phentolamine has been researched along with Insulin Resistance in 9 studies
Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
phentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phentolamine, which had no effect in the wild-type mice, normalised the insulin sensitivity in the mice lacking the nNOS gene." | 3.74 | Insulin resistance in mice lacking neuronal nitric oxide synthase is related to an alpha-adrenergic mechanism. ( Burcelin, R; Cook, S; Jayet, PY; Mathieu, C; Nicod, P; Sartori, C; Scherrer, U; Thalmann, S; Turini, P; Vollenweider, P, 2007) |
| " To test the role of the adrenergic system, alpha- and beta-adrenergic receptor antagonists, phentolamine and propranolol, were tested for the ability to block HDIR produced by hemorrhage." | 3.73 | Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in rats. ( Lautt, WW; Seredycz, LI, 2006) |
| "The isoproterenol-induced increase in EGC was higher after the training." | 2.71 | Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects. ( Berlan, M; Hejnova, J; Klimcakova, E; Lafontan, M; Langin, D; Majercik, M; Moro, C; Polak, J; Stich, V; Viguerie, N, 2005) |
| "Propranolol was also able to ameliorate the hepatic insulin resistance produced by TNF." | 1.29 | Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. ( Lang, CH, 1993) |
| " Dose-response curves for phentolamine and propranolol established maximally effective doses (3." | 1.28 | Influence of sympatho-adrenal system on insulin sensitivity using the euglycemic clamp technique. ( Funado, T; Iguchi, A; Iida, T; Kato, K; Kusunoki, M; Oshida, Y; Sakamoto, N; Sato, Y; Suga, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morton, GJ | 1 |
| Muta, K | 1 |
| Kaiyala, KJ | 1 |
| Rojas, JM | 1 |
| Scarlett, JM | 1 |
| Matsen, ME | 1 |
| Nelson, JT | 1 |
| Acharya, NK | 1 |
| Piccinini, F | 1 |
| Stefanovski, D | 1 |
| Bergman, RN | 1 |
| Taborsky, GJ | 1 |
| Kahn, SE | 1 |
| Schwartz, MW | 1 |
| Polak, J | 1 |
| Moro, C | 1 |
| Klimcakova, E | 1 |
| Hejnova, J | 1 |
| Majercik, M | 1 |
| Viguerie, N | 1 |
| Langin, D | 1 |
| Lafontan, M | 1 |
| Stich, V | 1 |
| Berlan, M | 1 |
| Seredycz, LI | 1 |
| Lautt, WW | 1 |
| Turini, P | 1 |
| Thalmann, S | 1 |
| Jayet, PY | 1 |
| Cook, S | 1 |
| Mathieu, C | 1 |
| Burcelin, R | 1 |
| Nicod, P | 1 |
| Vollenweider, P | 1 |
| Sartori, C | 1 |
| Scherrer, U | 1 |
| Fujimoto, K | 1 |
| Sakaguchi, T | 1 |
| Ui, M | 1 |
| Lang, CH | 1 |
| Virkamäki, A | 1 |
| Yki-Järvinen, H | 1 |
| Kusunoki, M | 1 |
| Oshida, Y | 1 |
| Iguchi, A | 1 |
| Iida, T | 1 |
| Suga, T | 1 |
| Funado, T | 1 |
| Sato, Y | 1 |
| Kato, K | 1 |
| Sakamoto, N | 1 |
| Bosquet, F | 1 |
| Grimaldi, A | 1 |
1 review available for phentolamine and Insulin Resistance
| Article | Year |
|---|---|
[Blood glucose counter-regulation].
Topics: Adrenergic beta-Antagonists; Blood Glucose; Diabetes Mellitus, Type 1; Epinephrine; Fatty Acids; Glu | 1985 |
1 trial available for phentolamine and Insulin Resistance
| Article | Year |
|---|---|
Dynamic strength training improves insulin sensitivity and functional balance between adrenergic alpha 2A and beta pathways in subcutaneous adipose tissue of obese subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Recept | 2005 |
7 other studies available for phentolamine and Insulin Resistance
| Article | Year |
|---|---|
Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Cold Temperature; Glucose Clamp Technique; Ins | 2017 |
Hemorrhage results in hepatic insulin-sensitizing substance-dependent insulin resistance mediated by somatostatin in rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Blood Glucose; Glucose Clamp Technique; Hemorrhage | 2006 |
Insulin resistance in mice lacking neuronal nitric oxide synthase is related to an alpha-adrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Female; Glucose Clamp Technique; Insulin Resis | 2007 |
Adrenergic mechanisms in the hyperglycaemia and hyperinsulinaemia of diabetic KK mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epinephrine; Insulin; Insulin Resistance; M | 1981 |
Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Glucose; Glucose Clamp Technique; Insulin; Insulin R | 1993 |
Mechanisms of insulin resistance during acute endotoxemia.
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Endotoxins; Glycogen; Glycolysis; Insulin Re | 1994 |
Influence of sympatho-adrenal system on insulin sensitivity using the euglycemic clamp technique.
Topics: Adrenal Medulla; Animals; Dose-Response Relationship, Drug; Epinephrine; Glucose; Glucose Clamp Tech | 1992 |