aspartic acid has been researched along with Insulin Resistance in 15 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baseline plasma aspartic acid and asparagine levels predicted progression to prediabetes, whereas histidine levels were protective of prediabetes risk." | 3.91 | Amino acid signature predictive of incident prediabetes: A case-control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort. ( Dagogo-Jack, S; Owei, I; Stentz, F; Umekwe, N; Wan, J, 2019) |
| "We identified a heterozygous missense mutation that substituted aspartic acid (GAC) for alanine (GCC) at codon 1048 of the insulin receptor gene in a patient who displayed typical symptoms of Type A syndrome of insulin resistance." | 3.68 | Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance. ( Egawa, K; Haruta, T; Imamura, T; Itazu, T; Iwanishi, M; Kobayashi, M; Maegawa, H; Takata, Y, 1993) |
| "The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP)." | 1.39 | In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. ( Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, Y | 3 |
| Zheng, Y | 3 |
| Zhao, X | 3 |
| Li, Z | 3 |
| Wang, G | 3 |
| Hofer, DC | 1 |
| Zirkovits, G | 1 |
| Pelzmann, HJ | 1 |
| Huber, K | 1 |
| Pessentheiner, AR | 1 |
| Xia, W | 1 |
| Uno, K | 1 |
| Miyazaki, T | 1 |
| Kon, K | 1 |
| Tsuneki, H | 1 |
| Pendl, T | 1 |
| Zoughbi, WA | 1 |
| Madreiter-Sokolowski, CT | 1 |
| Trausinger, G | 1 |
| Abdellatif, M | 1 |
| Schoiswohl, G | 1 |
| Schreiber, R | 1 |
| Eisenberg, T | 1 |
| Magnes, C | 1 |
| Sedej, S | 1 |
| Eckhardt, M | 1 |
| Sasahara, M | 1 |
| Sasaoka, T | 1 |
| Nitta, A | 1 |
| Hoefler, G | 1 |
| Graier, WF | 1 |
| Kratky, D | 1 |
| Auwerx, J | 1 |
| Bogner-Strauss, JG | 1 |
| Verrier, ER | 1 |
| Weiss, A | 1 |
| Bach, C | 1 |
| Heydmann, L | 1 |
| Turon-Lagot, V | 1 |
| Kopp, A | 1 |
| El Saghire, H | 1 |
| Crouchet, E | 1 |
| Pessaux, P | 1 |
| Garcia, T | 1 |
| Pale, P | 1 |
| Zeisel, MB | 1 |
| Sureau, C | 1 |
| Schuster, C | 1 |
| Brino, L | 1 |
| Baumert, TF | 1 |
| Vangipurapu, J | 1 |
| Stancáková, A | 1 |
| Smith, U | 1 |
| Kuusisto, J | 1 |
| Laakso, M | 1 |
| Owei, I | 1 |
| Umekwe, N | 1 |
| Stentz, F | 1 |
| Wan, J | 1 |
| Dagogo-Jack, S | 1 |
| Fried, PJ | 1 |
| Pascual-Leone, A | 1 |
| Bolo, NR | 1 |
| Murray, PG | 1 |
| Butcher, I | 1 |
| Dunn, WB | 1 |
| Stevens, A | 1 |
| Perchard, R | 1 |
| Hanson, D | 1 |
| Whatmore, A | 1 |
| Westwood, M | 1 |
| Clayton, PE | 1 |
| Chen, ZC | 1 |
| Shin, SJ | 1 |
| Kuo, KK | 1 |
| Lin, KD | 1 |
| Yu, ML | 1 |
| Hsiao, PJ | 1 |
| Ogawa, W | 1 |
| Iwamoto, K | 1 |
| Mori, H | 1 |
| Hashiramoto, M | 1 |
| Miyake, K | 1 |
| Sakaguchi, K | 1 |
| Kasuga, M | 1 |
| Barfield, E | 1 |
| Liu, YH | 1 |
| Kessler, M | 1 |
| Pawelczak, M | 1 |
| David, R | 1 |
| Shah, B | 1 |
| Lee, P | 1 |
| Leong, W | 1 |
| Tan, T | 1 |
| Lim, M | 1 |
| Han, W | 1 |
| Radda, GK | 1 |
| Haruta, T | 2 |
| Takata, Y | 2 |
| Iwanishi, M | 2 |
| Maegawa, H | 1 |
| Imamura, T | 2 |
| Egawa, K | 1 |
| Itazu, T | 1 |
| Kobayashi, M | 2 |
| Dubois-Laforgue, D | 1 |
| Caillat-Zucman, S | 1 |
| Boitard, C | 1 |
| Timsit, J | 1 |
| Stumvoll, M | 1 |
| Wahl, HG | 1 |
| Jacob, S | 1 |
| Rettig, A | 1 |
| Machicao, F | 1 |
| Häring, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for aspartic acid and Insulin Resistance
| Article | Year |
|---|---|
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes.
Topics: Adult; Aspartic Acid; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Cysteine; Diabetes Me | 2023 |
Topics: Acetyl Coenzyme A; Acetyltransferases; Adipocytes; Animals; Aspartic Acid; Brain; Diet, Fat-Restrict | 2019 |
Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets.
Topics: Antiviral Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Gluta | 2020 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow | 2019 |
Amino acid signature predictive of incident prediabetes: A case-control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort.
Topics: Adult; Amino Acids; Asparagine; Aspartic Acid; Black or African American; Blood Glucose; Case-Contro | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; | 2019 |
Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age.
Topics: Alanine; Amino Acids; Aspartic Acid; Body Height; Child; Child, Preschool; Female; Fibroblasts; Gest | 2016 |
Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance.
Topics: Adult; Aged; Amino Acid Substitution; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily G, | 2008 |
Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene.
Topics: Adolescent; Amino Acid Substitution; Aspartic Acid; Female; Genetic Carrier Screening; Genetic Varia | 2009 |
The prevalence of abnormal liver enzymes and metabolic syndrome in obese adolescent females with polycystic ovary syndrome.
Topics: Adolescent; Alanine Transaminase; Aspartic Acid; Child; Cross-Sectional Studies; Fatty Liver; Female | 2009 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2013 |
Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.
Topics: Adolescent; Adult; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Cell Line; C | 1993 |
Importance of Asp1191 for tyrosine kinase activity of the insulin receptor: functional difference of universally conserved Asp between tyrosine kinase and c-AMP dependent serine/threonine protein kinase.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Line; Conserved Sequence; Cyclic AMP-Dependent Pro | 1993 |
Clinical characteristics of type 2 diabetes in patients with mutations of HFE.
Topics: Amino Acid Substitution; Aspartic Acid; Cysteine; Diabetes Mellitus, Type 2; Female; Ferritins; Hemo | 2000 |
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
Topics: Adult; Alleles; Aspartic Acid; Blood Glucose; Exons; Fatty Acids, Nonesterified; Female; Glucose Cla | 2001 |