pyruvaldehyde has been researched along with Insulin Resistance in 47 studies
Pyruvaldehyde: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
methylglyoxal : A 2-oxo aldehyde derived from propanal.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the ability of scopoletin (SP) to protect against MG-induced hyperglycemia and insulin resistance." | 7.81 | Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. ( Chang, WC; Cheng, AS; Liao, BC; Wu, JF; Wu, SC; Xu, KD, 2015) |
| "Treatment with metformin significantly attenuates neointimal hyperplasia through inhibition of smooth muscle cell proliferation, migration, and inflammation as well as by improvement of the insulin signaling pathway." | 5.39 | The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats. ( Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D, 2013) |
| " Significant beneficial health effects were observed at 16-week with the doubling of ergothioneine from baseline, increases in the antioxidant marker ORAC (oxygen radical absorption capacity) and anti-inflammatory hormone, adiponectin and significant decreases in serum oxidative stress inducing factors, carboxymethyllysine (CML) and methylglyoxal (MG), but no change in the lipid oxidative stress marker 8-isoprostane, leptin or measures of insulin resistance or glucose metabolism." | 3.83 | A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms). ( Beelman, RB; Cai, W; Calvo, MS; Goh, BC; Kalaras, MD; Mehrotra, A; Nadkarni, G; Uribarri, J; Wang, L, 2016) |
| " In this study, we investigated the ability of scopoletin (SP) to protect against MG-induced hyperglycemia and insulin resistance." | 3.81 | Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. ( Chang, WC; Cheng, AS; Liao, BC; Wu, JF; Wu, SC; Xu, KD, 2015) |
| "We examined 172 young (<45 years old) and older (>60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N(epsilon)-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation." | 3.74 | Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. ( Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H, 2007) |
| "Vascular dysfunction, nephropathy and neuropathic pain are common diabetes complications." | 2.53 | Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies. ( Benham, CD; Lione, LA; Mackenzie, LS; Shamsaldeen, YA, 2016) |
| "Insulin resistance is characterized by an impaired responsiveness to the action of insulin at its multiple target organs." | 2.44 | Modulation of insulin action by advanced glycation endproducts: a new player in the field. ( Brouwers, O; Schalkwijk, CG; Stehouwer, CD, 2008) |
| "Atherosclerosis is a major global cause of morbidity and mortality, and diabetes patients are at increased risk of coronary heart disease development." | 2.44 | Advanced glycation: a novel outlook on atherosclerosis. ( Knight, SC; Price, CL, 2007) |
| "Insulin sensitivity was assessed as the Matsuda index." | 1.91 | Habitual Intake of Dietary Dicarbonyls is Associated with Greater Insulin Sensitivity and Lower Prevalence of Type 2 Diabetes: The Maastricht Study. ( Dagnelie, PC; Eussen, SJPM; Maasen, K; Opperhuizen, A; Schalkwijk, CG; Stehouwer, CDA; van Greevenbroek, MMJ, 2023) |
| "Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate." | 1.48 | Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents. ( Bains, Y; Caccavello, R; Garay-Sevilla, ME; Gugliucci, A; Luevano-Contreras, C; Rodríguez-Mortera, R; Solorio-Meza, S, 2018) |
