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thymidine and Insulin Resistance

thymidine has been researched along with Insulin Resistance in 12 studies

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"Insulin resistance in PLWH is associated with both use of thymidine analogues and/or didanosine and prior immunodeficiency suggesting that increased attention on blood glucose in these patients could be beneficial."8.12Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. ( Benfield, T; Gelpi, M; Gerstoft, J; Hove-Skovsgaard, M; Høgh, J; Jensen, AMR; Nielsen, SD; Storgaard, H, 2022)
"Insulin resistance in PLWH is associated with both use of thymidine analogues and/or didanosine and prior immunodeficiency suggesting that increased attention on blood glucose in these patients could be beneficial."4.12Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. ( Benfield, T; Gelpi, M; Gerstoft, J; Hove-Skovsgaard, M; Høgh, J; Jensen, AMR; Nielsen, SD; Storgaard, H, 2022)
" On examination, the biological activities of insulin and insulin-like growth factor I in the patient's cultured fibroblasts, insulin sensitivity of amino isobutyric acid uptake and thymidine incorporation was decreased, but insulin-like growth factor I action was normal."3.68A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance. ( Egawa, K; Haruta, T; Imamura, T; Ishibashi, O; Itazu, T; Iwanishi, M; Kobayashi, M; Naitou, K; Sasaoka, T; Takata, Y, 1993)
"To explore a possible mechanism for the diminished growth potential in a patient with an unusual form of insulin resistance, somatomedin C/insulin-like growth factor I (SM-C/IGF-I) and insulin stimulation of [3H]thymidine incorporation and cell replication were compared in skin fibroblasts from the patient (DF) and normal controls."3.67Impaired synergism between somatomedin C/insulin-like growth factor I and dexamethasone in the growth of fibroblasts from a patient with insulin resistance. ( Conover, CA; Hintz, RL; Rosenfeld, RG, 1987)
"The insulin analog LysB3,GluB29-insulin (glulisine) displays accelerated in vivo bioavailability compared with native insulin."1.33Effects of the rapid-acting insulin analog glulisine on cultured human skeletal muscle cells: comparisons with insulin and insulin-like growth factor I. ( Aroda, V; Carter, L; Ciaraldi, TP; Henry, RR; Mudaliar, S; Phillips, SA, 2005)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's3 (25.00)18.2507
2000's2 (16.67)29.6817
2010's0 (0.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Høgh, J1
Hove-Skovsgaard, M1
Gelpi, M1
Jensen, AMR1
Gerstoft, J1
Benfield, T1
Storgaard, H1
Nielsen, SD1
Ciaraldi, TP1
Phillips, SA1
Carter, L1
Aroda, V1
Mudaliar, S1
Henry, RR1
Kaplowitz, PB1
D'Ercole, AJ1
Tokuhiro, E1
Dean, H1
Winter, J1
Haworth, JC1
Imai, Y1
Friesen, HG1
Podskalny, JM1
Kahn, CR2
Iwanishi, M1
Haruta, T1
Takata, Y1
Ishibashi, O1
Sasaoka, T1
Egawa, K1
Imamura, T1
Naitou, K1
Itazu, T1
Kobayashi, M1
Dib, K1
Whitehead, JP1
Humphreys, PJ1
Soos, MA1
Baynes, KC1
Kumar, S1
Harvey, T1
O'Rahilly, S1
Hamer, I1
Foti, M1
Emkey, R1
Cordier-Bussat, M1
Philippe, J1
De Meyts, P1
Maeder, C1
Carpentier, JL1
Quon, MJ1
Cama, A1
Taylor, SI2
Low, L1
Chernausek, SD1
Sperling, MA1
Conover, CA1
Hintz, RL1
Rosenfeld, RG1
Gherzi, R1
Russell, DS1
Rosen, OM1

Other Studies

12 other studies available for thymidine and Insulin Resistance

ArticleYear
Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency.
    BMC infectious diseases, 2022, May-28, Volume: 22, Issue:1

    Topics: Diabetes Mellitus, Type 2; Didanosine; Female; HIV Infections; Humans; Insulin Resistance; Male; Mid

2022
Effects of the rapid-acting insulin analog glulisine on cultured human skeletal muscle cells: comparisons with insulin and insulin-like growth factor I.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:10

    Topics: Adult; Cells, Cultured; Diabetes Mellitus, Type 2; DNA; Female; Glucose; Humans; Hypoglycemic Agents

2005
Fibroblasts from a patient with leprechaunism are resistant to insulin, epidermal growth factor, and somatomedin C.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 55, Issue:4

    Topics: Aminoisobutyric Acids; Cell Division; Cells, Cultured; Drug Resistance; Dwarfism; Epidermal Growth F

1982
A new form of insulin resistance with growth retardation, fatty liver, and hypogonadotropic hypogonadism.
    Pediatric research, 1984, Volume: 18, Issue:7

    Topics: Adolescent; Cells, Cultured; Deoxyglucose; Erythrocytes; Fatty Liver; Fibroblasts; Growth Disorders;

1984
Cell culture studies on patients with extreme insulin resistance. II. Abnormal biological responses in cultured fibroblasts.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:2

    Topics: Acanthosis Nigricans; Adolescent; Adult; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Dwa

1982
A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.
    Diabetologia, 1993, Volume: 36, Issue:5

    Topics: Adult; Alleles; Amino Acid Sequence; Aminoisobutyric Acids; Base Sequence; Biological Transport; Blo

1993
Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance.
    The Journal of clinical investigation, 1998, Mar-01, Volume: 101, Issue:5

    Topics: Acromegaly; Adolescent; Adult; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Female

1998
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
    Diabetologia, 2002, Volume: 45, Issue:5

    Topics: Acanthosis Nigricans; Adult; Amino Acid Substitution; Animals; Arginine; CHO Cells; Cricetinae; Cyst

2002
Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation.
    Biochemistry, 1992, Oct-20, Volume: 31, Issue:41

    Topics: Cell Line; Deoxyglucose; DNA; Fibroblasts; Gene Expression; Genes, jun; Humans; Insulin; Insulin Res

1992
Acromegaloid patients with type A insulin resistance: parallel defects in insulin and insulin-like growth factor-I receptors and biological responses in cultured fibroblasts.
    The Journal of clinical endocrinology and metabolism, 1989, Volume: 69, Issue:2

    Topics: Acanthosis Nigricans; Acromegaly; Adolescent; Autoradiography; Binding Sites; Cells, Cultured; Femal

1989
Impaired synergism between somatomedin C/insulin-like growth factor I and dexamethasone in the growth of fibroblasts from a patient with insulin resistance.
    Pediatric research, 1987, Volume: 22, Issue:2

    Topics: Cell Division; Cells, Cultured; Dexamethasone; Drug Synergism; Epidermal Growth Factor; Fibroblasts;

1987
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor.
    The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35

    Topics: Acanthosis Nigricans; Antibodies; Deoxyglucose; DNA; Humans; Insulin Resistance; Monosaccharide Tran

1987