Compounds > 2-hydroxy-3-methylanthraquinone

2-hydroxy-3-methylanthraquinone and Insulin-Resistance

2-hydroxy-3-methylanthraquinone has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for 2-hydroxy-3-methylanthraquinone and Insulin-Resistance

Article	Year
Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation. Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1 AMP-activated protein kinase (AMPK) activators are known to increase energy metabolism and to reduce body weight, as well as to improve glucose uptake. During for searching AMPK activators, a new anthraquinone, modasima A (10), along with eighteen known analogues (1-9 and 11-19) were isolated from an ethanol extract of the roots of Morinda longissima Y. Z. Ruan (Rubiaceae). Using the fluorescent tagged glucose analogues, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-D-glucose (2-NBDG), insulin mimetics were screened with compounds 1-19 in 3T3-L1 adipocytes. Among them, compounds 2, 8 and 10 enhanced significantly glucose uptake into adipocytes and up-regulated the phosphorylated AMPK (Thr Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Anthraquinones; Dose-Response Relationship, Drug; Glucose; Insulin Resistance; Mice; Molecular Structure; Morinda; Plant Extracts; Plant Roots; Structure-Activity Relationship	2017

Article

Year

Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation.

Bioorganic & medicinal chemistry letters, 2017, 01-01, Volume: 27, Issue:1

AMP-activated protein kinase (AMPK) activators are known to increase energy metabolism and to reduce body weight, as well as to improve glucose uptake. During for searching AMPK activators, a new anthraquinone, modasima A (10), along with eighteen known analogues (1-9 and 11-19) were isolated from an ethanol extract of the roots of Morinda longissima Y. Z. Ruan (Rubiaceae). Using the fluorescent tagged glucose analogues, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-D-glucose (2-NBDG), insulin mimetics were screened with compounds 1-19 in 3T3-L1 adipocytes. Among them, compounds 2, 8 and 10 enhanced significantly glucose uptake into adipocytes and up-regulated the phosphorylated AMPK (Thr

Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Anthraquinones; Dose-Response Relationship, Drug; Glucose; Insulin Resistance; Mice; Molecular Structure; Morinda; Plant Extracts; Plant Roots; Structure-Activity Relationship

2017