Page last updated: 2024-08-03 16:31:52

gsk0660

Description

GSK0660: PPAR antagonist; structure in first source [MeSH]

3-[(4-anilino-2-methoxyphenyl)sulfamoyl]-2-thiophenecarboxylic acid methyl ester : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	46233311
CHEMBL ID	592652
SCHEMBL ID	14970321
CHEBI ID	94813
MeSH ID	M0522648

Synonyms (37)

Synonym
3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
gsk0660
1014691-61-2
CHEMBL592652 ,
bdbm50383373
3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester
S5817
BRD-K98684188-001-01-1
gsk-0660
methyl 3-[(4-anilino-2-methoxy-phenyl)sulfamoyl]thiophene-2-carboxylate
gtpl3441
gsk 0660
AM81226
2-thiophenecarboxylic acid, 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-, methyl ester
SCHEMBL14970321
methyl 3-(n-(2-methoxy-4-(phenylamino)phenyl)sulfamoyl)thiophene-2-carboxylate
AC-31444
AKOS024457626
mfcd12828770
CS-5416
HY-12377
J-000397
DTXSID10673163
methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate
EX-A768
CHEBI:94813
gsk0660, >=98% (hplc)
AS-74581
methyl 3-{[2-methoxy-4-(phenylamino)phenyl]sulfamoyl}thiophene-2-carboxylate
NCGC00370882-01
2-thiophenecarboxylic acid, 3-(((2-methoxy-4-(phenylamino)phenyl)amino)sulfonyl)-, methyl ester
BCP07112
HMS3677N06
Q27077861
HMS3413N06
gsk 0660 gsk 0660
3-[[[2-methoxy-4-(phenylamino)pheny l]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester

Drug Classes (1)

Class	Description
sulfonamide	An amide of a sulfonic acid RS(=O)2NR'2.

Protein Targets (11)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	1.5092	AID1645841
G	Vesicular stomatitis virus	Potency	2.3919	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	5.3547	AID1645840
Interferon beta	Homo sapiens (human)	Potency	2.3919	AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	2.3919	AID1645842
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	2.3919	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	2.3919	AID1645842

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Peroxisome proliferator-activated receptor delta	Mus musculus (house mouse)	IC50	0.1740	AID660960; AID660964
Peroxisome proliferator-activated receptor gamma	Homo sapiens (human)	IC50	10.0000	AID459602
Peroxisome proliferator-activated receptor delta	Homo sapiens (human)	IC50	0.2099	AID1201424; AID459603; AID459604
Peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Ki	0.0046	AID1701619
Peroxisome proliferator-activated receptor alpha	Homo sapiens (human)	IC50	10.0000	AID459601

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Peroxisome proliferator-activated receptor delta	Homo sapiens (human)	EC50	4.2850	AID1650504; AID1650505; AID1701628; AID1870357

Bioassays (28)

Assay ID	Title	Year	Journal	Article
AID1451042	Transrepression of human GST-tagged PPARdelta LBD assessed as induction of corepressor SMRT-ID2 peptide recruitment at 1 uM in presence of GW501516 by TR-FRET assay	2017	Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17 ISSN: 1520-4804	Polypharmacology of N
AID459603	Inhibition of human PPARdelta receptor by ligand displacement assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 ISSN: 1520-4804	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
AID459601	Displacement of [3H]GW2433 from human PPARalpha receptor by ligand displacement assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 ISSN: 1520-4804	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
AID1701613	Displacement of [125I]I-AB-MECA from recombinant human A3AR expressed in CHO cell membranes measured after 60 mins by gamma counter analysis	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 ISSN: 1520-4804
AID1451000	Agonist activity at PPARdelta in human bone marrow-derived mesenchymal stem cells assessed as induction of ANGPTL4 mRNA levels at 10 uM after 2 days by qRT-PCR method	2017	Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17 ISSN: 1520-4804	Polypharmacology of N
AID660960	Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay	2012	Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6 ISSN: 1520-4804	(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
AID459605	Antagonist activity at human PPARdelta ligand binding domain-mediated transcriptional activity in CV1 cells by Gal4 chimera reporter assay relative to control	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 ISSN: 1520-4804	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
AID1650504	Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assay	2020	Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1 ISSN: 1464-3391	Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ.
AID1701615	Binding affinity to PPAR-alpha (unknown origin) assessed as ligand replacement at 30 uM by TR-FRET assay relative to control	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 ISSN: 1520-4804
AID660964	Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis	2012	Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6 ISSN: 1520-4804	(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
AID459604	Antagonist activity at human PPARdelta ligand binding domain-mediated transcriptional activity in CV1 cells by Gal4 chimera reporter assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 ISSN: 1520-4804	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
AID1451001	Agonist activity at PPARdelta in human bone marrow-derived mesenchymal stem cells assessed as induction of PDK4 mRNA levels at 10 uM after 2 days by qRT-PCR method	2017	Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17 ISSN: 1520-4804	Polypharmacology of N
AID1870357	Antagonist activity at PPARdelta (unknown origin) by TR-FRET assay	2022	ACS medicinal chemistry letters, Jul-14, Volume: 13, Issue:7 ISSN: 1948-5875	Design, Synthesis, and Biological Activity of l-1'-Homologated Adenosine Derivatives.
AID1701628	Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 ISSN: 1520-4804
AID1201424	Binding affinity to N-terminal hexa-histidine tagged and fluorescein-labeled human PPAR-beta/delta (164 to 441 residues) expressed in Escherichia coli BL21-DE3 incubated for 1 hr by fluorescence anisotropy	2015	European journal of medicinal chemistry, Apr-13, Volume: 94ISSN: 1768-3254	Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618.
AID1701619	Binding affinity to PPAR-delta (unknown origin) by TR-FRET assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 ISSN: 1520-4804
AID1451020	Transrepression of human GST-tagged PPARdelta LBD assessed as induction of corepressor SMRT-ID2 peptide recruitment at 1 uM by TR-FRET assay	2017	Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17 ISSN: 1520-4804	Polypharmacology of N
AID660967	Inverse agonist activity at PPARbeta/delta in human WPMY-1 cells assessed as increase in HDAC3 recruitment to ANGPTL4 at 1 uM after 30 mins by chromatin immune precipitation analysis	2012	Journal of medicinal chemistry, Mar-22, Volume: 55, Issue:6 ISSN: 1520-4804	(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
AID1701616	Binding affinity to PPAR-gamma (unknown origin) assessed as ligand replacement at 30 uM by TR-FRET assay relative to control	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24 ISSN: 1520-4804
AID765053	Antiviral activity against HCV infected in african green monkey OR6 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay	2013	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17 ISSN: 1464-3405	Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.
AID1650505	Antagonist at PPARdelta LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 cotreated with PPARdelta agonist GW501516 by TR-FRET assay	2020	Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1 ISSN: 1464-3391	Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ.
AID459602	Inhibition of human PPARgamma receptor by ligand displacement assay	2010	Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4 ISSN: 1520-4804	Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346790	Human Peroxisome proliferator-activated receptor-beta/delta (1C. Peroxisome proliferator-activated receptors)	2008	Molecular endocrinology (Baltimore, Md.), Feb, Volume: 22, Issue:2 ISSN: 0888-8809	Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.