| "Treatment with metformin significantly attenuates neointimal hyperplasia through inhibition of smooth muscle cell proliferation, migration, and inflammation as well as by improvement of the insulin signaling pathway." | 1.39 | The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats. ( Adeli, K; Ji, J; Jiang, B; Liu, L; Lu, J; Meng, H; Meng, QH; Randell, E; Wang, D, 2013) |
| "Insulin resistance is accompanied by increased activity of carbonic anhydrase which is significantly related to increasing methylglyoxal levels." | 1.38 | Study on the changes of carbonic anhydrase activity in insulin resistance and the effect of methylglyoxal. ( Biswas, UK; Kumar, A, 2012) |
| "Ankaflavin (AK) is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects." | 1.38 | Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. ( Chang, YY; Hsu, WH; Hsu, YW; Kuo, HF; Lee, BH; Pan, TM, 2012) |
| "After 4-week treatment insulin resistance was evaluated by an euglycemic hyperinsulinemic glucose clamp technique." | 1.35 | Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats. ( Guo, Q; Hosoya, T; Hu, C; Ito, S; Jiang, Y; Kawamata, A; Miyata, T; Mori, T; Nakayama, M; Ogawa, S; Osaki, Y; Sun, Y; Yoneki, Y, 2009) |
| "Following 9 weeks of fructose treatment, an insulin resistance state was developed in Sprague-Dawley (SD) rats, demonstrated as increased triglyceride and insulin levels, high blood pressure, and decreased insulin-stimulated glucose uptake by adipose tissue." | 1.34 | Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats. ( Jia, X; Wu, L, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 8 (17.02) | 29.6817 |
| 2010's | 25 (53.19) | 24.3611 |
| 2020's | 13 (27.66) | 2.80 |
| Authors | Studies |
|---|---|
| Rabbani, N | 3 |
| Thornalley, PJ | 2 |
| Zhang, X | 1 |
| Schalkwijk, CG | 5 |
| Wouters, K | 1 |
| Fan, L | 1 |
| Yu, W | 1 |
| Zhang, B | 1 |
| Cao, B | 1 |
| Wang, M | 1 |
| Hu, X | 1 |
| Ng, SP | 1 |
| Nomura, W | 1 |
| Takahashi, H | 1 |
| Inoue, K | 1 |
| Kawada, T | 1 |
| Goto, T | 1 |
| Inoue, Y | 1 |
| Matthews, JJ | 1 |
| Turner, MD | 1 |
| Santos, L | 1 |
| Elliott-Sale, KJ | 1 |
| Sale, C | 1 |
| Van den Eynde, MDG | 1 |
| Houben, AJHM | 1 |
| Scheijen, JLJM | 1 |
| Linkens, AMA | 1 |
| Niessen, PM | 1 |
| Simons, N | 1 |
| Hanssen, NMJ | 1 |
| Kusters, YHAM | 1 |
| Eussen, SJMP | 1 |
| Miyata, T | 2 |
| Stehouwer, CDA | 2 |
| Maasen, K | 1 |
| Eussen, SJPM | 1 |
| Dagnelie, PC | 1 |
| Opperhuizen, A | 1 |
| van Greevenbroek, MMJ | 1 |
| Alouffi, S | 1 |
| Khan, MWA | 1 |
| Ahmad, K | 1 |
| Shaikh, S | 1 |
| Lee, EJ | 1 |
| Lee, YH | 1 |
| Choi, I | 1 |
| Gutierrez-Mariscal, FM | 1 |
| Cardelo, MP | 1 |
| de la Cruz, S | 1 |
| Alcala-Diaz, JF | 1 |
| Roncero-Ramos, I | 1 |
| Guler, I | 1 |
| Vals-Delgado, C | 1 |
| López-Moreno, A | 1 |
| Luque, RM | 1 |
| Delgado-Lista, J | 1 |
| Perez-Martinez, P | 1 |
| Yubero-Serrano, EM | 1 |
| Lopez-Miranda, J | 1 |
| Francisco, FA | 2 |
| Saavedra, LPJ | 2 |
| Junior, MDF | 1 |
| Barra, C | 1 |
| Matafome, P | 3 |
| Mathias, PCF | 2 |
| Gomes, RM | 2 |
| Xue, M | 1 |
| Weickert, MO | 1 |
| Rodrigues, T | 1 |
| Sereno, J | 1 |
| Almeida, J | 1 |
| Castelhano, J | 1 |
| Gamas, L | 1 |
| Neves, C | 1 |
| Gonçalves, S | 1 |
| Carvalho, C | 1 |
| Arslanagic, A | 1 |
| Wilcken, E | 1 |
| Fonseca, R | 1 |
| Simões, I | 1 |
| Conde, SV | 1 |
| Castelo-Branco, M | 1 |
| Seiça, R | 2 |
| Rodríguez-Mortera, R | 1 |
| Luevano-Contreras, C | 1 |
| Solorio-Meza, S | 1 |
| Caccavello, R | 2 |
| Bains, Y | 2 |
| Garay-Sevilla, ME | 1 |
| Gugliucci, A | 4 |
| Moraru, A | 1 |
| Wiederstein, J | 1 |
| Pfaff, D | 1 |
| Fleming, T | 2 |
| Miller, AK | 1 |
| Nawroth, P | 1 |
| Teleman, AA | 1 |
| Erkin-Cakmak, A | 1 |
| Noworolski, SM | 1 |
| Schwarz, JM | 1 |
| Mulligan, K | 1 |
| Lustig, RH | 1 |
| Lodd, E | 1 |
