Page last updated: 2024-08-22

acetylglucosamine and Insulin Resistance

acetylglucosamine has been researched along with Insulin Resistance in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (36.59)	29.6817
2010's	20 (48.78)	24.3611
2020's	6 (14.63)	2.80

Authors

Authors	Studies
Farrar, MA; Hogquist, KA; Liu, B; Moazzami, Z; Ruan, HB; Salgado, OC; Zhang, Z	1
Arumugam, TV; Jo, DG; Lai, MKP; Park, J	1
Bagul, HP; Budnar, S; Chakraborty, A; Chattopadhyay, T; Kamat, SS; Kolthur-Seetharam, U; Maniyadath, B; Rajendran, A; Shukla, A; Shukla, N	1
Aydogdu, G; Sermikli, BP; Yilmaz, E	1
Alejandro, EU; Avula, N; Beetch, M; Jo, S; Moore, M	1
Ameneiro, C; Beiroa, D; Bernardo, G; Bilbao, J; Bravo, SB; Carneiro, C; Cho, JW; Coppari, R; Cuñarro, J; Da Silva Lima, N; Dieguez, C; Dp Chantada-Vazquez, M; Fernandez, U; Fernández-Ramos, D; Ferno, J; Fidalgo, M; Fondevila, MF; Fruhbeck, G; Garcia-Vence, M; Gonzalez-Rellan, MJ; Guallar, D; Herzig, S; Iglesias, C; López, M; Lopitz-Otsoa, F; Martinez-Chantar, ML; Mato, JM; Millet, O; Müller, TD; Nogueiras, R; Novoa, E; Perez-Fernandez, R; Porteiro, B; Rodríguez, A; Sabio, G; Senra, A; Seoane, S; Tovar, S; Varela-Rey, M; Veyrat-Durebex, C; Vidal, A; Woodhoo, A; Yang, WH	1
Chen, Z; Li, X; Liu, C; Qin, X	1
Katakami, N	1
Dennis, JW; Hesketh, GG	1
Dehennaut, V; Lefebvre, T	1
Belke, DD; Myslicki, JP; Shearer, J	1
Choi, JH; Choi, SS; Jang, HJ; Kim, IS; Koh, A; Lee, GH; Lee, H; Lee, YH; Park, D; Ryu, SH; Seo, YK; Suh, PG; Yang, YR	1
Cui, S; Huang, J; Shen, A; Tang, Z; Tao, T; Wan, C; Wang, S; Xia, N; Zhang, D; Zhang, W; Zhao, Y; Zhu, X	1
El-Karim, EG; Teo, CF; Wells, L	1
Heo, RW; Jeon, BT; Jeong, EA; Kim, H; Kim, KE; Lee, JY; Roh, GS; Yi, CO	1
Escalante, A; Festa, A; Haffner, SM; Hanley, AJ; Lorenzo, C; Rewers, MJ	1
Cho, YM; Choi, HH; Chung, SS; Kim, JH; Lee, HK; Lee, KW; Park, HS; Park, KS	1
Bubb, AK; Davies, GJ; Macauley, MS; Martinez-Fleites, C; Vocadlo, DJ	1
Bhonagiri, P; Elmendorf, JS; Habegger, KM; Horvath, EM; McCarthy, AM; Pattar, GR	1
Hanover, JA; Krause, MW; Love, DC	1
Dehennaut, V; Drougat, L; Guinez, C; Lefebvre, T; Michalski, JC; Mir, AM; Mortuaire, M; Olivier, S; Vercoutter-Edouart, AS	1
Teo, CF; Wells, L; Wollaston-Hayden, EE	1
Dias, WB; Hart, GW; Lane, MD; Thiruneelakantapillai, L; Whelan, SA	1
Davies, GJ; Gloster, TM; He, Y; Macauley, MS; Stubbs, KA; Vocadlo, DJ	1
Gloster, TM; Macauley, MS; Shan, X; Vocadlo, DJ; Yuzwa, SA	1
Vosseller, K	1
Lefebvre, T; Michalski, JC; Mir, AM; Olivier, S	1
Balteau, M; Beauloye, C; Bertrand, L; Brady, NR; de Meester, C; Des Rosiers, C; Gailly, P; Ginion, A; Horman, S; Hue, L; Sommereyns, C; Tajeddine, N; Vanoverschelde, JL	1
Chatham, JC; Marsh, SA; McLarty, JL	1
Buse, MG; Schey, KL; Vincent, TS; Walgren, JL	1
Lund, KC; McClain, DA; Parker, GJ; Taylor, RP	1
Hart, GW; Vosseller, K; Wells, L	1
Arias, EB; Cartee, GD; Kim, J	1
Arias, EB; Cartee, GD	1
Akimoto, Y; Hart, GW; Hirano, H; Kawakami, H	1
Lee, W; Park, SY; Ryu, J	1
Hanover, JA; Love, DC	1
Ashwell, G; Forsythe, ME; Hanover, JA; Kim, EJ; Krause, MW; Lazarus, BD; Love, DC; Prinz, WA	1
Evans, RM; Field, SJ; Havstad, JC; Kudlow, JE; Michell, RH; Miles, PD; Olefsky, JM; Ongusaha, PP; So, WV; Yang, X; Zhang, F	1
Bullen, JW; Copeland, RJ; Hart, GW	1
Hart, GW; Lane, MD; Vosseller, K; Wells, L	1

Reviews

11 review(s) available for acetylglucosamine and Insulin Resistance

Article	Year
O-GlcNAcylation as a Therapeutic Target for Alzheimer's Disease. Neuromolecular medicine, 2020, Volume: 22, Issue:2 Topics: Acetylglucosamine; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antigens, Neoplasm; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Glycosylation; Hexosamines; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; Insulin Resistance; Molecular Structure; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroprotective Agents; Phosphorylation; Protein Isoforms; Protein Processing, Post-Translational; Stroke; tau Proteins; Uridine Diphosphate; Uridine Diphosphate N-Acetylgalactosamine	2020
Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus. Journal of atherosclerosis and thrombosis, 2018, Jan-01, Volume: 25, Issue:1 Topics: Acetylglucosamine; Animals; Arteries; Atherosclerosis; Cardiovascular Diseases; Diabetes Complications; Disease Progression; Dyslipidemias; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypertension; Inflammation; Insulin Resistance; Mice; Muscle, Smooth, Vascular; Obesity; Oxidative Stress; Polymers; Protein Kinase C; Quality of Life; Reactive Oxygen Species; Risk Factors	2018
Role of O-GlcNAcylation in nutritional sensing, insulin resistance and in mediating the benefits of exercise. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2014, Volume: 39, Issue:11 Topics: Acetylglucosamine; Animals; Exercise; Glucose; Humans; Insulin Resistance; Phosphorylation; Protein Processing, Post-Translational; Rest; Signal Transduction	2014
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochimica et biophysica acta, 2010, Volume: 1800, Issue:2 Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Caenorhabditis elegans; Catalytic Domain; Diabetes Mellitus, Type 2; Evolution, Molecular; Food; Gene Expression Regulation; Humans; Insulin Resistance; MAP Kinase Signaling System; Models, Animal; Models, Molecular; N-Acetylglucosaminyltransferases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Sirtuins; Starvation	2010
Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease. Biochimica et biophysica acta, 2010, Volume: 1800, Issue:2 Topics: Acetylglucosamine; Alzheimer Disease; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Homeodomain Proteins; HSP70 Heat-Shock Proteins; Humans; Insulin Resistance; Myocardial Reperfusion Injury; N-Acetylglucosaminyltransferases; Proteasome Endopeptidase Complex; Trans-Activators; Transcription Factors; Ubiquitins	2010
Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes. Molecular and cellular endocrinology, 2010, Apr-29, Volume: 318, Issue:1-2 Topics: Acetylglucosamine; Adipocytes; Animals; Glycosylation; Hexosamines; Humans; Insulin; Insulin Resistance	2010
Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart. Life sciences, 2013, Mar-28, Volume: 92, Issue:11 Topics: Acetylglucosamine; Diabetic Cardiomyopathies; Humans; Insulin Resistance; Models, Biological; Protein Processing, Post-Translational	2013
A role for N-acetylglucosamine as a nutrient sensor and mediator of insulin resistance. Cellular and molecular life sciences : CMLS, 2003, Volume: 60, Issue:2 Topics: Acetylglucosamine; Adipocytes; Animals; Diabetes Mellitus, Type 2; Forecasting; Glucose; Glycosylation; Hexosamines; Humans; Hyperglycemia; Insulin; Insulin Resistance; Models, Biological; Signal Transduction	2003
O-GlcNAc modification of nucleocytoplasmic proteins and diabetes. Medical molecular morphology, 2005, Volume: 38, Issue:2 Topics: Acetylglucosamine; Animals; Aorta; Cytoplasm; Diabetes Mellitus; Glycosylation; Hexosamines; Humans; Insulin Resistance; Nuclear Proteins; Pancreas	2005
The hexosamine signaling pathway: deciphering the "O-GlcNAc code". Science's STKE : signal transduction knowledge environment, 2005, Nov-29, Volume: 2005, Issue:312 Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Antigens, Neoplasm; beta-N-Acetylhexosaminidases; Caenorhabditis elegans Proteins; Computational Biology; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Hexosamines; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mammals; Mice; Mice, Transgenic; Multienzyme Complexes; N-Acetylglucosaminyltransferases; Neoplasm Proteins; Neurodegenerative Diseases; Plant Proteins; Protein Processing, Post-Translational; Signal Transduction; Stress, Physiological; Uridine Diphosphate N-Acetylglucosamine	2005
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:1 Topics: Acetylglucosamine; Acetylglucosaminidase; Acylation; Amino Acid Sequence; Animals; Diabetes Mellitus, Type 2; Hexosamines; Humans; Insulin Resistance; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Phosphorylation; Signal Transduction	2008