Research

Studies (53)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (1.89)	29.6817
2010's	38 (71.70)	24.3611
2020's	14 (26.42)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	55 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
acetazolamide	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
1-(4-methanesulfonamidophenoxy)-3-(n-methyl-3,4-dichlorophenylethylamino)-2-propanol	sulfonamide		low
amosulalol	sulfonamide		low
ampiroxicam	acetal; aminopyridine; benzothiazine; etabonate ester; monocarboxylic acid amide; sulfonamide	analgesic; antirheumatic drug; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug; prodrug	low
amsacrine	acridines; aromatic ether; sulfonamide	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	low
azosemide	monochlorobenzenes; sulfonamide; tetrazoles; thiophenes	loop diuretic	low
bendroflumethiazide	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic	low
benzothiazide	benzothiadiazine; sulfonamide	antihypertensive agent; diuretic	low
benzylhydrochlorothiazide	benzenes; benzothiadiazine; organochlorine compound; secondary amino compound; sulfonamide		low
bumetanide	amino acid; benzoic acids; sulfonamide	diuretic; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor	low
celecoxib	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug	low
chlorthalidone	isoindoles; monochlorobenzenes; sulfonamide		low
4-chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide	sulfonamide		low
dichlorphenamide	dichlorobenzene; sulfonamide	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor; ophthalmology drug	low
e 4031	sulfonamide		low
ethoxzolamide	aromatic ether; benzothiazoles; sulfonamide	antiglaucoma drug; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
famotidine	1,3-thiazoles; guanidines; sulfonamide	anti-ulcer drug; H2-receptor antagonist; P450 inhibitor	low
furosemide	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic	low
glimepiride	sulfonamide		low
n-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	isoquinolines; sulfonamide		low
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide	bromobenzenes; isoquinolines; olefinic compound; secondary amino compound; sulfonamide	EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor	low
hydrochlorothiazide	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic	low
hydroxymethyltolbutamide	benzyl alcohols; sulfonamide; ureas	metabolite	low
indapamide	indoles; organochlorine compound; sulfonamide	antihypertensive agent; diuretic	low
methazolamide	sulfonamide; thiadiazoles		low
metolazone	organochlorine compound; quinazolines; sulfonamide	antihypertensive agent; diuretic; ion transport inhibitor	low
monodansylcadaverine	aminonaphthalene; primary amino compound; sulfonamide; tertiary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor; fluorochrome; protective agent	low
n-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide	naphthalenes; organochlorine compound; primary amino compound; sulfonamide		low
naratriptan	heteroarylpiperidine; sulfonamide; tryptamines	serotonergic agonist; vasoconstrictor agent	low
nimesulide	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	low
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	aromatic ether; C-nitro compound; sulfonamide	antineoplastic agent; cyclooxygenase 2 inhibitor	low
5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide	sulfonamide		low
phthalylsulfathiazole	1,3-thiazoles; dicarboxylic acid monoamide; sulfonamide antibiotic; sulfonamide		low
probenecid	benzoic acids; sulfonamide	uricosuric drug	low
sulfadiazine	pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; antiprotozoal drug; coccidiostat; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic	low
sotalol	ethanolamines; secondary alcohol; secondary amino compound; sulfonamide	anti-arrhythmia drug; beta-adrenergic antagonist; environmental contaminant; xenobiotic	low
SU6656	oxindoles; sulfonamide	antineoplastic agent; Aurora kinase inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	low
sulfabenzamide	benzenes; sulfonamide antibiotic; sulfonamide	antibacterial drug; antimicrobial drug	low
sulfacytine	benzenes; sulfonamide		low
sulfadimethoxine	aromatic ether; pyrimidines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; antimicrobial agent; drug allergen; environmental contaminant; xenobiotic	low
sulfamerazine	pyrimidines; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen	low
sulfameter	pyrimidines; sulfonamide antibiotic; sulfonamide	antiinfective agent; leprostatic drug; renal agent	low
sulfamethazine	pyrimidines; sulfonamide antibiotic; sulfonamide	antibacterial drug; antiinfective agent; antimicrobial agent; carcinogenic agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; ligand; xenobiotic	low
sulfamethizole	sulfonamide antibiotic; sulfonamide; thiadiazoles	antiinfective agent; antimicrobial agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor	low
sulfamethoxazole	isoxazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; antiinfective agent; antimicrobial agent; drug allergen; EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; epitope; P450 inhibitor; xenobiotic	low
sulfamethoxypyridazine	pyridazines; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor	low
sulfamonomethoxine	benzenes; sulfonamide		low
sulfanilamide	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
sulfanitran	sulfonamide		low
sulfaphenazole	primary amino compound; pyrazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial drug; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor; P450 inhibitor	low
sulfapyridine	pyridines; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; dermatologic drug; drug allergen; environmental contaminant; xenobiotic	low
sulfaquinoxaline	benzenes; sulfonamide		low
sulfathiazole	1,3-thiazoles; substituted aniline; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; xenobiotic	low
sulfisomidine	pyrimidines; sulfonamide antibiotic; sulfonamide	antiinfective agent	low
sulfisoxazole	isoxazoles; sulfonamide antibiotic; sulfonamide	antibacterial drug; drug allergen	low
sulfoxone	sulfonamide		low
sulpiride	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist	low
sumatriptan	sulfonamide; tryptamines	serotonergic agonist; vasoconstrictor agent	low
delavirdine	aminopyridine; indolecarboxamide; N-acylpiperazine; sulfonamide	antiviral drug; HIV-1 reverse transcriptase inhibitor	low
zonisamide	1,2-benzoxazoles; sulfonamide	anticonvulsant; antioxidant; central nervous system drug; protective agent; T-type calcium channel blocker	low
4-toluenesulfonamide	sulfonamide		low
n-methyl-n-nitrosotoluene-p-sulfonamide	sulfonamide		low
sulfachlorpyridazine	organochlorine compound; pyridazines; sulfonamide	antibacterial drug; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor	low
acetyl sulfisoxazole	benzenes; sulfonamide		low
sulfaethidole	benzenes; sulfonamide		low
benzenesulfonamide	sulfonamide		low
carzenide	sulfonamide		low
sulfalene	pyrazines; sulfonamide antibiotic; sulfonamide		low
thioproperazine	N-alkylpiperazine; N-methylpiperazine; phenothiazines; sulfonamide	phenothiazine antipsychotic drug	low
carbutamide	benzenes; sulfonamide		low
glymidine	diether; pyrimidines; sulfonamide	hypoglycemic agent	low
thiazosulfone	sulfonamide		low
glybuthiazol	benzenes; sulfonamide		low
sulfanilylurea	benzenes; sulfonamide		low
metahexamide	benzenes; sulfonamide		low
clopamide	sulfonamide		low
tolcyclamide	sulfonamide		low
sulfamoxole	oxazole; sulfonamide antibiotic; sulfonamide	antimicrobial agent; drug allergen	low
sulfaethoxypyridazine	sulfonamide	antibacterial agent	low
4-((diethylamino)sulfonyl)benzoic acid	sulfonamide		low
dinsed	sulfonamide		low
amidephrine	sulfonamide		low
sulfadoxine	pyrimidines; sulfonamide	antibacterial drug; antimalarial	low
hydroxyhexamide	sulfonamide		low
asulam	carbamate ester; primary amino compound; substituted aniline; sulfonamide	agrochemical; EC 2.5.1.15 (dihydropteroate synthase) inhibitor; environmental contaminant; herbicide; xenobiotic	low
n-butylbenzenesulfonamide	sulfonamide	neurotoxin; plant metabolite	low
oryzalin	aromatic amine; C-nitro compound; sulfonamide; tertiary amino compound	agrochemical; antimitotic; herbicide	low
glisoxepide	sulfonamide		low
perfluidone	sulfonamide		low
mefluidide	sulfonamide		low
2-aminosulfonyl-benzoic acid methyl ester	benzoate ester; methyl ester; sulfonamide	marine xenobiotic metabolite	low
clorsulon	benzenes; sulfonamide		low
agreal	sulfonamide		low
n-acetylsulfapyridine	sulfonamide		low
tirofiban	L-tyrosine derivative; piperidines; sulfonamide	anticoagulant; fibrin modulating drug; platelet glycoprotein-IIb/IIIa receptor antagonist	low
n(4)-acetylsulfadiazine	acetamides; pyrimidines; sulfonamide	marine xenobiotic metabolite	low
amprenavir	carbamate ester; sulfonamide; tetrahydrofuryl ester	antiviral drug; HIV protease inhibitor	low
n(4)-acetylsulfamethoxazole	isoxazoles; sulfonamide	drug metabolite; marine xenobiotic metabolite	low
glisentide	sulfonamide		low
ebrotidine	sulfonamide		low
4-chlorobenzenesulfonamide	sulfonamide		low
4-amino-6-chloro-1,3-benzenedisulfonamide	sulfonamide		low
N(4)-acetylsulfathiazole	1,3-thiazoles; acetamides; sulfonamide	marine xenobiotic metabolite	low
2-benzothiazolesulfonamide	benzothiazoles; sulfonamide		low
brinzolamide	sulfonamide; thienothiazine	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
piloty's acid	sulfonamide		low
perfluorooctanesulfonamide	perfluorinated compound; sulfonamide	persistent organic pollutant	low
uk 68798	aromatic ether; sulfonamide; tertiary amino compound	anti-arrhythmia drug; potassium channel blocker	low
glyclopyramide	sulfonamide		low
fluoresone	sulfonamide		low
2-aminobenzenesulfonamide	benzenes; sulfonamide		low
4-chloro-5-sulfamoylanthranilic acid	benzenes; sulfonamide		low
sulfluramid	sulfonamide	acaricide; environmental contaminant; insecticide; xenobiotic	low
8-(4-tolylsulfonylamino)quinoline	sulfonamide		low
n-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl)phenyl)methanesulfonamide	dichlorobenzene; organofluorine compound; sulfonamide; triazoles	agrochemical; EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor; herbicide	low
cloransulam-methyl	methyl ester; monochlorobenzenes; organofluorine compound; sulfonamide; triazolopyrimidines	agrochemical; EC 2.2.1.6 (acetolactate synthase) inhibitor; herbicide	low
sdds	benzenes; sulfonamide		low
4-chlorobenzenesulfonylurea	sulfonamide		low
n-(2,6-difluorophenyl)-5-methyl(1,2,4)-triazol(1,5-a)pyrimidine-2-sulfonamide	sulfonamide		low
flazasulfuron	pyridines; sulfonamide		low
4-methyl-N-(phenylmethyl)benzenesulfonamide	sulfonamide		low
bosentan anhydrous	primary alcohol; pyrimidines; sulfonamide	antihypertensive agent; endothelin receptor antagonist	low
sulfamethoxazole hydroxylamine	isoxazoles; sulfonamide	allergen; metabolite	low