| Wiggenhauser, LM | 1 |
| Morgenstern, J | 1 |
| Fleming, TH | 2 |
| Poschet, G | 1 |
| Büttner, M | 1 |
| Tabler, CT | 1 |
| Wohlfart, DP | 1 |
| Nawroth, PP | 2 |
| Kroll, J | 1 |
| Lu, J | 1 |
| Ji, J | 1 |
| Meng, H | 1 |
| Wang, D | 1 |
| Jiang, B | 1 |
| Liu, L | 1 |
| Randell, E | 1 |
| Adeli, K | 1 |
| Meng, QH | 1 |
| Nigro, C | 4 |
| Raciti, GA | 4 |
| Leone, A | 3 |
| Longo, M | 3 |
| Prevenzano, I | 2 |
| Fiory, F | 2 |
| Mirra, P | 3 |
| D'Esposito, V | 1 |
| Ulianich, L | 1 |
| Formisano, P | 2 |
| Beguinot, F | 4 |
| Miele, C | 4 |
| Paneni, F | 1 |
| Costantino, S | 1 |
| Cosentino, F | 1 |
| Illien-Jünger, S | 1 |
| Lu, Y | 1 |
| Qureshi, SA | 1 |
| Hecht, AC | 1 |
| Cai, W | 3 |
| Vlassara, H | 2 |
| Striker, GE | 1 |
| Iatridis, JC | 1 |
| Chang, WC | 2 |
| Wu, SC | 1 |
| Xu, KD | 1 |
| Liao, BC | 1 |
| Wu, JF | 1 |
| Cheng, AS | 3 |
| Garrido, D | 1 |
| Rubin, T | 1 |
| Poidevin, M | 1 |
| Maroni, B | 1 |
| Le Rouzic, A | 1 |
| Parvy, JP | 1 |
| Montagne, J | 1 |
| Cheng, YH | 2 |
| Lee, CY | 1 |
| Chung, CY | 1 |
| Shamsaldeen, YA | 1 |
| Mackenzie, LS | 1 |
| Lione, LA | 1 |
| Benham, CD | 1 |
| de Courten, B | 1 |
| de Courten, MP | 1 |
| Soldatos, G | 1 |
| Dougherty, SL | 1 |
| Straznicky, N | 1 |
| Schlaich, M | 1 |
| Sourris, KC | 1 |
| Chand, V | 1 |
| Scheijen, JL | 1 |
| Kingwell, BA | 1 |
| Cooper, ME | 1 |
| Walker, KZ | 1 |
| Forbes, JM | 1 |
| Calvo, MS | 1 |
| Mehrotra, A | 1 |
| Beelman, RB | 1 |
| Nadkarni, G | 1 |
| Wang, L | 1 |
| Goh, BC | 1 |
| Kalaras, MD | 1 |
| Uribarri, J | 2 |
| Reichert, O | 1 |
| Neufang, G | 1 |
| Schmelz, M | 1 |
| Genth, H | 1 |
| Kaever, V | 1 |
| Wenck, H | 1 |
| Stäb, F | 1 |
| Terstegen, L | 1 |
| Kolbe, L | 1 |
| Roggenkamp, D | 1 |
| Andreozzi, F | 2 |
| Mannino, GC | 1 |
| Procopio, T | 2 |
| Davalli, AM | 1 |
| Sesti, G | 1 |
| Folli, F | 1 |
| Barella, LF | 1 |
| Silveira, SDS | 1 |
| Prates, KV | 1 |
| Alves, VS | 1 |
| Franco, CCDS | 1 |
| Miranda, RA | 1 |
| Ribeiro, TA | 1 |
| Tófolo, LP | 1 |
| Malta, A | 1 |
| Vieira, E | 1 |
| Palma-Rigo, K | 1 |
| Pavanello, A | 1 |
| Martins, IP | 1 |
| Moreira, VM | 1 |
| de Oliveira, JC | 1 |
| Brouwers, O | 1 |
| Stehouwer, CD | 1 |
| Guo, Q | 1 |
| Mori, T | 1 |
| Jiang, Y | 1 |
| Hu, C | 1 |
| Osaki, Y | 1 |
| Yoneki, Y | 1 |
| Sun, Y | 1 |
| Hosoya, T | 1 |
| Kawamata, A | 1 |
| Ogawa, S | 1 |
| Nakayama, M | 1 |
| Ito, S | 1 |
| Biswas, UK | 1 |
| Kumar, A | 1 |
| Chiou, CH | 1 |
| Chang, TL | 1 |
| Sena, C | 1 |
| Lee, BH | 1 |
| Hsu, WH | 1 |
| Chang, YY | 1 |
| Kuo, HF | 1 |
| Hsu, YW | 1 |
| Pan, TM | 1 |
| Chang, T | 1 |
| Wang, R | 1 |
| Wu, L | 2 |
| Dmitriev, LF | 1 |
| Dugin, SF | 1 |
| Peppa, M | 1 |
| Goodman, S | 1 |
| Ferrucci, L | 1 |
| Striker, G | 1 |
| Jia, X | 1 |
| Price, CL | 1 |
| Knight, SC | 1 |
| Vasdev, S | 1 |
| Ford, CA | 1 |
| Longerich, L | 1 |
| Parai, S | 1 |
| Gadag, V | 1 |
| Wadhawan, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Will Reduction in Dietary Advanced Glycation End- Products Reduce Chronic Low Grade Inflammation and Improve Insulin Sensitivity in Overweight and Obese Humans[NCT00422253] | 27 participants (Actual) | Interventional | 2006-11-30 | Completed | |||
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients[NCT05896878] | 20 participants (Anticipated) | Interventional | 2023-07-10 | Enrolling by invitation | |||
| A Double-blind, Randomized, Placebo-controlled, Parallel Design Study to Evaluate the Effects of the Cardio Formulation on Oxidized LDL in Individuals Who Are Overweight to Mildly Obese and Otherwise Healthy[NCT04317287] | 9 participants (Actual) | Interventional | 2019-12-10 | Terminated (stopped due to COVID-19 Pandemic) | |||
