sulpiride has been researched along with Insulin Resistance in 7 studies
Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulpiride is an old antipsychotic still frequently used in many developing countries." | 5.48 | The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance. ( Huang, X; Li, Y; Ren, L; Wang, C; Yu, Z; Zhou, X, 2018) |
| "In this study we compared the acute, non-adiposity related effects of a single dose of olanzapine, amisulpride and placebo on insulin sensitivity and secretion in 10 healthy subjects in a randomised, double blind cross-over design." | 5.16 | Insulin secretion and sensitivity after single-dose amisulpride, olanzapine or placebo in young male subjects: double blind, cross-over glucose clamp study. ( Deuschle, M; Gilles, M; Kopf, D; Lederbogen, F; Lehnert, H; Medlin, F; Paslakis, G, 2012) |
| "The present study aimed to investigate the effects of clozapine, olanzapine, risperidone, and sulpiride on glucose and lipid metabolism in first-episode schizophrenia." | 5.12 | Effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia. ( Guo, WB; Guo, XF; Liu, ZN; Tang, JS; Wu, RR; Zhai, JG; Zhao, JP, 2006) |
| " We conducted a prospective, open study comparing body weight, parameters of insulin resistance in schizophrenia patients treated with either clozapine (n = 10) or amisuLpride ( n = 12)." | 3.74 | Alterations of glucose metabolism during treatment with clozapine or amisulpride: results from a prospective 16-week study. ( Baumgartner, S; Ebenbichler, C; Edlinger, M; Hofer, A; Hummer, M; Kemmler, G; Lechleitner, M; Rettenbacher, MA; Wolfgang Fleischhacker, W, 2007) |
| " To assess the role of insulin in the development of the obesity induced by antipsychotic drugs, a glucose tolerance test was conducted in female rats after 0 or 30 days of sulpiride administration." | 3.70 | Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs. ( Alvarez, L; Baptista, T; de Mendoza, S; Hernández, L; Lacruz, A, 1999) |
| "Sulpiride is an old antipsychotic still frequently used in many developing countries." | 1.48 | The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance. ( Huang, X; Li, Y; Ren, L; Wang, C; Yu, Z; Zhou, X, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, X | 1 |
| Ren, L | 1 |
| Yu, Z | 1 |
| Huang, X | 1 |
| Li, Y | 1 |
| Wang, C | 1 |
| Valencia, NA | 1 |
| Thompson, DL | 1 |
| Mitcham, PB | 1 |
| Kopf, D | 1 |
| Gilles, M | 1 |
| Paslakis, G | 1 |
| Medlin, F | 1 |
| Lederbogen, F | 1 |
| Lehnert, H | 1 |
| Deuschle, M | 1 |
| Wu, RR | 1 |
| Zhao, JP | 1 |
| Liu, ZN | 1 |
| Zhai, JG | 1 |
| Guo, XF | 1 |
| Guo, WB | 1 |
| Tang, JS | 1 |
| Rettenbacher, MA | 1 |
| Hummer, M | 1 |
| Hofer, A | 1 |
| Baumgartner, S | 1 |
| Ebenbichler, C | 1 |
| Edlinger, M | 1 |
| Kemmler, G | 1 |
| Lechleitner, M | 1 |
| Wolfgang Fleischhacker, W | 1 |
| Baptista, T | 2 |
| Alvarez, L | 1 |
| Lacruz, A | 2 |
| de Mendoza, S | 1 |
| Hernández, L | 2 |
| Pàez, X | 1 |
| Beaulieu, S | 1 |
2 trials available for sulpiride and Insulin Resistance
| Article | Year |
|---|---|
Insulin secretion and sensitivity after single-dose amisulpride, olanzapine or placebo in young male subjects: double blind, cross-over glucose clamp study.
Topics: Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; C-Peptide; Cross-Over Studies; Double-Bli | 2012 |
Effects of typical and atypical antipsychotics on glucose-insulin homeostasis and lipid metabolism in first-episode schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Mass Index; C-Peptide; Cholesterol | 2006 |
5 other studies available for sulpiride and Insulin Resistance
| Article | Year |
|---|---|
The antipsychotics sulpiride induces fatty liver in rats via phosphorylation of insulin receptor substrate-1 at Serine 307-mediated adipose tissue insulin resistance.
Topics: Adipose Tissue; Animals; Antipsychotic Agents; Fatty Liver; Insulin Receptor Substrate Proteins; Ins | 2018 |
Changes in plasma melanocyte-stimulating hormone, ACTH, prolactin, GH, LH, FSH, and thyroid-stimulating hormone in response to injection of sulpiride, thyrotropin-releasing hormone, or vehicle in insulin-sensitive and -insensitive mares.
Topics: Adrenocorticotropic Hormone; Animals; Dopamine Antagonists; Female; Follicle Stimulating Hormone; Gr | 2013 |
Alterations of glucose metabolism during treatment with clozapine or amisulpride: results from a prospective 16-week study.
Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Body Mass Index; Clozapine; Female; Gluc | 2007 |
Glucose tolerance and serum insulin levels in an animal model of obesity induced by sub-acute or chronic administration of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Glucose Tolerance Test; Hyperinsulini | 1999 |
The antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin resistance involved?
Topics: Animals; Antipsychotic Agents; Body Weight; Dehydroepiandrosterone Sulfate; Dopamine; Dose-Response | 2002 |