gr 113808	indolyl carboxylate ester; piperidines; sulfonamide	serotonergic antagonist	low
valdecoxib	isoxazoles; sulfonamide	antipyretic; antirheumatic drug; cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	low
ym 12617	aromatic ether; secondary amino compound; sulfonamide		low
dansyllysine	L-lysine derivative; non-proteinogenic L-alpha-amino acid; sulfonamide	epitope	low
almotriptan	indoles; sulfonamide; tertiary amine	non-steroidal anti-inflammatory drug; serotonergic agonist; vasoconstrictor agent	low
4-nitrososulfamethoxazole	isoxazoles; nitroso compound; sulfonamide	allergen; metabolite	low
cki 7	isoquinolines; organochlorine compound; primary amino compound; sulfonamide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor	low
fosamprenavir	sulfonamide	prodrug	low
metipamide	sulfonamide		low
jte 522	1,3-oxazoles; organofluorine compound; sulfonamide	cyclooxygenase 2 inhibitor	low
carboxytolbutamide	sulfonamide		low
tevenel	sulfonamide		low
sulfachlorpyrazine	sulfonamide		low
n(4)-acetylsulfadimethoxine	acetamides; pyrimidines; sulfonamide	marine xenobiotic metabolite	low
dronedarone	1-benzofurans; aromatic ether; aromatic ketone; sulfonamide; tertiary amino compound	anti-arrhythmia drug; environmental contaminant; xenobiotic	low
darunavir	carbamate ester; furofuran; sulfonamide	antiviral drug; HIV protease inhibitor	low
cimicoxib	aromatic ether; imidazoles; organochlorine compound; organofluorine compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	low
dabuzalgron	aromatic ether; imidazoles; monochlorobenzenes; sulfonamide	alpha-adrenergic agonist	low
n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide	chloroindole; organochlorine compound; sulfonamide	antineoplastic agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
3,4-Dichlorobenzenesulfonamide	sulfonamide		low
N-cyclooctyl-4-methylbenzenesulfonamide	sulfonamide		low
tolpyrramide	sulfonamide		low
acetic acid [2-[acetyl-(4-methylphenyl)sulfonylamino]phenyl] ester	sulfonamide		low
1-(benzenesulfonyl)indole	sulfonamide		low
tosylphenylalanyl chloromethyl ketone	alpha-chloroketone; sulfonamide	alkylating agent; serine proteinase inhibitor	low
rosuvastatin	dihydroxy monocarboxylic acid; monofluorobenzenes; pyrimidines; statin (synthetic); sulfonamide	anti-inflammatory agent; antilipemic drug; cardioprotective agent; CETP inhibitor; environmental contaminant; xenobiotic	low
bms 214662	benzenes; benzodiazepine; imidazoles; nitrile; sulfonamide; thiophenes	antineoplastic agent; apoptosis inducer; EC 2.5.1.58 (protein farnesyltransferase) inhibitor	low
N-[4-(methanesulfonamido)phenyl]acetamide	sulfonamide		low
prinomastat	aromatic ether; hydroxamic acid; pyridines; sulfonamide; thiomorpholines	antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; matrix metalloproteinase inhibitor	low
glucosulfone	sulfonamide		low
1-[1-(benzenesulfonyl)-3-pyrrolyl]ethanone	sulfonamide		low
1-(4-bromo-2,5-dimethoxyphenyl)sulfonylazepane	sulfonamide		low
1-(4-chloro-3-methoxyphenyl)sulfonylazepane	sulfonamide		low
6-[(4-methylphenyl)sulfonyl]-6-azabicyclo[3.2.1]octane	sulfonamide		low
N-cyclopentyl-4-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]sulfonyl]benzenesulfonamide	sulfonamide		low
N4-cyclohexyl-N1-ethyl-N4-(2-pyridinylmethyl)benzene-1,4-disulfonamide	sulfonamide		low
2-[cyclohexyl-(2,4,6-trimethylphenyl)sulfonylamino]-N-(3-pyridinylmethyl)acetamide	sulfonamide		low
1-(3-chloro-4-methoxyphenyl)sulfonyl-N-(3-pyridinyl)-3-piperidinecarboxamide	sulfonamide		low
N-(3-ethoxyphenyl)-1-(4-methoxyphenyl)sulfonyl-3-piperidinecarboxamide	sulfonamide		low
N-[4-[[4-(4-methylphenyl)sulfonyl-1,4-diazepan-1-yl]sulfonyl]phenyl]acetamide	sulfonamide		low
N-[2-(2-furanylmethylthio)ethyl]-4-methoxybenzenesulfonamide	sulfonamide		low
4-[2-[1-(4-methoxyphenyl)sulfonyl-2-benzimidazolyl]ethyl]morpholine	sulfonamide		low
1-(2,5-dimethoxyphenyl)sulfonyl-N-(phenylmethyl)-4-piperidinecarboxamide	sulfonamide		low
1-[2-chloro-5-(trifluoromethyl)phenyl]sulfonylazepane	sulfonamide		low
4-[4-[(5,6-dimethyl-1-benzimidazolyl)sulfonyl]phenyl]sulfonylmorpholine	sulfonamide		low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-methoxyphenyl)sulfonylpiperazine	sulfonamide		low
4-methyl-N-(pyridin-4-ylmethyl)benzenesulfonamide	sulfonamide		low
N-cyclopropyl-4-(2,3-dihydroindol-1-ylsulfonyl)benzenesulfonamide	sulfonamide		low
2-[4-(benzenesulfonyl)phenyl]-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole	sulfonamide		low
N-(2-furanylmethyl)-2-[(4-methoxyphenyl)sulfonylamino]benzamide	sulfonamide		low
N-[4-(diethylsulfamoyl)phenyl]-2-(2-oxo-1,3-benzothiazol-3-yl)acetamide	sulfonamide		low
3-[[4-(1-benzotriazolyl)-1-piperidinyl]sulfonyl]-N-cyclopentylbenzenesulfonamide	sulfonamide		low
N,N-dimethyl-4-[[4-(5-methyl-1-benzotriazolyl)-1-piperidinyl]sulfonyl]benzamide	sulfonamide		low
4-(4-methoxyphenyl)sulfonyl-N-(phenylmethyl)-1-piperazinecarboxamide	sulfonamide		low
N-[4-(4-fluorophenyl)-2-thiazolyl]-2-[(4-methylphenyl)sulfonylamino]benzamide	sulfonamide		low
N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide	acetamides; piperidines; pyridines; sulfonamide		low
3,4,5-trimethoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide	sulfonamide		low
N-(4-phenylmethoxyphenyl)methanesulfonamide	sulfonamide		low
3-(diethylsulfamoyl)-N-(1,3,4-thiadiazol-2-yl)benzamide	sulfonamide		low
2-[(4-fluoro-3-methylphenyl)sulfonylamino]acetic acid	sulfonamide		low
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-thiophenesulfonamide	sulfonamide		low
N-(2-furanylmethyl)-4-methyl-N-(phenylmethyl)benzenesulfonamide	sulfonamide		low
2-(2-ethylphenoxy)-N-(4-sulfamoylphenyl)acetamide	sulfonamide		low
1-(4-chlorophenyl)-3-(4-sulfamoylphenyl)urea	sulfonamide		low
N-(3-chloro-4-hydroxy-2,5-dimethylphenyl)benzenesulfonamide	sulfonamide		low
2,4,6-trimethyl-n-(meta-3-trifluoromethylphenyl)benzenesulfonamide	sulfonamide		low
4-[(4-phenyl-2-thiazolyl)amino]benzenesulfonamide	sulfonamide		low
N-[2-(1-cyclohexenyl)ethyl]-2,5-dimethoxybenzenesulfonamide	sulfonamide		low
N-(1-ethyl-5-benzimidazolyl)-4-methylbenzenesulfonamide	sulfonamide		low
4-methyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)benzenesulfonamide	sulfonamide		low
4-chloro-N-(4-hydrazinyl-6-methyl-2-pyrimidinyl)benzenesulfonamide	sulfonamide		low
4-amino-N-(4-ethoxyphenyl)benzenesulfonamide	benzenes; sulfonamide		low
1-(2-nitrophenyl)sulfonylpiperidine	sulfonamide		low
N,4-dimethyl-N-(4-methylphenyl)benzenesulfonamide	sulfonamide		low
2,3,4-trimethyl-N-(3-pyridinyl)benzenesulfonamide	sulfonamide		low
2-[[4-(1-pyrrolidinylsulfonyl)phenyl]hydrazinylidene]propanedinitrile	sulfonamide		low
N-[1-(benzenesulfonyl)-2,2-dichloroethenyl]acetamide	sulfonamide		low
2-(4-fluoro-N-methylsulfonylanilino)-N-(3-methylphenyl)acetamide	sulfonamide		low
4-chloro-3-ethoxy-N-(4-ethylphenyl)benzenesulfonamide	sulfonamide		low
1-(3-chlorophenyl)sulfonylpyrrolidine	sulfonamide		low
1-cyclopropyl-3-(4-sulfamoylphenyl)thiourea	sulfonamide		low
N-[3-[methyl(methylsulfonyl)amino]phenyl]-2-phenoxyacetamide	sulfonamide		low
4-[methyl(methylsulfonyl)amino]-N-(2-phenylethyl)benzamide	sulfonamide		low
2-(2,6-dichloroanilino)-3-pyridinesulfonamide	pyridines; sulfonamide		low
4-(4-chloroanilino)-3-pyridinesulfonamide	pyridines; sulfonamide		low
1-ethyl-3-(4-methylphenyl)sulfonylthiourea	sulfonamide		low
6-chloro-N-(2-hydroxyphenyl)-3-pyridinesulfonamide	pyridines; sulfonamide		low
5-chloro-2-methoxy-N,N,4-trimethylbenzenesulfonamide	sulfonamide		low
2-[(2,5-dimethoxyphenyl)sulfonyl-methylamino]acetic acid	sulfonamide		low
N-(2-ethylphenyl)-2-methoxy-5-methylbenzenesulfonamide	sulfonamide		low
4-ethoxy-N-(4-fluorophenyl)-2,3-dimethylbenzenesulfonamide	sulfonamide		low
N-[2-(1-cyclohexenyl)ethyl]-4-[methyl(methylsulfonyl)amino]benzamide	sulfonamide		low
1-(2,5-dimethoxyphenyl)sulfonyl-4-ethylpiperazine	sulfonamide		low
N-[2-(methylthio)phenyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-(4-methoxyphenyl)-4-(methylthio)benzenesulfonamide	sulfonamide		low
2-methoxy-5-propan-2-yl-N-(2-pyridinyl)benzenesulfonamide	sulfonamide		low
2,3,5,6-tetramethyl-N-(2-methyl-1,3-benzothiazol-5-yl)benzenesulfonamide	sulfonamide		low
2-[4-chloro-2-methyl-5-(2-pyridinylsulfamoyl)phenoxy]acetamide	sulfonamide		low
N-(3-chlorophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylbenzenesulfonamide	sulfonamide		low
N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-(3-methyl-N-methylsulfonylanilino)acetamide	sulfonamide		low
2-[(5-bromo-2-thiophenyl)sulfonylamino]-N-(2-furanylmethyl)benzamide	sulfonamide		low
N-[4-[(2,6-dimethoxy-4-pyrimidinyl)sulfamoyl]phenyl]butanamide	sulfonamide		low
2-(3-pyridinyl)-4-[4-(1-pyrrolidinylsulfonyl)phenyl]thiazole	sulfonamide		low
5-bromo-6-chloro-N-(4-methyl-2-pyridinyl)-3-pyridinesulfonamide	pyridines; sulfonamide		low
4-(4-fluorophenyl)sulfonyl-2-(2-furanyl)-N-phenyl-5-oxazolamine	sulfonamide		low
2-[[4-(4-methylphenyl)sulfonyl-1-piperazinyl]methyl]-4-propan-2-ylphenol	sulfonamide		low
ethyl 4-{N-[(4-chlorophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate	carbamate ester; sulfonamide		low
N-[(2-chlorophenyl)methyl]-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide	sulfonamide		low
N-[4-(1-pyrrolidinylsulfonyl)phenyl]-2-thiophen-2-ylacetamide	sulfonamide		low
2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]-N-(2-pyridinylmethyl)acetamide	sulfonamide		low
2-[(4-ethoxyphenyl)sulfonylamino]-N-(2-furanylmethyl)benzamide	sulfonamide		low
1-(4-methylphenyl)sulfonyl-2-benzimidazolamine	sulfonamide		low
1-(4-chlorophenyl)sulfonyl-2-benzimidazolamine	sulfonamide		low
N-[4-(1-pyrrolidinylsulfonyl)phenyl]-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide	sulfonamide		low
N-[4-(1-piperidinylsulfonyl)phenyl]-2-thiophenesulfonamide	sulfonamide		low
N-(1,3-benzothiazol-2-yl)-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide	sulfonamide		low
1-cyclohexyl-3-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]urea	sulfonamide		low
N-(5-chloro-2-hydroxyphenyl)-1,3-dimethyl-2-oxo-5-benzimidazolesulfonamide	sulfonamide		low
2,5-dichloro-4-ethoxy-N-(2-pyridinylmethyl)benzenesulfonamide	sulfonamide		low
4-ethoxy-2,3,5-trimethyl-N-(3-pyridinylmethyl)benzenesulfonamide	sulfonamide		low
N-[4-[(3,4-dimethoxyphenyl)sulfamoyl]phenyl]acetamide	sulfonamide		low
3-(1-piperidinylsulfonyl)-N-(2-thiazolyl)benzamide	sulfonamide		low
4-chloro-3-(1-piperidinylsulfonyl)-N-(2-thiazolyl)benzamide	sulfonamide		low
2-[N-(benzenesulfonyl)-4-ethoxyanilino]-N-(2-methoxyphenyl)acetamide	sulfonamide		low
1-(2,5-dimethoxyphenyl)sulfonyl-4-(phenylmethyl)piperazine	sulfonamide		low
4-[(4-chlorophenyl)methyl-methylsulfonylamino]-N-(2-pyridinylmethyl)benzamide	sulfonamide		low
5-bromo-2-methoxy-N-(3-methyl-2-pyridinyl)benzenesulfonamide	sulfonamide		low
pyrabactin	naphthalenes; organobromine compound; pyridines; sulfonamide	abscisic acid receptor agonist; hormone; plant growth regulator	low