| Effect of Sevelamer Carbonate on Oxidative Stress in Patients With Diabetic Nephropathy[NCT00967629] | Phase 1 | 20 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for pyruvaldehyde and Insulin Resistance
| Article | Year |
|---|---|
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Induction; Glutathione; Glycos | 2022 |
Immunometabolism and the modulation of immune responses and host defense: A role for methylglyoxal?
Topics: Diabetes Mellitus, Type 2; Humans; Immunity; Insulin Resistance; Magnesium Oxide; Pyruvaldehyde | 2022 |
Dicarbonyls Generation, Toxicities, Detoxifications and Potential Roles in Diabetes Complications.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Ret | 2020 |
Consequences of Dicarbonyl Stress on Skeletal Muscle Proteins in Type 2 Diabetes.
Topics: Deoxyglucose; Diabetes Mellitus, Type 2; Extracellular Matrix Proteins; Gene Expression Regulation; | 2020 |
Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
Topics: Aging; Animals; Female; Fetus; Glycation End Products, Advanced; Humans; Infant; Infant, Newborn; In | 2021 |
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathi | 2016 |
Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage.
Topics: Animals; Endothelium, Vascular; Humans; Insulin Resistance; Lactoylglutathione Lyase; Models, Biolog | 2017 |
Modulation of insulin action by advanced glycation endproducts: a new player in the field.
Topics: Albumins; Animals; Glycation End Products, Advanced; Humans; Insulin; Insulin Resistance; Pyruvaldeh | 2008 |
Methylglyoxal, obesity, and diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Ob | 2013 |
[Mechanisms of hyperglycemia development and possible methods of carbohydrate metabolism normalization (review)].
Topics: Animals; Carbohydrate Metabolism; Humans; Hyperglycemia; Insulin; Insulin Resistance; Models, Biolog | 2005 |
Advanced glycation: a novel outlook on atherosclerosis.
Topics: Animals; Atherosclerosis; Bacterial Infections; Cysteine Endopeptidases; Dendritic Cells; Diabetes C | 2007 |
4 trials available for pyruvaldehyde and Insulin Resistance
| Article | Year |
|---|---|
Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.
Topics: Female; Glycation End Products, Advanced; Humans; Insulin Resistance; Magnesium Oxide; Maillard Reac | 2023 |
Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study.
Topics: Antigens, Neoplasm; Coronary Disease; Diabetes Mellitus, Type 2; Diet, Fat-Restricted; Diet, Mediter | 2021 |
Reversal of Insulin Resistance in Overweight and Obese Subjects by
Topics: Adult; Blood Pressure; Body Mass Index; Carrier Proteins; Correlation of Data; Cross-Over Studies; D | 2021 |
Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial.
Topics: Adult; Blood Glucose; Cross-Over Studies; Diet; Double-Blind Method; Female; Glucose Clamp Technique | 2016 |
32 other studies available for pyruvaldehyde and Insulin Resistance
| Article | Year |
|---|---|
Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes.
Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Humans; Hyperglycemia; Insulin R | 2022 |
Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism.
Topics: Animals; Glucose; Glycation End Products, Advanced; Insulin Resistance; Liver; Lysine; Magnesium Oxi | 2022 |
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
Topics: Adipocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mechanistic Ta | 2022 |
Carnosine increases insulin-stimulated glucose uptake and reduces methylglyoxal-modified proteins in type-2 diabetic human skeletal muscle cells.
Topics: beta-Alanine; Carnosine; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Resistance; Ma | 2023 |
Habitual Intake of Dietary Dicarbonyls is Associated with Greater Insulin Sensitivity and Lower Prevalence of Type 2 Diabetes: The Maastricht Study.
Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glyoxal; Humans; Insulin Resistance; Mag | 2023 |
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Fasting; Fibrosis; Glycated Hemoglobin; Glycoconjugates; Gl | 2017 |
Higher D-lactate levels are associated with higher prevalence of small dense low-density lipoprotein in obese adolescents.
Topics: Adolescent; Biomarkers; Body Mass Index; Carotid Intima-Media Thickness; Cross-Sectional Studies; Dy | 2018 |
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Drosophila melanogaster; Hyperglycemia; Insulin | 2018 |
Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome.
Topics: Adipose Tissue; Adolescent; Black or African American; Carbon-13 Magnetic Resonance Spectroscopy; Ch | 2019 |
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Topics: Animals; CRISPR-Cas Systems; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Disea | 2019 |
The protective effect and underlying mechanism of metformin on neointima formation in fructose-induced insulin resistant rats.
Topics: Animals; Blood Glucose; Carotid Arteries; Carotid Artery Injuries; Carotid Stenosis; Cells, Cultured | 2013 |
Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.
Topics: Animals; Endothelial Cells; Glutathione; Insulin; Insulin Receptor Substrate Proteins; Insulin Resis | 2014 |
p66(Shc)-induced redox changes drive endothelial insulin resistance.
Topics: Animals; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fatty Acids, Nonesterified; Insulin; | 2014 |
Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.
Topics: Aging; Animals; Diet; Glycation End Products, Advanced; Histological Techniques; Immunohistochemistr | 2015 |
Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation.
Topics: Animals; Glycation End Products, Advanced; Hyperglycemia; Insulin Resistance; Male; Pyruvaldehyde; R | 2015 |
Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.
Topics: Animals; Diabetes Mellitus, Type 2; Dietary Sucrose; Drosophila; Fatty Acid Synthase, Type I; Glycat | 2015 |
Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Disease Models, Animal; Glucose Tolerance Test; Hy | 2015 |
A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms).
Topics: Adiponectin; Adult; Agaricus; Antioxidants; beta-Glucans; Biomarkers; Body Mass Index; Chitin; Chole | 2016 |
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.
Topics: Adult; Aged; Animals; Diabetes Mellitus, Type 2; Female; Fibroblasts; Gene Silencing; Glucose; Healt | 2017 |
Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance.
Topics: Adenosine Monophosphate; Adenylate Kinase; Allosteric Site; AMP-Activated Protein Kinases; Animals; | 2016 |
The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism.
Topics: AMP-Activated Protein Kinases; Animals; Biological Transport; Cell Line; Deoxyglucose; Enzyme Activa | 2016 |
Methylglyoxal treatment in lactating mothers leads to type 2 diabetes phenotype in male rat offspring at adulthood.
Topics: Adiposity; Administration, Oral; Animals; Diabetes Mellitus, Type 2; Dyslipidemias; Environmental Po | 2018 |
The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells.
Topics: Animals; Cell Line; Diabetes Mellitus; Down-Regulation; Endothelial Cells; Glycolysis; Human Umbilic | 2017 |
Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats.
Topics: Animals; Blood Pressure; Body Composition; Glycation End Products, Advanced; Hypertension; Immunohis | 2009 |
"Blinding" of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?
Topics: Adenosine Monophosphate; Insulin Resistance; Liver; Protein Binding; Protein Kinases; Pyruvaldehyde | 2009 |
Study on the changes of carbonic anhydrase activity in insulin resistance and the effect of methylglyoxal.
Topics: Adult; Blood Glucose; Body Mass Index; Carbonic Anhydrases; Case-Control Studies; Diabetes Mellitus, | 2012 |
Resveratrol upregulates Nrf2 expression to attenuate methylglyoxal-induced insulin resistance in Hep G2 cells.
Topics: Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Heme Oxygenase-1; Hep G2 Cel | 2012 |
Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experiment | 2012 |
Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells.
Topics: Animals; Aorta; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Free Radicals; Glucose | 2005 |
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; G | 2007 |
Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats.
Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Adipose Tissue; Animals; Diet; Fluorescent Antibody Techni | 2007 |
Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine.
Topics: Acetylcysteine; Aldehydes; Animals; Arterioles; Blood Platelets; Blood Pressure; Body Weight; Calciu | 1998 |