Compounds > o-methylmurrayamine a
Page last updated: 2024-11-12

o-methylmurrayamine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O-methylmurrayamine A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14892681
CHEMBL ID3973266
MeSH IDM0558116

Synonyms (5)

Synonym
o-methylmurrayamine a
CHEMBL3973266
134779-20-7
9-methoxy-3,3,5-trimethyl-11h-pyrano[3,2-a]carbazole
AKOS040763274
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1315295Antidiabetic activity in overnight fasted STZ-induced albino Sprague-Dawley rat diabetic model assessed as decrease in blood glucose level at 100 mg/kg, po measured up to 5 hrs2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1315296Antidiabetic activity in overnight fasted STZ-induced albino Sprague-Dawley rat diabetic model assessed as decrease in blood glucose level at 100 mg/kg, po measured up to 24 hrs2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1871707Cytotoxicity against human HaCaT cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2022European journal of medicinal chemistry, Feb-05, Volume: 229Current status of carbazole hybrids as anticancer agents.
AID1315290Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increase in myc-tagged GLUT4-mediated 2-[3H]-deoxyglucose uptake incubated for 16 hrs measured for 5 mins by beta scintillation counting2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1871706Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2022European journal of medicinal chemistry, Feb-05, Volume: 229Current status of carbazole hybrids as anticancer agents.
AID1315288Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increase in insulin-stimulated myc-tagged GLUT4-mediated 2-[3H]-deoxyglucose uptake at 25 uM incubated for 16 hrs followed by insulin stimulation for 20 mins measured for 5 mins2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1315292Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as induction of myc-tagged GLUT4 translocation to cell surface at 25 uM incubated for 16 hrs by O-phenylenediamide based colorimetric assay relative to control2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1871705Cytotoxicity against human DLD-1 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2022European journal of medicinal chemistry, Feb-05, Volume: 229Current status of carbazole hybrids as anticancer agents.
AID1315293Metabolic stability in rat liver microsomes assessed as parent compound remaining after 90 mins in presence of NADPH by HPLC analysis2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1315294Half life in rat liver microsomes in presence of NADPH by HPLC analysis2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1315307Metabolic stability in rat liver microsomes assessed as drug degradation rate constant incubated for 90 mins by HPLC analysis2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
AID1315289Activation of Akt-dependent signalling pathway in rat L6 myotubes assessed as increase in myc-tagged GLUT4-mediated 2-[3H]-deoxyglucose uptake at 25 uM incubated for 16 hrs measured for 5 mins by beta scintillation counting relative to control2016Journal of natural products, 05-27, Volume: 79, Issue:5
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		3.5110indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		3.5110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
metformin
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.		2.1310guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
pioglitazone
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.. pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.		2.1310aromatic ether;
pyridines;
thiazolidinediones		antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic
carbazole
carbazole: structure in first source		2.1110carbazole
etoposide
[no description available]		3.5110beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
gemcitabine
gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.		3.5110organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
DNA synthesis inhibitor;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
environmental contaminant;
immunosuppressive agent;
photosensitizing agent;
prodrug;
radiosensitizing agent;
xenobiotic
rosiglitazone
[no description available]		2.1310aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
Koenimbine
koenimbin: has antineoplastic activity; isolated from curry leaf, Murraya koenigii; structure in first source		3.7120carbazoles
fosbretabulin
fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source		3.5110
mahanine
mahanine: structure in first source		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		02.1310
Insulin Sensitivity
[description not available]		02.1310
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		02.1310
Cancer of Colon
[description not available]		02.1510
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1510