2-(4-methoxyphenyl)-N-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]acetamide	sulfonamide		low
1,4-bis[(4-methoxy-2-methylphenyl)sulfonyl]-1,4-diazepane	sulfonamide		low
N-(2-furanylmethyl)-4-(1-pyrrolidinylsulfonyl)benzenesulfonamide	sulfonamide		low
4-(benzenesulfonyl)-N-methyl-N-phenyl-1-piperazinecarboxamide	sulfonamide		low
2-(3-ethylphenoxy)-N-[4-(2-pyridinylsulfamoyl)phenyl]acetamide	sulfonamide		low
N-[[1-(benzenesulfonyl)-4-piperidinyl]methyl]benzenesulfonamide	sulfonamide		low
1-(1,3-benzodioxol-5-yl)-3-[4-[(5-methyl-3-isoxazolyl)sulfamoyl]phenyl]urea	sulfonamide		low
1-(1,3-benzodioxol-5-yl)-3-[4-[(phenylmethyl)sulfamoyl]phenyl]urea	sulfonamide		low
1,3-diethyl-6-methyl-N-(2-methylphenyl)-2-oxo-5-benzimidazolesulfonamide	sulfonamide		low
N-(1,3-benzodioxol-5-ylmethyl)-4-methyl-3-(1-piperidinylsulfonyl)benzamide	sulfonamide		low
3-(1-azepanylsulfonyl)-N-(3-isoxazolyl)-4-methylbenzamide	sulfonamide		low
1-methylsulfonyl-N-(6,7,8,9-tetrahydrodibenzofuran-2-yl)-2,3-dihydroindole-5-sulfonamide	sulfonamide		low
2-[2-chloro-4-(2,3-dihydroindol-1-ylsulfonyl)phenoxy]-N-(2-pyridinylmethyl)acetamide	sulfonamide		low
1-(4-bromo-3-ethoxyphenyl)sulfonyl-3,5-dimethylpyrazole	sulfonamide		low
N-(4-hydroxy-3,5-dimethylphenyl)-2,5-dimethyl-3-thiophenesulfonamide	sulfonamide		low
5-[(5-tert-butyl-2,3-dimethylphenyl)sulfonylamino]-2-hydroxybenzoic acid	sulfonamide		low
1-(4-chloro-2,5-dimethoxyphenyl)sulfonylbenzotriazole	sulfonamide		low
2-[4-chloro-5-(cyclopentylsulfamoyl)-2-methylphenoxy]-N-cyclohexylacetamide	sulfonamide		low
2-(1,3-benzothiazol-2-ylthio)-N-(4-methylphenyl)sulfonylacetamide	sulfonamide		low
2,4-dichloro-5-(diethylsulfamoyl)-N-(1,3,4-thiadiazol-2-yl)benzamide	sulfonamide		low
N-cycloheptyl-1-(4-methylphenyl)sulfonyl-4-piperidinecarboxamide	sulfonamide		low
N-(2-methyl-1,3-benzothiazol-6-yl)-4-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
4-(dimethylsulfamoyl)-N-(4-thiophen-2-yl-2-thiazolyl)benzamide	sulfonamide		low
2-[1-(4-tert-butylphenyl)sulfonyl-4-piperidinyl]-6-chloro-1H-benzimidazole	sulfonamide		low
2-[[5-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-[4-(1-pyrrolidinylsulfonyl)phenyl]acetamide	sulfonamide		low
4-[[3-[(2-chlorophenyl)methyl]-5-cyclopropyl-7-triazolo[4,5-d]pyrimidinyl]amino]-N,N-dimethylbenzenesulfonamide	sulfonamide		low
7-methyl-2-[4-(4-methylphenyl)sulfonyl-1,4-diazepan-1-yl]-3-quinolinecarbonitrile	sulfonamide		low
6-amino-5-(benzenesulfonyl)-2-methoxy-3-pyridinecarbonitrile	sulfonamide		low
6-amino-5-(4-chlorophenyl)sulfonyl-2-oxo-1H-pyridine-3-carbonitrile	sulfonamide		low
2-[benzenesulfonyl(2-pyridinyl)amino]acetic acid	sulfonamide		low
2-[(4-chlorophenyl)sulfonyl-(2-pyridinyl)amino]acetic acid	sulfonamide		low
2,5-dichloro-N-(1,5,6-trimethyl-4-benzimidazolyl)benzenesulfonamide	sulfonamide		low
2-[(4-fluorophenyl)sulfonyl-(2-pyridinyl)amino]-N-phenylacetamide	sulfonamide		low
5-[1-(benzenesulfonyl)-3-pyrazolyl]-2-phenylthiazole	sulfonamide		low
5-[1-(4-fluorophenyl)sulfonyl-3-pyrazolyl]-2-phenylthiazole	sulfonamide		low
N-[1-[(3,4-dichlorophenyl)methyl]-6-oxo-3-pyridinyl]benzenesulfonamide	sulfonamide		low
2-(benzenesulfonylmethyl)-5-(4-chlorophenyl)cyclohexane-1,3-dione	sulfonamide		low
1-(benzenesulfonyl)-3-pyrazolidinone	sulfonamide		low
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methyl-4-pyrazolesulfonamide	sulfonamide		low
N-(4-methoxyphenyl)-2-(3-methylphenoxy)-N-(4-methylphenyl)sulfonylacetamide	sulfonamide		low
N-[4-(4-fluorophenyl)-2-thiazolyl]-4-methylbenzenesulfonamide	sulfonamide		low
2-[[[4-(diethylsulfamoyl)phenyl]-oxomethyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester	sulfonamide		low
tosylarginine methyl ester	guanidines; L-arginine ester; methyl ester; sulfonamide		low
n-(4-(n-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide	pyrazines; sulfonamide; thiophenes	necroptosis inhibitor; neuroprotective agent	low
N-[(benzenesulfonylhydrazo)-sulfanylidenemethyl]-4-methylbenzamide	sulfonamide		low
xl147	aromatic amine; benzothiadiazole; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	low
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indole	sulfonamide		low
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[(4-methyl-1-piperidinyl)sulfonyl]benzamide	sulfonamide		low
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[methyl-(phenylmethyl)sulfamoyl]benzamide	sulfonamide		low
4-(4-bromophenyl)sulfonyl-2-(2-furanyl)-5-(methylthio)oxazole	sulfonamide		low
4-(4-morpholinylsulfonyl)-N-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)benzamide	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-fluorophenyl)thio]ethanone	sulfonamide		low
4-methoxy-N-(3-methylbutyl)-3-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
N-(1,3-benzothiazol-2-yl)-3-(2,3-dihydroindol-1-ylsulfonyl)benzamide	sulfonamide		low
N-(1H-benzimidazol-2-yl)-3-[phenyl(prop-2-enyl)sulfamoyl]benzamide	sulfonamide		low
1-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-[(5,7-dimethyl-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)thio]ethanone	sulfonamide		low
3-[4-(4-morpholinylsulfonyl)phenyl]propanoic acid [2-[(5-chloro-2-pyridinyl)amino]-2-oxoethyl] ester	sulfonamide		low
2-[(5-chloro-2-thiophenyl)sulfonylamino]-N-(2-furanylmethyl)benzamide	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]thio]ethanone	sulfonamide		low
2,5-difluoro-N-[2-(4-morpholinylmethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl]benzenesulfonamide	sulfonamide		low
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-3-[methyl-(4-methylphenyl)sulfamoyl]benzamide	sulfonamide		low
N-(2-methyl-1,3-benzothiazol-6-yl)-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
3-[(4-acetyl-1-piperazinyl)sulfonyl]-N-(1H-benzimidazol-2-yl)benzamide	sulfonamide		low
3-[(3-hydroxy-5-benzotriazolyl)sulfonylamino]benzoic acid	sulfonamide		low
3-[(5-chloro-2,4-dimethoxyphenyl)-methylsulfamoyl]-N-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)benzamide	sulfonamide		low
2-(2-fluorophenoxy)-N-[4-(2-furanylmethylsulfamoyl)phenyl]acetamide	sulfonamide		low
3-[[[5-[3-(1-piperidinylsulfonyl)phenyl]-1,3,4-oxadiazol-2-yl]thio]methyl]-1,2,3-benzotriazin-4-one	sulfonamide		low
N-(1H-benzimidazol-2-yl)-3-[methyl-(4-methylphenyl)sulfamoyl]benzamide	sulfonamide		low
2,6-dichloro-N-[2-(methylthio)-1,3-benzothiazol-6-yl]benzenesulfonamide	sulfonamide		low
4-fluoro-3-methoxy-N-(2-pyridinyl)benzenesulfonamide	sulfonamide		low
N-(5-ethyl-1,3,4-oxadiazol-2-yl)-4-[methyl(phenyl)sulfamoyl]benzamide	sulfonamide		low
4-[bis(2-methoxyethyl)sulfamoyl]-N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)benzamide	sulfonamide		low
4-(dipropylsulfamoyl)-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
4-[butyl(methyl)sulfamoyl]-N-[5-[(methylthio)methyl]-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
4-[ethyl-(phenylmethyl)sulfamoyl]-N-(5-methyl-1,3,4-oxadiazol-2-yl)benzamide	sulfonamide		low
4-[ethyl-(phenylmethyl)sulfamoyl]-N-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
4-[bis(2-methylpropyl)sulfamoyl]-N-[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-methyl-2-thiazolyl)thio]ethanone	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)thio]ethanone	sulfonamide		low
N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-4-nitrobenzenesulfonamide	sulfonamide		low
2-[(5-butyl-1H-1,2,4-triazol-3-yl)thio]-N-(4-sulfamoylphenyl)acetamide	sulfonamide		low
2-ethoxy-N-[4-(2-pyrimidinylsulfamoyl)phenyl]acetamide	sulfonamide		low
N-[4-(dibutylsulfamoyl)phenyl]-2-thiophen-2-ylacetamide	sulfonamide		low
2,3-dichloro-4-methoxy-N-(3-methoxypropyl)benzenesulfonamide	sulfonamide		low
2-[(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)thio]-N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]acetamide	sulfonamide		low
N-(2-furanylmethyl)-2-[4-(propylsulfamoyl)phenoxy]acetamide	sulfonamide		low
4-(benzenesulfonamido)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzamide	sulfonamide		low
4-methyl-N-[2-(phenylmethyl)-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazol-8-yl]benzenesulfonamide	sulfonamide		low
2-[4-chloro-5-(cyclohexylsulfamoyl)-2-methylphenoxy]-N-(1,3,4-thiadiazol-2-yl)acetamide	sulfonamide		low
N-[2-(cyclohexylthio)ethyl]-4-methyl-3-[(4-methylphenyl)sulfamoyl]benzamide	sulfonamide		low
1-(3-chlorophenyl)-3-[3-[methyl(methylsulfonyl)amino]phenyl]urea	sulfonamide		low
N-[4-(cyanomethyl)phenyl]-4-cyclohexylbenzenesulfonamide	sulfonamide		low
N-(4-ethoxyphenyl)-4-[[4-(methylthio)phenyl]sulfonylamino]benzenesulfonamide	sulfonamide		low
2-(methanesulfonamido)-N-[2-(phenylmethylthio)ethyl]benzamide	sulfonamide		low
N-(2-fluorophenyl)-4-methoxy-2,5-dimethylbenzenesulfonamide	sulfonamide		low
2-[benzenesulfonyl-(phenylmethyl)amino]-N-ethylacetamide	sulfonamide		low
4-[benzenesulfonyl(methyl)amino]-N-[2-[(4-chlorophenyl)methylthio]ethyl]benzamide	sulfonamide		low
N-(3,4-dimethyl-2-sulfanylidene-5-thiazolyl)carbamic acid 2-[(2,5-dimethylphenyl)sulfonylamino]ethyl ester	sulfonamide		low
2-[cyclohexyl-(4-methylphenyl)sulfonylamino]-N-(3-methoxypropyl)acetamide	sulfonamide		low
N-[4-[(4-sulfamoylphenyl)sulfamoyl]phenyl]cyclopropanecarboxamide	sulfonamide		low
N-(1H-benzimidazol-2-yl)-4-(dimethylsulfamoyl)benzamide	sulfonamide		low
1-(3-chlorophenyl)-3-[2-(thiophen-2-ylsulfonylamino)phenyl]urea	sulfonamide		low
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one	sulfonamide		low
N-(1H-benzimidazol-2-ylmethyl)-3-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
2-[(4-fluoro-2-methylphenyl)sulfonylamino]-N-(3-pyridinylmethyl)benzamide	sulfonamide		low
2-[(4-cyanophenyl)methylthio]-N-(2-methoxyphenyl)-1,3-benzoxazole-5-sulfonamide	sulfonamide		low
2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]thio]-N-[4-(4-morpholinylsulfonyl)phenyl]acetamide	sulfonamide		low
3-(1-azepanylsulfonyl)-4-chloro-N-(1H-1,2,4-triazol-5-yl)benzamide	sulfonamide		low
sr 3335	sulfonamide		low
N-(1H-benzimidazol-2-ylmethyl)-4-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
2-[(4-chlorophenyl)methylthio]-5-[3-(1-piperidinylsulfonyl)phenyl]-1,3,4-oxadiazole	sulfonamide		low
4-chloro-3-[(4-chlorophenyl)sulfamoyl]-N-(1H-1,2,4-triazol-5-yl)benzamide	sulfonamide		low
1-(2-fluorophenyl)-1-cyclopentanecarboxylic acid [2-oxo-2-(4-sulfamoylanilino)ethyl] ester	sulfonamide		low
3-[(4-methyl-1-piperazinyl)sulfonyl]-N-(4-phenyl-2-thiazolyl)benzamide	sulfonamide		low
N-(2-methoxyphenyl)-2-(2-oxopropylthio)-1,3-benzoxazole-5-sulfonamide	sulfonamide		low
2-[5-(1-pyrrolidinylsulfonyl)-2-thiophenyl]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide	sulfonamide		low
1-(4-fluorophenyl)-1-cyclopentanecarboxylic acid [2-oxo-2-(4-sulfamoylanilino)ethyl] ester	sulfonamide		low
3-(2-chlorophenyl)sulfonylpropanoic acid [2-[(3,5-dichloro-6-methyl-2-pyridinyl)amino]-2-oxoethyl] ester	sulfonamide		low
2-[4-[benzenesulfonyl(methyl)amino]phenoxy]-N-(1,3-benzothiazol-2-yl)acetamide	sulfonamide		low
