Assay ID | Title | Year | Journal | Article |
AID1852344 | Selectivity ratio of EC50 for human MC4R to EC50 for human MC1R | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1852338 | Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1812562 | Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1852339 | Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1852341 | Selectivity ratio of Ki for human MC3R to Ki for human MC1R | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1852335 | Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1852336 | Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1812563 | Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1812559 | Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1812560 | Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1812557 | Agonist activity at human melanocortin receptor 1 expressed in human T-Rex-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1852340 | Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1852337 | Agonist activity at human MC1R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1812558 | Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1852334 | Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintillation proximity assay | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1812567 | Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1852343 | Selectivity ratio of EC50 for human MC3R to EC50 for human MC1R | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1812561 | Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillation proximity assay | 2021 | Journal of medicinal chemistry, 07-22, Volume: 64, Issue:14
| Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework. |
AID1852342 | Selectivity ratio of Ki for human MC4R to Ki for human MC1R | 2022 | Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19
| Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. |
AID1346171 | Human MC4 receptor (Melanocortin receptors) | 2009 | Peptides, Oct, Volume: 30, Issue:10
| Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. |
AID1346178 | Human MC3 receptor (Melanocortin receptors) | 2009 | Peptides, Oct, Volume: 30, Issue:10
| Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. |
AID1346180 | Human MC5 receptor (Melanocortin receptors) | 2009 | Peptides, Oct, Volume: 30, Issue:10
| Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. |
AID1346224 | Rat MC4 receptor (Melanocortin receptors) | 2009 | Peptides, Oct, Volume: 30, Issue:10
| Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. |
AID1346231 | Human MC1 receptor (Melanocortin receptors) | 2009 | Peptides, Oct, Volume: 30, Issue:10
| Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |