Toxicity

ExcerptReferenceRelevance
" No treatment-related effects were noted at cesarean section, nor were there any fetal morphologic observations except for an increased frequency of seventh cervical and rudimentary lumbar ribs at the maternally toxic exposure level of 1000 mg/kg/d."( Developmental toxicity of di-isodecyl and di-isononyl phthalates in rats.
Ambroso, JL; Harris, SB; Keller, LH; Nikiforov, AI; Trimmer, GW; Waterman, SJ,
)
0.13

Dosage Studied

ExcerptRelevanceReference
" Adjuvant effect was accepted to be present if a statistical increase in antibody production occurred in a test group as compared to an ovalbumin control group together with the fulfillment of dose-response relationships."( Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice.
Larsen, ST; Lund, RM; Nielsen, GD; Poulsen, OM; Thygesen, P, 2002
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
phthalate ester
diesterA diester is a compound containing two ester groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.76960.006038.004119,952.5996AID1159521
AR proteinHomo sapiens (human)Potency9.77000.000221.22318,912.5098AID743035; AID743063
retinoid X nuclear receptor alphaHomo sapiens (human)Potency37.26840.000817.505159.3239AID1159527; AID1159531
estrogen nuclear receptor alphaHomo sapiens (human)Potency2.18720.000229.305416,493.5996AID743075
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency1.737419.739145.978464.9432AID1159509
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (7.14)18.7374
1990's3 (7.14)18.2507
2000's12 (28.57)29.6817
2010's20 (47.62)24.3611
2020's4 (9.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 57.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index57.27 (24.57)
Research Supply Index3.89 (2.92)
Research Growth Index5.07 (4.65)
Search Engine Demand Index90.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (57.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (6.25%)6.00%
Case Studies2 (4.17%)4.05%
Observational0 (0.00%)0.25%
Other43 (89.58%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]