N-(6-methoxy-1,3-benzothiazol-2-yl)-3-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
N-cyclopentyl-3,4-dimethylbenzenesulfonamide	sulfonamide		low
6-amino-1-(2-methoxyethyl)-N-(4-methylphenyl)sulfonyl-2,4-dioxo-5-pyrimidinecarboxamide	sulfonamide		low
3-(benzenesulfonyl)propanoic acid [2-[(3,5-dichloro-4-methyl-2-pyridinyl)amino]-2-oxoethyl] ester	sulfonamide		low
N-[[2-cyanoethyl(methyl)amino]-sulfanylidenemethyl]-4-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methanone	sulfonamide		low
[4-(4-bromo-2-chlorophenyl)sulfonyl-1-piperazinyl]-(2-sulfanylidene-1H-pyridin-3-yl)methanone	sulfonamide		low
[1-(4-fluorophenyl)sulfonyl-4-piperidinyl]-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methanone	sulfonamide		low
N-[(1S)-1-(1H-benzimidazol-2-yl)-2-methylpropyl]-3-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
1-[4-(3-chloro-2,4,6-trifluorophenyl)sulfonyl-1-piperazinyl]ethanone	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[4-(1,3,4-oxadiazol-2-yl)phenoxy]ethanone	sulfonamide		low
2-(4-methoxyphenyl)-N-[4-(2-pyrimidinylsulfamoyl)phenyl]acetamide	sulfonamide		low
N1-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide	sulfonamide		low
2-(benzenesulfonylmethyl)-5-(4-methoxyphenyl)cyclohexane-1,3-dione	sulfonamide		low
2-[bis(2-methylpropoxy)phosphoryl]-3,3,3-trifluoro-2-[(4-methylphenyl)sulfonylamino]propanoic acid ethyl ester	sulfonamide		low
N1-{3-[2-(2-pyridyl)ethyl]phenyl}-4-chlorobenzene-1-sulfonamide	sulfonamide		low
ethyl 1-[4-(4-chlorobenzenesulfonamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate	ethyl ester; monochlorobenzenes; organofluorine compound; pyrazoles; sulfonamide		low
2,3-dichloro-N'-[4-(trifluoromethyl)-2-pyrimidinyl]benzenesulfonohydrazide	sulfonamide		low
1-(4-ethyl-2-pyridinyl)-3-(4-methylphenyl)sulfonylurea	sulfonamide		low
1-(3,5-dimethylphenyl)-3-[5-(dimethylsulfamoyl)-2-methylphenyl]urea	sulfonamide		low
N-{5-[(dimethylamino)sulfonyl]-2-methylphenyl}cyclohexanecarboxamide	sulfonamide		low
1-tert-butyl-3-[(4-methylphenyl)sulfonylamino]thiourea	sulfonamide		low
2-[(4-methylphenyl)sulfonylamino]pentanoic acid	sulfonamide		low
3-methyl-4,7-bis(methylsulfonyl)-3a,5,6,7a-tetrahydro-1H-imidazo[4,5-b]pyrazin-2-one	imidazopyrazine; sulfonamide; ureas		low
N-(3-acetyl-2-methyl-5-benzofuranyl)-N-(4-chloro-3-nitrophenyl)sulfonylacetamide	sulfonamide		low
2-[(4-chlorophenyl)thio]-N-[4-[(2,4-dimethylphenyl)sulfamoyl]phenyl]propanamide	sulfonamide		low
4-chloro-N-[2-(4-morpholinyl)cyclohexyl]benzenesulfonamide	sulfonamide		low
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzene	C-nitro compound; sulfonamide; toluenes	bone density conservation agent; EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor; geroprotector	low
[4-(benzenesulfonyl)-1-piperazinyl]-(1-piperidinyl)methanone	sulfonamide		low
N-[3-(2-furanyl)-3-phenylpropyl]-4-methylbenzenesulfonamide	sulfonamide		low
N-[4-(butylsulfamoyl)phenyl]-2-phenyl-2-(phenylthio)acetamide	sulfonamide		low
N-[2,6-dimethyl-3-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N,4-dimethylbenzenesulfonamide	sulfonamide		low
2-[4-(1-adamantyl)-N-methylsulfonylanilino]acetic acid	sulfonamide		low
N-[4-[4-(1-pyrrolidinylsulfonyl)phenyl]-2-thiazolyl]-2,3-dihydro-1,4-benzodioxin-3-carboxamide	sulfonamide		low
4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1h-pyrazol-1-yl)benzenesulfonamide	sulfonamide		low
4-[oxo-[1-(2,4,6-trimethylphenyl)sulfonyl-4-piperidinyl]methyl]-1-piperazinecarboxylic acid ethyl ester	sulfonamide		low
N,4-dimethyl-N-{2-oxo-2-[4-(pyridin-2-yl)piperazin-1-yl]ethyl}benzenesulfonamide	sulfonamide		low
N-[2-(1-phenylethyl)-3,4-dihydro-1H-pyrazino[1,2-a]benzimidazol-8-yl]methanesulfonamide	sulfonamide		low
N-[1-(4-chlorophenyl)sulfonyl-2-pyrrolidinyl]-4-methyl-1-piperazinecarboxamide	sulfonamide		low
1-[4-(benzenesulfonyl)-1-piperazinyl]-2-[[1-(2-methylpropyl)-2-benzimidazolyl]thio]ethanone	sulfonamide		low
N-[4-[(4-hydroxyphenyl)-methylsulfamoyl]phenyl]acetamide	sulfonamide		low
6-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-ethyl-N-phenyl-3-pyridinesulfonamide	pyridines; sulfonamide		low
4-chloro-N-(1-propyl-2-benzimidazolyl)-3-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
2,3-dihydro-1,4-benzodioxin-3-yl-[4-(3,4-dimethylphenyl)sulfonyl-1-piperazinyl]methanone	sulfonamide		low
N-(1-propyl-2-benzimidazolyl)-3-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
1-(benzenesulfonyl)-2-benzimidazolamine	sulfonamide		low
1-(4-nitrophenyl)sulfonyl-2-benzimidazolamine	sulfonamide		low
sulfatolamide	benzenes; sulfonamide		low
e 7010	sulfonamide		low
deracoxib	organofluorine compound; pyrazoles; sulfonamide	cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	low
diclosulam	sulfonamide		low
benzene-1-3-disulfonamide	sulfonamide		low
N-[2-[(2-chloro-1-oxopropyl)hydrazo]-2-oxoethyl]benzenesulfonamide	sulfonamide		low
3-nitro-N-(pyridin-4-ylmethyl)benzenesulfonamide	sulfonamide		low
2-[2-[(4-acetamidophenyl)sulfonylamino]-4-thiazolyl]acetic acid ethyl ester	sulfonamide		low
1-[3-(benzenesulfonyl)-2-(1-piperidinyl)propyl]piperidine	sulfonamide		low
6-(2-furanyl)-4-[4-(methanesulfonamido)phenyl]-2-oxo-1-cyclohex-3-enecarboxylic acid ethyl ester	sulfonamide		low
3-(benzenesulfonyl)-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]propanamide	sulfonamide		low
1-(2-furanylmethyl)-3-[[[4-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]thiourea	sulfonamide		low
N1-butan-2-yl-N4-[2-(3,4-dimethoxyphenyl)ethyl]-N4-(thiophen-2-ylmethyl)benzene-1,4-disulfonamide	sulfonamide		low
1-(4-chlorophenyl)sulfonyl-N'-[oxo-[4-(1-piperidinylsulfonyl)phenyl]methyl]-4-piperidinecarbohydrazide	sulfonamide		low
N,N-dimethyl-4-[[3-[3-(5-methyl-2-furanyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]sulfonyl]benzenesulfonamide	sulfonamide		low
1-(4-methylphenyl)sulfonyl-3-methylsulfonylimidazolidine	sulfonamide		low
1-(4-bromophenyl)sulfonyl-4-[(3-methoxyphenyl)methyl]-1,4-diazepane	sulfonamide		low
2-[[4-[(2,6-dimethyl-4-morpholinyl)sulfonyl]phenyl]-oxomethyl]imino-3,4-dimethyl-5-thiazolecarboxylic acid ethyl ester	sulfonamide		low
1-(4-chlorophenyl)sulfonyl-N-(2-thiazolyl)-1-cyclopropanecarboxamide	sulfonamide		low
1-methyl-N-[4-(trifluoromethyl)phenyl]-4-imidazolesulfonamide	sulfonamide		low
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[N-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methylanilino]acetamide	sulfonamide		low
N,N-diethyl-4-[[5-oxo-6-(phenylmethyl)-7H-pyrrolo[3,4-b]pyridin-7-yl]amino]benzenesulfonamide	sulfonamide		low
N-(1,3-benzodioxol-5-yl)-5-bromo-1-[cyclopropyl(oxo)methyl]-N-ethyl-2,3-dihydroindole-7-sulfonamide	sulfonamide		low
N-(3,4-dimethylphenyl)-2-[N-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methoxyanilino]acetamide	sulfonamide		low
3,4-dimethoxy-N-[3-(methylthio)phenyl]benzenesulfonamide	sulfonamide		low
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[N-[(3,5-dimethyl-4-isoxazolyl)sulfonyl]-4-methylanilino]acetamide	sulfonamide		low
cyclopentanecarboxylic acid [4-(benzenesulfonyl)-2-tert-butyl-5-methyl-3-pyrazolyl] ester	sulfonamide		low
4-[[(4-acetamidophenyl)sulfonylamino]methyl]-N-(3-methoxypropyl)benzamide	sulfonamide		low
4-methyl-N-[2,4,6-trioxo-1-phenyl-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzenesulfonamide	sulfonamide		low
6-ethyl-2-[[[4-(4-morpholinylsulfonyl)phenyl]-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	sulfonamide		low
4-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-3-nitrobenzenesulfonamide	benzenes; sulfonamide		low
4-[[(4-methylphenyl)sulfonylamino]methyl]-N-[2-[(phenylmethyl)-propan-2-ylamino]ethyl]benzamide	sulfonamide		low
2-[(5-chloro-1,3-benzothiazol-2-yl)thio]-N-[3-(4-morpholinylsulfonyl)phenyl]propanamide	sulfonamide		low
N-(6-ethoxy-1,3-benzothiazol-2-yl)-4-methoxy-3-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
2-ethoxy-3-pyridinecarboxylic acid [2-[2-methyl-5-(4-morpholinylsulfonyl)anilino]-2-oxoethyl] ester	sulfonamide		low
N-[4-[2-(2-ethyl-1-oxobutyl)-3-phenyl-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide	sulfonamide		low
N-[3-[(2-chlorophenyl)sulfamoyl]-4-methoxyphenyl]-4-oxo-4-thiophen-2-ylbutanamide	sulfonamide		low
2-(4-methyl-N-(4-methylphenyl)sulfonylanilino)-N-[(1-methyl-4-piperidinylidene)amino]acetamide	sulfonamide		low
fh535	sulfonamide		low
1-[4-chloro-3-[(2-methoxyphenyl)sulfamoyl]phenyl]-3-(2-methoxyphenyl)urea	sulfonamide		low
N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-2-(2-pyrimidinylthio)acetamide	sulfonamide		low
2-[[[5-(dimethylsulfamoyl)-2-methylanilino]-sulfanylidenemethyl]hydrazo]-2-oxoacetamide	sulfonamide		low
1-(4-butylphenyl)-3-[4-chloro-3-(dimethylsulfamoyl)phenyl]thiourea	sulfonamide		low
6-methyl-2-[[oxo-[4-(1-pyrrolidinylsulfonyl)phenyl]methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	sulfonamide		low
2-(1,3-benzothiazol-2-ylthio)-N-[2-hydroxy-5-(4-morpholinylsulfonyl)phenyl]acetamide	sulfonamide		low
1-butyl-4,6-dimethyl-3-(2-methylphenyl)sulfonyl-2-pyridinone	sulfonamide		low
4-(4-methylphenyl)sulfonyl-3-phenyl-2,3-dihydro-1,4-benzoxazine	sulfonamide		low
N-[3-(4-methyl-1-piperazinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamide	1,4-naphthoquinones; piperazines; sulfonamide		low
N-(2,2,4-trimethyl-3H-benzofuran-7-yl)benzenesulfonamide	sulfonamide		low
2-furanyl-[4-(4-propan-2-ylphenyl)sulfonyl-1-piperazinyl]methanone	sulfonamide		low
5-amino-2-(diethylamino)-N-(2-methoxyphenyl)benzenesulfonamide	benzenes; sulfonamide		low
N-(1,3-dimethyl-2-oxo-5-benzimidazolyl)-4-fluoro-3-methylbenzenesulfonamide	sulfonamide		low
N-[5-(diethylsulfamoyl)-2-methoxyphenyl]-2-[(2,5-dimethylphenyl)thio]acetamide	sulfonamide		low
2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]-N-[3-(1-piperidinylsulfonyl)phenyl]acetamide	sulfonamide		low
4-[(2,6-dimethyl-4-morpholinyl)sulfonyl]-N-[3-(1-imidazolyl)propyl]benzamide	sulfonamide		low
2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid	sulfonamide		low
N-[(1,2-dimethyl-5-indolyl)methyl]-4-methoxybenzenesulfonamide	sulfonamide		low
N,6-dimethyl-2-[[[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	sulfonamide		low
N-cyclopropyl-4-methylbenzenesulfonamide	sulfonamide		low
N-[1-(1H-benzimidazol-2-yl)ethyl]-3-(dimethylsulfamoyl)benzamide	sulfonamide		low
N-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-[(3-methyl-1-piperidinyl)sulfonyl]benzamide	sulfonamide		low
N-[4-[(1,2-dimethyl-5-indolyl)methylsulfamoyl]phenyl]acetamide	sulfonamide		low
2,3-dihydro-1,4-benzodioxin-3-carboxylic acid [2-[2-methyl-5-(4-morpholinylsulfonyl)anilino]-2-oxoethyl] ester	sulfonamide		low
2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]thio]-N-[3-(3,4,5,6-tetrahydro-2H-azepin-7-ylsulfamoyl)phenyl]acetamide	sulfonamide		low
2-(1,3-benzothiazol-2-ylthio)-N-[2-chloro-5-(4-morpholinylsulfonyl)phenyl]acetamide	sulfonamide		low
