alpha-methylserotonin has been researched along with Insulin Resistance in 3 studies
alpha-methylserotonin: potent agonist at M & D receptors of serotonin; RN given refers to parent cpd
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to determine the effect of acute insulin resistance caused by the peripheral vasoconstrictor alpha-methylserotonin (alphaMT) on microvascular vasomotion in muscle." | 3.75 | Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance. ( Clark, MG; Dwyer, RM; Newman, JM; Rattigan, S; Richards, SM; St-Pierre, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Newman, JM | 1 |
| Dwyer, RM | 1 |
| St-Pierre, P | 1 |
| Richards, SM | 1 |
| Clark, MG | 2 |
| Rattigan, S | 2 |
| Wiernsperger, N | 1 |
| Bouskela, E | 1 |
| Barrett, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome[NCT02633488] | 19 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)[NCT03883412] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-02-28 | Recruiting | ||
| The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans[NCT02490124] | 7 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes[NCT03174288] | 32 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
brachial artery ultrasonography % flow-mediated dilatation (FMD) for assessing endothelial function before and after an insulin clamp to assess insulin's effect on the vasculature (NCT02633488)
Timeframe: before and after 12 weeks on placebo or metformin
| Intervention | percentage of artery dilation (Mean) |
|---|---|
| Pre and Post Placebo 12 Weeks | 6.1 |
| Pre and Post Metformin 12 Weeks | 6.2 |
3 other studies available for alpha-methylserotonin and Insulin Resistance
| Article | Year |
|---|---|
Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance.
Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Disease Models, Animal; | 2009 |
Microvascular haemodynamic reactions to insulin.
Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Disease Models, Animal; | 2009 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Glucose Clamp Technique; Hemodynamics; Hindlimb | 1999 |