indomethacin has been researched along with Insulin Resistance in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks." | 7.80 | Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 7.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 5.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| " The results showed that amygdalin and cinnamic acid inhibit serine phosphorylation of IRS-1 through targeting JNK serine kinase and enhance insulin sensitivity." | 3.81 | Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance. ( Kim, MJ; Rangasamy, S; Shim, Y; Song, JM, 2015) |
| " To examine how administration of the anti-inflammatory compound indomethacin, a general cyclooxygenase inhibitor, affected obesity development and insulin sensitivity, we fed obesity-prone male C57BL/6J mice a high fat/high sucrose (HF/HS) diet or a regular diet supplemented or not with indomethacin (±INDO) for 7 weeks." | 3.80 | Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ( Aune, UL; Borkowski, K; Fjære, E; Haj, FG; Hudson, BD; Keenan, AH; Kristensen, DM; Kristiansen, K; Liaset, B; Ma, T; Madsen, L; Mandrup-Poulsen, T; Milligan, G; Newman, JW; Novotny, GW; Røen, K; Xi, Y, 2014) |
| "To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)." | 3.74 | Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008) |
| "Metformin treatment improved these alterations." | 1.38 | Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. ( Akamine, EH; Carvalho, MH; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS; Pariz, JR; Tostes, RC, 2012) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 1.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xian, T | 1 |
| Gan, Y | 1 |
| Lu, Y | 1 |
| Wang, M | 1 |
| Yuan, W | 1 |
| Zhou, Y | 1 |
| Chen, J | 1 |
| Wang, K | 1 |
| Xiong, S | 1 |
| Huang, Q | 1 |
| Fjære, E | 1 |
| Aune, UL | 1 |
| Røen, K | 1 |
| Keenan, AH | 1 |
| Ma, T | 1 |
| Borkowski, K | 1 |
| Kristensen, DM | 1 |
| Novotny, GW | 1 |
| Mandrup-Poulsen, T | 1 |
| Hudson, BD | 1 |
| Milligan, G | 1 |
| Xi, Y | 1 |
| Newman, JW | 1 |
| Haj, FG | 1 |
| Liaset, B | 1 |
| Kristiansen, K | 1 |
| Madsen, L | 1 |
| Kim, MJ | 1 |
| Rangasamy, S | 1 |
| Shim, Y | 1 |
| Song, JM | 1 |
| Xue, W | 1 |
| Zhang, M | 1 |
| Li, J | 1 |
| Wu, D | 1 |
| Niu, L | 1 |
| Liang, Y | 1 |
| Katakam, PV | 1 |
| Domoki, F | 1 |
| Snipes, JA | 1 |
| Busija, AR | 1 |
| Jarajapu, YP | 1 |
| Busija, DW | 3 |
| Zhang, J | 1 |
| Wang, J | 1 |
| Wu, H | 1 |
| He, Y | 2 |
| Zhu, G | 1 |
| Cui, X | 1 |
| Tang, L | 1 |
| Wu, HT | 1 |
| Chen, W | 1 |
| Cheng, KC | 1 |
| Yeh, CH | 1 |
| Shen, KH | 1 |
| Cheng, JT | 1 |
| Lobato, NS | 1 |
| Filgueira, FP | 1 |
| Hagihara, GN | 1 |
| Akamine, EH | 1 |
| Pariz, JR | 1 |
| Tostes, RC | 1 |
| Carvalho, MH | 1 |
| Fortes, ZB | 1 |
| Ettarh, RR | 1 |
| Arikawe, AP | 1 |
| Wasner, HK | 1 |
| Weber, S | 1 |
| Partke, HJ | 1 |
| Amini-Hadi-Kiashar, H | 1 |
| Kashiwagi, A | 1 |
| Shinozaki, K | 1 |
| Nishio, Y | 1 |
| Okamura, T | 1 |
| Toda, N | 1 |
| Kikkawa, R | 1 |
| MacLeod, KM | 1 |
| Erdös, B | 1 |
| Miller, AW | 2 |
| Tulbert, C | 1 |
| Puskar, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Acute or Chronic Ingestion of Sucralose on Serum Insulin in Young and Healthy Adults: a Randomized, Double-blind, Placebo-controlled Trial[NCT03703141] | 95 participants (Actual) | Interventional | 2016-09-27 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for indomethacin and Insulin Resistance
| Article | Year |
|---|---|
Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug | 2018 |
Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.
Topics: Animals; Cell Line; Cyclooxygenase Inhibitors; Diet, High-Fat; Fatty Acids, Nonesterified; Glucose T | 2014 |
Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Aspirin; Cinnamates; Forkhead Box Protein O1; F | 2015 |
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure; | 2008 |
Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.
Topics: Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Diazoxide; Disease Models, Animal; Dose-Respo | 2009 |
Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cyclooxygenase | 2009 |
Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model.
Topics: Adipose Tissue; Animals; Cell Movement; Cotton Fiber; Cyclooxygenase 2; Dinoprostone; Disease Models | 2010 |
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Dyslipidemias; Epoprost | 2012 |
Effects of diabetes and insulin resistance in pregnant rats on ex vivo vascular reaction to magnesium.
Topics: Alloxan; Animals; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Female; In Vitro Techniques | 2004 |
Indomethacin treatment causes loss of insulin action in rats: involvement of prostaglandins in the mechanism of insulin action.
Topics: Adipocytes; Animals; Blood Glucose; Cyclic AMP; Indomethacin; Inositol Phosphates; Insulin; Insulin | 1994 |
Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state.
Topics: Acetylcholine; Animals; Calcimycin; Endothelium, Vascular; Free Radicals; Fructose; Hyperinsulinism; | 1999 |
Modulation of noradrenaline-induced vasoconstriction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin.
Topics: Animals; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Indomethacin; Insulin; Insulin | 2002 |
Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Calcimycin; Endothelium, Vascular; Enz | 2002 |
Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dose-Response Relationship, Drug; Endothelin Receptor Antagon | 2002 |