1-[3-(dimethylsulfamoyl)phenyl]-3-(2-furanylmethyl)thiourea	sulfonamide		low
5-nitro-2-furancarboxylic acid [2-oxo-2-[3-(1-piperidinylsulfonyl)anilino]ethyl] ester	sulfonamide		low
N-[2-(4-methoxyphenyl)ethyl]-2-nitro-4-(1-pyrrolidinylsulfonyl)aniline	benzenes; sulfonamide		low
N-(2-ethoxyphenyl)-2,1,3-benzothiadiazole-4-sulfonamide	sulfonamide		low
N-[3-[2-(4-fluorophenyl)sulfonyl-3-thiophen-2-yl-3,4-dihydropyrazol-5-yl]phenyl]ethanesulfonamide	sulfonamide		low
N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-4-[(2-methyl-1-piperidinyl)sulfonyl]benzamide	sulfonamide		low
N-[(3,5-dimethyl-1-piperidinyl)-sulfanylidenemethyl]-2-methyl-5-(4-morpholinylsulfonyl)benzamide	sulfonamide		low
4-[bis(2-methoxyethyl)sulfamoyl]-N-[5-(methoxymethyl)-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
2-(benzenesulfonamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester	isopropyl ester; sulfonamide		low
2-(3,4-dichlorophenyl)-N-[3-(dimethylsulfamoyl)-4-methylphenyl]acetamide	sulfonamide		low
N-Cyclopentyl-2-(N-methyl3-chlorobenzenesulfonamido)acetamide	sulfonamide	anticoronaviral agent	low
N-[5-(1-azepanylsulfonyl)-2-chlorophenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)thio]acetamide	sulfonamide		low
1-(4-methoxyphenyl)-3-[3-(1-piperidinylsulfonyl)phenyl]thiourea	sulfonamide		low
1-[2-(trifluoromethyl)phenyl]sulfonyl-4-piperidinecarboxylic acid [2-[(4-fluorophenyl)methylamino]-2-oxoethyl] ester	sulfonamide		low
6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid [2-[4-methyl-3-(1-piperidinylsulfonyl)anilino]-2-oxoethyl] ester	sulfonamide		low
3-[4-(4-butan-2-ylphenyl)sulfonyl-1-piperazinyl]butanoic acid	sulfonamide		low
3-[(2,6-dimethyl-4-morpholinyl)sulfonyl]-N-(5-methyl-2-thiazolyl)benzamide	sulfonamide		low
2-[[4-(2-methoxyphenyl)sulfonyl-1-piperazinyl]sulfonyl]benzonitrile	sulfonamide		low
2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]-N-[3-(diethylsulfamoyl)phenyl]acetamide	sulfonamide		low
3-[(4-methyl-1-piperazinyl)sulfonyl]-N-(4-phenyl-2-thiazolyl)-N-prop-2-enylbenzamide	sulfonamide		low
1-(7-methyloctyl)-3-[4-(4-morpholinylsulfonyl)phenyl]thiourea	sulfonamide		low
5-[(5-bromo-2-ethoxyphenyl)sulfonylamino]-2-chloro-N,N-dimethylbenzenesulfonamide	sulfonamide		low
2-[[5-[(4-fluorophenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-N-(3-sulfamoylphenyl)acetamide	sulfonamide		low
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide	sulfonamide		low
N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-4-(1-pyrrolidinylsulfonyl)benzamide	sulfonamide		low
4-(dimethylsulfamoyl)-N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]benzamide	sulfonamide		low
N-methyl-2-[[[4-[methyl(phenyl)sulfamoyl]phenyl]-oxomethyl]amino]-6-propyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide	sulfonamide		low
1-[4-chloro-3-(4-morpholinylsulfonyl)phenyl]-3-phenylurea	sulfonamide		low
dorzolamide	sulfonamide; thiophenes	antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor	low
3-(4-methylphenyl)sulfonyl-3-azabicyclo[2.2.1]hept-5-ene-2-carboxylic acid	sulfonamide		low
N-(3,4-difluorophenyl)-2-[N-[(3,5-dimethyl-4-isoxazolyl)sulfonyl]-4-ethoxyanilino]acetamide	sulfonamide		low
5-[(4-methoxyphenyl)sulfonylmethyl]-N-(3-methoxypropyl)-2-furancarboxamide	sulfonamide		low
N-cyclohexyl-N-ethyl-1,3-dimethyl-2,4-dioxo-5-pyrimidinesulfonamide	pyrimidone; sulfonamide		low
1,3-dimethyl-2,4-dioxo-N-(4-propan-2-ylphenyl)-5-pyrimidinesulfonamide	sulfonamide		low
2,5-dimethoxy-N-[[2-(4-methoxyphenyl)-4-thiazolyl]methyl]benzenesulfonamide	sulfonamide		low
kn 93	monochlorobenzenes; monomethoxybenzene; primary alcohol; sulfonamide; tertiary amino compound	EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor; geroprotector	low
ro 4-6790	benzenes; sulfonamide		low
jnj-7706621	sulfonamide		low
famotidine	1,3-thiazoles; guanidines; sulfonamide	anti-ulcer drug; H2-receptor antagonist; P450 inhibitor	low
sultan	sulfonamide		low
1-[2-furanyl(oxo)methyl]-N-[4-[(3-methyl-1-piperidinyl)sulfonyl]phenyl]-4-piperidinecarboxamide	sulfonamide		low
sb 269970	sulfonamide		low
belinostat	hydroxamic acid; olefinic compound; sulfonamide	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor	low
2-bromo-N-(phenylmethyl)benzenesulfonamide	sulfonamide		low
2-(2,5-dichlorophenyl)sulfonyl-N-methyl-N-[(2-methylphenyl)methyl]ethanamine	sulfonamide		low
((3z)-n-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1h-pyrrol-2-yl)methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide)	sulfonamide		low
N-[2-methyl-5-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[[4-[oxo-[4-(phenylmethyl)-1-piperazinyl]methyl]phenyl]methyl]benzenesulfonamide	sulfonamide		low
5-chloro-N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-thiophenesulfonamide	sulfonamide		low
4-methyl-N-[[4-[oxo-[4-(phenylmethyl)-1-piperazinyl]methyl]phenyl]methyl]benzenesulfonamide	sulfonamide		low
4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl)benzenesulfonamide	organofluorine compound; pyrazoles; sulfonamide	cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug	low
bm 567	benzenes; sulfonamide		low
mre 269	aromatic amine; ether; monocarboxylic acid; pyrazines; sulfonamide; tertiary amino compound	drug metabolite; orphan drug; platelet aggregation inhibitor; prostacyclin receptor agonist; vasodilator agent	low
pazopanib	aminopyrimidine; indazoles; sulfonamide	angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	low
azd2858	aromatic amine; N-methylpiperazine; pyrazines; pyridines; secondary carboxamide; sulfonamide	antineoplastic agent; bone density conservation agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; Wnt signalling activator	low
4-(2-((1r)-1-(((4-chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic acid	sulfonamide		low
apratastat	sulfonamide		low
N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide	sulfonamide		low
florasulam	sulfonamide		low
(1S,2R)-2-[[4-[(2,4-dimethylphenyl)sulfamoyl]anilino]-oxomethyl]-1-cyclohexanecarboxylic acid	sulfonamide		low
3-[1-(4-bromophenyl)sulfonyl-3,6-dihydro-2H-pyridin-4-yl]-1,2-dimethylindole	sulfonamide		low
4-[3-(3-fluorophenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide	sulfonamide		low
2-[[[4-[(2,6-dimethyl-4-morpholinyl)sulfonyl]phenyl]-oxomethyl]amino]-3-thiophenecarboxamide	sulfonamide		low
4-[3-(4-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide	sulfonamide		low
N-[5-[ethyl(phenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamide	sulfonamide		low
calcium crimson	ammonium betaine; sulfonamide	fluorochrome	low
4-methoxy-N-[[1-[(3-methyl-2-thiophenyl)-oxomethyl]-3-piperidinyl]methyl]benzenesulfonamide	sulfonamide		low
N'-[[3-(4-methylphenyl)sulfonyl-2-oxazolidinyl]methyl]-N-[2-(4-sulfamoylphenyl)ethyl]oxamide	sulfonamide		low
tg101209	N-alkylpiperazine; N-arylpiperazine; pyrimidines; secondary amino compound; sulfonamide	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	low
fedratinib	sulfonamide		low
WAY-316606	(trifluoromethyl)benzenes; piperidines; secondary amino compound; sulfonamide; sulfone	secreted frizzled-related protein 1 inhibitor	low
azd5438	sulfonamide		low
gdc 0941	indazoles; morpholines; piperazines; sulfonamide; thienopyrimidine	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor	low
4-methoxy-N-[[4-[oxo-[4-(phenylmethyl)-1-piperazinyl]methyl]phenyl]methyl]benzenesulfonamide	sulfonamide		low
N-[5-[methyl-(3-methylphenyl)sulfamoyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamide	sulfonamide		low
gsk 1016790a	1-benzothiophenes; aromatic primary alcohol; dichlorobenzene; N-acylpiperazine; sulfonamide; tertiary carboxamide	TRPV4 agonist	low
plx 4720	aromatic ketone; difluorobenzene; organochlorine compound; pyrrolopyridine; sulfonamide	antineoplastic agent; B-Raf inhibitor	low
gsk 2126458	aromatic ether; difluorobenzene; pyridazines; pyridines; quinolines; sulfonamide	anticoronaviral agent; antineoplastic agent; autophagy inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor; radiosensitizing agent	low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(4-fluorophenyl)sulfonylpiperazine	sulfonamide		low
(2R)-4-(2,6-difluorophenyl)sulfonyl-1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2-methylpiperazine	sulfonamide		low
[4-(2,6-difluorophenyl)sulfonyl-1-piperazinyl]-(2,3-dihydro-1,4-benzodioxin-6-yl)methanone	sulfonamide		low
(2R)-1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2-methylpiperazine	sulfonamide		low
(2S)-4-(2,6-difluorophenyl)sulfonyl-1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2-methylpiperazine	sulfonamide		low
(2S)-1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2-methylpiperazine	sulfonamide		low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-pyridinylsulfonyl)piperazine	pyridines; sulfonamide		low
N-[1-(2,6-difluorophenyl)sulfonyl-4-piperidinyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepane	sulfonamide		low
N-[4-[(2,6-difluorophenyl)sulfonylamino]cyclohexyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[3-(trifluoromethyl)phenyl]sulfonylpiperazine	sulfonamide		low
N-[[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-3-azetidinyl]methyl]-2,6-difluorobenzenesulfonamide	sulfonamide		low
N-[[1-(2,6-difluorophenyl)sulfonyl-3-azetidinyl]methyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-3-pyrrolidinyl]-2,6-difluorobenzenesulfonamide	sulfonamide		low
N-[3-[(2,6-difluorophenyl)sulfonylamino]propyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[5-[(2,6-difluorophenyl)sulfonylamino]pentyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[6-[(2,6-difluorophenyl)sulfonylamino]hexyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[2-[(2,6-difluorophenyl)sulfonylamino]ethyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[1-(2,6-difluorophenyl)sulfonyl-3-pyrrolidinyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
N-[4-[(2,6-difluorophenyl)sulfonylamino]butyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-nitrophenyl)sulfonylpiperazine	sulfonamide		low
4-[4-(4-methylphenyl)sulfonyl-1-piperazinyl]-2-thiophen-2-ylquinazoline	sulfonamide		low
plx4032	aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide	antineoplastic agent; B-Raf inhibitor	low
N-[[4-[(2,6-difluorophenyl)sulfonylamino]cyclohexyl]methyl]-2,3-dihydro-1,4-benzodioxin-6-sulfonamide	sulfonamide		low
1-(3-chlorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine	sulfonamide		low
1-(3-bromophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine	sulfonamide		low
(1S,4S)-2-(2,6-difluorophenyl)sulfonyl-5-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-2,5-diazabicyclo[2.2.1]heptane	sulfonamide		low
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2,4,6-trifluorophenyl)sulfonylpiperazine	sulfonamide		low
N-(1-cyano-3-pyrrolidinyl)-3-methoxybenzenesulfonamide	sulfonamide		low
N-(1-cyano-3-pyrrolidinyl)-4-(trifluoromethyl)benzenesulfonamide	sulfonamide		low
