Compounds > 9,10-dihydroxystearic acid
Page last updated: 2024-12-07

9,10-dihydroxystearic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

9,10-dihydroxyoctadecanoic acid : A hydroxy-fatty acid formally derived from octacecanoic (stearic) acid by hydroxy substitution at positions 9 and 10. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
ViciagenusA plant genus of the family FABACEAE that is widely used as ground cover and forage and known for the edible beans, VICIA FABA.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Vicia sativaspeciesA plant species of the genus VICIA, family FABACEAE. The seed is used for food and contains THIOCYANATES such as prunasin, cyanoalanine, cyanogen, and vicine.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID89377
CHEMBL ID4747409
CHEBI ID28724
SCHEMBL ID317522
MeSH IDM0200177

Synonyms (50)

Synonym
c18h36o4
octadecanoic acid,10-dihydroxy-
nsc-60305
9,10-dihydroxyoctadecanoic acid
theta, etha - dihydroxystearic acid
nsc60305
9,10-dihydroxystearic acid ,
120-87-6
NCIOPEN2_007703
AKOS000277636
dioxystearinsaeure
9,10-dhsa
CHEBI:28724
dhsa
9,10-dihydroxystearinsaeure
9,10-dioh c18:0
9,10-dioh 18:0
FT-0667157
LMFA02000142
C19622
9,10-dihydroxy-octadecanoic acid
AKOS024319019
octadecanoic acid, 9,10-dihydroxy-
einecs 204-432-2
unii-6c8dc6uq5a
6c8dc6uq5a ,
nsc 60305
ai3-14192
einecs 300-158-3
calcium (9 or 10)-hydroxy-(10 or 9)-oxidooctadecanoate
trans-9,10-dihydroxystearic acid
(9r,10r)-rel-9,10-dihydroxyoctadecanoic acid
SCHEMBL317522
9,10-dihydroxyoctadecanoic acid, threo-
mfcd00046726
J-015271
FT-0701127
Q27103863
DTXSID30870475
rashayan dihydroxystearic acid
di hydroxy stearic acid
AC9026
A906813
(+/-)-erythro-9,10-dihydroxyoctadecanoic acid
SY263007
EN300-18537468
CS-0145562
HY-N8522
CHEMBL4747409
PD070894
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
dihydroxy monocarboxylic acidAny hydroxy monocarboxylic acid carrying at least two hydroxy groups.
hydroxyoctadecanoic acidA hydroxy fatty acid that is ocatadecanoic acid (stearic acid) in which the aliphatic chain has been substituted by one or more hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1675096Binding affinity to rat DNA polymerase beta with homo-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE2020Bioorganic & medicinal chemistry, 09-01, Volume: 28, Issue:17
An assay for DNA polymerase β lyase inhibitors that engage the catalytic nucleophile for binding.
AID1675094Binding affinity to wild type rat DNA polymerase beta assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE analysis2020Bioorganic & medicinal chemistry, 09-01, Volume: 28, Issue:17
An assay for DNA polymerase β lyase inhibitors that engage the catalytic nucleophile for binding.
AID1675095Binding affinity to rat DNA polymerase beta with methyl-lysine modification at 72 assessed as inhibition of dRP excision in presence of 32P-end labelled duplex DNA at 10 uM by SDS PAGE2020Bioorganic & medicinal chemistry, 09-01, Volume: 28, Issue:17
An assay for DNA polymerase β lyase inhibitors that engage the catalytic nucleophile for binding.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.95 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
protocatechuic acid
protocatechuic acid: RN given refers to parent cpd; structure. 3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.		2.2510catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite
lipoamide
Lipozyme: lipase from Rhizomucor miehei immobilized on anion exchange resin		2.0210dithiolanes;
monocarboxylic acid amide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0210aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
stearic acid
octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.		6.9210long-chain fatty acid;
saturated fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
human metabolite;
plant metabolite
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		2.0210alkane
9,10-epoxystearic acid
9,10-epoxystearic acid: RN given refers to parent cpd with unspecified isomeric designation; structure. 9,10-epoxyoctadecanoic acid : An epoxy fatty acid consisting of octadecanoic (stearic) acid with a single epoxide located between positions 9 and 10.		2.3920epoxystearic acidhuman metabolite
metaperiodate
Periodic Acid: A strong oxidizing agent.		1.9210iodine oxoacid
metaperiodate
metaperiodate: RN given refers to periodic acid, Na salt; structure. periodate : A monovalent inorganic anion obtained by deprotonation of periodic acid.		1.9210iodine oxoanion;
monovalent inorganic anion
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		1.9810octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
nadp
[no description available]		210
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.25103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		02.0510
Insulin Sensitivity
[description not available]		02.0510
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		02.0510