Other Studies

30 other study(ies) available for acetylglucosamine and Insulin Resistance

Article	Year
An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism. Frontiers in immunology, 2022, Volume: 13 Topics: Acetylglucosamine; Animals; Insulin Resistance; Iron; Mice; N-Acetylglucosaminyltransferases; Obesity; STAT5 Transcription Factor; T-Lymphocytes, Regulatory	2022
Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. Proceedings of the National Academy of Sciences of the United States of America, 2020, 03-24, Volume: 117, Issue:12 Topics: Acetylglucosamine; Aging; Animals; Fasting; Gluconeogenesis; Glycosylation; HEK293 Cells; Homeostasis; Humans; Hyperglycemia; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Protein Processing, Post-Translational; Sirtuin 1; Spatio-Temporal Analysis	2020
Role of the O-GlcNAc modification on insulin resistance and endoplasmic reticulum stress in 3T3-L1 cells. Molecular biology reports, 2020, Volume: 47, Issue:8 Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Drug Resistance; Endoplasmic Reticulum Stress; Glucosamine; Glycolysis; Hexosamines; Insulin Resistance; Mice; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Protein Processing, Post-Translational; RNA Interference; RNA, Small Interfering; Signal Transduction; Tunicamycin; Unfolded Protein Response	2020
Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring. International journal of molecular sciences, 2021, Jun-28, Volume: 22, Issue:13 Topics: Acetylglucosamine; Animals; Body Weight; Female; Insulin; Insulin Resistance; Male; Mice; N-Acetylglucosaminyltransferases; Placenta; Pregnancy	2021
O-GlcNAcylated p53 in the liver modulates hepatic glucose production. Nature communications, 2021, 08-20, Volume: 12, Issue:1 Topics: Acetylglucosamine; Animals; Base Sequence; Caloric Restriction; Cell Line; Colforsin; Diabetes Mellitus, Type 2; Epinephrine; Glucagon; Glucocorticoids; Gluconeogenesis; Glucose; Glycosylation; Hepatocytes; Humans; Hydrocortisone; Hyperglycemia; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; Protein Binding; Protein Stability; Pyruvic Acid; RNA, Messenger; Transcription, Genetic; Tumor Suppressor Protein p53	2021
A novel mechanism of pre-transplant insulin resistance contributing to post-transplant complications: Cyclosporin A-induced O-GlcNAcylation. Biochemical and biophysical research communications, 2017, 10-14, Volume: 492, Issue:2 Topics: Acetylglucosamine; Acylation; Animals; Apoptosis; Cell Line; Cyclosporine; Immunosuppressive Agents; Insulin Resistance; Membrane Potential, Mitochondrial; Mice; Muscle Fibers, Skeletal; Proteins; Reactive Oxygen Species; Transplantation Conditioning	2017
N-acetylglucosamine: more than a silent partner in insulin resistance. Glycobiology, 2017, 07-01, Volume: 27, Issue:7 Topics: Acetylglucosamine; Amino Acids, Branched-Chain; Animals; Humans; Insulin; Insulin Resistance; Metabolome; Mice	2017
Proteomics and PUGNAcity will overcome questioning of insulin resistance induction by nonselective inhibition of O-GlcNAcase. Proteomics, 2013, Volume: 13, Issue:20 Topics: 3T3-L1 Cells; Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Chromatography, Affinity; Glycosylation; Hep G2 Cells; Humans; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Proteomics	2013
Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga(+/-) mice. Diabetologia, 2015, Volume: 58, Issue:12 Topics: Acetylglucosamine; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; beta-N-Acetylhexosaminidases; Blood Glucose; Body Weight; Cell Differentiation; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose Intolerance; Insulin Resistance; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Signal Transduction; Thermogenesis	2015
The Role of PTP1B O-GlcNAcylation in Hepatic Insulin Resistance. International journal of molecular sciences, 2015, Sep-22, Volume: 16, Issue:9 Topics: Acetylglucosamine; Acylation; Hep G2 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Protein Tyrosine Phosphatase, Non-Receptor Type 1	2015
Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin. Glycobiology, 2016, Volume: 26, Issue:11 Topics: Acetylglucosamine; Animals; Apoptosis; beta-N-Acetylhexosaminidases; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Enzyme Inhibitors; Insulin; Insulin Resistance; Oximes; Phenylcarbamates; Structure-Activity Relationship	2016
Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice. Neurobiology of aging, 2016, Volume: 44 Topics: Acetylglucosamine; Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Caloric Restriction; Diabetes Complications; Fatty Liver; Hippocampus; Insulin Resistance; Learning; Learning Disabilities; Male; Mice, Inbred C57BL; Mice, Obese; N-Acetylglucosaminyltransferases; Phosphorylation; tau Proteins	2016
Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion. Diabetes care, 2017, Volume: 40, Issue:3 Topics: Acetylglucosamine; Biomarkers; Blood Glucose; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Galactosamine; Glucose Tolerance Test; Humans; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Polysaccharides	2017
Activation of PPARgamma negatively regulates O-GlcNAcylation of Sp1. Biochemical and biophysical research communications, 2008, Aug-08, Volume: 372, Issue:4 Topics: Acetylglucosamine; Acylation; Animals; Cell Line; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Processing, Post-Translational; Rosiglitazone; Sp1 Transcription Factor; Thiazolidinediones; Transcription, Genetic; Zinc Fingers	2008
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. The Journal of biological chemistry, 2008, Dec-12, Volume: 283, Issue:50 Topics: 3T3-L1 Cells; Acetylglucosamine; Acetylglucosaminidase; Adipocytes; Animals; Bridged Bicyclo Compounds, Heterocyclic; Catalytic Domain; Dose-Response Relationship, Drug; Insulin Resistance; Kinetics; Mice; Models, Biological; Models, Chemical; Molecular Conformation; Phosphorylation; Protein Processing, Post-Translational	2008
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin. Endocrinology, 2009, Volume: 150, Issue:4 Topics: 3T3-L1 Cells; Acetylglucosamine; Actins; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Cytoskeleton; Fluorescent Antibody Technique; Glycosylation; Hexosamines; Insulin; Insulin Resistance; Mice; Phosphatidylinositol 4,5-Diphosphate; Signal Transduction	2009
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. The Journal of biological chemistry, 2010, Feb-19, Volume: 285, Issue:8 Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Amino Acid Motifs; Animals; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction	2010
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chemistry & biology, 2010, Sep-24, Volume: 17, Issue:9 Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Deoxyglucose; Enzyme Inhibitors; Humans; Indolizines; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphorylation; Proto-Oncogene Proteins c-akt	2010
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chemistry & biology, 2010, Sep-24, Volume: 17, Issue:9 Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Inhibitors; G(M2) Ganglioside; Glucose; Insulin Resistance; Mice; Rats; Rats, Sprague-Dawley; Signal Transduction	2010
O-GlcNAc and aging: C. elegans as a genetic model to test O-GlcNAc roles in type II diabetic insulin resistance. Aging, 2010, Volume: 2, Issue:11 Topics: Acetylglucosamine; Aging; Animals; Caenorhabditis elegans; Diabetes Mellitus, Type 2; Insulin; Insulin Resistance; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational; Signal Transduction	2010
[Signaling and metabolic predispositions linked to the colorectal cancer]. Medecine sciences : M/S, 2011, Volume: 27, Issue:5 Topics: Acetylglucosamine; Adenocarcinoma; beta Catenin; Colorectal Neoplasms; Diet; Disease Progression; Disease Susceptibility; Energy Metabolism; Genes, p53; Genes, Tumor Suppressor; Glycosylation; Humans; Insulin Resistance; Intestinal Mucosa; Metabolic Syndrome; Models, Biological; Oncogenes; Protein Processing, Post-Translational; Receptor Protein-Tyrosine Kinases; Risk Factors; Signal Transduction; Wnt Proteins	2011
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovascular research, 2011, Nov-01, Volume: 92, Issue:2 Topics: 6-Aminonicotinamide; Acetylglucosamine; Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glycosylation; Hyperglycemia; Insulin Resistance; Male; Membrane Glycoproteins; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidases; Pentose Phosphate Pathway; Phlorhizin; Protein Processing, Post-Translational; Protein Transport; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Reactive Oxygen Species; Sodium-Glucose Transporter 1	2011
High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:2 Topics: Acetylglucosamine; Animals; Cells, Cultured; Glucose; Glycosylation; HSP70 Heat-Shock Proteins; Hypoglycemic Agents; Insulin; Insulin Resistance; Mass Spectrometry; Membrane Proteins; Muscle Cells; Sp1 Transcription Factor; Tubulin	2003
Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine. The Journal of biological chemistry, 2003, Mar-21, Volume: 278, Issue:12 Topics: 3T3 Cells; Acetylglucosamine; Animals; Cells, Cultured; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase; Glycosylation; Insulin Resistance; Mice; Phosphorylation	2003
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle. Diabetes, 2004, Volume: 53, Issue:4 Topics: Acetylglucosamine; Animals; Biological Transport; Glucose; Glycosylation; Insulin; Insulin Resistance; Kinetics; Male; Muscle Proteins; Muscle, Skeletal; Oximes; Phenylcarbamates; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Processing, Post-Translational; Rats; Rats, Wistar	2004
Relationship between protein O-linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O-(2-acetamido-2-deoxy-d-glucopyranosylidene)amino-N-phenylcarbamate. Acta physiologica Scandinavica, 2005, Volume: 183, Issue:3 Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Biological Transport, Active; Caloric Restriction; Electrophoresis, Polyacrylamide Gel; Glucose; Glycosylation; Insulin; Insulin Resistance; Liver; Male; Muscle Proteins; Muscle, Skeletal; Oximes; Phenylcarbamates; Rats; Rats, Inbred F344; Tissue Culture Techniques	2005
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes. Experimental & molecular medicine, 2005, Jun-30, Volume: 37, Issue:3 Topics: Acetylglucosamine; Adipocytes; Animals; beta-N-Acetylhexosaminidases; Deoxyglucose; Glucose Transporter Type 5; Glycosylation; Immunoprecipitation; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Subcellular Fractions	2005
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proceedings of the National Academy of Sciences of the United States of America, 2006, Aug-08, Volume: 103, Issue:32 Topics: Acetylglucosamine; Acetylglucosaminidase; Alleles; Animals; Animals, Genetically Modified; beta-N-Acetylhexosaminidases; Caenorhabditis elegans; Disease Models, Animal; Hexosamines; Histone Acetyltransferases; Insulin; Insulin Resistance; Molecular Sequence Data; Multienzyme Complexes; Mutation; Phosphorylation; Signal Transduction	2006
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature, 2008, Feb-21, Volume: 451, Issue:7181 Topics: Acetylglucosamine; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Insulin; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Second Messenger Systems	2008
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proceedings of the National Academy of Sciences of the United States of America, 2002, Apr-16, Volume: 99, Issue:8 Topics: 3T3 Cells; Acetylglucosamine; Adipocytes; Animals; beta Catenin; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Cell Line; Cell Nucleus; Cytoplasm; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Glucosamine; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Glycosylation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Oximes; Phenylcarbamates; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; Trans-Activators; Tyrosine	2002