N-(1-cyano-4-piperidinyl)-4-(trifluoromethyl)benzenesulfonamide	sulfonamide		low
4-[3-(3-methylphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide	sulfonamide		low
4-[3-(3-bromophenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide	sulfonamide		low
1-cyclohexyl-3-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-2-[[(4-methoxyphenyl)sulfonyl-methylamino]methyl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]urea	sulfonamide		low
N-[(2S,3S)-2-[[(3,4-dichlorophenyl)methyl-methylamino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-2-thiophenesulfonamide	sulfonamide		low
N-[(2S,3S)-2-[[(4-fluorophenyl)sulfonyl-methylamino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]cyclopropanecarboxamide	sulfonamide		low
N-[(2S,3S)-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]methanesulfonamide	sulfonamide		low
N-[[(2S,3S)-10-(dimethylamino)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-4-methoxy-N-methylbenzenesulfonamide	sulfonamide		low
N-[(2R,3S)-2-[[(4-chlorophenyl)sulfonyl-methylamino]methyl]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-9-yl]-4,4,4-trifluorobutanamide	sulfonamide		low
3-cyclohexyl-1-[[(2S,3S)-8-[(4-fluorophenyl)sulfonylamino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methylurea	sulfonamide		low
3-cyclohexyl-1-[[(2R,3R)-10-[(4-fluorophenyl)sulfonylamino]-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl]-1-methylurea	sulfonamide		low
4-chloro-N-[(2R,3R)-5-[(2S)-1-hydroxypropan-2-yl]-3-methyl-2-[[methyl(pyridin-4-ylmethyl)amino]methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]benzenesulfonamide	sulfonamide		low
1-[(2S,3S)-2-[[benzenesulfonyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-3-[4-(trifluoromethyl)phenyl]urea	sulfonamide		low
N-[(2S,3S)-2-[[cyclohexylmethyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-methoxybenzenesulfonamide	sulfonamide		low
N-[(2S,3S)-2-[[benzenesulfonyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-pyridinecarboxamide	sulfonamide		low
4-fluoro-N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-(methylaminomethyl)-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]benzenesulfonamide	sulfonamide		low
N-[(2R,3R)-2-[[(4-fluorophenyl)sulfonyl-methylamino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-2-(1-methyl-3-indolyl)acetamide	sulfonamide		low
1-[(2R,3R)-2-[[benzenesulfonyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-8-yl]-3-[4-(trifluoromethyl)phenyl]urea	sulfonamide		low
baricitinib	azetidines; nitrile; pyrazoles; pyrrolopyrimidine; sulfonamide	anti-inflammatory agent; antirheumatic drug; antiviral agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; immunosuppressive agent	low
1-(4-methoxyphenyl)sulfonyl-2-benzimidazolamine	sulfonamide		low
5,6-dimethyl-1-(4-methylphenyl)sulfonyl-2-benzimidazolamine	sulfonamide		low
sr1001	sulfonamide		low
N-[(2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-2-(methylaminomethyl)-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-10-yl]-4-methoxybenzenesulfonamide	sulfonamide		low
dabrafenib	1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide	anticoronaviral agent; antineoplastic agent; B-Raf inhibitor	low
3-[[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1,4-diazepan-1-yl]sulfonyl]aniline	benzenes; sulfonamide		low
4-[[(4-ethylphenyl)sulfonylamino]methyl]-N-[2-[(phenylmethyl)-propan-2-ylamino]ethyl]benzamide	sulfonamide		low
EG00229	benzothiadiazole; dicarboxylic acid monoamide; L-arginine derivative; secondary carboxamide; sulfonamide; thiophenes	angiogenesis inhibitor; antineoplastic agent; neuropilin receptor antagonist	low
xl765	aromatic amine; aromatic ether; benzamides; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor	low
N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)-oxomethyl]-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide	sulfonamide		low
tipranavir	sulfonamide	antiviral drug; HIV protease inhibitor	low
abt-333	aromatic ether; naphthalenes; pyrimidone; sulfonamide	antiviral drug; nonnucleoside hepatitis C virus polymerase inhibitor	low
pik 75	sulfonamide		low
vx-970	sulfonamide		low
pf-543	sulfonamide		low
ML355	benzothiazoles; monomethoxybenzene; phenols; secondary amino compound; substituted aniline; sulfonamide	EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; platelet aggregation inhibitor	low
sr9243	bromobenzenes; sulfonamide; sulfone	antineoplastic agent; apoptosis inducer; liver X receptor inverse agonist	low
sildenafil	piperazines; pyrazolopyrimidine; sulfonamide	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent	low
da 8159	sulfonamide		low
3-[[2-[4-(4-chlorophenyl)sulfonyl-1-piperazinyl]-2-oxoethyl]thio]-6-methyl-2H-1,2,4-triazin-5-one	sulfonamide		low
N-tert-butyl-3-(3-tert-butyl-1-methyl-7-oxo-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonamide	sulfonamide		low
N-[4-[2-[3-(dimethylsulfamoyl)anilino]-6H-1,3,4-thiadiazin-5-yl]phenyl]acetamide	sulfonamide		low
N-[2-[(4-chlorophenyl)methylthio]-4-oxo-1H-pyrimidin-6-yl]benzenesulfonamide	sulfonamide		low
N-[2-[(2-chlorophenyl)methylthio]-4-oxo-1H-pyrimidin-6-yl]-4-methylbenzenesulfonamide	sulfonamide		low
N-(4-methoxyphenyl)-2-[[6-[(4-methylphenyl)sulfonylamino]-4-oxo-1H-pyrimidin-2-yl]thio]acetamide	sulfonamide		low
mirodenafil	aromatic ether; N-alkylpiperazine; primary alcohol; pyrrolopyrimidine; sulfonamide	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent	low
da-8164	sulfonamide		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
caffeine	1	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic	2017	2017	7.0	low	0	1	0
glyburide	2	monochlorobenzenes; N-sulfonylurea	anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent	2017	2022	4.5	low	0	1	1
1-methyl-3-isobutylxanthine	1	3-isobutyl-1-methylxanthine		2017	2017	7.0	low	0	1	0
pioglitazone	2	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic	2020	2022	3.0	low	0	1	1
troglitazone	2	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent	2017	2020	5.5	low	0	2	0
ribavirin	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor	2013	2013	11.0	low	0	1	0
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine	2	adenosines; monocarboxylic acid amide; organoiodine compound	adenosine A3 receptor agonist	2017	2020	5.5	low	0	2	0
2-chloro-n(6)cyclopentyladenosine	1			2017	2017	7.0	low	0	1	0
adenosine-5'-(n-ethylcarboxamide)	1	adenosines; monocarboxylic acid amide	adenosine A1 receptor agonist; adenosine A2A receptor agonist; antineoplastic agent; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; vasodilator agent	2017	2017	7.0	low	0	1	0
4-dimethylaminostilbene	1			2012	2012	12.0	low	0	1	0
t 0070907	1	carbonyl compound; organohalogen compound		2013	2013	11.0	low	0	1	0
gsk 3787	3			2010	2017	10.0	high	1	2	0
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide	2			2017	2020	5.5	low	0	2	0
2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine	1	adenosines; dicarboxylic acid monoamide; monocarboxylic acid	adenosine A2A receptor agonist; anti-inflammatory agent	2017	2017	7.0	low	0	1	0
gw 7647	2	aryl sulfide; monocarboxylic acid; ureas	PPARalpha agonist	2017	2022	4.5	low	0	1	1
mre 3008-f20	1			2017	2017	7.0	low	0	1	0
gw 1929	3	benzophenones		2017	2022	4.3	low	0	2	1
gw 501516	5	1,3-thiazoles; aromatic ether; aryl sulfide; monocarboxylic acid; organofluorine compound	carcinogenic agent; PPARbeta/delta agonist	2010	2022	7.2	low	1	3	1
lj 529	2			2017	2020	5.5	medium	0	2	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
hydrogen sulfide	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent	2023	2023	1.0	low	0	0	1
3,4-dihydroxyphenylacetic acid	1	catechols; dihydroxyphenylacetic acid	human metabolite	2013	2013	11.0	low	0	1	0
formaldehyde	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2020	2020	4.0	low	0	1	0
palmitic acid	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite	2015	2015	9.0	low	0	1	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	2	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector	2010	2019	9.5	low	1	1	0
oxidopamine	1	benzenetriol; catecholamine; primary amino compound	drug metabolite; human metabolite; neurotoxin	2023	2023	1.0	low	0	0	1
pirinixic acid	1	aryl sulfide; organochlorine compound; pyrimidines		2016	2016	8.0	low	0	1	0
tyrosine	4	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical	2010	2020	7.8	low	1	3	0
thiophenes	39	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent	2008	2021	8.7	high	6	31	2
oxazoles	3	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2016	2020	5.7	low	0	3	0
thiazoles	24	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2008	2023	9.1	medium	5	18	1
vanadates	1	trivalent inorganic anion; vanadium oxoanion	EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor	2014	2014	10.0	low	0	1	0
telmisartan	1	benzimidazoles; biphenyls; carboxybiphenyl	angiotensin receptor antagonist; antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; environmental contaminant; xenobiotic	2016	2016	8.0	low	0	1	0
rosiglitazone	1	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug	2016	2016	8.0	low	0	1	0
cannabidiolic acid	1	dihydroxybenzoic acid; phytocannabinoid; polyketide; resorcinols		2020	2020	4.0	low	0	1	0
angiotensin ii	1	amino acid zwitterion; angiotensin II	human metabolite	2016	2016	8.0	low	0	1	0
sb 203580	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	2019	2019	5.0	low	0	1	0
3-nitrotyrosine	1	2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid		2010	2010	14.0	low	1	0	0
elastin	1	oligopeptide		2014	2014	10.0	low	0	1	0
oleic acid	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent	2019	2019	5.0	low	0	1	0
gw 6471	3			2016	2020	5.7	low	0	3	0
gw9662	4	benzamides		2010	2020	7.8	low	1	3	0
digoxin	1	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope	2010	2010	14.0	low	1	0	0
n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine	1	toluenes		2019	2019	5.0	low	0	1	0
l 663536	1	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist	2019	2019	5.0	low	0	1	0
20-hydroxy-5,8,11,14-eicosatetraenoic acid	1	HETE; hydroxy monocarboxylic acid	human metabolite; mouse metabolite	2019	2019	5.0	low	0	1	0
lysophosphatidylcholines	1	1-O-acyl-sn-glycero-3-phosphocholine		2016	2016	8.0	low	0	1	0
l-165041	1	aromatic ketone		2010	2010	14.0	low	1	0	0
gw 501516	7	1,3-thiazoles; aromatic ether; aryl sulfide; monocarboxylic acid; organofluorine compound	carcinogenic agent; PPARbeta/delta agonist	2010	2023	7.3	low	1	5	1
etomoxir	1	aromatic ether		2010	2010	14.0	low	1	0	0
mocetinostat	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent	2010	2010	14.0	low	1	0	0
gw0742	17	monocarboxylic acid		2008	2020	9.9	medium	4	13	0
calcimycin	2	benzoxazole		2015	2016	8.5	low	0	2	0
gyy 4137	1	organic molecular entity		2023	2023	1.0	low	0	0	1
sapropterin	1	5,6,7,8-tetrahydrobiopterin	coenzyme; cofactor; diagnostic agent; human metabolite	2019	2019	5.0	low	0	1	0
leptin	2			2021	2021	3.0	low	0	0	2

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's	post-2020
Acute Lung Injury	2	2014	2014	10.0	low	0	2	0
Alloxan Diabetes	2	2010	2017	10.5	low	1	1	0
Autosomal Dominant Juvenile Parkinson Disease	1	2013	2013	11.0	low	0	1	0
Blood Poisoning	1	2018	2018	6.0	low	0	1	0
Blood Pressure, High	2	2015	2016	8.5	low	0	2	0
Breast Cancer	1	2020	2020	4.0	low	0	1	0
Breast Neoplasms	1	2020	2020	4.0	low	0	1	0
Cancer of Prostate	1	2016	2016	8.0	low	0	1	0
Cardiac Hypertrophy	2	2018	2021	4.5	low	0	1	1
Cardiac Remodeling, Ventricular	1	2021	2021	3.0	low	0	0	1
Cardiomegaly	2	2018	2021	4.5	low	0	1	1
Congenital Zika Syndrome	1	2020	2020	4.0	low	0	1	0
Depression	1	2019	2019	5.0	low	0	1	0
Diabetic Glomerulosclerosis	1	2019	2019	5.0	low	0	1	0
Diabetic Nephropathies	1	2019	2019	5.0	low	0	1	0
Disease Models, Animal	7	2010	2023	9.0	low	1	5	1
Endotoxin Shock	1	2010	2010	14.0	low	1	0	0
Hepatitis C	1	2013	2013	11.0	low	0	1	0
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted	1	2013	2013	11.0	low	0	1	0
Hyperglycemia	1	2018	2018	6.0	low	0	1	0
Hyperglycemia, Postprandial	1	2018	2018	6.0	low	0	1	0
Hyperoxia	1	2014	2014	10.0	low	0	1	0
Hypertension	2	2015	2016	8.5	low	0	2	0
Idiopathic Parkinson Disease	1	2023	2023	1.0	low	0	0	1
Infertility, Female	1	2020	2020	4.0	low	0	1	0
Inflammation	6	2016	2023	4.7	low	0	4	2
Injuries, Spinal Cord	1	2010	2010	14.0	low	1	0	0
Injury, Ischemia-Reperfusion	1	2023	2023	1.0	low	0	0	1
Innate Inflammatory Response	6	2016	2023	4.7	low	0	4	2
Insulin Resistance	3	2010	2017	10.0	low	1	2	0
Insulin Sensitivity	3	2010	2017	10.0	low	1	2	0
Ischemia	1	2023	2023	1.0	low	0	0	1
Leukostasis	1	2020	2020	4.0	low	0	1	0
Lung Injury, Acute	2	2014	2014	10.0	low	0	2	0
Neovascularization, Optic Disc	1	2013	2013	11.0	low	0	1	0
Neuroretinitis	1	2020	2020	4.0	low	0	1	0
Nociceptive Pain	1	2020	2020	4.0	low	0	1	0
Obesity	1	2015	2015	9.0	low	0	1	0
Palmoplantaris Pustulosis	1	2012	2012	12.0	low	0	1	0
Parkinson Disease	1	2023	2023	1.0	low	0	0	1
Parkinsonian Disorders	1	2013	2013	11.0	low	0	1	0
Prostatic Neoplasms	1	2016	2016	8.0	low	0	1	0
Psoriasis	1	2012	2012	12.0	low	0	1	0
Reperfusion Injury	1	2023	2023	1.0	low	0	0	1
Retinal Diseases	1	2013	2013	11.0	low	0	1	0
Retinal Neovascularization	1	2013	2013	11.0	low	0	1	0
Retinitis	1	2020	2020	4.0	low	0	1	0
Sepsis	1	2018	2018	6.0	low	0	1	0
Shock, Septic	1	2010	2010	14.0	low	1	0	0
Spinal Cord Injuries	1	2010	2010	14.0	low	1	0	0
Sterility, Female	1	2020	2020	4.0	low	0	1	0
Zika Virus Infection	1	2020	2020	4.0	low	0	1	0

Safety/Toxicity (2)

Article	Year
Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation. Lipids, , Volume: 50, Issue:10	2015
Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels. Experimental lung research, , Volume: 40, Issue:3	2014

Bioavailability (4)

Article	Year
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5	2019
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction. Biochemical pharmacology, , 06-15, Volume: 110-111	2016
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction. Clinical science (London, England : 1979), , Volume: 129, Issue:9	2015
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. Journal of medicinal chemistry, , Mar-22, Volume: 55, Issue:6	2012

Dosage (1)

Article	Year
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility? The Journal of clinical endocrinology and metabolism, , 09-01, Volume: 105, Issue:9	2020